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Book ; Online ; E-Book: Tourism Transformations in Protected Area Gateway Communities

Slocum, Susan L. / Wiltshier, Peter / IV, John Basil Read / Bohn, Dorothee / Botelho, Andrea Zita / Bricker, Kelly S. / Bristow, Robert S. / Casimiro, Karina H. / Chaparro, Rosa Suárez / Costa, Ana Cristina

2022

Abstract: Gateway communities are those located adjacent to protected areas and are often the communities most impacted by tourism visitation and are dependent on tourism revenue. This book presents informed, interpreted, and nuanced approaches towards protect ... ...

Abstract	Gateway communities are those located adjacent to protected areas and are often the communities most impacted by tourism visitation and are dependent on tourism revenue. This book presents informed, interpreted, and nuanced approaches towards protect area management and conservation, based on bottom-up local experiences by the gateway communities.
Keywords	Tourism/Environmental aspects ; Ecotourism ; Protected areas/Public use.
Subject code	333.72
Language	English
Size	1 online resource (287 pages)
Publisher	CAB International
Publishing place	Oxford
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	1-78924-904-X ; 1-78924-905-8 ; 9781789249033 ; 978-1-78924-904-0 ; 978-1-78924-905-7 ; 1789249031
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Real-time monitoring of infant theta power during naturalistic social experiences.

Throm, Elena / Gui, Anna / Haartsen, Rianne / da Costa, Pedro F / Leech, Robert / Jones, Emily J H

Developmental cognitive neuroscience

2023 Volume 63, Page(s) 101300

Abstract: Infant-directed speech and direct gaze are important social cues that shape infant's attention to their parents. Traditional methods for probing their effect on infant attention involve a small number of pre-selected screen-based stimuli, which do not ... ...

Abstract	Infant-directed speech and direct gaze are important social cues that shape infant's attention to their parents. Traditional methods for probing their effect on infant attention involve a small number of pre-selected screen-based stimuli, which do not capture the complexity of real-world interactions. Here, we used neuroadaptive Bayesian Optimization (NBO) to search a large 'space' of different naturalistic social experiences that systematically varied in their visual (gaze direct to averted) and auditory properties (infant directed speech to nonvocal sounds). We measured oscillatory brain responses (relative theta power) during episodes of naturalistic social experiences in 57 typically developing 6- to 12-month-old infants. Relative theta power was used as input to the NBO algorithm to identify the naturalistic social context that maximally elicited attention in each individual infant. Results showed that individual infants were heterogeneous in the stimulus that elicited maximal theta with no overall stronger attention for direct gaze or infant-directed speech; however, individual differences in attention towards averted gaze were related to interpersonal skills and greater likelihood of preferring speech and direct gaze was observed in infants whose parents showed more positive affect. Our work indicates NBO may be a fruitful method for probing the role of distinct social cues in eliciting attention in naturalistic social contexts at the individual level.
MeSH term(s)	Humans ; Infant ; Bayes Theorem ; Brain/physiology ; Speech ; Cues ; Parents ; Fixation, Ocular
Language	English
Publishing date	2023-09-21
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2572271-2
ISSN	1878-9307 ; 1878-9307
ISSN (online)	1878-9307
ISSN	1878-9307
DOI	10.1016/j.dcn.2023.101300
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Article: Virtual Fly Brain-An interactive atlas of the

Court, Robert / Costa, Marta / Pilgrim, Clare / Millburn, Gillian / Holmes, Alex / McLachlan, Alex / Larkin, Aoife / Matentzoglu, Nicolas / Kir, Huseyin / Parkinson, Helen / Brown, Nicolas H / O'Kane, Cahir J / Armstrong, J Douglas / Jefferis, Gregory S X E / Osumi-Sutherland, David

Frontiers in physiology

2023 Volume 14, Page(s) 1076533

Abstract: As a model organism, ...

Abstract	As a model organism,
Language	English
Publishing date	2023-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2023.1076533
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Article: Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2.

Junqueira Alves, Chrystian / Hannah, Theodore / Sadia, Sita / Kolsteeg, Christy / Dixon, Angela / Wiener, Robert J / Nguyen, Ha / Tipping, Murray J / Ladeira, Júlia Silva / Franklin, Paula Fernandes da Costa / Dutra de Nigro, Nathália de Paula / Dias, Rodrigo Alves / Zabala Capriles, Priscila V / Rodrigues Furtado de Mendonça, José P / Slesinger, Paul / Costa, Kevin / Zou, Hongyan / Friedel, Roland H

bioRxiv : the preprint server for biology

2024

Abstract: Glioblastoma (GBM) is a malignant brain tumor with uncontrolled invasive growth. Here, we demonstrate how GBM cells usurp guidance receptor Plexin-B2 to gain biomechanical plasticity for polarized migration through confined space. Using live-cell imaging ...

Abstract	Glioblastoma (GBM) is a malignant brain tumor with uncontrolled invasive growth. Here, we demonstrate how GBM cells usurp guidance receptor Plexin-B2 to gain biomechanical plasticity for polarized migration through confined space. Using live-cell imaging to track GBM cells negotiating microchannels, we reveal active endocytosis at cell front and filamentous actin assembly at rear to propel GBM cells through constrictions. These two processes are interconnected and governed by Plexin-B2 that orchestrates cortical actin and membrane tension, shown by biomechanical assays. Molecular dynamics simulations predict that balanced membrane and actin tension are required for optimal migratory velocity and consistency. Furthermore, Plexin-B2 mechanosensitive function requires a bendable extracellular ring structure and affects membrane internalization, permeability, phospholipid composition, as well as inner membrane surface charge. Together, our studies unveil a key element of membrane tension and mechanoelectrical coupling via Plexin-B2 that enables GBM cells to adapt to physical constraints and achieve polarized confined migration.
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.02.573660
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Article ; Online: In-vitro biological evaluation of 3,3',5,5'-tetramethoxy-biphenyl-4,4'-diol and molecular docking studies on trypanothione reductase and Gp63 from Leishmania amazonensis demonstrated anti-leishmania potential.

Schirmann, Jéseka G / Bortoleti, Bruna T S / Gonçalves, Manoela D / Tomiotto-Pellissier, Fernanda / Camargo, Priscila G / Miranda-Sapla, Milena M / Lima, Camilo H S / Bispo, Marcelle L F / Costa, Idessania N / Conchon-Costa, Ivete / Pavanelli, Wander R / Dekker, Robert F H / Barbosa-Dekker, Aneli M

Scientific reports

2023 Volume 13, Issue 1, Page(s) 6928

Abstract: Available treatments for leishmaniasis have been widely used since the 1940s but come at a high cost, variable efficacy, high toxicity, and adverse side-effects. 3,3',5,5'-Tetramethoxy-biphenyl-4,4'-diol (TMBP) was synthesized through laccase-catalysis ... ...

Abstract	Available treatments for leishmaniasis have been widely used since the 1940s but come at a high cost, variable efficacy, high toxicity, and adverse side-effects. 3,3',5,5'-Tetramethoxy-biphenyl-4,4'-diol (TMBP) was synthesized through laccase-catalysis of 2,6-dimethoxyphenol and displayed antioxidant and anticancer activity, and is considered a potential drug candidate. Thus, this study aimed to evaluate the anti-leishmanial effect of TMBP against promastigote and amastigote forms of Leishmania (L.) amazonensis and investigated the mechanisms involved in parasite death. TMBP treatment inhibited the proliferation (IC
MeSH term(s)	Animals ; Sheep ; Mice ; Leishmania ; Molecular Docking Simulation ; Antiprotozoal Agents/pharmacology ; Antiprotozoal Agents/chemistry ; Leishmania mexicana ; Mice, Inbred BALB C
Chemical Substances	trypanothione reductase (EC 1.8.1.12) ; diphenyl (2L9GJK6MGN) ; Antiprotozoal Agents
Language	English
Publishing date	2023-04-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-34124-9
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Article ; Online: Bladder Stones in Renal Transplant Patients: Presentation, Management, and Follow-up.

Sandberg, Maxwell / Cohen, Adam / Escott, Megan / Temple, Davis / Marie-Costa, Claudia / Rodriguez, Rainer / Gordon, Alex / Rong, Anita / Andres-Robusto, Brian / Roebuck, Emily H / Whitman, Wyatt / Webb, Christopher J / Stratta, Robert J / Assimos, Dean / Wood, Kyle / Mirzazadeh, Maajid

Urologia internationalis

2024

Abstract: Introduction: The study aim was to analyze the presentation, management, and follow-up of renal transplant patients developing bladder calculi.: Methods: Patients who underwent renal transplant with postoperative follow-up at our institution were ... ...

Abstract	Introduction: The study aim was to analyze the presentation, management, and follow-up of renal transplant patients developing bladder calculi. Methods: Patients who underwent renal transplant with postoperative follow-up at our institution were retrospectively analyzed (1984-2023) to assess for the development of post-transplant bladder stones. All bladder stones were identified by computerized tomography (CT) imaging and stone size was measured using this imaging modality. Results: The prevalence of bladder calculi post-renal transplantation during the study window was 0.22% (N=20/8835) with a median time to bladder stone diagnosis of 13 years post-transplant. Of all bladder stone patients, 6 (30%) received deceased donor and 14 (70%) living donor transplants. There were 11 patients with known bladder stone composition available; the most common being calcium oxalate (N=6). Eleven (55%) patients had clinical signs or symptoms (most commonly microhematuria). Fourteen of the bladder stone cohort patients (70%) underwent treatment including cystolitholapaxy in 12 subjects. Of these 14 patients, 9 (64%) were found to have non-absorbable suture used for their ureteroneocystotomy closure. Conclusions: The prevalence of bladder stones post-renal transplant is low. The utilization of non-absorbable suture for ureteral implantation was the main risk factor identified in our series. This technique is no longer used at our institution. Other factors contributing to bladder stone formation in this population warrant identification.
Language	English
Publishing date	2024-04-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	204045-1
ISSN	1423-0399 ; 0042-1138
ISSN (online)	1423-0399
ISSN	0042-1138
DOI	10.1159/000539091
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Article ; Online: The role of the lateral orbitofrontal cortex in creating cognitive maps.

Costa, Kauê Machado / Scholz, Robert / Lloyd, Kevin / Moreno-Castilla, Perla / Gardner, Matthew P H / Dayan, Peter / Schoenbaum, Geoffrey

Nature neuroscience

2022 Volume 26, Issue 1, Page(s) 107–115

Abstract: We use mental models of the world-cognitive maps-to guide behavior. The lateral orbitofrontal cortex (lOFC) is typically thought to support behavior by deploying these maps to simulate outcomes, but recent evidence suggests that it may instead support ... ...

Abstract	We use mental models of the world-cognitive maps-to guide behavior. The lateral orbitofrontal cortex (lOFC) is typically thought to support behavior by deploying these maps to simulate outcomes, but recent evidence suggests that it may instead support behavior by underlying map creation. We tested between these two alternatives using outcome-specific devaluation and a high-potency chemogenetic approach. Selectively inactivating lOFC principal neurons when male rats learned distinct cue-outcome associations, but before outcome devaluation, disrupted subsequent inference, confirming a role for the lOFC in creating new maps. However, lOFC inactivation surprisingly led to generalized devaluation, a result that is inconsistent with a complete mapping failure. Using a reinforcement learning framework, we show that this effect is best explained by a circumscribed deficit in credit assignment precision during map construction, suggesting that the lOFC has a selective role in defining the specificity of associations that comprise cognitive maps.
MeSH term(s)	Male ; Rats ; Animals ; Prefrontal Cortex/physiology ; Learning/physiology ; Reinforcement, Psychology ; Choice Behavior/physiology ; Cognition
Language	English
Publishing date	2022-12-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1420596-8
ISSN	1546-1726 ; 1097-6256
ISSN (online)	1546-1726
ISSN	1097-6256
DOI	10.1038/s41593-022-01216-0
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Zs.A 4891: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Machine Learning Links T-cell Function and Spatial Localization to Neoadjuvant Immunotherapy and Clinical Outcome in Pancreatic Cancer.

Blise, Katie E / Sivagnanam, Shamilene / Betts, Courtney B / Betre, Konjit / Kirchberger, Nell / Tate, Benjamin J / Furth, Emma E / Dias Costa, Andressa / Nowak, Jonathan A / Wolpin, Brian M / Vonderheide, Robert H / Goecks, Jeremy / Coussens, Lisa M / Byrne, Katelyn T

Cancer immunology research

2024 Volume 12, Issue 5, Page(s) 544–558

Abstract: Tumor molecular data sets are becoming increasingly complex, making it nearly impossible for humans alone to effectively analyze them. Here, we demonstrate the power of using machine learning (ML) to analyze a single-cell, spatial, and highly multiplexed ...

Abstract	Tumor molecular data sets are becoming increasingly complex, making it nearly impossible for humans alone to effectively analyze them. Here, we demonstrate the power of using machine learning (ML) to analyze a single-cell, spatial, and highly multiplexed proteomic data set from human pancreatic cancer and reveal underlying biological mechanisms that may contribute to clinical outcomes. We designed a multiplex immunohistochemistry antibody panel to compare T-cell functionality and spatial localization in resected tumors from treatment-naïve patients with localized pancreatic ductal adenocarcinoma (PDAC) with resected tumors from a second cohort of patients treated with neoadjuvant agonistic CD40 (anti-CD40) monoclonal antibody therapy. In total, nearly 2.5 million cells from 306 tissue regions collected from 29 patients across both cohorts were assayed, and over 1,000 tumor microenvironment (TME) features were quantified. We then trained ML models to accurately predict anti-CD40 treatment status and disease-free survival (DFS) following anti-CD40 therapy based on TME features. Through downstream interpretation of the ML models' predictions, we found anti-CD40 therapy reduced canonical aspects of T-cell exhaustion within the TME, as compared with treatment-naïve TMEs. Using automated clustering approaches, we found improved DFS following anti-CD40 therapy correlated with an increased presence of CD44+CD4+ Th1 cells located specifically within cellular neighborhoods characterized by increased T-cell proliferation, antigen experience, and cytotoxicity in immune aggregates. Overall, our results demonstrate the utility of ML in molecular cancer immunology applications, highlight the impact of anti-CD40 therapy on T cells within the TME, and identify potential candidate biomarkers of DFS for anti-CD40-treated patients with PDAC.
MeSH term(s)	Humans ; Machine Learning ; Pancreatic Neoplasms/immunology ; Pancreatic Neoplasms/therapy ; Pancreatic Neoplasms/pathology ; Tumor Microenvironment/immunology ; Neoadjuvant Therapy ; Immunotherapy/methods ; Carcinoma, Pancreatic Ductal/immunology ; Carcinoma, Pancreatic Ductal/therapy ; Carcinoma, Pancreatic Ductal/pathology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; CD40 Antigens/metabolism ; Treatment Outcome ; Female ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Male
Chemical Substances	CD40 Antigens
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2732489-8
ISSN	2326-6074 ; 2326-6066
ISSN (online)	2326-6074
ISSN	2326-6066
DOI	10.1158/2326-6066.CIR-23-0873
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Article ; Online: Exploring the merits of research performance measures that comply with the San Francisco Declaration on Research Assessment and strategies to overcome barriers of adoption: qualitative interviews with administrators and researchers.

Boury, Himani / Albert, Mathieu / Chen, Robert H C / Chow, James C L / DaCosta, Ralph / Hoffman, Michael M / Keshavarz, Behrang / Kontos, Pia / McAndrews, Mary Pat / Protze, Stephanie / Gagliardi, Anna R

Health research policy and systems

2023 Volume 21, Issue 1, Page(s) 43

Abstract: Background: In prior research, we identified and prioritized ten measures to assess research performance that comply with the San Francisco Declaration on Research Assessment, a principle adopted worldwide that discourages metrics-based assessment. ... ...

Abstract	Background: In prior research, we identified and prioritized ten measures to assess research performance that comply with the San Francisco Declaration on Research Assessment, a principle adopted worldwide that discourages metrics-based assessment. Given the shift away from assessment based on Journal Impact Factor, we explored potential barriers to implementing and adopting the prioritized measures. Methods: We identified administrators and researchers across six research institutes, conducted telephone interviews with consenting participants, and used qualitative description and inductive content analysis to derive themes. Results: We interviewed 18 participants: 6 administrators (research institute business managers and directors) and 12 researchers (7 on appointment committees) who varied by career stage (2 early, 5 mid, 5 late). Participants appreciated that the measures were similar to those currently in use, comprehensive, relevant across disciplines, and generated using a rigorous process. They also said the reporting template was easy to understand and use. In contrast, a few administrators thought the measures were not relevant across disciplines. A few participants said it would be time-consuming and difficult to prepare narratives when reporting the measures, and several thought that it would be difficult to objectively evaluate researchers from a different discipline without considerable effort to read their work. Strategies viewed as necessary to overcome barriers and support implementation of the measures included high-level endorsement of the measures, an official launch accompanied by a multi-pronged communication strategy, training for both researchers and evaluators, administrative support or automated reporting for researchers, guidance for evaluators, and sharing of approaches across research institutes. Conclusions: While participants identified many strengths of the measures, they also identified a few limitations and offered corresponding strategies to address the barriers that we will apply at our organization. Ongoing work is needed to develop a framework to help evaluators translate the measures into an overall assessment. Given little prior research that identified research assessment measures and strategies to support adoption of those measures, this research may be of interest to other organizations that assess the quality and impact of research.
Language	English
Publishing date	2023-06-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2101196-5
ISSN	1478-4505 ; 1478-4505
ISSN (online)	1478-4505
ISSN	1478-4505
DOI	10.1186/s12961-023-01001-w
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Article ; Online: SAM68 directs STING signaling to apoptosis in macrophages.

Communications biology

2024 Volume 7, Issue 1, Page(s) 283

Abstract: DNA is a danger signal sensed by cGAS to engage signaling through STING to activate innate immune functions. The best-studied downstream responses to STING activation include expression of type I interferon and inflammatory genes, but STING also ... ...

Abstract	DNA is a danger signal sensed by cGAS to engage signaling through STING to activate innate immune functions. The best-studied downstream responses to STING activation include expression of type I interferon and inflammatory genes, but STING also activates other pathways, including apoptosis. Here, we report that STING-dependent induction of apoptosis in macrophages occurs through the intrinsic mitochondrial pathway and is mediated via IRF3 but acts independently of gene transcription. By intersecting four mass spectrometry datasets, we identify SAM68 as crucial for the induction of apoptosis downstream of STING activation. SAM68 is essential for the full activation of apoptosis. Still, it is not required for STING-mediated activation of IFN expression or activation of NF-κB. Mechanistic studies reveal that protein trafficking is required and involves SAM68 recruitment to STING upon activation, with the two proteins associating at the Golgi or a post-Golgi compartment. Collectively, our work identifies SAM68 as a STING-interacting protein enabling induction of apoptosis through this DNA-activated innate immune pathway.
MeSH term(s)	Membrane Proteins/metabolism ; Signal Transduction ; Macrophages/metabolism ; Cell Cycle Proteins/metabolism ; DNA/metabolism ; Apoptosis
Chemical Substances	Membrane Proteins ; Cell Cycle Proteins ; DNA (9007-49-2)
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-024-05969-1
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