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Article ; Online: Treatment of advanced squamous cell carcinoma of the external auditory canal: Critical analysis of persistent failures in diagnosis and surgery with a competing-risk model.

Mazzoni, Antonio / Cazzador, Diego / Marioni, Gino / Zanoletti, Elisabetta

2022 Volume 44, Issue 8, Page(s) 1918–1926

Abstract: Background: A series of temporal bone squamous cell carcinomas (TBSCCs) was analyzed with the aim of (i) better understanding the causes for the persistent high failure rate in advanced SCCs and (ii) discussing a possible way out from this stalemate in ... ...

Abstract	Background: A series of temporal bone squamous cell carcinomas (TBSCCs) was analyzed with the aim of (i) better understanding the causes for the persistent high failure rate in advanced SCCs and (ii) discussing a possible way out from this stalemate in treatment. Methods: Forty-five TBSCCs consecutively treated surgically were reviewed. Results: The 5-year cumulative incidence for postoperative local recurrence was 41.8%. At multivariable analysis, pT3-4 stages were associated with eightfold relative incidence of developing local recurrence during follow-up (sHR = 9.06, 95% confidence interval [CI] = 1.18-69.46, p = 0.034) and cause-specific death (sHR = 7.95, 95%CI = 1.01-62.27, p = 0.048). Conclusions: The poor outcome in advanced TBSCC occurred because of local recurrence due to defective resection. The fundamental pitfall of surgery on advanced TBSCC appeared to be the insufficient knowledge of microscopic tumor growth in the different sites and subsites of the temporal bone. The serial histopathological study of the en bloc surgical specimen and autopsy temporal bones seems to represent a way to enhance our understanding of these tumors.
MeSH term(s)	Carcinoma, Squamous Cell/pathology ; Ear Canal/pathology ; Ear Canal/surgery ; Ear Neoplasms/pathology ; Ear Neoplasms/surgery ; Humans ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging ; Retrospective Studies ; Temporal Bone/pathology ; Temporal Bone/surgery
Language	English
Publishing date	2022-06-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.27111
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Zs.A 1493: Show issues

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Article: Facial Surface Electromyography: A Novel Approach to Facial Nerve Functional Evaluation after Vestibular Schwannoma Surgery.

Franz, Leonardo / Marioni, Gino / Daloiso, Antonio / Biancoli, Elia / Tealdo, Giulia / Cazzador, Diego / Nicolai, Piero / de Filippis, Cosimo / Zanoletti, Elisabetta

Journal of clinical medicine

2024 Volume 13, Issue 2

Abstract: Background: Vestibular schwannoma (VS) surgery may cause facial nerve damage. However, a comprehensive evaluation of post-operative facial outcomes may be difficult to achieve. Surface electromyography (sEMG) is a promising non-invasive evaluation tool. ...

Abstract	Background: Vestibular schwannoma (VS) surgery may cause facial nerve damage. However, a comprehensive evaluation of post-operative facial outcomes may be difficult to achieve. Surface electromyography (sEMG) is a promising non-invasive evaluation tool. However, its use in the follow-up after VS surgery has not been reported yet. The main objective was to develop and validate a new sEMG application specifically for the post-VS surgery setting. Secondary goals were to provide a systematic description of facial muscle activity after VS surgery and assess the association between sEMG parameters and Sunnybrook scale scores. Methods: Thirty-three patients with facial palsy following VS surgery were included. The clinical outcomes (Sunnybrook symmetry, movement, and synkinesis scores) and sEMG parameters (signal amplitude normalized by the maximal voluntary contraction (NEMG) and sEMG synkinesis score (ESS, number of synkinesis per movement sequence)) were evaluated at the end of the follow-up. Results: In all tested muscles, NEMG variance was significantly higher on the affected side than the contralateral (variance ratio test, Conclusions: We described and preliminarily validated a novel multiparametric sEMG approach based on both signal amplitude and synkinesis evaluation specifically for oto-neurosurgery. Large-scale studies are mandatory to further characterize the semiological and prognostic value of facial sEMG.
Language	English
Publishing date	2024-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13020590
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Article ; Online: Tracheostomy During COVID-19 Pandemic-In Search of Lost Timing.

Cazzador, Diego / Franchella, Sebastiano / Navalesi, Paolo

JAMA otolaryngology-- head & neck surgery

2020 Volume 146, Issue 10, Page(s) 981–982

MeSH term(s)	COVID-19 ; Disease Outbreaks ; Humans ; Pandemics ; Respiration, Artificial ; SARS-CoV-2 ; Tracheostomy
Keywords	covid19
Language	English
Publishing date	2020-09-03
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2701825-8
ISSN	2168-619X ; 2168-6181
ISSN (online)	2168-619X
ISSN	2168-6181
DOI	10.1001/jamaoto.2020.2627
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Article ; Online: From "Extended total parotidectomy" to "Temporo-parotid resection" for locally advanced parotid tumors: Outlining a shift in surgical perspective.

Zanoletti, Elisabetta / Tealdo, Giulia / Franz, Leonardo / Cazzador, Diego / Nicolai, Piero / Mazzoni, Antonio

Oral oncology

2022 Volume 131, Page(s) 105975

MeSH term(s)	Humans ; Parotid Gland/surgery ; Parotid Neoplasms/surgery ; Postoperative Complications ; Retrospective Studies ; Salivary Glands
Language	English
Publishing date	2022-06-17
Publishing country	England
Document type	Letter
ZDB-ID	1120465-5
ISSN	1879-0593 ; 0964-1955 ; 1368-8375
ISSN (online)	1879-0593
ISSN	0964-1955 ; 1368-8375
DOI	10.1016/j.oraloncology.2022.105975
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Zs.A 4869: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

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Article ; Online: 18F-FDG PET/MRI of Rhinosporidiosis of the Upper Airways.

Cazzador, Diego / Cecchin, Diego / Colangeli, Roberta / Crimì, Filippo / Emanuelli, Enzo

Clinical nuclear medicine

2020 Volume 45, Issue 10, Page(s) e461–e462

Abstract: A 41-year-old man from South Asia presented with a several months' history of unilateral nasal obstruction and bleeding. At nasal endoscopy, two strawberry-like, friable, polypoid masses in the upper airways were detected. The patient's clinical trait ... ...

Abstract	A 41-year-old man from South Asia presented with a several months' history of unilateral nasal obstruction and bleeding. At nasal endoscopy, two strawberry-like, friable, polypoid masses in the upper airways were detected. The patient's clinical trait was compatible with an infectious disease. F-FDG PET/MRI was performed to evaluate the disease extension. Two lesions occupying the nasal cavity and the nasopharynx, slightly hyperintense in T2-weighted sequences, with intense radiopharmaceutical uptake were evidenced. Endoscopic resection was performed with histopathologic diagnosis of rhinosporidiosis, a chronic granulomatous disease caused by Rhinosporidium seeberi. Although rare, rhinosporidiosis should be considered in the differential diagnoses of sinonasal hypermetabolic lesions.
MeSH term(s)	Adult ; Animals ; Diagnosis, Differential ; Endoscopy ; Fluorodeoxyglucose F18 ; Humans ; Magnetic Resonance Imaging ; Male ; Positron-Emission Tomography ; Respiratory System/diagnostic imaging ; Rhinosporidiosis/diagnostic imaging ; Rhinosporidiosis/pathology
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2020-08-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000003138
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Zs.A 1276: Show issues

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Article: Survival Outcomes in Squamous Cell Carcinoma of the External Auditory Canal: A Systematic Review and Meta-Analysis.

Cazzador, Diego / Franz, Leonardo / Tealdo, Giulia / Carobbio, Andrea Luigi Camillo / Ferraro, Maria / Mazzoni, Antonio / Marioni, Gino / Zanoletti, Elisabetta

Journal of clinical medicine

2023 Volume 12, Issue 7

Abstract: Squamous cell carcinomas (SCC) of the external auditory canal (EAC) are rare tumors representing a surgical challenge. Current knowledge is based largely on case series; thus, the level of evidence is weak. This study sought to systematically review the ... ...

Abstract	Squamous cell carcinomas (SCC) of the external auditory canal (EAC) are rare tumors representing a surgical challenge. Current knowledge is based largely on case series; thus, the level of evidence is weak. This study sought to systematically review the available SCC of the EAC literature and to identify risk factors for overall survival (OS) and disease-specific survival (DSS). A systematic review and meta-analysis of papers searched up to December 2022 through PubMed, Scopus, Web of Science, and Cochrane Library databases was conducted. Quality assessment of the eligible studies was done according to the Newcastle-Ottawa Scale. Pooled univariate and multivariable analyses and meta-analysis using a random-effects or fixed-effects Mantel-Haenszel model were performed. Fifteen articles (282 patients) met the inclusion criteria and were included in the quantitative analysis. The pooled multivariable analysis revealed cT3 and cT4 as independent prognostic factors for OS (
Language	English
Publishing date	2023-03-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12072490
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Article ; Online: Tumor budding to investigate local invasion, metastasis, and prognosis of head and neck carcinoma: A systematic review.

Zanoletti, Elisabetta / Daloiso, Antonio / Nicolè, Lorenzo / Cazzador, Diego / Mondello, Tiziana / Franz, Leonardo / Astolfi, Laura / Marioni, Gino

Head & neck

2023 Volume 46, Issue 3, Page(s) 651–671

Abstract: The aim of this systematic review is to shed light on the role of tumor budding (TB) in the biology, behavior, and prognosis of head and neck squamous cell carcinoma (HNSCC). A search was run in PubMed, Scopus, and Embase databases following PRISMA ... ...

Abstract	The aim of this systematic review is to shed light on the role of tumor budding (TB) in the biology, behavior, and prognosis of head and neck squamous cell carcinoma (HNSCC). A search was run in PubMed, Scopus, and Embase databases following PRISMA guidelines. After full-text screening and application of inclusion/exclusion criteria, 36 articles were included. Several investigations support the prognostic role of TB, which might play a role in selecting rational treatment strategies. To achieve this goal, further research is needed for greater standardization in TB quantification. Although TB is not included as a negative prognostic factor in the current management guidelines, it might be reasonable to consider a closer follow-up for HNSCC cases with high histopathological evidence of TB.
MeSH term(s)	Humans ; Squamous Cell Carcinoma of Head and Neck ; Neoplasm Invasiveness/pathology ; Head and Neck Neoplasms/therapy ; Prognosis
Language	English
Publishing date	2023-11-28
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.27583
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Zs.A 1493: Show issues

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Article ; Online: Early Translabyrinthine Surgery for Small- and Medium-Sized Vestibular Schwannomas: Consecutive Cohort Analysis of Outcomes.

Zanoletti, Elisabetta / Mazzoni, Antonio / Chiumenti, Francesca Angela / d'Avella, Domenico / Cazzador, Diego

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

2022 Volume 43, Issue 8, Page(s) 962–967

Abstract: Objective: Reappraisal of the role of translabyrinthine (TLAB) surgery in small- and medium-sized vestibular schwannomas (VSs).: Study design: Retrospective study.: Setting: Tertiary referral center.: Patients: A total of 330 consecutive ... ...

Abstract	Objective: Reappraisal of the role of translabyrinthine (TLAB) surgery in small- and medium-sized vestibular schwannomas (VSs). Study design: Retrospective study. Setting: Tertiary referral center. Patients: A total of 330 consecutive patients diagnosed between 1973 and 2019 with small- and medium-sized VS up to 20 mm in the extrameatal portion submitted to surgical treatment. Interventions: VS removal through microscopic TLAB approach. Main outcome measures: Facial nerve function according to the House-Brackmann scale at 12-month follow-up, postoperative complications and entity of tumor resection assessed with postoperative MRI. A comparative analysis of outcomes between two groups of patients was further conducted, according to tumor size: Group A, small-sized (intrameatal or ≤10 mm extrameatal tumors) and Group B, medium-sized VSs (extrameatal between 11 and 20 mm). Results: Complete tumor removal was achieved in all cases. The overall complication rate was 5.5%, being cerebrospinal fluid leak the most frequent. Patients with small-sized VS (n = 121) presented a significantly better facial nerve function than patients with medium-sized tumors (n = 209), showing House-Brackmann Grades I to II in 92.6% versus 73.6% of cases, respectively ( p < 0.001). A nearly 4.5-fold higher risk of poor facial nerve function at 12 months affects patients with medium-sized tumors (odds ratio, 4.473; 95% confidence interval, 2.122-9.430; p < 0.001). Conclusion: In the current scenario of multioptional VS management, when hearing preservation is not feasible, early TLAB approach as first-line treatment for small-sized VSs showed favorable results. Factors supporting such proactive surgical treatment include long-term definitive cure, no major complications, good facial nerve outcomes, and the possibility of simultaneous hearing rehabilitation with a cochlear implant.
MeSH term(s)	Cohort Studies ; Facial Nerve/pathology ; Humans ; Neuroma, Acoustic/pathology ; Neurosurgical Procedures/methods ; Postoperative Complications/etiology ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2022-08-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2036790-9
ISSN	1537-4505 ; 1531-7129
ISSN (online)	1537-4505
ISSN	1531-7129
DOI	10.1097/MAO.0000000000003608
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Zs.A 1554: Show issues

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Article ; Online: Tumor Microenvironment in Sporadic Vestibular Schwannoma: A Systematic, Narrative Review.

Cazzador, Diego / Astolfi, Laura / Daloiso, Antonio / Tealdo, Giulia / Simoni, Edi / Mazzoni, Antonio / Zanoletti, Elisabetta / Marioni, Gino

International journal of molecular sciences

2023 Volume 24, Issue 7

Abstract: Although diagnosis and treatment of vestibular schwannomas (VSs) improved in recent years, no factors have yet been identified as being capable of predicting tumor growth. Molecular rearrangements occur in neoplasms before any macroscopic morphological ... ...

Abstract	Although diagnosis and treatment of vestibular schwannomas (VSs) improved in recent years, no factors have yet been identified as being capable of predicting tumor growth. Molecular rearrangements occur in neoplasms before any macroscopic morphological changes become visible, and the former are the underlying cause of disease behavior. Tumor microenvironment (TME) encompasses cellular and non-cellular elements interacting together, resulting in a complex and dynamic key of tumorigenesis, drug response, and treatment outcome. The aim of this systematic, narrative review was to assess the level of knowledge on TME implicated in the biology, behavior, and prognosis of sporadic VSs. A search (updated to November 2022) was run in Scopus, PubMed, and Web of Science electronic databases according to the PRISMA guidelines, retrieving 624 titles. After full-text evaluation and application of inclusion/exclusion criteria, 37 articles were included. VS microenvironment is determined by the interplay of a dynamic ecosystem of stromal and immune cells which produce and remodel extracellular matrix, vascular networks, and promote tumor growth. However, evidence is still conflicting. Further studies will enhance our understanding of VS biology by investigating TME-related biomarkers able to predict tumor growth and recognize immunological and molecular factors that could be potential therapeutic targets for medical treatment.
MeSH term(s)	Humans ; Ecosystem ; Neuroma, Acoustic/genetics ; Neuroma, Acoustic/pathology ; Treatment Outcome ; Tumor Burden ; Tumor Microenvironment
Language	English
Publishing date	2023-03-30
Publishing country	Switzerland
Document type	Journal Article ; Systematic Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24076522
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Article ; Online: Benefits of bone conduction hearing aid in children with unilateral aural atresia.

Brotto, Davide / Sorrentino, Flavia / Cazzador, Diego / Maritan, Francesca / Montino, Silvia / Agostinelli, Anna / Zanoletti, Elisabetta / Martini, Alessandro / Bovo, Roberto / Trevisi, Patrizia

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

2023 Volume 43, Issue 3, Page(s) 221–226

Abstract: Objective: To assess the hearing benefit with a unilateral bone conduction hearing aid in a cohort of children with unilateral aural atresia.: Methods: Cross-sectional case series pilot study involving 7 children (median age: 10 years, range 6-11). ... ...

Abstract	Objective: To assess the hearing benefit with a unilateral bone conduction hearing aid in a cohort of children with unilateral aural atresia. Methods: Cross-sectional case series pilot study involving 7 children (median age: 10 years, range 6-11). All patients underwent pure-tone, speech, aided sound field and aided speech audiometry and Simplified Italian Matrix Test (SIMT) with and without bone conduction hearing aid (Baha 5 Results: The mean air conduction pure-tone average (PTA) of the atretic ear was 63.2 ± 6.9 dB, while the bone conduction PTA was 12.6 ± 4.7 dB. Speech discrimination score of the atretic ear was 88.6 ± 3.8 dB, while with the hearing aid it was 52.8 ± 1.9 dB. In the contralateral ear, there was no significant air-bone gap, and PTAs for air and bone conduction thresholds were within normal range (PTA ≤ 25 dB). The mean aided air conduction hearing threshold was 26.2 ± 7.97. Mean speech recognition threshold without the hearing aid was -5.1 ± 1.9 dB, and -6.0 ± 1.7 dB with the hearing aid tested with the SIMT. The mean score of the cognitive test was 46.8 ± 42.8. Conclusions: These preliminary findings should encourage clinicians in proposing a unilateral bone conduction hearing aid in children with unilateral atresia.
MeSH term(s)	Humans ; Child ; Hearing Aids ; Bone Conduction ; Cross-Sectional Studies ; Pilot Projects ; Ear/abnormalities ; Hearing Loss, Conductive ; Speech Perception ; Treatment Outcome
Language	English
Publishing date	2023-06-02
Publishing country	Italy
Document type	Journal Article
ZDB-ID	604898-5
ISSN	1827-675X ; 0392-100X
ISSN (online)	1827-675X
ISSN	0392-100X
DOI	10.14639/0392-100X-N2271
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