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Book ; Online ; Thesis: Male circumcision for HIV prevention – assessing awareness among people living in rural Uganda

Wilcken, Andrea

2013

Title variant	Die Kenntnis von Jugendlichen und Erwachsenen in ländlichen Gegenden Ugandas über männliche Beschneidung zur Prävention von HIV
Author's details	Andrea Wilcken
Language	English
Size	Online-Ressource
Publisher	Medizinische Fakultät Charité - Universitätsmedizin Berlin
Publishing place	Berlin
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	Berlin, Medizinische Fakultät Charité - Universitätsmedizin Berlin, Diss., 2013
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Online ; Thesis: Male circumcision for HIV prevention – assessing awareness among people living in rural Uganda

Wilcken, Andrea [Verfasser]

2013

Author's details	Andrea Wilcken
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	English
Publisher	Medizinische Fakultät Charité - Universitätsmedizin Berlin
Publishing place	Berlin
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Benchmarking Different QM Levels for Usage with COSMO-RS.

Reinisch, Jens / Diedenhofen, Michael / Wilcken, Rainer / Udvarhelyi, Anikó / Glöß, Andreas

Journal of chemical information and modeling

2019 Volume 59, Issue 11, Page(s) 4806–4813

Abstract: The COSMO-RS method is an established method for the prediction of fluid phase properties such as activity coefficients, liquid-liquid equilibria, and free energy of solvation. It is also frequently used in quantum chemistry-based chemical reaction ... ...

Abstract	The COSMO-RS method is an established method for the prediction of fluid phase properties such as activity coefficients, liquid-liquid equilibria, and free energy of solvation. It is also frequently used in quantum chemistry-based chemical reaction modeling to predict the solvation contribution to the reactions. The COSMO
MeSH term(s)	Electrons ; Hexanes/chemistry ; Models, Chemical ; Models, Molecular ; Quantum Theory ; Small Molecule Libraries/chemistry ; Solubility ; Solvents/chemistry ; Thermodynamics ; Water/chemistry
Chemical Substances	Hexanes ; Small Molecule Libraries ; Solvents ; Water (059QF0KO0R)
Language	English
Publishing date	2019-11-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	190019-5
ISSN	1549-960X ; 0095-2338
ISSN (online)	1549-960X
ISSN	0095-2338
DOI	10.1021/acs.jcim.9b00659
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Traditional male circumcision in eastern and southern Africa: a systematic review of prevalence and complications.

Wilcken, Andrea / Keil, Thomas / Dick, Bruce

Bulletin of the World Health Organization

2010 Volume 88, Issue 12, Page(s) 907–914

Abstract: Objective: to systematically review studies on the prevalence and complications of traditional male circumcision (i.e. circumcision by a traditional provider with no formal medical training), whose coverage and safety are unclear.: Methods: we ... ...

Abstract	Objective: to systematically review studies on the prevalence and complications of traditional male circumcision (i.e. circumcision by a traditional provider with no formal medical training), whose coverage and safety are unclear. Methods: we systematically searched databases and reports for studies on the prevalence and complications of traditional male circumcision in youth 10-24 years of age in eastern and southern Africa, and also determined the ages at which traditional circumcision is most frequently performed. Findings: six studies reported the prevalence of traditional male circumcision, which had been practised in 25-90% of all circumcised male study participants. Most circumcisions were performed in boys 13-20 years of age. Only two of the six studies on complications reported overall complication rates (35% and 48%) following traditional male circumcision. The most common complications were infection, incomplete circumcision requiring re-circumcision and delayed wound healing. Infection was the most frequent cause of hospitalization. Mortality related to traditional male circumcision was 0.2%. Conclusion: published studies on traditional male circumcision in eastern and southern Africa are limited; thus, it is not possible to accurately assess the prevalence of complications following the procedure or the impact of different traditional practices on subsequent adverse events. Also, differences in research methods and the absence of a standard reporting format for complications make it difficult to compare studies. Research into traditional male circumcision procedures, practices and complication rates using standardized reporting formats is needed.
MeSH term(s)	Adolescent ; Africa, Eastern/epidemiology ; Africa, Southern/epidemiology ; Circumcision, Male/adverse effects ; Circumcision, Male/statistics & numerical data ; Humans ; Male ; Medicine, African Traditional ; Postoperative Complications/classification ; Postoperative Complications/epidemiology ; Young Adult
Language	English
Publishing date	2010-10-29
Publishing country	Switzerland
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	80213-x
ISSN	1564-0604 ; 0042-9686 ; 0366-4996 ; 0510-8659
ISSN (online)	1564-0604
ISSN	0042-9686 ; 0366-4996 ; 0510-8659
DOI	10.2471/BLT.09.072975
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS

Lorthiois, Edwige / Gerspacher, Marc / Beyer, Kim S / Vaupel, Andrea / Leblanc, Catherine / Stringer, Rowan / Weiss, Andreas / Wilcken, Rainer / Guthy, Daniel A / Lingel, Andreas / Bomio-Confaglia, Claudio / Machauer, Rainer / Rigollier, Pascal / Ottl, Johannes / Arz, Dorothee / Bernet, Pascal / Desjonqueres, Gaëlle / Dussauge, Solene / Kazic-Legueux, Malika /

Lozac'h, Marie-Anne / Mura, Christophe / Sorge, Mickaël / Todorov, Milen / Warin, Nicolas / Zink, Florence / Voshol, Hans / Zecri, Frederic J / Sedrani, Richard C / Ostermann, Nils / Brachmann, Saskia M / Cotesta, Simona

Journal of medicinal chemistry

2022 Volume 65, Issue 24, Page(s) 16173–16203

Abstract: Rapid emergence of tumor resistance via RAS pathway reactivation has been reported from clinical studies of covalent ... ...

Abstract	Rapid emergence of tumor resistance via RAS pathway reactivation has been reported from clinical studies of covalent KRAS
MeSH term(s)	Animals ; Humans ; Mice ; Disease Models, Animal ; Drug Design ; Mutation ; Neoplasms/drug therapy ; Neoplasms/genetics ; Proto-Oncogene Proteins p21(ras) ; Pyrazoles/pharmacology ; Pyrazoles/therapeutic use
Chemical Substances	KRAS protein, human ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; Pyrazoles ; JDQ443
Language	English
Publishing date	2022-11-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.2c01438
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Article ; Online: Tracing the evolution of the p53 tetramerization domain.

Joerger, Andreas C / Wilcken, Rainer / Andreeva, Antonina

Structure (London, England : 1993)

2014 Volume 22, Issue 9, Page(s) 1301–1310

Abstract: The tetrameric transcription factors p53, p63, and p73 evolved from a common ancestor and play key roles in tumor suppression and development. Surprisingly, p63 and p73 require a second helix in their tetramerization domain for the formation of stable ... ...

Abstract	The tetrameric transcription factors p53, p63, and p73 evolved from a common ancestor and play key roles in tumor suppression and development. Surprisingly, p63 and p73 require a second helix in their tetramerization domain for the formation of stable tetramers that is absent in human p53, raising questions about the evolutionary processes leading to diversification. Here we determined the crystal structure of the zebrafish p53 tetramerization domain, which contains a second helix, reminiscent of p63 and p73, combined with p53-like features. Through comprehensive phylogenetic analyses, we systematically traced the evolution of vertebrate p53 family oligomerization domains back to the beginning of multicellular life. We provide evidence that their last common ancestor also had an extended p63/p73-like domain and pinpoint evolutionary events that shaped this domain during vertebrate radiation. Domain compaction and transformation of a structured into a flexible, intrinsically disordered region may have contributed to the expansion of the human p53 interactome.
MeSH term(s)	Amino Acid Sequence ; Animals ; Conserved Sequence ; Crystallography, X-Ray ; Evolution, Molecular ; Humans ; Molecular Sequence Data ; Phylogeny ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Protein Structure, Quaternary ; Protein Structure, Secondary ; Sequence Analysis, Protein ; Tumor Suppressor Protein p53/chemistry ; Tumor Suppressor Protein p53/genetics ; Zebrafish ; Zebrafish Proteins/chemistry ; Zebrafish Proteins/genetics
Chemical Substances	Tumor Suppressor Protein p53 ; Zebrafish Proteins
Language	English
Publishing date	2014-09-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1213087-4
ISSN	1878-4186 ; 0969-2126
ISSN (online)	1878-4186
ISSN	0969-2126
DOI	10.1016/j.str.2014.07.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Traditional male circumcision in eastern and southern Africa

Andrea Wilcken / Thomas Keil / Bruce Dick

Bulletin of the World Health Organization, Vol 88, Iss 12, Pp 907-

a systematic review of prevalence and complications

2010 Volume 914

Abstract: OBJECTIVE: To systematically review studies on the prevalence and complications of traditional male circumcision (i.e. circumcision by a traditional provider with no formal medical training), whose coverage and safety are unclear. METHODS: We ... ...

Abstract	OBJECTIVE: To systematically review studies on the prevalence and complications of traditional male circumcision (i.e. circumcision by a traditional provider with no formal medical training), whose coverage and safety are unclear. METHODS: We systematically searched databases and reports for studies on the prevalence and complications of traditional male circumcision in youth 10-24 years of age in eastern and southern Africa, and also determined the ages at which traditional circumcision is most frequently performed. FINDINGS: Six studies reported the prevalence of traditional male circumcision, which had been practised in 25-90% of all circumcised male study participants. Most circumcisions were performed in boys 13-20 years of age. Only two of the six studies on complications reported overall complication rates (35% and 48%) following traditional male circumcision. The most common complications were infection, incomplete circumcision requiring re-circumcision and delayed wound healing. Infection was the most frequent cause of hospitalization. Mortality related to traditional male circumcision was 0.2%. CONCLUSION: Published studies on traditional male circumcision in eastern and southern Africa are limited; thus, it is not possible to accurately assess the prevalence of complications following the procedure or the impact of different traditional practices on subsequent adverse events. Also, differences in research methods and the absence of a standard reporting format for complications make it difficult to compare studies. Research into traditional male circumcision procedures, practices and complication rates using standardized reporting formats is needed.
Keywords	Public aspects of medicine ; RA1-1270 ; Medicine ; R
Subject code	590
Language	English
Publishing date	2010-12-01T00:00:00Z
Publisher	World Health Organization
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Journal ; Article ; Online: Traditional male circumcision in eastern and southern Africa

Wilcken, Andrea / Keil, Thomas / Dick, Bruce

a systematic review of prevalence and complications

2010

Abstract: ... 907 ... ...

Abstract	907 914
Keywords	Research
Language	English
Publishing date	2010-12-01
Publisher	World Health Organization
Document type	Journal ; Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Novel Dual Topoisomerase Inhibitor P8-D6 Shows Anti-myeloma Activity

Klausz, Katja / Kellner, Christian / Gehlert, Carina Lynn / Krohn, Steffen / Wilcken, Hauke / Floerkemeier, Inken / Günther, Andreas / Bauerschlag, Dirk O / Clement, Bernd / Gramatzki, Martin / Peipp, Matthias

Molecular cancer therapeutics

2021 Volume 21, Issue 1, Page(s) 70–78

Abstract: P8-D6 is a novel dual inhibitor of human topoisomerase I (TOP1) and II (TOP2) with broad pro-apoptotic antitumor activity. NCI-60 screening revealed markedly improved cytotoxicity of P8-D6 against solid and leukemia cell lines compared with other single ... ...

Abstract	P8-D6 is a novel dual inhibitor of human topoisomerase I (TOP1) and II (TOP2) with broad pro-apoptotic antitumor activity. NCI-60 screening revealed markedly improved cytotoxicity of P8-D6 against solid and leukemia cell lines compared with other single and dual topoisomerase inhibitors, for example, irinotecan, doxorubicin, or pyrazoloacridine. In this study, we investigated the capacity of P8-D6 to inhibit myeloma cell growth
MeSH term(s)	Animals ; Cell Line, Tumor ; Humans ; Mice ; Mice, Nude ; Mice, SCID ; Multiple Myeloma/drug therapy ; Multiple Myeloma/pathology ; Naphthalenes/pharmacology ; Naphthalenes/therapeutic use ; Topoisomerase II Inhibitors/pharmacology ; Topoisomerase II Inhibitors/therapeutic use
Chemical Substances	1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl (E)-2-(4-(3-oxo-3-(3-(trifluoromethoxy)phenyl)prop-1-en-1-yl)phenoxy)acetate ; Naphthalenes ; Topoisomerase II Inhibitors
Language	English
Publishing date	2021-11-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2063563-1
ISSN	1538-8514 ; 1535-7163
ISSN (online)	1538-8514
ISSN	1535-7163
DOI	10.1158/1535-7163.MCT-21-0119
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.

Weiss, Andreas / Lorthiois, Edwige / Barys, Louise / Beyer, Kim S / Bomio-Confaglia, Claudio / Burks, Heather / Chen, Xueying / Cui, Xiaoming / de Kanter, Ruben / Dharmarajan, Lekshmi / Fedele, Carmine / Gerspacher, Marc / Guthy, Daniel Alexander / Head, Victoria / Jaeger, Ashley / Núñez, Eloísa Jiménez / Kearns, Jeffrey D / Leblanc, Catherine / Maira, Sauveur-Michel /

Cancer discovery

2022 Volume 12, Issue 6, Page(s) 1500–1517

Abstract: Covalent inhibitors of KRASG12C have shown antitumor activity against advanced/metastatic KRASG12C-mutated cancers, though resistance emerges and additional strategies are needed to improve outcomes. JDQ443 is a structurally unique covalent inhibitor of ... ...

Abstract	Covalent inhibitors of KRASG12C have shown antitumor activity against advanced/metastatic KRASG12C-mutated cancers, though resistance emerges and additional strategies are needed to improve outcomes. JDQ443 is a structurally unique covalent inhibitor of GDP-bound KRASG12C that forms novel interactions with the switch II pocket. JDQ443 potently inhibits KRASG12C-driven cellular signaling and demonstrates selective antiproliferative activity in KRASG12C-mutated cell lines, including those with G12C/H95 double mutations. In vivo, JDQ443 induces AUC exposure-driven antitumor efficacy in KRASG12C-mutated cell-derived (CDX) and patient-derived (PDX) tumor xenografts. In PDX models, single-agent JDQ443 activity is enhanced by combination with inhibitors of SHP2, MEK, or CDK4/6. Notably, the benefit of JDQ443 plus the SHP2 inhibitor TNO155 is maintained at reduced doses of either agent in CDX models, consistent with mechanistic synergy. JDQ443 is in clinical development as monotherapy and in combination with TNO155, with both strategies showing antitumor activity in patients with KRASG12C-mutated tumors. Significance: JDQ443 is a structurally novel covalent KRASG12C inhibitor with a unique binding mode that demonstrates potent and selective antitumor activity in cell lines and in vivo models. In preclinical models and patients with KRASG12C-mutated malignancies, JDQ443 shows potent antitumor activity as monotherapy and in combination with the SHP2 inhibitor TNO155. This article is highlighted in the In This Issue feature, p. 1397.
MeSH term(s)	Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Humans ; Indazoles/chemistry ; Indazoles/pharmacology ; Mutation ; Neoplasms/drug therapy ; Neoplasms/enzymology ; Neoplasms/genetics ; Proto-Oncogene Proteins p21(ras)/antagonists & inhibitors ; Proto-Oncogene Proteins p21(ras)/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism
Chemical Substances	Enzyme Inhibitors ; Indazoles ; KRAS protein, human ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
Language	English
Publishing date	2022-04-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2625242-9
ISSN	2159-8290 ; 2159-8274
ISSN (online)	2159-8290
ISSN	2159-8274
DOI	10.1158/2159-8290.CD-22-0158
Database	MEDical Literature Analysis and Retrieval System OnLINE

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