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Book ; Online ; E-Book: Atlas of craniocervical junction and cervical spine surgery

Boriani, Stefano / Presutti, Livio / Gasbarrini, Alessandro / Mattioli, Francesco

2017

Author's details	Stefano Boriani, Livio Presutti, Alessandro Gasbarrini, Francesco Mattioli editors
Language	English
Size	1 Online-Ressource (x, 227 Seiten), Illustrationen
Publisher	Springer
Publishing place	Cham
Publishing country	Germany
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019410320
ISBN	978-3-319-42737-9 ; 9783319427355 ; 3-319-42737-7 ; 3319427350
DOI	10.1007/978-3-319-42737-9
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: A neural network potential with self-trained atomic fingerprints: A test with the mW water potential.

Guidarelli Mattioli, Francesco / Sciortino, Francesco / Russo, John

The Journal of chemical physics

2023 Volume 158, Issue 10, Page(s) 104501

Abstract: We present a neural network (NN) potential based on a new set of atomic fingerprints built upon two- and three-body contributions that probe distances and local orientational order, respectively. Compared with the existing NN potentials, the atomic ... ...

Abstract	We present a neural network (NN) potential based on a new set of atomic fingerprints built upon two- and three-body contributions that probe distances and local orientational order, respectively. Compared with the existing NN potentials, the atomic fingerprints depend on a small set of tunable parameters that are trained together with the NN weights. In addition to simplifying the selection of the atomic fingerprints, this strategy can also considerably increase the overall accuracy of the network representation. To tackle the simultaneous training of the atomic fingerprint parameters and NN weights, we adopt an annealing protocol that progressively cycles the learning rate, significantly improving the accuracy of the NN potential. We test the performance of the network potential against the mW model of water, which is a classical three-body potential that well captures the anomalies of the liquid phase. Trained on just three state points, the NN potential is able to reproduce the mW model in a very wide range of densities and temperatures, from negative pressures to several GPa, capturing the transition from an open random tetrahedral network to a dense interpenetrated network. The NN potential also reproduces very well properties for which it was not explicitly trained, such as dynamical properties and the structure of the stable crystalline phases of mW.
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0139245
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Are Neural Network Potentials Trained on Liquid States Transferable to Crystal Nucleation? A Test on Ice Nucleation in the mW Water Model.

Guidarelli Mattioli, Francesco / Sciortino, Francesco / Russo, John

The journal of physical chemistry. B

2023 Volume 127, Issue 17, Page(s) 3894–3901

Abstract: Neural network potentials (NNPs) are increasingly being used to study processes that happen on long time scales. A typical example is crystal nucleation, which rate is controlled by the occurrence of a rare fluctuation, i.e., the appearance of the ... ...

Abstract	Neural network potentials (NNPs) are increasingly being used to study processes that happen on long time scales. A typical example is crystal nucleation, which rate is controlled by the occurrence of a rare fluctuation, i.e., the appearance of the critical nucleus. Because the properties of this nucleus are far from those of the bulk crystal, it is yet unclear whether NN potentials trained on equilibrium liquid states can accurately describe nucleation processes. So far, nucleation studies on NNPs have been limited to ab initio models whose nucleation properties are unknown, preventing an accurate comparison. Here we train a NN potential on the mW model of water─a classical three-body potential whose nucleation time scale is accessible in standard simulations. We show that a NNP trained only on a small number of liquid state points can reproduce with great accuracy the nucleation rates and free energy barriers of the original model, computed from both spontaneous and biased trajectories, strongly supporting the use of NNPs to study nucleation events.
Language	English
Publishing date	2023-04-19
Publishing country	United States
Document type	Journal Article
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.3c00693
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tracing Allostery in the Spliceosome Ski2-like RNA Helicase Brr2.

Guidarelli Mattioli, Francesco / Saltalamacchia, Andrea / Magistrato, Alessandra

The journal of physical chemistry letters

2024 Volume 15, Issue 13, Page(s) 3502–3508

Abstract: RNA ATPases/helicases remodel substrate RNA-protein complexes in distinct ways. The different RNA ATPases/helicases, taking part in the spliceosome complex, reshape the RNA/RNA-protein contacts to enable premature-mRNA splicing. Among them, the bad ... ...

Abstract	RNA ATPases/helicases remodel substrate RNA-protein complexes in distinct ways. The different RNA ATPases/helicases, taking part in the spliceosome complex, reshape the RNA/RNA-protein contacts to enable premature-mRNA splicing. Among them, the bad response to refrigeration 2 (Brr2) helicase promotes U4/U6 small nuclear (sn)RNA unwinding via ATP-driven translocation of the U4 snRNA strand, thus playing a pivotal role during the activation, catalytic, and disassembly phases of splicing. The plastic Brr2 architecture consists of an enzymatically active N-terminal cassette (N-cassette) and a structurally similar but inactive C-terminal cassette (C-cassette). The C-cassette, along with other allosteric effectors and regulators, tightly and timely controls Brr2's function via an elusive mechanism. Here, microsecond-long molecular dynamics simulations, dynamical network theory, and community network analysis are combined to elucidate how allosteric effectors/regulators modulate the Brr2 function. We unexpectedly reveal that U4 snRNA itself acts as an allosteric regulator, amplifying the cross-talk of distal Brr2 domains and triggering a conformational reorganization of the protein. Our findings offer fundamental understanding into Brr2's mechanism of action and broaden our knowledge on the sophisticated regulatory mechanisms by which spliceosome ATPases/helicases control gene expression. This includes their allosteric regulation exerted by client RNA strands, a mechanism that may be broadly applicable to other RNA-dependent ATPases/helicases.
MeSH term(s)	Humans ; Adenosine Triphosphatases/metabolism ; Ribonucleoprotein, U4-U6 Small Nuclear/chemistry ; Ribonucleoprotein, U4-U6 Small Nuclear/genetics ; Ribonucleoprotein, U4-U6 Small Nuclear/metabolism ; RNA/metabolism ; RNA Helicases/chemistry ; RNA Helicases/genetics ; RNA Helicases/metabolism ; Spliceosomes/genetics ; Spliceosomes/metabolism ; Ribonucleoproteins, Small Nuclear/metabolism
Chemical Substances	Adenosine Triphosphatases (EC 3.6.1.-) ; Ribonucleoprotein, U4-U6 Small Nuclear ; RNA (63231-63-0) ; RNA Helicases (EC 3.6.4.13) ; SNRNP200 protein, human ; Ribonucleoproteins, Small Nuclear
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Journal Article
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.3c03538
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Post-Covid-19 Airway Stenosis: Tracheal Resection-Anastomosis Using The Tritube® Ventilation.

Molteni, Gabriele / Dallari, Virginia / Segato, Erika / Mattioli, Francesco

The Laryngoscope

2023 Volume 134, Issue 2, Page(s) 897–900

Abstract: We present a video of a tracheal resection and anastomosis performed on a patient affected by A-shaped tracheal stenosis. The condition was a consequence of a percutaneous tracheostomy following a Sars-Cov2 infection. Airways management during the ... ...

Abstract	We present a video of a tracheal resection and anastomosis performed on a patient affected by A-shaped tracheal stenosis. The condition was a consequence of a percutaneous tracheostomy following a Sars-Cov2 infection. Airways management during the surgery was obtained with the Tritube®, an innovative device with a very small lumen that combines stable lung parameters and good visualization of surgical field. Laryngoscope, 134:897-900, 2024.
MeSH term(s)	Humans ; Intubation, Intratracheal ; Constriction, Pathologic/etiology ; Constriction, Pathologic/surgery ; RNA, Viral ; COVID-19 ; SARS-CoV-2 ; Anastomosis, Surgical ; Lung ; Trachea/surgery
Chemical Substances	RNA, Viral
Language	English
Publishing date	2023-07-19
Publishing country	United States
Document type	Case Reports
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.30859
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Article: Surgical and radiological perspectives for the spinal accessory nerve passing through a fenestrated internal jugular vein: case series and literature review.

Guarino, Pierre / Tesauro, Paolo / Giordano, Leone / Caporale, Claudio Donadio / Presutti, Livio / Mattioli, Francesco

Journal of surgical case reports

2024 Volume 2024, Issue 4, Page(s) rjae099

Abstract: The preservation of the spinal accessory nerve represents a key goal in head and neck oncologic surgery during selective neck dissection. This study aims to illustrate the anatomical variants of the XI cranial nerve, delving into the relationship between ...

Abstract	The preservation of the spinal accessory nerve represents a key goal in head and neck oncologic surgery during selective neck dissection. This study aims to illustrate the anatomical variants of the XI cranial nerve, delving into the relationship between the spinal nerve and the internal jugular vein, as well as the surgical implications. Two cases of patients who underwent oncologic surgery with neck dissection are described. Both cases found the spinal accessory nerve passing through the fenestration of the internal jugular vein. Alongside this case series, an independent literature review was conducted using the Medline and PubMed databases. In the majority of cases (67% - 96%), the spinal accessory nerve traces a lateral course to the internal jugular vein. Less frequently, the XI cranial nerve courses medial to the internal jugular vein. More rarely, as described in this case series, the nerve crosses through the fenestration of the vein (0.48% - 3.3%).
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Case Reports
ZDB-ID	2580919-2
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjae099
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Could the replacement of a tracheotomy tube be potentially fatal?

Ghirelli, Michael / Molinari, Giulia / Livio, Presutti / Mattioli, Francesco

Acta otorrinolaringologica espanola

2021 Volume 72, Issue 5, Page(s) 332–333

MeSH term(s)	Humans ; Intubation, Intratracheal ; Tracheostomy ; Tracheotomy/adverse effects
Language	English
Publishing date	2021-10-12
Publishing country	Spain
Document type	Journal Article
ISSN	2173-5735
ISSN (online)	2173-5735
DOI	10.1016/j.otoeng.2020.06.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Shoulder Tendinopathies and Occupational Biomechanical Overload: A Critical Appraisal of Available Evidence.

Curti, Stefania / Mattioli, Stefano / Violante, Francesco Saverio

La Medicina del lavoro

2023 Volume 114, Issue 4, Page(s) e2023033

Abstract: Background: The aim of this study is to evaluate the association between occupational exposure to biomechanical risk factors and shoulder tendinopathies.: Methods: We updated recent systematic reviews about specific shoulder disorders and work- ... ...

Abstract	Background: The aim of this study is to evaluate the association between occupational exposure to biomechanical risk factors and shoulder tendinopathies. Methods: We updated recent systematic reviews about specific shoulder disorders and work-related risk factors. MEDLINE was searched up to September 2022. Studies satisfying the following criteria were included: i) the diagnosis was based on physical examination plus imaging data (when available), and ii) the exposure assessment was based on video analysis and/or directly measured. Results: Five studies met the inclusion criteria: three cross-sectional studies identified from published systematic reviews and two cohort studies retrieved from the update. Two studies investigated shoulder tendinitis, one supraspinatus tendinitis, and the other two rotator cuff syndrome. The diagnosis was based on physical examination, not supported by imaging techniques for all the included studies. In four out of five studies, the exposure was assessed by experienced ergonomists with the support of video recordings. In two studies, the exposure assessment was further supplemented by force gauge measurements or direct measurements of upper arm elevation. Only the combined exposure of working with arms above shoulder level with forceful hand exertion appears to be associated with rotator cuff syndrome: i) a cohort study reported an HR=1.11 (95%CI 1.01-1.22) for each unit increase in forceful repetition rate when the upper arm is flexed ≥45° for ≥29% of the working time; and ii) a cross-sectional study showed an OR=2.43 (95%CI 1.04-5.68) for the combination of upper arm flexion ≥45° for more than 15% of the time with a duty cycle of forceful exertions more than 9% of the time. Conclusions: There is moderate evidence of a causal association between shoulder tendinopathy and combined exposures of working above shoulder level with forceful hand exertion. The evidence is insufficient for any single biomechanical exposure on its own. High-quality cohort studies with direct exposure measures and objective diagnostic criteria are needed. The occupational origin of shoulder tendinopathies is still an open question that must be properly answered.
MeSH term(s)	Humans ; Shoulder ; Cross-Sectional Studies ; Cohort Studies ; Upper Extremity ; Tendinopathy/etiology
Language	English
Publishing date	2023-08-02
Publishing country	Italy
Document type	Journal Article
ZDB-ID	123678-7
ISSN	0025-7818
ISSN	0025-7818
DOI	10.23749/mdl.v114i4.14537
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Article ; Online: A time-correlated single photon counting SPAD array camera with a bespoke data-processing algorithm for lightsheet fluorescence lifetime imaging (FLIM) and FLIM videos.

Nedbal, Jakub / Mattioli Della Rocca, Francesco / Ivanova, Iveta T / Allan, Andrew / Graham, Jeremy / Walker, Richard / Henderson, Robert K / Suhling, Klaus

Scientific reports

2024 Volume 14, Issue 1, Page(s) 7247

Abstract: A wide-field microscope with epi-fluorescence and selective plane illumination was combined with a single-photon avalanche diode (SPAD) array camera to enable live-cell fluorescence lifetime imaging (FLIM) using time-correlated single-photon counting ( ... ...

Abstract	A wide-field microscope with epi-fluorescence and selective plane illumination was combined with a single-photon avalanche diode (SPAD) array camera to enable live-cell fluorescence lifetime imaging (FLIM) using time-correlated single-photon counting (TCSPC). The camera sensor comprised of
MeSH term(s)	Microscopy, Fluorescence/methods ; Algorithms
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-56122-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: A neural network potential with self-trained atomic fingerprints

Mattioli, Francesco Guidarelli / Sciortino, Francesco / Russo, John

a test with the mW water potential

2023

Abstract: We present a neural network (NN) potential based on a new set of atomic fingerprints built upon two- and three-body contributions that probe distances and local orientational order respectively. Compared to existing NN potentials, the atomic fingerprints ...

Abstract	We present a neural network (NN) potential based on a new set of atomic fingerprints built upon two- and three-body contributions that probe distances and local orientational order respectively. Compared to existing NN potentials, the atomic fingerprints depend on a small set of tuneable parameters which are trained together with the neural network weights. To tackle the simultaneous training of the atomic fingerprint parameters and neural network weights we adopt an annealing protocol that progressively cycles the learning rate, significantly improving the accuracy of the NN potential. We test the performance of the network potential against the mW model of water, which is a classical three-body potential that well captures the anomalies of the liquid phase. Trained on just three state points, the NN potential is able to reproduce the mW model in a very wide range of densities and temperatures, from negative pressures to several GPa, capturing the transition from an open random tetrahedral network to a dense interpenetrated network. The NN potential also reproduces very well properties for which it was not explicitly trained, such as dynamical properties and the structure of the stable crystalline phases of mW. Comment: 14 pages, 11 figures
Keywords	Condensed Matter - Soft Condensed Matter ; Condensed Matter - Disordered Systems and Neural Networks ; Condensed Matter - Materials Science
Subject code	000
Publishing date	2023-01-27
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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