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Article ; Online: Dr. Richard Fitzpatrick July 21, 1944-July 12, 2014.

Goldman, Mitchel P

2014 Volume 46, Issue 7, Page(s) 527

MeSH term(s)	Dermatologic Surgical Procedures/history ; History, 20th Century ; History, 21st Century ; Laser Therapy/history
Language	English
Publishing date	2014-09
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article ; Portraits
ZDB-ID	604493-1
ISSN	1096-9101 ; 0196-8092
ISSN (online)	1096-9101
ISSN	0196-8092
DOI	10.1002/lsm.22282
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Article: Richard lister.

Eckardt, M / Goldman, D / Linnoila, M / Weingartner, H

Journal of psychopharmacology (Oxford, England)

1991 Volume 5, Issue 4, Page(s) iv

Language	English
Publishing date	1991-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	639313-5
ISSN	0269-8811
ISSN	0269-8811
DOI	10.1177/026988119100500403
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Article ; Online: Chemistry-mediated Ostwald ripening in carbon-rich C/O systems at extreme conditions.

Lindsey, Rebecca K / Goldman, Nir / Fried, Laurence E / Bastea, Sorin

Nature communications

2022 Volume 13, Issue 1, Page(s) 1424

Abstract: ... but experimental challenges preclude elucidating the processes governing nanocarbon production from carbon-rich ...

Abstract	There is significant interest in establishing a capability for tailored synthesis of next-generation carbon-based nanomaterials due to their broad range of applications and high degree of tunability. High pressure (e.g., shockwave-driven) synthesis holds promise as an effective discovery method, but experimental challenges preclude elucidating the processes governing nanocarbon production from carbon-rich precursors that could otherwise guide efforts through the prohibitively expansive design space. Here we report findings from large scale atomistically-resolved simulations of carbon condensation from C/O mixtures subjected to extreme pressures and temperatures, made possible by machine-learned reactive interatomic potentials. We find that liquid nanocarbon formation follows classical growth kinetics driven by Ostwald ripening (i.e., growth of large clusters at the expense of shrinking small ones) and obeys dynamical scaling in a process mediated by carbon chemistry in the surrounding reactive fluid. The results provide direct insight into carbon condensation in a representative system and pave the way for its exploration in higher complexity organic materials. They also suggest that simulations using machine-learned interatomic potentials could eventually be employed as in-silico design tools for new nanomaterials.
Language	English
Publishing date	2022-03-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-29024-x
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Book: Oxford textbook of palliative care for children

Rapoport, Adam / Hain, Richard / Goldman, Ann

(Oxford textbooks in palliative medicine)

2021

Title variant	Textbook of palliative care for children ; Palliative care for children
Author's details	edited by Richard Hain, Ann Goldman with Adam Rapoport, Michelle Meiring
Series title	Oxford textbooks in palliative medicine
Keywords	Terminally ill children/Care ; Palliative treatment
Subject code	618.920029
Language	English
Size	536 Seiten, Illustrationen, 28 cm
Edition	Third edition
Publisher	Oxford University Press
Publishing place	Oxford
Publishing country	Great Britain
Document type	Book
Note	Includes bibliographical references and index
HBZ-ID	HT020993067
ISBN	978-0-19-882131-1 ; 0-19-882131-X
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2021 A 948	available for loan (reading room)	Lesesaal EG

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Article ; Online: Protecting biodiversity and economic returns in resource-rich tropical forests.

Ball, James G C / Burgman, Mark A / Goldman, Elizabeth D / Lessmann, Janeth

Conservation biology : the journal of the Society for Conservation Biology

2020

Abstract: ... into tropical forests. These activities seed access to remote, biologically rich areas, thereby endangering global ...

Abstract	In pursuit of socioeconomic development, many countries are expanding oil and mineral extraction into tropical forests. These activities seed access to remote, biologically rich areas, thereby endangering global biodiversity. Here we demonstrate that conservation solutions that effectively balance the protection of biodiversity and economic revenues are possible in biologically valuable regions. Using spatial data on oil profits and predicted species and ecosystem extents, we optimise the protection of 741 terrestrial species and 20 ecosystems of the Ecuadorian Amazon, across a range of opportunity costs (i.e. sacrifices of extractive profit). For such an optimisation, giving up 5% of a year's oil profits (US$ 221 million) allows for a protected area network that retains of an average of 65% of the extent of each species/ecosystem. This performance far exceeds that of the network produced by simple land area optimisation which requires a sacrifice of approximately 40% of annual oil profits (US$ 1.7 billion), and uses only marginally less land, to achieve equivalent levels of ecological protection. Applying spatial statistics to remotely sensed, historic deforestation data, we further focus the optimisation to areas most threatened by imminent forest loss. We identify Emergency Conservation Targets: areas that are essential to a cost-effective conservation reserve network and at imminent risk of destruction, thus requiring urgent and effective protection. Governments should employ the methods presented here when considering extractive led development options, to responsibly manage the associated ecological-economic trade-offs and protect natural capital. Article Impact Statement: Governments controlling resource extraction from tropical forests can arrange production and conservation to retain biodiversity and profits. This article is protected by copyright. All rights reserved.
Language	English
Publishing date	2020-05-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	58735-7
ISSN	1523-1739 ; 0888-8892
ISSN (online)	1523-1739
ISSN	0888-8892
DOI	10.1111/cobi.13534
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Article ; Online: Chemistry-mediated Ostwald ripening in carbon-rich C/O systems at extreme conditions

Rebecca K. Lindsey / Nir Goldman / Laurence E. Fried / Sorin Bastea

Nature Communications, Vol 13, Iss 1, Pp 1-

2022 Volume 7

Abstract: Modelling the growth of carbon nanoclusters in shock experiments is computationally demanding. Here the authors employ a machine-learned reactive interatomic model to perform large-scale simulations of nanocarbon formation from prototypical shocked C/O- ... ...

Abstract	Modelling the growth of carbon nanoclusters in shock experiments is computationally demanding. Here the authors employ a machine-learned reactive interatomic model to perform large-scale simulations of nanocarbon formation from prototypical shocked C/O-containing precursor.
Keywords	Science ; Q
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Nitrogen oxides as a chemistry trap in detonating oxygen-rich materials.

Goldman, Nir / Bastea, Sorin

The journal of physical chemistry. A

2014 Volume 118, Issue 16, Page(s) 2897–2903

Abstract: ... we have conducted quantum molecular dynamics (QMD) simulations of zero oxygen balance and oxygen-rich ... those from thermochemical models for the zero oxygen balance mixture. In contrast, for the oxygen-rich mixture, we observe ... could have implications for the design and modeling of oxygen-rich energetics in common military and ...

Abstract	Despite decades of research, the chemical processes and states of matter that govern the behavior of energetic materials under detonation conditions are not well understood, including the molecular-level processes that determine decomposition kinetics and energy release. Oxygen content is often employed as a simple and intuitive guide to the development and practical use of explosives, but its effect on detonation chemistry remains little studied, especially for the case of oxygen overabundance. To this end, we have conducted quantum molecular dynamics (QMD) simulations of zero oxygen balance and oxygen-rich mixtures of hydrogen peroxide and nitromethane under detonation-like conditions to near-equilibrium time scales. We find excellent agreement between our extrapolated chemical equilibrium properties and those from thermochemical models for the zero oxygen balance mixture. In contrast, for the oxygen-rich mixture, we observe the formation of nitrogen oxide intermediates, particularly nitrate ions (NO3), that effectively act as an oxygen/nitrogen "trap" by precluding the formation of the equilibrium products N2 and CO2. Our results could have implications for the design and modeling of oxygen-rich energetics in common military and industrial use.
Language	English
Publishing date	2014-04-24
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/jp501455z
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Article ; Online: Modified Frailty Index Associates With Transoral Robotic Surgery Complications and Survival: A National Database Study.

Jain, Amiti / Goldberg, Zachary N / Briggs, Erin / Amin, Dev R / Urdang, Zachary D / Goldman, Richard A / Cognetti, David M / Curry, Joseph M

The Laryngoscope

2024

Abstract: Objective: The modified frailty index (mFI-5) is a National Surgical Quality Improvement Program-derived 5-factor index that has been proven to reflect frailty and predict morbidity and mortality. We hypothesize that mFI-5 is a valid predictive measure ... ...

Abstract	Objective: The modified frailty index (mFI-5) is a National Surgical Quality Improvement Program-derived 5-factor index that has been proven to reflect frailty and predict morbidity and mortality. We hypothesize that mFI-5 is a valid predictive measure in the transoral robotic surgery (TORS) population. Methods: Retrospective study utilizing the TriNetX US-collaborative health records network querying for TORS patients. Cohorts were stratified by mFI-5 score which uses five ICD-10 codes: nonindependent functional status, hypertension, obstructive respiratory disease, heart failure, and diabetes mellitus. Cohorts were matched by age using propensity score matching. Outcome measures included survival, infection, pneumonia, tracheostomy dependence, and percutaneous endoscopic gastrostomy dependence. Reported odds ratios were normalized to mFI-5 = 0. Results: A total of 9,081 patients were included in the final analysis. Greater mFI-5 scores predicted decreased survival and increased incidence of postoperative infection and pneumonia. Odds of 5-year mortality were 1.93 (p = 0.0003) for mFI-5 = 2 and 1.90 (p = 0.0002) for mFI-5 = 3. Odds of 2-year mortality were 1.25 (p = 0.0125) for mFI-5 = 1, 1.58 (p = 0.0002) for mFI-5 = 2, and 1.87 (p = 0.003) for mFI-5 = 3. Odds of postoperative infection were 1.51 (p = 0.02) for mFI-5 = 2 and 1.78 (p = 0.05) for mFI-5 = 3. Two-year odds of developing pneumonia were 1.69 (p = 0.0001) for mFI-5 = 2 and 2.84 (p < 0.0001) for mFI-5 = 3. Two-month odds of pneumonia were 1.50 (p = 0.0259) for mFI-5 = 2 and 2.55 (p = 0.0037) for mFI-5 = 3. mFI-5 = 4 or 5 had too few patients to analyze. Using polynomial regression to model age versus incident 5-year post-TORS death (R Conclusion: This study demonstrates that mFI-5 predicts mortality, pneumonia, and postoperative infection independently of age. Level of evidence: 4 Laryngoscope, 2024.
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.31458
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Ul II Zs.82: Show issues

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Article ; Online: Increased markers of cardiac vagal activity in leucine-rich repeat kinase 2-associated Parkinson's disease.

Carricarte Naranjo, Claudia / Marras, Connie / Visanji, Naomi P / Cornforth, David J / Sanchez-Rodriguez, Lazaro / Schüle, Birgitt / Goldman, Samuel M / Estévez, Mario / Stein, Phyllis K / Lang, Anthony E / Jelinek, Herbert F / Machado, Andrés

Clinical autonomic research : official journal of the Clinical Autonomic Research Society

2019 Volume 29, Issue 6, Page(s) 603–614

Abstract: Purpose: Cardiac autonomic dysfunction manifests as reduced heart rate variability (HRV) in idiopathic Parkinson's disease (PD), but no significant reduction has been found in PD patients who carry the LRRK2 mutation. Novel HRV features have not been ... ...

Abstract	Purpose: Cardiac autonomic dysfunction manifests as reduced heart rate variability (HRV) in idiopathic Parkinson's disease (PD), but no significant reduction has been found in PD patients who carry the LRRK2 mutation. Novel HRV features have not been investigated in these individuals. We aimed to assess cardiac autonomic modulation through standard and novel approaches to HRV analysis in individuals who carry the LRRK2 G2019S mutation. Methods: Short-term electrocardiograms were recorded in 14 LRRK2-associated PD patients, 25 LRRK2-non-manifesting carriers, 32 related non-carriers, 20 idiopathic PD patients, and 27 healthy controls. HRV measures were compared using regression modeling, controlling for age, sex, mean heart rate, and disease duration. Discriminant analysis highlighted the feature combination that best distinguished LRRK2-associated PD from controls. Results: Beat-to-beat and global HRV measures were significantly increased in LRRK2-associated PD patients compared with controls (e.g., deceleration capacity of heart rate: p = 0.006) and idiopathic PD patients (e.g., 8th standardized moment of the interbeat interval distribution: p = 0.0003), respectively. LRRK2-associated PD patients also showed significantly increased irregularity of heart rate dynamics, as quantified by Rényi entropy, when compared with controls (p = 0.002) and idiopathic PD patients (p = 0.0004). Ordinal pattern statistics permitted the identification of LRRK2-associated PD individuals with 93% sensitivity and 93% specificity. Consistent results were found in a subgroup of LRRK2-non-manifesting carriers when compared with controls. Conclusions: Increased beat-to-beat HRV in LRRK2 G2019S mutation carriers compared with controls and idiopathic PD patients may indicate augmented cardiac autonomic cholinergic activity, suggesting early impairment of central vagal feedback loops in LRRK2-associated PD.
MeSH term(s)	Aged ; Female ; Heart Rate/physiology ; Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Male ; Middle Aged ; Mutation ; Parkinson Disease/complications ; Parkinson Disease/genetics ; Parkinson Disease/physiopathology ; Primary Dysautonomias/etiology ; Vagus Nerve/physiopathology
Chemical Substances	LRRK2 protein, human (EC 2.7.11.1) ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 (EC 2.7.11.1)
Language	English
Publishing date	2019-08-23
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1080007-4
ISSN	1619-1560 ; 0959-9851
ISSN (online)	1619-1560
ISSN	0959-9851
DOI	10.1007/s10286-019-00632-w
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Zs.A 3270: Show issues

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Article ; Online: A novel cysteine-rich peptide regulates cell expansion in the tobacco pistil and influences its final size.

Brito, Michael S / DePaoli, Henrique C / Cossalter, Viviani / Avanci, Nilton C / Ferreira, Pedro B / Azevedo, Mariana S / Strini, Edward J / Quiapim, Andréa C / Goldman, Gustavo H / Peres, Lázaro E P / Goldman, Maria Helena S

Plant science : an international journal of experimental plant biology

2018 Volume 277, Page(s) 55–67

Abstract: ... rich plant peptide (68 amino acids), encoded by a small open reading frame gene (sORF). It is ...

Abstract	Plant morphogenesis is dependent on cell proliferation and cell expansion, which are responsible for establishing final organ size and shape during development. Several genes have been described as encoding components of the plant cell development machinery, among which are the plant peptides. Here we describe a novel cysteine-rich plant peptide (68 amino acids), encoded by a small open reading frame gene (sORF). It is specifically expressed in the reproductive organs of Nicotiana tabacum and is developmentally regulated. N- and C-terminal translational fusions with GFP in protoplasts have demonstrated that the peptide is not secreted. Knockdown transgenic plants produced by RNAi exhibited enlarged pistils due to cell expansion and the gene was named Small Peptide Inhibitor of Cell Expansion (SPICE). Estimation of nuclear DNA content using flow cytometry has shown that cell expansion in pistils was not correlated with endoreduplication. Decreased SPICE expression also affected anther growth and pollen formation, resulting in male sterility in at least one transgenic plant. Our results revealed that SPICE is a novel reproductive organ specific gene that controls cell expansion, probably as a component of a signal transduction pathway.
MeSH term(s)	Flow Cytometry ; Flowers/genetics ; Flowers/growth & development ; Gene Expression Regulation, Plant/genetics ; Gene Expression Regulation, Plant/physiology ; Open Reading Frames/genetics ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Nicotiana/genetics ; Nicotiana/growth & development
Chemical Substances	Plant Proteins
Language	English
Publishing date	2018-09-07
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	742010-9
ISSN	1873-2259 ; 0168-9452
ISSN (online)	1873-2259
ISSN	0168-9452
DOI	10.1016/j.plantsci.2018.09.002
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