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  1. Article: Médicaments, sexe et genre.

    Buclin, Thierry / Rothuizen, Laura E / Livio, Françoise

    Revue medicale suisse

    2021  Volume 17, Issue 744-2, Page(s) 1262–1264

    Abstract: Sex-related differences affecting pharmacokinetic and pharmacodynamic processes result mostly from sex dimorphisms in body composition, and liver and kidney function, in addition to hormonal regulation of enzymes, transporters and drug receptors. Gender ... ...

    Title translation Medicines, sex and gender.
    Abstract Sex-related differences affecting pharmacokinetic and pharmacodynamic processes result mostly from sex dimorphisms in body composition, and liver and kidney function, in addition to hormonal regulation of enzymes, transporters and drug receptors. Gender biases have long compromised the identification of these differences in clinical trials. They also modulate prescription patterns and therapeutic benefits. Men and women would benefit from different standard dosages of some anti-infectives, anticancer agents and other treatments requiring precise dosage adjustment. This would alleviate the well-documented excess of adverse reactions affecting women. However, the variability of pharmacological responses within each sex exceeds the average male-female difference, highlighting the importance of other criteria for therapeutic individualisation.
    MeSH term(s) Antineoplastic Agents ; Female ; Humans ; Liver ; Male ; Sex Characteristics ; Sex Factors
    Chemical Substances Antineoplastic Agents
    Language French
    Publishing date 2021-07-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5998: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Traitements aggravant une infection par le COVID-19 : vraiment ?

    Rothuizen, Laura E / Livio, Françoise / Buclin, Thierry

    Revue medicale suisse

    2020  Volume 16, Issue N° 691-2, Page(s) 852–854

    Abstract: The safety of NSAIDs, corticosteroids and renin-angiotensin inhibitors in COVID-19 is challenged. NSAIDs may interfere with the defense process against viral infection and are best avoided. Systemic corticosteroids have not shown benefit in viral ... ...

    Title translation Drugs that aggravate the course of COVID-19 : really ?
    Abstract The safety of NSAIDs, corticosteroids and renin-angiotensin inhibitors in COVID-19 is challenged. NSAIDs may interfere with the defense process against viral infection and are best avoided. Systemic corticosteroids have not shown benefit in viral infection, including other coronavirus; thus they should be avoided, unless prescribed for another indication. The benefit-risk ratio is however clearly in favor of continuing inhaled corticosteroids in patients with asthma or COPD. ACE inhibitors and sartans upregulate the expression of angiotensin-converting enzyme 2 (ACE2), the pulmonary receptor for SARS-CoV-2. Any possible clinical impact of these treatments on COVID-19 infection remains to be clarified; in the meantime, they should be continued.
    MeSH term(s) Adrenal Cortex Hormones/administration & dosage ; Adrenal Cortex Hormones/adverse effects ; Angiotensin-Converting Enzyme Inhibitors/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Chemical Substances Adrenal Cortex Hormones ; Angiotensin-Converting Enzyme Inhibitors ; Anti-Inflammatory Agents, Non-Steroidal
    Keywords covid19
    Language French
    Publishing date 2020-06-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Estimating glomerular filtration rate from serum creatinine concentration in children with augmented renal clearance: all formulas are equivocal, but some are more equivocal than others.

    André, Pascal / Chtioui, Haithem / Dao, Kim / Rothuizen, Laura E / Di Paolo, Ermindo R / Diezi, Manuel / Crisinel, Pierre-Alex / Cachat, François / Chehade, Hassib / Buclin, Thierry

    Kidney international

    2023  Volume 103, Issue 1, Page(s) 225–226

    MeSH term(s) Humans ; Child ; Glomerular Filtration Rate ; Creatinine ; Renal Insufficiency ; Kidney ; Kidney Function Tests
    Chemical Substances Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2023-01-02
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.10.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Pharmacovigilance - Vaccins à ARNm contre le Covid-19 : le point sur les effets indésirables.

    Favre, Valérie / Ekobena, Pierre / Chtioui, Haithem / Rothuizen, Laura E / Livio, Françoise / Genton, Blaise / Buclin, Thierry

    Revue medicale suisse

    2022  Volume 18, Issue 767, Page(s) 190–197

    Abstract: The COVID-19 pandemic has stimulated the rapid development and large-scale use of technologically innovative vaccines, such as the mRNA vaccines Spikevax (Moderna) and Comirnaty (Pfizer-BioNTech). This unprecedented deployment has challenged ... ...

    Title translation Pharmacovigilance - mRNA COVID-19 vaccines : current state of knowledge on their adverse effects.
    Abstract The COVID-19 pandemic has stimulated the rapid development and large-scale use of technologically innovative vaccines, such as the mRNA vaccines Spikevax (Moderna) and Comirnaty (Pfizer-BioNTech). This unprecedented deployment has challenged pharmacovigilance, requiring combined skills in safety monitoring, prompt data analysis and continuous dissemination of knowledge. Main recognised adverse events of these vaccines are moderate and transient, linked to their significant reactogenicity. Active post-marketing surveillance has identified rare adverse events such as myopericarditis and a variety of skin reactions. A number of potential rare adverse events are being evaluated and could be retained at the individual level, but do not question the overall safety of these vaccines.
    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; Pandemics ; Pharmacovigilance ; RNA, Messenger ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines ; RNA, Messenger
    Language French
    Publishing date 2022-01-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    DOI 10.53738/REVMED.2022.18.767.190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5998: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Four cases of audio-vestibular disorders related to immunisation with SARS-CoV-2 mRNA vaccines.

    Ekobena, Pierre / Rothuizen, Laura E / Bedussi, Francesca / Guilcher, Pierre / Meylan, Sylvain / Ceschi, Alessandro / Girardin, François / Dao, Kim

    International journal of audiology

    2022  Volume 62, Issue 6, Page(s) 587–591

    Abstract: Objective: To gain medical insight into the clinical course and safety of otolaryngologic disorders following immunisation with severe acute respiratory coronavirus (SARS-CoV-2) mRNA-based vaccines.: Design: Case description.: Study sample: We ... ...

    Abstract Objective: To gain medical insight into the clinical course and safety of otolaryngologic disorders following immunisation with severe acute respiratory coronavirus (SARS-CoV-2) mRNA-based vaccines.
    Design: Case description.
    Study sample: We report four cases of transient audio-vestibular symptoms, which occurred shortly after inoculation of two BNT162b2 (Pfizer-BioNTech
    Results: Hearing loss was unilateral in all cases and recovered at least partially: it was associated with persistent gait instability in two cases, after 1 and 7 months. Trigger mechanisms underpinning audio-vestibular impairment remain uncertain. Immune tolerance mechanisms with off-target innate activation of T-lymphocytes may be involved in vestibulocochlear nerve disorders, as for other cranial nerves involvement.
    Conclusions: The occurrence of audio-vestibular manifestations following mRNA-based vaccines needs ENT monitoring to support their causality in such rare vaccine-related adverse events. Audio-vestibular disorders appeared of transitory nature, including hearing loss, and should not deter further efforts in large-scale vaccination campaigns against SARS-CoV-2.
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19 Vaccines/adverse effects ; BNT162 Vaccine ; COVID-19/prevention & control ; Immunization ; Vestibular Diseases/etiology ; Vestibular Diseases/genetics ; Deafness ; RNA, Messenger
    Chemical Substances COVID-19 Vaccines ; BNT162 Vaccine ; RNA, Messenger
    Language English
    Publishing date 2022-05-05
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2073098-6
    ISSN 1708-8186 ; 1499-2027
    ISSN (online) 1708-8186
    ISSN 1499-2027
    DOI 10.1080/14992027.2022.2056721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 549: Show issues Location:
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  6. Article: [Drugs that aggravate the course of COVID-19 : really ?]

    Rothuizen, Laura E. / Livio, Françoise / Buclin, Thierry

    Revue medicale suisse

    Abstract: The safety of NSAIDs, corticosteroids and renin-angiotensin inhibitors in COVID-19 is challenged NSAIDs may interfere with the defense process against viral infection and are best avoided Systemic corticosteroids have not shown benefit in viral infection, ...

    Abstract The safety of NSAIDs, corticosteroids and renin-angiotensin inhibitors in COVID-19 is challenged NSAIDs may interfere with the defense process against viral infection and are best avoided Systemic corticosteroids have not shown benefit in viral infection, including other coronavirus;thus they should be avoided, unless prescribed for another indication The benefit-risk ratio is however clearly in favor of continuing inhaled corticosteroids in patients with asthma or COPD ACE inhibitors and sartans upregulate the expression of angiotensin-converting enzyme 2 (ACE2), the pulmonary receptor for SARS-CoV-2 Any possible clinical impact of these treatments on COVID-19 infection remains to be clarified;in the meantime, they should be continued
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #141715
    Database COVID19

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  7. Article: Infections aiguës des voies respiratoires et urinaires au cabinet médical : quelques traitements en médecine complémentaire.

    Dumitrascu, Andra / Senn, Laurence / Rothuizen, Laura E / Rodondi, Pierre-Yves

    Revue medicale suisse

    2019  Volume 15, Issue 648, Page(s) 875–881

    Abstract: Respiratory tract infections such as bronchitis or sinusitis and urinary tract infections are common in the family doctor's office. Bronchitis and sinusitis are mostly of viral origin and antibiotics rarely hold a place in their management, while urinary ...

    Title translation Acute respiratory and urinary tract infections in medical practice : a selection of complementary medicines.
    Abstract Respiratory tract infections such as bronchitis or sinusitis and urinary tract infections are common in the family doctor's office. Bronchitis and sinusitis are mostly of viral origin and antibiotics rarely hold a place in their management, while urinary tract infections most often require the prescription of antibiotics. In both situations, patients often seek complementary medicines to relieve symptoms or prevent recurrences. This article aims to synthesize available data on efficacy and safety of some treatments in complementary medicine used in these indications, such as South African geranium, the combination of thyme-primrose or thyme-ivy, Echinacea or cranberry.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Bronchitis/therapy ; Complementary Therapies ; Humans ; Respiratory Tract Infections/therapy ; Sinusitis/therapy ; Urinary Tract Infections/therapy
    Chemical Substances Anti-Bacterial Agents
    Language French
    Publishing date 2019-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5998: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Drugs that aggravate the course of COVID-19 : really ? TT - Traitements aggravant une infection par le COVID-19 : vraiment ?

    Rothuizen, Laura E. / Livio, Francoise / Buclin, Thierry

    Revue medicale suisse

    Abstract: The safety of NSAIDs, corticosteroids and renin-angiotensin inhibitors in COVID-19 is challenged NSAIDs may interfere with the defense process against viral infection and are best avoided Systemic corticosteroids have not shown benefit in viral infection, ...

    Abstract The safety of NSAIDs, corticosteroids and renin-angiotensin inhibitors in COVID-19 is challenged NSAIDs may interfere with the defense process against viral infection and are best avoided Systemic corticosteroids have not shown benefit in viral infection, including other coronavirus;thus they should be avoided, unless prescribed for another indication The benefit-risk ratio is however clearly in favor of continuing inhaled corticosteroids in patients with asthma or COPD ACE inhibitors and sartans upregulate the expression of angiotensin-converting enzyme 2 (ACE2), the pulmonary receptor for SARS-CoV-2 Any possible clinical impact of these treatments on COVID-19 infection remains to be clarified;in the meantime, they should be continued La securite des AINS, corticoides et antihypertenseurs agissant sur le systeme renine-angiotensine lors dinfection a COVID-19 est mise en question Les AINS pourraient interferer avec le processus de defense face a une infection virale ;ils sont donc plutot a eviter Les corticoides systemiques nont pas montre de benefice lors dinfections virales, y compris a dautres coronavirus ;ils sont a eviter, sauf si prescrits pour une autre indication Le rapport benefice/risque est en revanche clairement en faveur de la poursuite des corticosteroides inhales chez les asthmatiques ou BPCO Les IEC et les sartans modulent lexpression de lenzyme de conversion de langiotensine 2 (ACE2), recepteur pulmonaire du SARS-CoV-2 Limpact clinique de ces traitements sur linfection a COVID-19 reste a preciser ;en attendant, ils sont a poursuivre
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #154680
    Database COVID19

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  9. Article: Drugs that aggravate the course of COVID-19 : really ?/ Traitements aggravant une infection par le COVID-19 : vraiment ?

    Rothuizen, Laura E. / Livio, Francoise / Buclin, Thierry

    Revue medicale suisse

    Abstract: The safety of NSAIDs, corticosteroids and renin-angiotensin inhibitors in COVID-19 is challenged NSAIDs may interfere with the defense process against viral infection and are best avoided Systemic corticosteroids have not shown benefit in viral infection, ...

    Abstract The safety of NSAIDs, corticosteroids and renin-angiotensin inhibitors in COVID-19 is challenged NSAIDs may interfere with the defense process against viral infection and are best avoided Systemic corticosteroids have not shown benefit in viral infection, including other coronavirus;thus they should be avoided, unless prescribed for another indication The benefit-risk ratio is however clearly in favor of continuing inhaled corticosteroids in patients with asthma or COPD ACE inhibitors and sartans upregulate the expression of angiotensin-converting enzyme 2 (ACE2), the pulmonary receptor for SARS-CoV-2 Any possible clinical impact of these treatments on COVID-19 infection remains to be clarified;in the meantime, they should be continued La securite des AINS, corticoides et antihypertenseurs agissant sur le systeme renine-angiotensine lors dinfection a COVID-19 est mise en question Les AINS pourraient interferer avec le processus de defense face a une infection virale ;ils sont donc plutot a eviter Les corticoides systemiques nont pas montre de benefice lors dinfections virales, y compris a dautres coronavirus ;ils sont a eviter, sauf si prescrits pour une autre indication Le rapport benefice/risque est en revanche clairement en faveur de la poursuite des corticosteroides inhales chez les asthmatiques ou BPCO Les IEC et les sartans modulent lexpression de lenzyme de conversion de langiotensine 2 (ACE2), recepteur pulmonaire du SARS-CoV-2 Limpact clinique de ces traitements sur linfection a COVID-19 reste a preciser ;en attendant, ils sont a poursuivre
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #154680
    Database COVID19

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    Inter-library loan at ZB MED

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  10. Article: Ensuring Sufficient Trough Plasma Concentrations for Broad-Spectrum Beta-Lactam Antibiotics in Children With Malignancies: Beware of Augmented Renal Clearance!

    André, Pascal / Diezi, Léonore / Dao, Kim / Crisinel, Pierre Alex / Rothuizen, Laura E / Chtioui, Haithem / Decosterd, Laurent Arthur / Diezi, Manuel / Asner, Sandra / Buclin, Thierry

    Frontiers in pediatrics

    2022  Volume 9, Page(s) 768438

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2022-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.768438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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