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Article: [Algal community structure and water quality assessment on drawdown area of Kaixian waters in Three Gorges Reservoir during winter storage period].

Guo, Jing-Song / Xie, Dan / Li, Zhe / Chen, Yuan / Sun, Zhi-Yu / Chen, Yong-Bo / Long, Man

Huan jing ke xue= Huanjing kexue

2012 Volume 33, Issue 4, Page(s) 1129–1135

Abstract: The old town area of Kaixian county was flooded and showed reservoir characteristics after ... nutritional status of Kaixian drawdown area after water storage are still rarely reported. To understand the current ... water environment and changes in algal community structure of Kaixian drawdown area after 172.8 m ...

Abstract	The old town area of Kaixian county was flooded and showed reservoir characteristics after the water level of Three Gorges Reservoir got 172. 8 m in December 2008. The aquatic ecology and nutritional status of Kaixian drawdown area after water storage are still rarely reported. To understand the current water environment and changes in algal community structure of Kaixian drawdown area after 172.8 m water level, the algal composition, abundance, biomass distribution and changes of its sampling spots including Hanfeng Lake were observed twice during winter storage period in January and December 2009. The trends in phytoplankton community structure were analyzed and the water quality assessment of nutritional status was carried out. The results indicated that 6 phylums, 37 genera, 69 species of phytoplankton in total were identified in the two sampling, and the dominant species were Dinophyta and Cryptophyta. The cell density and biomass in December 2009 were lower than those in January 2009. The evaluation results of algal population structure and pollution indicators showed that the nutrition level of Kaixian drawdown area during the winter storage period was mesotrophic to eutrophic type, while diversity analysis result indicated moderate pollution.
MeSH term(s)	China ; Cryptophyta/growth & development ; Dinoflagellida/growth & development ; Environmental Monitoring ; Eutrophication ; Phytoplankton/classification ; Phytoplankton/growth & development ; Seasons ; Water Pollutants, Chemical/analysis ; Water Quality ; Water Supply/analysis
Chemical Substances	Water Pollutants, Chemical
Language	Chinese
Publishing date	2012-04
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	0250-3301
ISSN	0250-3301
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Real-time and accurate estimation

Chen, Haitao / Liu, Kaixian / Jiang, Yuxuan / Liu, Yafeng / Deng, Yong

Biomedical optics express

2023 Volume 14, Issue 4, Page(s) 1818–1832

Abstract: Double integrating sphere measurements obtained from ... ...

Abstract	Double integrating sphere measurements obtained from thin
Language	English
Publishing date	2023-03-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2572216-5
ISSN	2156-7085
ISSN	2156-7085
DOI	10.1364/BOE.489079
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Book: Science & technology on public health in China

Chen, Kaixian / Lin, Qishui / Wu, Jiarui

a roadmap to 2050

2010

Title variant	Science and technology on public health in China
Institution	Zhong guo ke xue yuan
Author's details	Kaixian Chen ; Qishui Lin ; Jiarui Wu. Chinese Academy of Sciences
Keywords	China ; Öffentliches Gesundheitswesen ; Sozioökonomischer Wandel ; Wissenschaftlich-technischer Fortschritt ; Prognose 2050
Subject	Technisch-wissenschaftlicher Fortschritt ; Sozioökonomische Entwicklung ; Sozioökonomisches System ; Wirtschaftsentwicklung ; Öffentlicher Gesundheitsdienst ; Public health system
Subject code	362.10951 ; 338.95106
Language	English
Size	XXIII, 62 S. : Ill., graph. Darst.
Publisher	Science Press ; Springer
Publishing place	Beijing ; Berlin u.a.
Publishing country	China
Document type	Book
Note	Literaturangaben
HBZ-ID	HT016486958
ISBN	978-7-03-025620-1 ; 978-3-642-05337-5 ; 9783642053382 ; 7-03-025620-4 ; 3-642-05337-8 ; 3642053386
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Article ; Online: Development and validation of a dried blood spots assay for metabolic profiling of ginsenosides using ultra-high performance liquid chromatography-mass spectrometry.

Shi, Mengge / Han, Han / Yang, Li / Wang, Zhengtao / Chen, Kaixian

Journal of ethnopharmacology

2024 Volume 329, Page(s) 118136

Abstract: Ethnopharmacological relevance: Panax ginseng C.A. Meyer., a famous and valuable traditional Chinese medicine with thousand years of history for its healthcare and therapeutic effects. It is necessary and meaningful to study the pharmacokinetic behavior ...

Abstract	Ethnopharmacological relevance: Panax ginseng C.A. Meyer., a famous and valuable traditional Chinese medicine with thousand years of history for its healthcare and therapeutic effects. It is necessary and meaningful to study the pharmacokinetic behavior of ginsenosides in vivo as they are the most active components. Dried blood spots (DBS) are a mature and advanced blood collection method with meet the needs for the measurement of numerous analytes. Aim of the study: This study aimed to explore the feasibility on DBS in the metabolic profile analysis of complex herbal products. Materials and methods: An ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS/MS) method was developed and validated for the determination of ginsenosides. The preparation of DBS samples was conducted by spiking the whole blood with analytes to obtain 20 μL of blood spots on Whatman 903 collection card. A punched dish of 10 mm in diameter was extracted with 70 % methanol aqueous solution, digoxin was used as an internal standard. Target compounds were separated on a Waters T3 column (2.1 × 100 mm, 1.8 μm) with acetonitrile and water (0.1 % formic acid) at a flow rate of 0.4 mL/min. Results: The various ginsenosides showed good linearity in the range of 1-2000 ng/mL. The extraction recoveries and matrix effects of the target analytes were above 82.2%. The intra- and inter-batch accuracy and precision were within the limits of ≤15% for all tested concentrations. Moreover, the collected dried blood spot samples could be stably stored at room temperature for 14 days and 4 °C for 1 month without being affected. And it is delightful that the DBS-based analysis is compatible or even superior to the conventional protein precipitation in terms of sensitivity, linearity, and stability. In particular, the target analytes are stable in the DBS sampling under normal storing condition and the sensitivity for some trace metabolites of ginsenosides, such as 20(S)-Rg3, 20(R)-Rg3, F1, Rk1, Rg5, etc. increases 3-4 folds as evaluated by LLOQ. Conclusions: The established method was successfully applied to pharmacokinetic studies of ginseng extract in mice, this suggests a more feasible strategy for pharmacokinetic study of traditional and natural medicines both in animal tests and clinical trials.
Language	English
Publishing date	2024-04-06
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.118136
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Article: Corrigendum: SbWRKY75- and SbWRKY41- mediated jasmonic acid signaling regulates baicalin biosynthesis.

Fang, Shiyuan / Zhang, Chen / Qiu, Shi / Xiao, Ying / Chen, Kaixian / Lv, Zongyou / Chen, Wansheng

Frontiers in plant science

2023 Volume 14, Page(s) 1302112

Abstract: This corrects the article DOI: 10.3389/fpls.2023.1213662.]. ...

Abstract	[This corrects the article DOI: 10.3389/fpls.2023.1213662.].
Language	English
Publishing date	2023-11-08
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2023.1302112
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Article: SbWRKY75- and SbWRKY41-mediated jasmonic acid signaling regulates baicalin biosynthesis.

Fang, Shiyuan / Zhang, Chen / Qiu, Shi / Xiao, Ying / Chen, Kaixian / Lv, Zongyou / Chen, Wansheng

Frontiers in plant science

2023 Volume 14, Page(s) 1213662

Abstract: Introduction: Scutellaria baicalensis: Methods: In this study, we conducted transcriptome deep sequencing analysis of : Results: Our findings demonstrated that SbWRKY75 directly regulates the expression of the flavonoid biosynthetic gene : ... ...

Abstract	Introduction: Scutellaria baicalensis Methods: In this study, we conducted transcriptome deep sequencing analysis of Results: Our findings demonstrated that SbWRKY75 directly regulates the expression of the flavonoid biosynthetic gene Discussion: This study provides valuable insights into the molecular mechanisms underlying JA-mediated baicalin biosynthesis in
Language	English
Publishing date	2023-06-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2023.1213662
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Article ; Online: Ameliorative effect of salidroside on the cyclophosphamide-induced premature ovarian failure in a rat model.

Chen, Lixuan / Mo, Qinglin / Wu, Yingnan / Chen, Wancheng / Deng, Kaixian / Xiao, Yang

Free radical research

2024 Volume 58, Issue 2, Page(s) 107–116

Abstract: Background: Oxidative stress injury is an important pathological factor of premature ovarian failure (POF). Salidroside, extracted from the Chinese herb-: Purpose: This study aims to assess the therapeutic effects of salidroside in chemotherapy- ... ...

Abstract	Background: Oxidative stress injury is an important pathological factor of premature ovarian failure (POF). Salidroside, extracted from the Chinese herb- Purpose: This study aims to assess the therapeutic effects of salidroside in chemotherapy-induced ovarian failure rats. Methods: A POF rat model was established by injection of cyclophosphamide, followed by treatment with salidroside. The therapeutic effect of salidroside was evaluated based on hormone levels, follicle count, and reproductive ability. Oxidative stress injury was assessed by the detection of SOD enzyme activity and MDA levels. Differential gene expression of Keap1, Nrf2, HMOX1, NQO1, AMH, BMP15, and GDF9, were identified by qRT‑PCR. The protein expression of Keap1, Nrf2, P53, and Bcl-2 were detected by western blot. Results: Salidroside treatment markedly restored FSH, E2, and AMH hormone secretion levels, reduced follicular atresia, and increased antral follicle numbers in POF rats. In addition, salidroside improves fertility in POF rats, activates the Nrf2 signaling pathway, and reduces the level of oxidative stress. The recovery function of high dose salidroside (50 mg/kg) in a reproductive assay was significantly improved than that of lower dose salidroside (25 mg/kg). Meanwhile, the safety evaluation of salidroside treatment in rats showed that salidroside was safe for POF rats at doses of 25-50 mg/kg. Conclusions: Salidroside therapy improved premature ovarian failure significantly through antioxidant function and activating Nrf2 signaling.
MeSH term(s)	Humans ; Rats ; Female ; Animals ; Primary Ovarian Insufficiency/chemically induced ; Primary Ovarian Insufficiency/drug therapy ; Primary Ovarian Insufficiency/pathology ; Kelch-Like ECH-Associated Protein 1 ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; NF-E2-Related Factor 2 ; Follicular Atresia ; Cyclophosphamide/adverse effects ; Hormones ; Glucosides ; Phenols
Chemical Substances	rhodioloside (M983H6N1S9) ; Kelch-Like ECH-Associated Protein 1 ; Antioxidants ; NF-E2-Related Factor 2 ; Cyclophosphamide (8N3DW7272P) ; Hormones ; Glucosides ; Phenols
Language	English
Publishing date	2024-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1194130-3
ISSN	1029-2470 ; 1071-5762
ISSN (online)	1029-2470
ISSN	1071-5762
DOI	10.1080/10715762.2024.2320383
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Article ; Online: Iridoids and derivatives from Catalpa ovata with their antioxidant activities.

Zhang, Liuqiang / Wu, Longlong / Liu, Jingwen / Chen, Kaixian / Li, Yiming

Fitoterapia

2023 Volume 169, Page(s) 105599

Abstract: Six new iridoid derivatives (1-6)，together with twelve known compounds (7-18), were isolated and identified from the dried fruits of Catalpa ovata G. Don. Their chemical structures were mainly established through the relative spectroscopic data, while ... ...

Abstract	Six new iridoid derivatives (1-6)，together with twelve known compounds (7-18), were isolated and identified from the dried fruits of Catalpa ovata G. Don. Their chemical structures were mainly established through the relative spectroscopic data, while the absolute configurations of compounds 2 and 3 were elucidated on the electronic circular dichroism calculations. Their antioxidant activities were evaluated by activating the Nrf2 transcriptional pathway in 293 T cells in vitro. Among them, Compounds 1, 3, 4, 6-8, 10-12, 14, 15, 17 and 18 showed significant Nrf2 agonistic effect compared with the control group at 25 μM. Finally, The hypothetical biosynthetic pathway for 1-13 was discussed.
MeSH term(s)	Antioxidants/pharmacology ; Antioxidants/chemistry ; Molecular Structure ; Iridoids/pharmacology ; Iridoids/chemistry ; NF-E2-Related Factor 2 ; Circular Dichroism ; Bignoniaceae/chemistry
Chemical Substances	Antioxidants ; Iridoids ; NF-E2-Related Factor 2
Language	English
Publishing date	2023-06-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	412385-2
ISSN	1873-6971 ; 0367-326X
ISSN (online)	1873-6971
ISSN	0367-326X
DOI	10.1016/j.fitote.2023.105599
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Article ; Online: Bisphenol A triggers apoptosis in mouse pre-antral follicle granulosa cells via oxidative stress.

Wang, Chen / He, Chaofan / Xu, Shumin / Gao, Yuanyuan / Wang, Kaixian / Liang, Meng / Hu, Ke

Journal of ovarian research

2024 Volume 17, Issue 1, Page(s) 20

Abstract: Background: Bisphenol A (BPA), an endocrine disrupting chemical with weak estrogenic and anti-androgenic activity, is widely present in various environmental media and organisms. It has certain reproductive toxicity and can cause a variety of female ... ...

Abstract	Background: Bisphenol A (BPA), an endocrine disrupting chemical with weak estrogenic and anti-androgenic activity, is widely present in various environmental media and organisms. It has certain reproductive toxicity and can cause a variety of female reproductive system diseases. Although BPA-stimulated apoptosis of granulosa cells has been widely elaborated, the effect of BPA on mouse pre-antral follicle granulosa cells (mpGCs) has not been well elucidated. Results: In this study, the results of live-dead cell staining showed that high concentrations of BPA severely impaired mpGCs growth viability and affected the cell cycle transition of mpGCs. We confirmed that BPA promotes the production of reactive oxygen species (ROS) and facilitates oxidative stress in mpGCs. In addition, immunofluorescence, transmission electron microscopy, and flow cytometry experiments demonstrated that BPA treatment for mpGCs resulted in apoptotic features, such as rounding, cytoplasmic crinkling, and mitochondrial damage. This was accompanied by a large production of ROS and apoptosis-inducing factor (AIF) translocation from the mitochondria to the nucleus. RNA-seq data showed that several apoptosis-related pathways were enriched in the high concentration BPA-treated group compared with the normal group, such as the p53 pathway, MAPK pathway, etc. CONCLUSIONS: These results suggest that cells undergo oxidative stress effects and apoptosis after BPA treatment for mpGCs, which affects normal follicle development. The potential mechanism of BPA-induced female reproductive toxicity was elucidated, while providing a research basis for the prevention and treatment of female reproductive diseases.
MeSH term(s)	Mice ; Animals ; Female ; Reactive Oxygen Species/metabolism ; Oxidative Stress ; Apoptosis ; Granulosa Cells/metabolism ; Benzhydryl Compounds ; Phenols
Chemical Substances	Reactive Oxygen Species ; bisphenol A (MLT3645I99) ; Benzhydryl Compounds ; Phenols
Language	English
Publishing date	2024-01-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2455679-8
ISSN	1757-2215 ; 1757-2215
ISSN (online)	1757-2215
ISSN	1757-2215
DOI	10.1186/s13048-023-01322-y
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Article ; Online: The transcription factors SbMYB45 and SbMYB86.1 regulate flavone biosynthesis in Scutellaria baicalensis.

Fang, Shiyuan / Qiu, Shi / Chen, Kaixian / Lv, Zongyou / Chen, Wansheng

Plant physiology and biochemistry : PPB

2023 Volume 200, Page(s) 107794

Abstract: Scutellaria baicalensis Georgi is an important Chinese medicinal plant that is rich in the flavones baicalin, wogonoside, and wogonin, providing it with anti-cancer, anti-inflammatory, and antibacterial properties. However, although the biosynthetic ... ...

Abstract	Scutellaria baicalensis Georgi is an important Chinese medicinal plant that is rich in the flavones baicalin, wogonoside, and wogonin, providing it with anti-cancer, anti-inflammatory, and antibacterial properties. However, although the biosynthetic pathways of baicalin and its derivates have been elucidated, the regulation of flavone biosynthesis in S. baicalensis is poorly understood. Here, we found that the contents of baicalin and its derivates increased and that baicalin biosynthetic pathway genes were induced in response to light, and baicalin and baicalein are not exclusively produced in the roots of S. baicalensis. Based on the fact that MYB transcription factors are known to play important roles in flavone biosynthesis, we identified SbMYB45 and SbMYB86.1 in S. baicalensis and determined that they bind to the promoter of the flavone biosynthesis gene SbCHI to enhance its transcription. Moreover, overexpressing SbMYB45 and SbMYB86.1 enhanced the accumulation of baicalin in S. baicalensis leaves. We demonstrate that SbMYB45 and SbMYB86.1 bind to the cis-acting element MBSII in the promoter of CHI to redundantly induce its expression upon light exposure. These findings indicate that SbMYB45 and SbMYB86.1 transcriptionally activate SbCHI in response to light and enhance flavone contents in S. baicalensis.
MeSH term(s)	Scutellaria baicalensis/genetics ; Scutellaria baicalensis/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Flavanones/metabolism ; Flavonoids/genetics ; Flavonoids/metabolism ; Flavones ; Plant Roots/genetics ; Plant Roots/metabolism
Chemical Substances	Transcription Factors ; Flavanones ; Flavonoids ; Flavones
Language	English
Publishing date	2023-05-24
Publishing country	France
Document type	Journal Article
ZDB-ID	742978-2
ISSN	1873-2690 ; 0981-9428
ISSN (online)	1873-2690
ISSN	0981-9428
DOI	10.1016/j.plaphy.2023.107794
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