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Article ; Online: Revascularization of vertebrobasilar tandem occlusions: a meta-analysis.

Mahmoud, Mohamed Nabil / Zaitoun, Mohamed M A / Abdalla, Mohamed A

2021 Volume 64, Issue 4, Page(s) 637–645

Abstract: ... patients (seven studies). We found no significant difference regarding 3 m functional independence [4 ...

Abstract	Purpose: To investigate the difference in mechanical thrombectomy (MT) outcomes between vertebrobasilar tandem occlusion (VBTO) and isolated basilar artery (BA) occlusion (non-VBTO) and the difference in rates of successful recanalization between the clean-road and dirty-road pathways, in VBTO. Methods: We conducted a meta-analysis after searching PubMed, EMBASE, and Google Scholar databases as of April 2021. We only included adult patients who underwent MT to treat acute ischemic stroke (AIS) due to VBTO, and the following outcomes should be reported: successful recanalization, functional outcome at 90 days, and symptomatic intracerebral hemorrhage (sICH). The main effect size measures were odds ratio and risk difference, and the software used was RevMan 5.4. Results: The analysis included 81 VBTO and 324 non-VBTO patients (seven studies). We found no significant difference regarding 3 m functional independence [4 studies: OR = 1.71 (95% CI, 0.54, 5.43), I Conclusion: The results of this meta-analysis support the use of MT for AIS patients with VBTO. In VBTO patients, none of the clean-road or dirty-road pathways proved to be superior to the other.
MeSH term(s)	Adult ; Basilar Artery ; Brain Ischemia ; Humans ; Ischemic Stroke ; Stroke/therapy ; Thrombectomy ; Treatment Outcome
Language	English
Publishing date	2021-11-25
Publishing country	Germany
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	123305-1
ISSN	1432-1920 ; 0028-3940
ISSN (online)	1432-1920
ISSN	0028-3940
DOI	10.1007/s00234-021-02866-w
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Article ; Conference proceedings: Transfemoral versus Transradial Partial Splenic Artery Embolization in Patients with Hypersplenism

Eladl, Ibrahim M. / Zaitoun, Mohamed M. A.

The Arab Journal of Interventional Radiology

2023 Volume 07, Issue S 01

Event/congress	PAIRS 2023 Annual Congress, Grand Hyatt Hotel, Dubai, UAE, 2023-02-11
Language	English
Publishing date	2023-02-01
Publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ISSN	2542-7083 ; 2542-7075
ISSN (online)	2542-7083
ISSN	2542-7075
DOI	10.1055/s-0043-1763408
Database	Thieme publisher's database

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Article ; Online: Application of supraclavicular island flap in oral and maxillofacial reconstruction.

Zaitoun, Abdalla / Fata, Mohamed / Shafei, Mohamed El / Abdeldayem, Mohamed / Koraitim, Mohamed

Oral and maxillofacial surgery

2024

Abstract: Several surgical modalities are available for maxillofacial reconstruction as locoregional or microvascular free flaps.: Purpose: (a) Evaluate the reliability of the supraclavicular flap in cervico-orofacial region; (b) investigate the role of ... ...

Abstract	Several surgical modalities are available for maxillofacial reconstruction as locoregional or microvascular free flaps. Purpose: (a) Evaluate the reliability of the supraclavicular flap in cervico-orofacial region; (b) investigate the role of computed tomography angiography (CTA) in predicting the post-operative viability of the flap; (c) assess the speech, feeding, and esthetics after reconstruction using this flap. Methods: Eleven patients included in this study underwent either conventional or delayed harvesting of the supraclavicular flap (SCF). All the patients had diagnostic computed tomography angiography (CTA) of the supraclavicular flap before the surgery. Results: The mean harvesting time of the flap was 45.45 ± 4.16 min. The average length of the flap was 22.64 ± 1.12 cm, whereas the mean width of the flap was 6.14 ± 1.14 cm. The flap survived in 9 patients, while two patients had complete flap loss. After the surgery, three patients complained of speech difficulties. Two patients had swallowing problems. After the surgery, three patients complained of speech difficulties. Two patients had swallowing problems. Only two patients complained of weakness in the donor site. None of the patients reported that the weakness or pain at the donor site affected their daily activities or quality of life. Conclusion: The pedicled SCF represents a safe and feasible option that can be used to reconstruct a wide array of maxillofacial oncologic defects. However, a study with a larger sample size is recommended to achieve more reliable clinical results for the modified delayed technique modification in terms of their effect on the survival of the supraclavicular flap.
Language	English
Publishing date	2024-02-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2406731-3
ISSN	1865-1569 ; 1865-1550
ISSN (online)	1865-1569
ISSN	1865-1550
DOI	10.1007/s10006-024-01225-2
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Article ; Online: Explosomes: A new modality for DEB-TACE local delivery of sorafenib: In vivo proof of sustained release.

Sakr, Omar S / Zaitoun, Mohamed M A / Amer, Mohamed S / Qubisi, Mahmoud / Elshafeey, Ahmed H / Jordan, Olivier / Borchard, Gerrit

Journal of controlled release : official journal of the Controlled Release Society

2023 Volume 364, Page(s) 12–22

Abstract: The current medical practice in treating Hepatocellular carcinoma (HCC) using Drug Eluting Transarterial chemoembolization (DEB-TACE) technique is limited only to hydrophilic ionizable drugs, that can be attached ionically to the oppositely charged beads. ...

Abstract	The current medical practice in treating Hepatocellular carcinoma (HCC) using Drug Eluting Transarterial chemoembolization (DEB-TACE) technique is limited only to hydrophilic ionizable drugs, that can be attached ionically to the oppositely charged beads. This limitation has forced physicians to subscribe the more hydrophobic, first treatment option drugs, like sorafenib systemically via the oral route, thus flooding the patient system with a very powerful, non-specific, multiple-receptor tyrosine kinase inhibitor that is associated with notorious side effects. In this paper, a new modality is introduced, where highly charged, drug loaded liposomes are added to oppositely charged DEBs in a manner causing them to "explode" and the drug is eventually attached to the beads in the lipid patches covering their surfaces; therefore we call them "Explosomes". After fully describing the preparation process and in vitro characterization, this manuscript delves into an in vivo pharmacokinetic study over 50 New Zealand rabbits, where explosomal loading is challenged vs oral as well as current practice of emulsifying sorafenib in lipiodol. Over 14 days of follow up, and compared to other groups, explosomal loading of SRF on embolic beads proved to cause a slower release pattern with longer T
MeSH term(s)	Humans ; Animals ; Rabbits ; Sorafenib ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/therapy ; Delayed-Action Preparations/therapeutic use ; Doxorubicin ; Chemoembolization, Therapeutic/methods ; Treatment Outcome
Chemical Substances	Sorafenib (9ZOQ3TZI87) ; Delayed-Action Preparations ; Doxorubicin (80168379AG)
Language	English
Publishing date	2023-10-23
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2023.10.013
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Article: A quantitative and qualitative assessment of sugar beet genotype resistance to root-knot nematode,

Gohar, Ibrahim M A / Alyamani, Amal / Shafi, Manal E / Mohamed, Elshaimaa A E / Ghareeb, Rehab Y / Desoky, Elsayed M / Hasan, Mohamed E / Zaitoun, Amera F / Abdelsalam, Nader R / El-Tarabily, Khaled A / Elnahal, Ahmed S M

Frontiers in plant science

2023 Volume 13, Page(s) 966377

Abstract: Sugar beet productivity is highly constrained by the root-knot nematode (RKN) ...

Abstract	Sugar beet productivity is highly constrained by the root-knot nematode (RKN)
Language	English
Publishing date	2023-01-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2022.966377
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Article ; Online: Constrained spherical deconvolution -based tractography of major language tracts reveals post-stroke bilateral white matter changes correlated to aphasia.

Soliman, Radwa Kamel / Tax, Chantal M W / Abo-Elfetoh, Noha / Zaitoun, Mohamed M A / Khedr, Eman M

Magnetic resonance imaging

2022 Volume 95, Page(s) 19–26

Abstract: Purpose: Using constrained spherical deconvolution (CSD)-based tractography, we aimed to obtain conjoint analysis of diffusion measures of major language white matter (WM) tracts in post-stroke aphasic patients bilaterally, and to correlate the measures ...

Abstract	Purpose: Using constrained spherical deconvolution (CSD)-based tractography, we aimed to obtain conjoint analysis of diffusion measures of major language white matter (WM) tracts in post-stroke aphasic patients bilaterally, and to correlate the measures of each tract to the different language deficits. Material and methods: 17 aphasic patients with left hemispheric stroke, at the subacute stage, and ten age- matched controls underwent diffusion MRI examination. CSD-based tractography was performed. Diffusion measures [fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), axial diffusivity (AD)] were extracted after dissection of major language tracts bilaterally. Aphasia was assessed using language subset of hemispheric stroke scale. Comparisons of diffusion measures, for all tracts, between the two groups were performed. Partial correlations between the diffusion measures and different language components were obtained. Results: In the left hemisphere, significant lower FA and or higher MD with higher RD of patients' WM tracts compared to the control group. Significant differences of diffusion measures were also evident in the right hemisphere yet, less prominent. All changes reflected damage of the tracts' integrity. Significant correlations were found between comprehension and FA of the left arcuate fasciculus (AF) and left inferior longitudinal fasciculus. Additionally, a significant correlation was found between MD of the right AF and repetition. Conclusion: Conjoint analysis of diffusion measures, based on CSD tractography, can provide important markers for the underlying WM changes bilaterally. Moreover, our findings emphasize that language processing can be mediated by both ventral and dorsal streams and further highlight the contribution of the right AF in repetition.
MeSH term(s)	Humans ; White Matter/diagnostic imaging ; Language ; Diffusion Tensor Imaging ; Neural Pathways ; Aphasia/diagnostic imaging ; Aphasia/etiology ; Stroke/complications ; Stroke/diagnostic imaging
Language	English
Publishing date	2022-10-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604885-7
ISSN	1873-5894 ; 0730-725X
ISSN (online)	1873-5894
ISSN	0730-725X
DOI	10.1016/j.mri.2022.10.004
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Article ; Online: Prophylactic common iliac artery temporary clamping versus balloon occlusion for management of placenta accreta spectrum disorders: A prospective clinical trial.

Bessar, Ahmed Awad / Heraiz, Ahmed Ismail / Ibrahim, Ahmed Gamil / Salem, Mahmoud M A / Zaitoun, Mohamed Moustafa / Aboelfateh, Amr Mostafa Kamel / Gad, Abdalla Hassan

The journal of obstetrics and gynaecology research

2023 Volume 50, Issue 3, Page(s) 373–380

Abstract: Objective: The present study aims to compare prophylactic common iliac artery (CIA) temporary clamping and preoperative balloon occlusion for managing placenta accreta spectrum (PAS) disorders.: Study design: Between January 2019 and June 2020, 46 ... ...

Abstract	Objective: The present study aims to compare prophylactic common iliac artery (CIA) temporary clamping and preoperative balloon occlusion for managing placenta accreta spectrum (PAS) disorders. Study design: Between January 2019 and June 2020, 46 patients with PAS disorders were included. Of them, 26 patients were offered CIA balloon occlusion (Group A), while temporary CIA clamping was done for the other 20 patients (Group B). Primary outcomes were procedure-related complications, and secondary outcomes included intraoperative and postoperative complications, reoperation rates, total procedure time, blood loss, and amount of blood transfusion. Results: Blood loss was statistically non-significant higher in group B than in group A (p-value = 0.143). Only one patient in group A and three in group B needed reoperation. The bleeding continued for a mean of 1.6 days in group A and 1.7 days in group B, with non-significant statistical differences between both groups p value = 0.71. Nine patients in group A (34.6%) and four in group B (20%) required ICU admission. The mean Apgar score was 7 and 6.6 in babies of group A and group B patients, respectively. The median number of allogeneic blood transfusions performed was two in patients in group A and 1 in group B (p-value = 0.001). Conclusion: Both techniques offer good choices for patients with PAS to decrease mortality and morbidity rates. The selection of a better technique depends on institutional references and physicians' experience.
MeSH term(s)	Infant ; Female ; Pregnancy ; Humans ; Constriction ; Iliac Artery/surgery ; Placenta Accreta/surgery ; Prospective Studies ; Balloon Occlusion ; Placenta Diseases
Language	English
Publishing date	2023-12-18
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1327307-3
ISSN	1447-0756 ; 1341-8076
ISSN (online)	1447-0756
ISSN	1341-8076
DOI	10.1111/jog.15856
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Article ; Online: Partial splenic artery embolization (PSE) in a patient with grey platelet syndrome (GPS)

Mohamed M. A. Zaitoun / Rania Mohammad Abdullah / Nahla A. Zaitoun / Shahenda Shahin / Mohammad Abd Alkhalik Basha

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 53, Iss 1, Pp 1-

a case report

2022 Volume 5

Abstract: Abstract Background Grey platelet syndrome (GPS) is a rare cause of mild-to-severe bleeding. Up till now, there has been no definite treatment for GPS. Case presentation We reported a case diagnosed as GPS and presented with menorrhagia, metrorrhagia, ... ...

Abstract	Abstract Background Grey platelet syndrome (GPS) is a rare cause of mild-to-severe bleeding. Up till now, there has been no definite treatment for GPS. Case presentation We reported a case diagnosed as GPS and presented with menorrhagia, metrorrhagia, gingival bleeding, and left hypochondrial pain. The platelet count was 18 thousand/cmm. Ultrasound splenic diameter was 22.0 cm. The multidisciplinary team decided to perform splenectomy; however, the patient was unfit for surgery. Partial splenic artery embolization (PSE) was performed. Follow-up after 24 months showed a normal menstrual cycle and absent pain. Platelet count rise to 70, 55, and 51 thousand/cmm after 1, 12, and 24 months, respectively. Splenic diameter showed a significant decrease to 11.2 cm after 24 months. Conclusion PSE is effective and safe in symptomatic patients with GPS.
Keywords	Grey platelet syndrome ; Thrombocytopenia ; Splenomegaly ; Partial splenic artery embolization ; Case report ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
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Article: Immunohistochemical evaluation of forkhead box A1 and EphA5 markers in serous ovarian carcinomas, and their impact on the clinical outcome of patients.

Abouhashem, Nehal / Harb, Ola / Elwan, Amira / Zaitoun, Mohamed / Saraya, Yasser

Polish journal of pathology : official journal of the Polish Society of Pathologists

2022 Volume 73, Issue 2, Page(s) 120–133

Abstract: Ovarian cancer is the most lethal gynaecological neoplasm in females. In ovarian cancer, forkhead box A1 (FOXA1) aids transcription of YAP-associated protein mediated by the cyclic adenosine monophosphate response element-binding protein. As a result, ... ...

Abstract	Ovarian cancer is the most lethal gynaecological neoplasm in females. In ovarian cancer, forkhead box A1 (FOXA1) aids transcription of YAP-associated protein mediated by the cyclic adenosine monophosphate response element-binding protein. As a result, cellular proliferation and migration increased. The roles of erythropoietin-producing human hepatocellular carcinoma cell (Eph) receptors and ephrin ligands in cell adhesion, migration, cell proliferation regulation in various cancers, and angiogenesis are well characterized. This study included formalin-fixed, paraffin-embedded tissue specimens from 41 patients with ovarian serous cystadenocarcinoma, including both low- and high-grade tumours. For each case, a paraffin block with tumour tissue was chosen for an immunohistochemical procedure using primary antibodies against EphA5 and FOXA1. By the end of 2017, patients finished their chemotherapy and were followed for the next 3 years. Positive FOXA1 and EphA5 results were presented in 68.3% and 39% of patients, respectively. A statistically significant correlation was detected between FOXA1 expression and each of CA-125 level, tumour stage, tumour grade, and the presence of lymph node metastasis. In our work, the overall survival was positively correlated with EphA5 expression and inversely correlated to FOXA1 immunoreactivity. The estimated disease-free survival (DFS) and EphA5 immunoreactivity had a significant positive association, whereas DFS and FOXA1 protein expression had a significant inverse link. FOXA1 and EphA5 expression play a role in ovarian cancer progression and prognosis prediction.
MeSH term(s)	Female ; Humans ; Biomarkers, Tumor ; Cystadenocarcinoma, Serous ; Hepatocyte Nuclear Factor 3-alpha/metabolism ; Immunohistochemistry ; Ovarian Neoplasms/pathology ; Prognosis ; Receptor, EphA5
Chemical Substances	Biomarkers, Tumor ; EPHA5 protein, human (EC 2.7.10.1) ; Hepatocyte Nuclear Factor 3-alpha ; Receptor, EphA5 (EC 2.7.10.1) ; FOXA1 protein, human
Language	English
Publishing date	2022-11-08
Publishing country	Poland
Document type	Journal Article
ZDB-ID	1283064-1
ISSN	1233-9687 ; 0031-3114
ISSN	1233-9687 ; 0031-3114
DOI	10.5114/pjp.2022.120097
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Article ; Online: Renal arterial resistive index versus novel biomarkers for the early prediction of sepsis-associated acute kidney injury.

Zaitoun, Taysser / Megahed, Mohamed / Elghoneimy, Hesham / Emara, Doaa M / Elsayed, Ibrahim / Ahmed, Islam

Internal and emergency medicine

2024

Abstract: Acute kidney injury (AKI) is a critical complication of sepsis. There is a continuous need to identify and validate biomarkers for early detection. Serum and urinary biomarkers have been investigated, such as neutrophil gelatinase associated lipocalin ( ... ...

Abstract	Acute kidney injury (AKI) is a critical complication of sepsis. There is a continuous need to identify and validate biomarkers for early detection. Serum and urinary biomarkers have been investigated, such as neutrophil gelatinase associated lipocalin (NGAL) and cystatin C (Cys C), but their reliability in the intensive care unit (ICU) remains unknown. Renal hemodynamics can be investigated by measuring the renal resistive index (RRI). This study aimed to compare the performance of RRI, serum NGAL (sNGAL), urinary NGAL (uNGAL), and serum Cys C levels as early predictors of the diagnosis and persistence of sepsis-associated AKI. A total of 166 adult patients with sepsis syndrome were enrolled immediately after ICU admission. Biomarkers were measured directly (T1) and on day 3 (T3). RRI was measured directly (T1) and 24 h later (T2). Patients were categorized (according to the occurrence and persistence of AKI within the first 7 days) into three groups: no AKI, transient AKI, and persistent AKI. The incidence rate of sepsis-associated AKI was 60.2%. Sixty-six patients were categorized as in the no AKI group, while another 61 were in transient AKI and only 39 were in persistent AKI. The RRI value (T1 ≥ 0.72) was the best tool for predicting AKI diagnosis (area under the receiver operating characteristic curve, AUROC = 0.905). Cys C (T1 ≥ 15.1 mg/l) was the best tool to predict the persistence of AKI (AUROC = 0.977). RRI (T1) was the best predictive tool for sepsis-associated AKI, while Cys C was the best predictor of its persistence and 28-day mortality.
Language	English
Publishing date	2024-03-06
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-024-03558-y
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