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  1. Article ; Online: Response to Jia and Wang.

    Liu, Xu / Liu, Qi / Yao, Xueting / Zhang, Miao / Cui, Cheng / Li, Haiyan / Liu, Dongyang

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 73, Issue 2, Page(s) 352–353

    MeSH term(s) Humans ; Methotrexate
    Chemical Substances Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2020-11-09
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa1390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1505: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 480: Show issues

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  2. Article ; Online: Identification of absorbed compounds of Xiao Yao San Jia Wei and pharmacokinetic study in depressed rats by force swimming stress.

    Shan, Chenxiao / Li, Jia / Sun, Bo / Zhou, Runze / Xu, Min / Zhao, Qiulong / Ren, Ping / Wen, Hongmei / Huang, Xi

    RSC advances

    2022  Volume 12, Issue 8, Page(s) 4455–4468

    Abstract: Xiao-Yao-San-Jia-Wei (XYSJW) is a commonly prescribed formulation for depression and anorexia ...

    Abstract Xiao-Yao-San-Jia-Wei (XYSJW) is a commonly prescribed formulation for depression and anorexia in the Jiang Su Province Hospital of Chinese Medicine. Unfortunately, the proper dosage of this formulation is still unclear due to its limited chemical and pharmacokinetic profiles. Thus, in the present study, a sensitive, precise, and rapid procedure for the identification of absorbed compounds (Cs) in the plasma of depressed rats together with a pharmacokinetic analysis was established with the help of ultra-flow liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UFLC-Q-TOF MS/MS) and ultra-flow liquid chromatography coupled with electrospray ionization triple quadrupole tandem mass spectrometry (UFLC-QQQ MS/MS). Based on the characteristic fragmentation, neutral loss, mass defect filter, relevant literature and reference standards, 225 Cs in the XYSJW extract and 20 Cs in the plasma of the depressed rats were tentatively recognized
    Language English
    Publishing date 2022-02-04
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d1ra08778a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The pharmacological mechanism of chaihu-jia-longgu-muli-tang for treating depression: integrated meta-analysis and network pharmacology analysis.

    Zhao, Yang / Xu, Dan / Wang, Jing / Zhou, Dandan / Liu, Anlan / Sun, Yingying / Yuan, Yuan / Li, Jianxiang / Guo, Weifeng

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1257617

    Abstract: Aim: ...

    Abstract Aim:
    Language English
    Publishing date 2023-09-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1257617
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Identification of absorbed compounds of Xiao Yao San Jia Wei and pharmacokinetic study in depressed rats by force swimming stress

    Shan, Chenxiao / Li, Jia / Sun, Bo / Zhou, Runze / Xu, Min / Zhao, Qiulong / Ren, Ping / Wen, Hongmei / Huang, Xi

    RSC advances. 2022 Feb. 04, v. 12, no. 8

    2022  

    Abstract: Xiao-Yao-San-Jia-Wei (XYSJW) is a commonly prescribed formulation for depression and anorexia ...

    Abstract Xiao-Yao-San-Jia-Wei (XYSJW) is a commonly prescribed formulation for depression and anorexia in the Jiang Su Province Hospital of Chinese Medicine. Unfortunately, the proper dosage of this formulation is still unclear due to its limited chemical and pharmacokinetic profiles. Thus, in the present study, a sensitive, precise, and rapid procedure for the identification of absorbed compounds (Cs) in the plasma of depressed rats together with a pharmacokinetic analysis was established with the help of ultra-flow liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UFLC-Q-TOF MS/MS) and ultra-flow liquid chromatography coupled with electrospray ionization triple quadrupole tandem mass spectrometry (UFLC-QQQ MS/MS). Based on the characteristic fragmentation, neutral loss, mass defect filter, relevant literature and reference standards, 225 Cs in the XYSJW extract and 20 Cs in the plasma of the depressed rats were tentatively recognized via UFLC-Q-TOF MS/MS and UFLC-QQQ MS/MS. Then, the 12 major absorbed Cs in the depressed rats after oral XYSJW administration were chosen to further investigate its pharmacokinetic profile by UFLC-QQQ MS/MS. This study provides a systematic approach for the rapid and qualitative analysis of absorbed Cs in depressed rats and investigating the pharmacokinetics of XYSJW. More importantly, our work provides key information on the chemical and pharmacokinetic profiles of XYSJW in vitro and in vivo, which may benefit its therapeutic efficacy and further pharmacological studies involving this formulation.
    Keywords Oriental traditional medicine ; anorexia ; electrospray ionization mass spectrometry ; hospitals ; liquid chromatography ; pharmacokinetics ; qualitative analysis ; tandem mass spectrometry ; therapeutics
    Language English
    Dates of publication 2022-0204
    Size p. 4455-4468.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ISSN 2046-2069
    DOI 10.1039/d1ra08778a
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Thoracic Jia-Ji electro-acupuncture mitigates low skeletal muscle atrophy and improves motor function recovery following thoracic spinal cord injury in rats.

    Zhang, Xinyi / Xu, Hailiang / Zhu, Lei / Huang, Dageng / Kong, Lingbo / Wang, Zhiyuan / Tian, Fang / Lu, Botao / Wu, Weidong / Jiang, Chao / Liu, Youjun / Wang, Chengwen / Jia, Shuaijun / Li, Yongliang / Yang, Minyi / Liu, Xifang / Hao, Dingjun

    American journal of translational research

    2022  Volume 14, Issue 11, Page(s) 8103–8116

    Abstract: Objectives: The goal of this study was to determine whether electro-acupuncture (EA) stimulation might protect the motor endplate, minimize muscle atrophy in the hind limbs, and enhance functional recovery of rats with spinal cord injury (SCI).: ... ...

    Abstract Objectives: The goal of this study was to determine whether electro-acupuncture (EA) stimulation might protect the motor endplate, minimize muscle atrophy in the hind limbs, and enhance functional recovery of rats with spinal cord injury (SCI).
    Methods: Sprague-Dawley adult female rats (n = 30) were randomly assigned into Sham, SCI, and EA + SCI groups (n = 10 each). Rats in the Sham and SCI groups were bound in prone position only for 30 min, and rats in the EA + SCI group were treated with electro-acupuncture. The EA was conducted from the first day after surgery, lasted for 30 mins, once every day for 28 consecutive days.
    Results: EA significantly prevented motor endplate degeneration, improved electrophysiological function, and ameliorated hindlimb muscle atrophy after SCI. Meanwhile, EA upregulated Tuj-1 expression, downregulated GFAP expression, and reduced glial scar formation. Additionally, after 4 weeks of EA treatment, the serum of SCI rats exhibited a reduced inflammatory response.
    Conclusion: These findings suggest that EA can preserve the motor endplate and reduce muscular atrophy. In addition, EA has been shown to improve the function of upper and lower neurons, reduce glial scar formation, suppress systemic inflammation, and improve axon regeneration.
    Language English
    Publishing date 2022-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Inhibition Ras/MEK/ERK pathway: An important mechanism of Baihu Jia Guizhi Decoction ameliorated rheumatoid arthritis.

    Chen, Qi / Yang, Jinming / Chen, Huan / Pan, Ting / Liu, Panwang / Xu, Shi-Jun

    Journal of ethnopharmacology

    2022  Volume 304, Page(s) 116072

    Abstract: ... treatment for rheumatoid arthritis (RA). Baihu Jia Guizhi Decoction (BHJGZ) is a classic prescription and ...

    Abstract Ethnopharmacological relevance: Alleviating rheumatism by inhibiting synovitis is a routine treatment for rheumatoid arthritis (RA). Baihu Jia Guizhi Decoction (BHJGZ) is a classic prescription and has a long history of application for treating RA with a good anti-inflammatory action. However, the underlying molecular mechanisms have not been fully elucidated.
    Aim of the study: This work aimed to decipher the potential mechanism of BHJGZ against RA focusing on Ras/MEK/ERK pathway.
    Materials and methods: Based on the prediction of network pharmacology, the inhibition action of BHJGZ on Ras/MEK/ERK pathway was firstly validated in vivo and in vitro. Moreover, the affinity with the ingredients of BHJGZ in serum and the targets of Ras/MEK/ERK pathway were evaluated. Finally, the efficacy of BHJGZ for relieving RA was assessed in AA rats.
    Results: The Ras/MEK/ERK pathway was predicted by network pharmacology as one of important mechanisms of BHJGZ to treat RA. The high expression of Ras protein in synovitis of AA rats was significantly reduced by the treatment with BHJGZ, and the activation of Ras/MEK/ERK pathway in vivo and in vitro was also markedly inhibited (p < 0.05 or p < 0.01). Moreover, the level of p-ERK/ERK, IL-6 and TNF-α in vitro were further suppressed after Ras or MEK was inhibited by mirdametinib or lonafarnib respectively (p < 0.01). Furthermore, the results of molecular docking showed a good affinity and stable binding with the ingredients of BHJGZ in serum and multiple key proteins of the Ras/MEK/ERK pathway. Finally, paw swelling, paw circumference and pathological changes of joint synovitis were significantly reduced by BHJGZ in AA rats (p < 0.05).
    Conclusion: The inhibition of Ras/MEK/ERK pathway is one of crucial mechanisms of BHJGZ for ameliorating synovitis of RA.
    MeSH term(s) Rats ; Animals ; MAP Kinase Signaling System ; Molecular Docking Simulation ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/pathology ; Synovitis/drug therapy ; Mitogen-Activated Protein Kinase Kinases
    Chemical Substances guizhi decoction ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2)
    Language English
    Publishing date 2022-12-18
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2022.116072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book: Jia

    Bu, Wancang / Li, Pingqian / Xu, Xinfu / Yang, Xiaozhong

    = The family

    1953  

    Author's details [Regie: Bu Wancang, Xu Xinfu, Yang Xiaozhong, Li Pingqian]
    Language Chinese
    Size 1 VCD, 60 Min
    Publishing place China
    Document type Book
    Note Audiosprache: Chinesisch
    Database Former special subject collection: coastal and deep sea fishing

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  8. Book: Jia

    Bu, Wancang / Li, Pingqian / Xu, Xinfu / Yang, Xiaozhong

    The family

    1953  

    Author's details [Regie: Bu Wancang, Xu Xinfu, Yang Xiaozhong, Li Pingqian]
    Language Chinese
    Publishing place China
    Document type Book
    Note Audiosprache: Chinesisch
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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  9. Book: Jia

    Bu, Wancang / Li, Pingqian / Xu, Xinfu / Yang, Xiaozhong

    = The family

    1953  

    Author's details [Regie: Bu Wancang, Xu Xinfu, Yang Xiaozhong, Li Pingqian]
    Language Chinese
    Size 2 VCDs, 117 Min
    Publishing place China
    Document type Book
    Note Audiosprache: Chinesisch
    Database Former special subject collection: coastal and deep sea fishing

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  10. Book: Jia you ! jia you

    Xu, Jialu / Chen, Fu / Wang, Ruojiang / Zhu, Ruiping

    Chinese for the Global Community

    2007  

    Language Chinese ; English
    Dates of publication 2007-9999
    Publishing place Sheng zhi xue xi chu ban ji tuan
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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