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Article: Case Report: Primary Thoracic Low-Grade Fibromyxoid Sarcoma in a Young Girl Presenting With Mediastinal Mass Syndrome.

Chan, Yat Chi / Kan, Amanda N C / Yuen, Liz Y P / Wan, Innes Y P / Fung, Kevin K F / Cheung, Yiu-Fai / Leung, Karen K Y / Ku, Dennis T L / Liu, Anthony P Y

Frontiers in pediatrics

2022 Volume 10, Page(s) 885068

Abstract: Low-grade fibromyxoid sarcomas (LGFMSs) are typically adult-onset tumors that arise from the extremities. Here, we report an exceptional case of primary thoracic LGFMS in an 8-year-old girl that resulted in mediastinal syndrome. In reporting this case, ... ...

Abstract	Low-grade fibromyxoid sarcomas (LGFMSs) are typically adult-onset tumors that arise from the extremities. Here, we report an exceptional case of primary thoracic LGFMS in an 8-year-old girl that resulted in mediastinal syndrome. In reporting this case, we discuss the clinical challenges, role of molecular profiling and review reported cases of pediatric thoracic LGFMSs.
Language	English
Publishing date	2022-06-17
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2022.885068
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Ten-Year Experience of Chest Wall Reconstruction: Retrospective Review of a Titanium Plate MatrixRIB™ System.

Wong, Teddy H Y / Siu, Ivan C H / Lo, Kareem K N / Tsang, Ethan Y H / Wan, Innes Y P / Lau, Rainbow W H / Chiu, T W / Ng, Calvin S H

Frontiers in surgery

2022 Volume 9, Page(s) 947193

Abstract: Chest wall tumor resection can result in a large defect that can pose a challenge in reconstruction in restoring chest wall contour, maintaining respiratory mechanics, and improving cosmesis. Titanium plates were first introduced for treating a traumatic ...

Abstract	Chest wall tumor resection can result in a large defect that can pose a challenge in reconstruction in restoring chest wall contour, maintaining respiratory mechanics, and improving cosmesis. Titanium plates were first introduced for treating a traumatic flail chest, which yielded promising results in restoring chest wall stability. Subsequently, the applications of titanium plates in chest wall reconstruction surgery were demonstrated in case reports and series. Our center has adopted this technique for a decade, and patients are actively followed up after operation. Here, we retrospectively analyze our 10-year experience of using titanium plates and other reconstruction approaches for chest wall reconstruction, in terms of clinical outcomes, complications, and reasons for reoperation to determine long-term safety and efficacy. Thirty-eight patients who underwent chest wall resection and reconstruction surgery were identified. Of these, 11 had titanium plate insertion, 11 had patch repair or flap reconstruction, and the remaining 16 had primary closure of defects. Chest wall reconstruction using titanium plate(s) and patch repair (with or without flap reconstruction) was associated with larger chest wall defects and more sternal resections than primary closure. Subgroup analysis also showed that reconstruction by the titanium plate technique was associated with larger chest wall defects than patch repair or flap reconstruction [286.80 cm
Language	English
Publishing date	2022-07-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2022.947193
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Article ; Online: Uniportal video-assisted thoracic surgery for major lung resection is associated with less immunochemokine disturbances than multiportal approach.

Yu, Peter S Y / Chan, Kin Wai / Lau, Rainbow W H / Wan, Innes Y P / Chen, George G / Ng, Calvin S H

Scientific reports

2021 Volume 11, Issue 1, Page(s) 10369

Abstract: Multiportal video-assisted thoracic surgery (VATS) for major lung resection causes less immunochemokine production compared to thoracotomy. Whether uniportal VATS is similarly associated with lower early postoperative circulating levels of ... ...

Abstract	Multiportal video-assisted thoracic surgery (VATS) for major lung resection causes less immunochemokine production compared to thoracotomy. Whether uniportal VATS is similarly associated with lower early postoperative circulating levels of immunochemokines compared to multiportal VATS have not been studied. Selected patients who received uniportal or multiportal VATS major lung resection were recruited. Blood samples were collected preoperatively and on postoperative days 1 and 3 for enzyme linked immunosorbent assay of serum levels of Tissue Inhibitor of Metalloproteinase (TIMP)-1, Insulin Growth Factor Binding Protein (IGFBP)-3, and Matrix Metalloproteinase (MMP)-9. A linear mixed-effects models were used to analyze the effects of uniportal VATS on the postoperative circulating chemokine levels. From March 2014 to April 2017, 68 consecutive patients consented for the prospective study and received major lung resection by either uniportal VATS (N = 29) or multiportal VATS (N = 39) were identified. Uniportal VATS major lung resection was associated with lower post-operative levels of TIMP-1 and MMP-9 compared to multiportal VATS after controlling for the effects of the corresponding baseline level and the time of follow-up measurement. No difference was observed for the level of IGFBP-3. Less immunochemokine disturbances was observed after uniportal VATS major lung resection compared to multiportal VATS.
MeSH term(s)	Aged ; Biomarkers/blood ; Biomarkers/metabolism ; Carcinoma, Non-Small-Cell Lung/surgery ; Chemokines/blood ; Chemokines/metabolism ; Female ; Humans ; Inflammation/blood ; Inflammation/diagnosis ; Inflammation/immunology ; Insulin-Like Growth Factor Binding Protein 3/blood ; Insulin-Like Growth Factor Binding Protein 3/metabolism ; Lung Neoplasms/surgery ; Male ; Matrix Metalloproteinase 9/blood ; Matrix Metalloproteinase 9/metabolism ; Middle Aged ; Pneumonectomy/adverse effects ; Pneumonectomy/methods ; Postoperative Complications/blood ; Postoperative Complications/diagnosis ; Postoperative Complications/immunology ; Prospective Studies ; Severity of Illness Index ; Thoracic Surgery, Video-Assisted/adverse effects ; Thoracic Surgery, Video-Assisted/methods ; Tissue Inhibitor of Metalloproteinase-1/blood ; Tissue Inhibitor of Metalloproteinase-1/metabolism
Chemical Substances	Biomarkers ; Chemokines ; IGFBP3 protein, human ; Insulin-Like Growth Factor Binding Protein 3 ; TIMP1 protein, human ; Tissue Inhibitor of Metalloproteinase-1 ; MMP9 protein, human (EC 3.4.24.35) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
Language	English
Publishing date	2021-05-14
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-89598-2
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Article ; Online: EGFR mutation exists in squamous cell lung carcinoma.

Cheung, Alvin Ho-Kwan / Tong, Joanna Hung-Man / Chung, Lau-Ying / Chau, Shuk-Ling / Ng, Calvin Sze-Hang / Wan, Innes Y P / To, Ka-Fai

Pathology

2020 Volume 52, Issue 3, Page(s) 323–328

Abstract: Whether EGFR mutation occurs in lung squamous cell carcinoma (SCC) remains a controversial issue. Although numerous trials have shown positive response to tyrosine kinase inhibitors in SCC, these observations have not been well correlated with presence ... ...

Abstract	Whether EGFR mutation occurs in lung squamous cell carcinoma (SCC) remains a controversial issue. Although numerous trials have shown positive response to tyrosine kinase inhibitors in SCC, these observations have not been well correlated with presence or absence of EGFR mutation. A complicating issue is that adenosquamous carcinoma, a mimic of SCC, frequently harbours EGFR mutations. We evaluated the EGFR mutation status of 191 cases initially diagnosed as SCC of lung origin in years 2000-2011, and performed a panel of markers including p40, p63, CK5/6, TTF-1, mucicarmine on the tissue microarray or tissue blocks from each case, to ascertain the squamous differentiation of each case. Four cases were found to have EGFR mutations, with three showing typical squamous morphological features and immunohistochemical profile on all available tumour blocks, and one reclassified as adenosquamous carcinoma. Mixed responses were noted for two of the patients with EGFR-mutated SCC treated with tyrosine kinase inhibitors. In conclusion, we report that a small subset of rigorously proven SCC harbours EGFR mutation. It also appears in our cohort that EGFR-mutated tumours, in the context of SCC, may have relatively poor response to tyrosine kinase inhibitors.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell/genetics ; ErbB Receptors/genetics ; Female ; Humans ; Lung Neoplasms/genetics ; Male ; Middle Aged ; Mutation ; Retrospective Studies
Chemical Substances	EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2020-02-27
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	7085-3
ISSN	1465-3931 ; 0031-3025
ISSN (online)	1465-3931
ISSN	0031-3025
DOI	10.1016/j.pathol.2019.12.003
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Article ; Online: Uniportal video-assisted thoracic surgery for major lung resection is associated with less immunochemokine disturbances than multiportal approach

Peter S. Y. Yu / Kin Wai Chan / Rainbow W. H. Lau / Innes Y. P. Wan / George G. Chen / Calvin S. H. Ng

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 6

Abstract: Abstract Multiportal video-assisted thoracic surgery (VATS) for major lung resection causes less immunochemokine production compared to thoracotomy. Whether uniportal VATS is similarly associated with lower early postoperative circulating levels of ... ...

Abstract	Abstract Multiportal video-assisted thoracic surgery (VATS) for major lung resection causes less immunochemokine production compared to thoracotomy. Whether uniportal VATS is similarly associated with lower early postoperative circulating levels of immunochemokines compared to multiportal VATS have not been studied. Selected patients who received uniportal or multiportal VATS major lung resection were recruited. Blood samples were collected preoperatively and on postoperative days 1 and 3 for enzyme linked immunosorbent assay of serum levels of Tissue Inhibitor of Metalloproteinase (TIMP)-1, Insulin Growth Factor Binding Protein (IGFBP)-3, and Matrix Metalloproteinase (MMP)-9. A linear mixed-effects models were used to analyze the effects of uniportal VATS on the postoperative circulating chemokine levels. From March 2014 to April 2017, 68 consecutive patients consented for the prospective study and received major lung resection by either uniportal VATS (N = 29) or multiportal VATS (N = 39) were identified. Uniportal VATS major lung resection was associated with lower post-operative levels of TIMP-1 and MMP-9 compared to multiportal VATS after controlling for the effects of the corresponding baseline level and the time of follow-up measurement. No difference was observed for the level of IGFBP-3. Less immunochemokine disturbances was observed after uniportal VATS major lung resection compared to multiportal VATS.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Evidence for surgical resections in oligometastatic lung cancer.

Fernandez, Rafael A S / Lau, Rainbow W H / Ho, Jacky Y K / Yu, Peter S Y / Chow, Simon C Y / Wan, Innes Y P / Ng, Calvin S H

Journal of thoracic disease

2019 Volume 11, Issue Suppl 7, Page(s) S969–S975

Abstract: With the advent of advanced technology in performing diagnostics for lung cancer, an incremental increase in the number of patients with oligometastatic disease is currently being managed with intent to cure. As treatment of selected types of patients ... ...

Abstract	With the advent of advanced technology in performing diagnostics for lung cancer, an incremental increase in the number of patients with oligometastatic disease is currently being managed with intent to cure. As treatment of selected types of patients with oligometastasis show favourable outcomes, the past notion of managing these patients palliatively is fast becoming extinct. Selection of patients based on established criterion together with surgical metastasectomy combined with multiple ablative techniques with or without systemic chemotherapy offers a reasonable rate of treatment success which provides basis for treating such patient population. As more evidence becomes available to suggest that the oligometastatic state of lung cancer does exist, and are potentially curable, a better understanding of the condition is necessary for clinicians, and surgeons to provide optimal care. In this review we present some of the clinical basis which may cause a paradigm shift in management of patients with oligometastatic lung disease.
Language	English
Publishing date	2019-06-05
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd.2019.04.09
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Article ; Online: Arch in the Neck--Haughton Type D Aortic Arch Aneurysm.

Chow, Simon C Y / Wong, Randolph H L / Yu, Simon C H / Wan, Innes Y P / Kwok, Micky W T / Underwood, Malcolm J

The Annals of thoracic surgery

2016 Volume 101, Issue 2, Page(s) 774–775

MeSH term(s)	Adult ; Aortic Aneurysm, Thoracic/classification ; Aortic Aneurysm, Thoracic/diagnostic imaging ; Female ; Humans ; Imaging, Three-Dimensional ; Neck ; Tomography, X-Ray Computed
Language	English
Publishing date	2016-02
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2015.09.025
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Zs.A 252: Show issues

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Article: Multi-dimensional printing in thoracic surgery: current and future applications.

Kwok, Jackson K S / Lau, Rainbow W H / Zhao, Ze-Rui / Yu, Peter S Y / Ho, Jacky Y K / Chow, Simon C Y / Wan, Innes Y P / Ng, Calvin S H

Journal of thoracic disease

2018 Volume 10, Issue Suppl 6, Page(s) S756–S763

Abstract: Three-dimensional (3D) printing has been gaining much attention in the medical field in recent years. At present, 3D printing most commonly contributes in pre-operative surgical planning of complicated surgery. It is also utilized for producing ... ...

Abstract	Three-dimensional (3D) printing has been gaining much attention in the medical field in recent years. At present, 3D printing most commonly contributes in pre-operative surgical planning of complicated surgery. It is also utilized for producing personalized prosthesis, well demonstrated by the customized rib cage, vertebral body models and customized airway splints. With on-going research and development, it will likely play an increasingly important role across the surgical fields. This article reviews current application of 3D printing in thoracic surgery and also provides a brief overview on the extended and updated use of 3D printing in bioprinting and 4D printing.
Language	English
Publishing date	2018-04-26
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd.2018.02.91
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Article ; Online: Robotic thymectomy: The Hong Kong experience.

Hsin, Michael K Y / Wan, Innes Y P

Thoracic cancer

2011 Volume 2, Issue 3, Page(s) 84–89

Abstract: Thymectomy is widely employed as part of the management for generalized myasthenia gravis. The surgical approach has evolved over the years, and although there is no consensus regarding the optimal surgical approach, minimally invasive techniques such as ...

Abstract	Thymectomy is widely employed as part of the management for generalized myasthenia gravis. The surgical approach has evolved over the years, and although there is no consensus regarding the optimal surgical approach, minimally invasive techniques such as video-assisted thoracoscopic thymectomy have gained popularity. Robotic-assisted surgical systems have been employed in recent years to perform thymectomies as the robotic arm allows extra wrist action of the instruments which provide seven degrees of movement, giving improved dexterity compared to the conventional thoracoscopic approach. Here we describe our early experience with the da Vinci system in thymectomy. Between April 2006 and November 2009, 12 robotic-assisted complete thymectomy procedures were performed with no need for conversion to open procedures. Operation times ranged from 100 minutes to 200 minutes (mean time 140 minutes). There were no intraoperative or postoperative complications. Nearly all chest drains were removed on postoperative day 1 and the mean hospital stay was 4 days. The follow-up period ranged from 2 to 44 months. Early postoperative evaluations showed one patient had complete remission of symptoms (DeFilippi class 1) and 11 patients became asymptomatic or less symptomatic with a decreased medication requirement (DeFilippi class 2 and 3). Our early experience suggests that robotic thymectomy is comparable to video-assisted thoracic surgery thymectomy, and our results appear to be comparable to those reported in the literature. A larger number of cases and more extended follow up is needed to fully evaluate the merits of robotic thymectomy.
Language	English
Publishing date	2011-08
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2625856-0
ISSN	1759-7714 ; 1759-7706
ISSN (online)	1759-7714
ISSN	1759-7706
DOI	10.1111/j.1759-7714.2011.00052.x
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Article: The choice of mitral annuloplastic ring-beyond "surgeon's preference".

Wan, Song / Lee, Alex P W / Jin, Chun-Na / Wong, Randolph H L / Chan, Herman H M / Ng, Calvin S H / Wan, Innes Y P / Underwood, Malcolm J

Annals of cardiothoracic surgery

2015 Volume 4, Issue 3, Page(s) 261–265

Language	English
Publishing date	2015-08-20
Publishing country	China
Document type	Journal Article
ZDB-ID	2713627-9
ISSN	2304-1021 ; 2225-319X
ISSN (online)	2304-1021
ISSN	2225-319X
DOI	10.3978/j.issn.2225-319X.2015.01.05
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