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Article: Cognitive Functions, Theory of Mind Abilities, and Personality Dispositions as Potential Predictors of the Detection of Reciprocity in Deceptive and Cooperative Contexts through Different Age Groups.

Florkin, Anne-Lise / Rosi, Alessia / Lecce, Serena / Cavallini, Elena

Behavioral sciences (Basel, Switzerland)

2023 Volume 13, Issue 12

Abstract: Reciprocity is a fundamental element in social interactions and implies an adequate response to the previous actions of our interactant. It is thus crucial to detect if a person is cooperating, deceiving, or cheating, to properly respond. However, older ... ...

Abstract	Reciprocity is a fundamental element in social interactions and implies an adequate response to the previous actions of our interactant. It is thus crucial to detect if a person is cooperating, deceiving, or cheating, to properly respond. However, older adults have been shown to have a lower ability to detect reciprocity compared to younger adults, partially tying this decline to cognitive functions. Another likely association to reciprocity in literature is made with personality dispositions, i.e., agreeableness, altruism, and empathic concern, and Theory of Mind (ToM). Consequently, the present study investigated age-related differences in the detection of the different components of reciprocity, as well as examined the predictors of reciprocity, such as cognitive measures, personality dispositions, and true and false beliefs in young (
Language	English
Publishing date	2023-12-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651997-5
ISSN	2076-328X
ISSN	2076-328X
DOI	10.3390/bs13121007
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Article ; Online: Theory of mind in chronic migraine with medication overuse assessed with the MASC.

Bottiroli, Sara / Rosi, Alessia / Lecce, Serena / Sances, Grazia / Allena, Marta / De Icco, Roberto / Vecchi, Tomaso / Tassorelli, Cristina / Cavallini, Elena

Scientific reports

2024 Volume 14, Issue 1, Page(s) 6998

Abstract: Theory of Mind (ToM) is the ability to infer one's own and others' mental states. Growing research indicates that ToM is impaired in Chronic Migraine with Medication Overuse (CM + MO). However, the research in this field has been conducted using static ... ...

Abstract	Theory of Mind (ToM) is the ability to infer one's own and others' mental states. Growing research indicates that ToM is impaired in Chronic Migraine with Medication Overuse (CM + MO). However, the research in this field has been conducted using static scenario-based tasks, often failing to test mentalization in everyday situations and measuring only performance accuracy. We filled this gap by administering the Movie for the Assessment of Social Cognition (MASC) to subjects with CM + MO compared to episodic migraine (EM). This test allows us to assess both affective and cognitive ToM and which, in addition to being accurate, also analyzes the type of error in attribution of mental states, distinguishing between hypo-mentalization and hyper-mentalization. Thirty patients suffering from CM + MO and 42 from EM were enrolled. Results showed that CM + MO patients were less accurate in mental state attribution than EM. In addition, compared to EM, CM + MO individuals were more impaired in the affective ToM dimensions and committed more errors of hypo-mentalization. In conclusion, the application of MASC in patients with CM + MO allowed for the detection of an alteration in their ability to correctly draw conclusions about other people's mental states. This latter contributes critically to appropriate social reactions and also, possibly, to satisfactory social interactions.
MeSH term(s)	Humans ; Social Cognition ; Theory of Mind ; Motion Pictures ; Prescription Drug Overuse ; Migraine Disorders
Language	English
Publishing date	2024-03-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-57559-0
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Article ; Online: Education degree predicts cardiovascular outcomes in men suffering from erectile dysfunction.

Yannas, Dimitri / Zago, Elena / Cavallini, Elena / Todisco, Tommaso / Vignozzi, Linda / Corona, Giovanni / Maggi, Mario / Rastrelli, Giulia

Andrology

2023 Volume 11, Issue 6, Page(s) 1086–1095

Abstract: Background: The level of education has been recognized as a cardiovascular risk factor; nevertheless, it is often neglected in cardiovascular risk prediction.: Objectives: To evaluate the psychobiological correlates of the level of education and if ... ...

Abstract	Background: The level of education has been recognized as a cardiovascular risk factor; nevertheless, it is often neglected in cardiovascular risk prediction. Objectives: To evaluate the psychobiological correlates of the level of education and if it could predict incident major adverse cardiovascular events in men consulting for erectile dysfunction. Methods: Total 3733 men (49.8 ± 13.7 years old) attending an andrology outpatient clinic for erectile dysfunction were studied. Sexual and psychological symptoms, hormonal and metabolic, as well as instrumental (penile color Doppler ultrasound) parameters were evaluated according to the education level (university, upper secondary, lower secondary, and primary degree). For a subset of 956 patients, data on incident major adverse cardiovascular events were retrospectively collected for 3.9 ± 2.4 years. Results: As compared with men with university degree, those with a lower education had an increased frequency of moderate-severe erectile dysfunction (odds ratio = 1.21 [0.99;1.48], 1.41 [1.14;1.73], 1.70 [1.26;2.30] for upper secondary, lower secondary, and primary school, respectively) and reduced flaccid peak systolic velocity at penile color Doppler ultrasound. Men with a lower level of education tend to suffer from metabolic syndrome (odds ratio = 1.38 [1.06;1.79], 1.73 [1.34;2.24], 1.72 [1.24;2.37] for upper secondary, lower secondary, and primary school, respectively) and were more likely to have history of previous cardiovascular events. In the longitudinal study, men with a higher level of education had a significantly lower incidence of major adverse cardiovascular events. The role of higher education as an independent predictor of major adverse cardiovascular events was established by multivariable Cox regressions (hazard ratio = 2.14 [1.24-3.69]). Discussion: In erectile dysfunction subjects, lower level of education is associated with a more severely impaired erectile function with atherogenic pathogenesis and with a worse cardio-metabolic profile. In addition, a lower level of education predicts forthcoming major adverse cardiovascular events. Therefore, education level should be considered as a costless but valuable information in the assessment of cardiovascular risk in patients with erectile dysfunction.
MeSH term(s)	Male ; Humans ; Adult ; Middle Aged ; Erectile Dysfunction/complications ; Erectile Dysfunction/epidemiology ; Longitudinal Studies ; Retrospective Studies ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/epidemiology ; Risk Factors ; Educational Status
Language	English
Publishing date	2023-01-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2696108-8
ISSN	2047-2927 ; 2047-2919
ISSN (online)	2047-2927
ISSN	2047-2919
DOI	10.1111/andr.13389
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Zs.A 6983: Show issues

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Article ; Online: Social cognition in chronic migraine with medication overuse: a cross-sectional study on different aspects of mentalization and social relationships.

Bottiroli, Sara / Rosi, Alessia / Sances, Grazia / Allena, Marta / De Icco, Roberto / Lecce, Serena / Vecchi, Tomaso / Tassorelli, Cristina / Cavallini, Elena

The journal of headache and pain

2023 Volume 24, Issue 1, Page(s) 47

Abstract: Background: Social cognition refers to all mental operations to decipher information needed in social interactions. Here we aimed to outline the socio-cognitive profile of Chronic Migraine with Medication Overuse (CM + MO), given they are recognized to ... ...

Abstract	Background: Social cognition refers to all mental operations to decipher information needed in social interactions. Here we aimed to outline the socio-cognitive profile of Chronic Migraine with Medication Overuse (CM + MO), given they are recognized to be at risk of socio-cognitive difficulties. Given the multidimensionality of this construct, we considered: (1) socio-cognitive abilities, (2) socio-cognitive beliefs, (3) alexithymia and autism traits, and (4) social relationships. Methods: Seventy-one patients suffering from CM + MO, 61 from episodic migraine (EM), and 80 healthy controls (HC) were assessed with a comprehensive battery: (1) the Faux Pas test (FP), the Strange Stories task (SS), the Reading Mind in the Eyes test (RMET), (2) the Tromsø Social Intelligence Scale, (3) the Toronto Alexithymia Scale, the Autism Spectrum Quotient, (4) the Lubben Social Network Scale, the Friendship Scale. Results: CM + MO: (1) performed similar to EM but worse than HC in the FP and SS, while they were worse than EM and HC in the RMET; (2) were similar to EM and HC in social intelligence; (3) had more alexithymic/autistic traits than EM and HC; (4) reported higher levels of contact with their family members but felt little support from the people around them than HC. Conclusions: CM + MO results characterized by a profile of compromised socio-cognitive abilities that affects different dimensions. These findings may have a relevant role in multiple fields related to chronic headache: from the assessment to the management.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Social Cognition ; Prescription Drug Overuse ; Mentalization ; Cognition ; Migraine Disorders/drug therapy ; Interpersonal Relations
Language	English
Publishing date	2023-04-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2036768-5
ISSN	1129-2377 ; 1129-2369
ISSN (online)	1129-2377
ISSN	1129-2369
DOI	10.1186/s10194-023-01578-1
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Zs.A 5464: Show issues

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Article ; Online: Non-immersive virtual reality based treatment for children with unilateral cerebral palsy: Preliminary results.

Meriggi, Paolo / Mandalà, Martina / Randazzo, Mattia / Brazzoli, Elena / Castagna, Anna / Di Giusto, Valentina / Cavallini, Anna / Marzegan, Alberto / Lencioni, Tiziana / Olivieri, Ivana

Journal of pediatric rehabilitation medicine

2024 Volume 17, Issue 1, Page(s) 107–123

Abstract: Purpose: Unilateral cerebral palsy (UCP) represents about 30-40% of overall cerebral palsy diagnoses. Upper limb impairment has a significant negative impact on activities of daily living (ADL), and recent studies have shown that the use of virtual ... ...

Abstract	Purpose: Unilateral cerebral palsy (UCP) represents about 30-40% of overall cerebral palsy diagnoses. Upper limb impairment has a significant negative impact on activities of daily living (ADL), and recent studies have shown that the use of virtual reality (VR) can increase motivation and promote an improvement in ADL. This preliminary study was aimed at exploring the acceptability and usability of a VR rehabilitation treatment, using the VITAMIN Platform, for children with UCP. A secondary goal of the study was to compare the results of usual standardized clinical scales and questionnaires with kinematic results as well as with the quantitative measures acquired by the VITAMIN platform in each exercise of the rehabilitation sessions. Methods: Six children with UCP (aged 7-15) were recruited for a preliminary investigation in using a non-immersive VR system. The treatment was composed of 10 weekly sessions of 45 minutes. Each child played five types of exergames, using the impaired upper limb to hit virtual objects projected on a wide screen. Standardized clinical scales, kinematic analysis, and questionnaires were used to extensively assess upper limb function before and at the end of treatment. Five typically-developing children provided a reference for the instrumented kinematic assessment. Results: At the end of the treatment, Melbourne Assessment 2 (MA2) scores increased for all the participants (mean increase in range of movement (ROM) + 19.1%, accuracy + 4.6%, dexterity + 13.1%, fluency + 10.3%). Shoulder flexion-extension ROM also improved (mean increase + 10.5°), and according to the kinematic analysis, shoulder movements became more similar to reference profiles. These results were confirmed by a general improvement in performing ADL, assessed by the ABILHAND-Kids questionnaire. Finally, a general agreement among the different measures and indexes emerged from the acquired data. Conclusion: The results show that VR treatment with the VITAMIN platform could be engaging and functional for rehabilitation of children with UCP. The good agreement among the qualitative and quantitative measures and indexes confirms the potential of such novel treatment. However, due to the limited sample size and small number of sessions, further and larger investigations are required to evaluate the effectiveness and to generalize the results.
MeSH term(s)	Child ; Humans ; Cerebral Palsy ; Activities of Daily Living ; Movement ; Virtual Reality ; Vitamins
Chemical Substances	Vitamins
Language	English
Publishing date	2024-03-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2403637-7
ISSN	1875-8894 ; 1874-5393
ISSN (online)	1875-8894
ISSN	1874-5393
DOI	10.3233/PRM-230028
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Article: The Singular Evolution of

Mascagni, Flavia / Barghini, Elena / Ceccarelli, Marilena / Baldoni, Luciana / Trapero, Carlos / Díez, Concepción Muñoz / Natali, Lucia / Cavallini, Andrea / Giordani, Tommaso

Frontiers in plant science

2022 Volume 13, Page(s) 869048

Abstract: The current view of plant genome evolution proposes that genome size has mainly been determined by polyploidisation and amplification/loss of transposons, with a minor role played by other repeated sequences, such as tandem repeats. In cultivated olive ( ...

Abstract	The current view of plant genome evolution proposes that genome size has mainly been determined by polyploidisation and amplification/loss of transposons, with a minor role played by other repeated sequences, such as tandem repeats. In cultivated olive (
Language	English
Publishing date	2022-03-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2022.869048
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Article ; Online: Bright light therapy accelerates the antidepressant effect of repetitive transcranial magnetic stimulation in treatment resistant depression: a pilot study.

Barbini, Barbara / Attanasio, Francesco / Manfredi, Elena / Cavallini, Maria Cristina / Zanardi, Raffaella / Colombo, Cristina

International journal of psychiatry in clinical practice

2021 Volume 25, Issue 4, Page(s) 375–377

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Antidepressive Agents/therapeutic use ; Combined Modality Therapy ; Depressive Disorder, Treatment-Resistant/drug therapy ; Depressive Disorder, Treatment-Resistant/therapy ; Humans ; Phototherapy ; Pilot Projects ; Transcranial Magnetic Stimulation ; Treatment Outcome
Chemical Substances	Antidepressive Agents
Language	English
Publishing date	2021-03-18
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1465531-7
ISSN	1471-1788 ; 1365-1501
ISSN (online)	1471-1788
ISSN	1365-1501
DOI	10.1080/13651501.2021.1894579
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Zs.A 4995: Show issues

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Article ; Online: Prosocial behavior in aging: which factors can explain age-related differences in social-economic decision making?

Rosi, Alessia / Nola, Marta / Lecce, Serena / Cavallini, Elena

International psychogeriatrics

2019 Volume 31, Issue 12, Page(s) 1747–1757

Abstract: Objectives: Older adults tend to exhibit more prosocial behavior than younger adults. However, little research has focused on understanding the factors that may explain such differences in the social decision-making process. The first aim was to examine ...

Abstract	Objectives: Older adults tend to exhibit more prosocial behavior than younger adults. However, little research has focused on understanding the factors that may explain such differences in the social decision-making process. The first aim was to examine if, and to what degree, the content of social information about a recipient has an impact on young vs. older adults' prosocial behavior. The second aim was to understand if empathic concern, Theory of Mind, and reasoning explain the (expected) age differences in prosociality. Design: Cross-sectional study. Setting: The study was conducted in northern Italy in a laboratory setting. Participants: Forty-eight younger adults (Mage = 23.29; SD = 2.20) and 48 older adults (Mage = 70.19; SD = 5.13). Measurements: Prosocial behavior was measured using the Dictator Game in which participants split a sum of money with recipients presented with four levels of description: no information, physical description, positive psychological description, and negative psychological description. In addition, participants performed tasks on emphatic concern, Theory of Mind, and reasoning. Results: Results showed that older adults are more prosocial than younger adults in the Dictator Game. This finding was evident when the recipient was described with positive psychological and physical features. This pattern of results was statistically explained by the reduction in reasoning ability. Conclusion: These findings suggest a relationship between age-related reduction in reasoning ability and older adults' prosocial behavior. The theoretical and practical implication of the empirical findings are discussed.
MeSH term(s)	Adult ; Age Factors ; Aged ; Aged, 80 and over ; Aging/psychology ; Cross-Sectional Studies ; Decision Making ; Empathy/physiology ; Female ; Humans ; Italy ; Male ; Middle Aged ; Social Behavior ; Socioeconomic Factors ; Theory of Mind ; Young Adult
Language	English
Publishing date	2019-02-20
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	1038825-4
ISSN	1741-203X ; 1041-6102
ISSN (online)	1741-203X
ISSN	1041-6102
DOI	10.1017/S1041610219000061
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Zs.A 2621: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Early investigation of a novel SI306 theranostic prodrug for glioblastoma treatment.

Vagaggini, Chiara / Petroni, Debora / D'Agostino, Ilaria / Poggialini, Federica / Cavallini, Chiara / Cianciusi, Annarita / Salis, Annalisa / D'Antona, Lucia / Francesconi, Valeria / Manetti, Fabrizio / Damonte, Gianluca / Musumeci, Francesca / Menichetti, Luca / Dreassi, Elena / Carbone, Anna / Schenone, Silvia

Drug development research

2024 Volume 85, Issue 1, Page(s) e22158

Abstract: Glioblastoma multiforme (GBM) is one of the most aggressive malignancies with a high recurrence rate and poor prognosis. Theranostic, combining therapeutic and diagnostic approaches, arises as a successful strategy to improve patient outcomes through ... ...

Abstract	Glioblastoma multiforme (GBM) is one of the most aggressive malignancies with a high recurrence rate and poor prognosis. Theranostic, combining therapeutic and diagnostic approaches, arises as a successful strategy to improve patient outcomes through personalized medicine. Src is a non-receptor tyrosine kinase (nRTK) whose involvement in GBM has been extensively demonstrated. Our previous research highlighted the effectiveness of the pyrazolo[3,4-d]pyrimidine SI306 and its more soluble prodrug CMP1 as Src inhibitors both in in vitro and in vivo GBM models. In this scenario, we decided to develop a theranostic prodrug of SI306, ProSI-DOTA(
MeSH term(s)	Humans ; Precision Medicine ; Glioblastoma/diagnostic imaging ; Glioblastoma/drug therapy ; Blood-Brain Barrier ; Cell Line ; Prodrugs/pharmacology
Chemical Substances	Prodrugs
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	604587-x
ISSN	1098-2299 ; 0272-4391
ISSN (online)	1098-2299
ISSN	0272-4391
DOI	10.1002/ddr.22158
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Zs.B 2542: Show issues

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Article: Unveiling the morphogenetic code: A new path at the intersection of physical energies and chemical signaling.

Tassinari, Riccardo / Cavallini, Claudia / Olivi, Elena / Taglioli, Valentina / Zannini, Chiara / Ventura, Carlo

World journal of stem cells

2021 Volume 13, Issue 10, Page(s) 1382–1393

Abstract: In this editorial, we discuss the remarkable role of physical energies in the control of cell signaling networks and in the specification of the architectural plan of both somatic and stem cells. In particular, we focus on the biological relevance of ... ...

Abstract	In this editorial, we discuss the remarkable role of physical energies in the control of cell signaling networks and in the specification of the architectural plan of both somatic and stem cells. In particular, we focus on the biological relevance of bioelectricity in the pattern control that orchestrates both developmental and regenerative pathways. To this end, the narrative starts from the dawn of the first studies on animal electricity, reconsidering the pioneer work of Harold Saxton Burr in the light of the current achievements. We finally discuss the most recent evidence showing that bioelectric signaling is an essential component of the informational processes that control pattern specification during embryogenesis, regeneration, or even malignant transformation. We conclude that there is now mounting evidence for the existence of a Morphogenetic Code, and that deciphering this code may lead to unprecedented opportunities for the development of novel paradigms of cure in regenerative and precision medicine.
Language	English
Publishing date	2021-10-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2583482-4
ISSN	1948-0210
ISSN	1948-0210
DOI	10.4252/wjsc.v13.i10.1382
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