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  1. Article: Complementary and alternative medicine during COVID-19 pandemic: What we have done.

    Ling, Chang-Quan

    Journal of integrative medicine

    2021  Volume 20, Issue 1, Page(s) 1–3

    MeSH term(s) COVID-19 ; Complementary Therapies ; Humans ; Medicine, Chinese Traditional ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-11-27
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2705612-0
    ISSN 2095-4964
    ISSN 2095-4964
    DOI 10.1016/j.joim.2021.11.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6322: Show issues Location:
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  2. Article: Traditional Chinese medicine is a resource for drug discovery against 2019 novel coronavirus (SARS-CoV-2).

    Ling, Chang-Quan

    Journal of integrative medicine

    2020  Volume 18, Issue 2, Page(s) 87–88

    MeSH term(s) Animals ; Betacoronavirus ; COVID-19/drug therapy ; Coronavirus ; Coronavirus Infections/drug therapy ; Drug Discovery ; Drugs, Chinese Herbal ; Medicine, Chinese Traditional ; SARS Virus ; SARS-CoV-2
    Chemical Substances Drugs, Chinese Herbal
    Keywords covid19
    Language English
    Publishing date 2020-02-19
    Publishing country Netherlands
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2705612-0
    ISSN 2095-4964
    ISSN 2095-4964
    DOI 10.1016/j.joim.2020.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Traditional Chinese medicine is a resource for drug discovery against 2019 novel coronavirus (SARS-CoV-2)

    Ling, Chang-quan

    Journal of Integrative Medicine

    2020  Volume 18, Issue 2, Page(s) 87–88

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2705612-0
    ISSN 2095-4964
    ISSN 2095-4964
    DOI 10.1016/j.joim.2020.02.004
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

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  5. Book ; Online: Changes in the resistance of Plasmodium falciparum to chloroquine in Hainan, China / Liu De-quan . [et al.]

    Liu, De-quan / Liu, Rui-jun / Ren, Dao-xing / Gao, Da-qing / Zhang, Chun-yong / Qiu, Chi-ping / Cai, Xianzheng / Ling, Cui-fen / Song, Ai-hua / Tang Xian

    1995  

    Keywords Chloroquine ; Drug resistance ; Plasmodium falciparum ; Antimalarials ; China ; Parasitic Diseases and their Control
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Book ; Online: Changes in the resistance of Plasmodium falciparum to chloroquine in Hainan, China / Liu De-quan . [et al.]

    Liu, De-quan / Liu, Rui-jun / Ren, Dao-xing / Gao, Da-qing / Zhang, Chun-yong / Qiu, Chi-ping / Cai, Xianzheng / Ling, Cui-fen / Song, Ai-hua / Tang Xian

    1995  

    Keywords Chloroquine ; Drug resistance ; Plasmodium falciparum ; Antimalarials ; China ; Parasitic Diseases and their Control
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Melittin analog p5RHH enhances recombinant adeno-associated virus transduction efficiency.

    Meng, Jing-Shun / He, Yun / Yang, Heng-Bin / Zhou, Li-Ping / Wang, Si-Yuan / Feng, Xi-Lin / Yahya Al-Shargi, Omar / Yu, Xiao-Min / Zhu, Li-Qing / Ling, Chang-Quan

    Journal of integrative medicine

    2024  Volume 22, Issue 1, Page(s) 72–82

    Abstract: ... in a significant improvement in rAAV-mediated transgene expression. While further modifications remain an area ... Feng X, Al-shargi OY, Yu X, Zhu L, Ling, C. Melittin analog p5RHH enhances recombinant ...

    Abstract Objective: Melittin and its derivative have been developed to support effective gene delivery systems. Their ability to facilitate endosomal release enhances the delivery of nanoparticle-based gene therapy. Nevertheless, its potential application in the context of viral vectors has not received much attention. Therefore, we would like to optimize the rAAV vector by Melittin analog to improve the transduction efficiency of rAAV in liver cancer cells and explore the mechanism of Melittin analog on rAAV.
    Methods: Various melittin-derived peptides were inserted into loop VIII of the capsid protein in recombinant adeno-associated virus vectors. These vectors carrying either gfp or fluc genes were subjected to quantitative polymerase chain reaction assays and transduction assays in human embryonic kidney 293 (HEK293T) cells to investigate the efficiency of vector production and gene delivery. In addition, the ability of a specific p5RHH-rAAV vector to deliver genes was examined through in vitro transduction of different cultured cells and in vivo tail vein administration to C57BL/6 mice. Finally, the intricate details of the vector-mediated transduction mechanisms were explored by using pharmacological inhibitors of every stage of the rAAV2 intracellular life cycle.
    Results: A total of 76 melittin-related peptides were identified from existing literature. Among them, CMA-3, p5RHH and aAR3 were found to significantly inhibit transduction of rAAV2 vector crude lysate. The p5RHH-rAAV2 vectors efficiently transduced not only rAAV-potent cell lines but also cell lines previously considered resistant to rAAV. Mechanistically, bafilomycin A1, a vacuolar endosome acidification inhibitor, completely inhibited the transgene expression mediated by the p5RHH-rAAV2 vectors. Most importantly, p5RHH-rAAV8 vectors also increased hepatic transduction in vivo in C57BL/6 mice.
    Conclusion: The incorporation of melittin analogs into the rAAV capsids results in a significant improvement in rAAV-mediated transgene expression. While further modifications remain an area of interest, our studies have substantially broadened the pharmacological prospects of melittin in the context of viral vector-mediated gene delivery. Please cite this article as: Meng J, He Y, Yang H, Zhou L, Wang S, Feng X, Al-shargi OY, Yu X, Zhu L, Ling, C. Melittin analog p5RHH enhances recombinant adeno-associated virus transduction efficiency. J Integr Med. 2024; 22(1): 72-82.
    MeSH term(s) Mice ; Male ; Animals ; Humans ; Dependovirus/genetics ; Melitten/pharmacology ; Melitten/genetics ; Transduction, Genetic ; HEK293 Cells ; Mice, Inbred C57BL ; Genetic Vectors
    Chemical Substances Melitten (20449-79-0)
    Language English
    Publishing date 2024-01-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2705612-0
    ISSN 2095-4964
    ISSN 2095-4964
    DOI 10.1016/j.joim.2024.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6322: Show issues Location:
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  8. Article ; Online: Comprehensive evaluation of military training-induced fatigue among soldiers in China: A Delphi consensus study.

    Ruan, Yi / Song, Shang-Jin / Yin, Zi-Fei / Wang, Man / Huang, Nian / Gu, Wei / Ling, Chang-Quan

    Frontiers in public health

    2022  Volume 10, Page(s) 1004910

    Abstract: Objective: Military training-induced fatigue (MIF) often results into non-combat attrition. However, standard evaluation of MIF is unavailable. This study aimed to provide credible suggestions about MIF-evaluation.: Methods: A 3-round Delphi study ... ...

    Abstract Objective: Military training-induced fatigue (MIF) often results into non-combat attrition. However, standard evaluation of MIF is unavailable. This study aimed to provide credible suggestions about MIF-evaluation.
    Methods: A 3-round Delphi study was performed. The authority of the experts was assessed by the authority coefficient (
    Results: Twenty-three experts participated with credible authority coefficient (mean
    Conclusion: This study developed a reliable foundation for the comprehensive evaluation of MIF among soldiers.
    MeSH term(s) Humans ; Delphi Technique ; Military Personnel ; Surveys and Questionnaires ; Clinical Competence ; Fatigue/etiology
    Language English
    Publishing date 2022-11-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.1004910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Comprehensive evaluation of military training-induced fatigue among soldiers in China

    Yi Ruan / Shang-jin Song / Zi-fei Yin / Man Wang / Nian Huang / Wei Gu / Chang-quan Ling

    Frontiers in Public Health, Vol

    A Delphi consensus study

    2022  Volume 10

    Abstract: ... and the coefficient of variation (CV) of each aspect for an indicator was < 0.5. If round 3 could not ...

    Abstract ObjectiveMilitary training-induced fatigue (MIF) often results into non-combat attrition. However, standard evaluation of MIF is unavailable. This study aimed to provide credible suggestions about MIF-evaluation.MethodsA 3-round Delphi study was performed. The authority of the experts was assessed by the authority coefficient (Aa). In round 1, categories of indicators were collected via anonymous survey of experts, then potential indicators were selected via literature search. In round 2, experts should evaluate the clinical implication, practical value, and importance of each potential indicators, or recommend new indicators based on feedback of round 1. Indicators with recommendation proportions ≥ 70% and new recommended indicators would be included in round 3 to be rated on a 5-point Likert scale. “Consensus in” was achieved when coefficient of concordance (Kendall's W) of a round was between 0.2 and 0.5 and the coefficient of variation (CV) of each aspect for an indicator was < 0.5. If round 3 could not achieve “consensus in,” more rounds would be conducted iteratively based on round 3. Indicators included in the recommendation set were ultimately classified into grade I (highly recommended) or grade II (recommended) according to the mean score and CV of the aspects.ResultsTwenty-three experts participated with credible authority coefficient (mean Aa = 0.733). “Consensus in” was achieved in round 3 (Kendall's W = 0.435, p < 0.001; all CV < 0.5). Round 1 recommended 10 categories with 73 indicators identified from 2,971 articles. After 3-round consultation, consensus was reached on 28 indicators focusing on the cardiovascular system (n = 4), oxygen transport system (n = 5), energy metabolism/metabolite level (n = 6), muscle/tissue damage level (n = 3), neurological function (n = 2), neuropsychological/psychological function (n = 3), endocrine function (n = 3), and exercise capacity (n = 2). Among these, 11 indicators were recommended as grade I: basic heart rate, heart-rate recovery time, heart rate ...
    Keywords evaluation ; military training ; fatigue ; soldier ; Delphi study ; Public aspects of medicine ; RA1-1270
    Subject code 001
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Opposite effect of basic combat training on mood state of recruits with different physical fitness: A study from perspective of fatigue.

    Ruan, Yi / Song, Shang-Jin / Yin, Zi-Fei / Wang, Xin / Zou, Bin / Wang, Huan / Gu, Wei / Ling, Chang-Quan

    Frontiers in psychology

    2022  Volume 13, Page(s) 961351

    Abstract: Objective: Basic combat training (BCT) is a kind of necessary high-intensity training to help each military recruit convert into a qualified soldier. In China, both the physical fatigue and passive psychological state have been observed in new recruits ... ...

    Abstract Objective: Basic combat training (BCT) is a kind of necessary high-intensity training to help each military recruit convert into a qualified soldier. In China, both the physical fatigue and passive psychological state have been observed in new recruits during BCT. However, after same-intensity training, the degree of fatigue and passive mood vary among recruits. Therefore, this study aimed to explore the effect of BCT on mood state of recruits with different physical fitness levels from a perspective of fatigue.
    Materials and methods: Before and after BCT, the degree of fatigue and mood state of participants were evaluated via the Borg Rating of Perceived Exertion Scale and Profile of Mood States Questionnaire immediately after 20 push-ups as RPE and POMS scores [total mood disturbance (TMD), passive mood (T
    Result: A total of 564 recruits were included (group 1: 456/564, 80.85%; group 2: 108/564, 19.15%). After BCT, in group 1, TMD (from 95.65 ± 17.89 to 87.52 ± 17.63) and passive mood T
    Conclusion: BCT could alleviate passive mood and add to positive mood for recruits with better physical fitness, while had no ameliorative effects on or even deteriorate most of the passive mood for recruits with worse physical fitness.
    Language English
    Publishing date 2022-09-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.961351
    Database MEDical Literature Analysis and Retrieval System OnLINE

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