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Article ; Online: Genetic insights into the dissolution of dioecy in diploid persimmon Diospyros oleifera Cheng.

Sun, Peng / Nishiyama, Soichiro / Li, Huawei / Mai, Yini / Han, Weijuan / Suo, Yujing / Liang, Chengzhi / Du, Huilong / Diao, Songfeng / Wang, Yiru / Yuan, Jiaying / Zhang, Yue / Tao, Ryutaro / Li, Fangdong / Fu, Jianmin

BMC plant biology

2023 Volume 23, Issue 1, Page(s) 606

Abstract: Background: Dioecy, a sexual system of single-sexual (gynoecious/androecious) individuals, is rare in flowering plants. This rarity may be a result of the frequent transition from dioecy into systems with co-sexual individuals.: Results: In this ... ...

Abstract	Background: Dioecy, a sexual system of single-sexual (gynoecious/androecious) individuals, is rare in flowering plants. This rarity may be a result of the frequent transition from dioecy into systems with co-sexual individuals. Results: In this study, co-sexual expression (monoecy and hermaphroditic development), previously thought to be polyploid-specific in Diospyros species, was identified in the diploid D. oleifeara historically. We characterized potential genetic mechanisms that underlie the dissolution of dioecy to monoecy and andro(gyno)monoecy, based on multiscale genome-wide investigations of 150 accessions of Diospyros oleifera. We found all co-sexual plants, including monoecious and andro(gyno)monoecious individuals, possessed the male determinant gene OGI, implying the presence of genetic factors controlling gynoecia development in genetically male D. oleifera. Importantly, discrepancies in the OGI/MeGI module were found in diploid monoecious D. oleifera compared with polyploid monoecious D. kaki, including no Kali insertion on the promoter of OGI, no different abundance of smRNAs targeting MeGI (a counterpart of OGI), and no different expression of MeGI between female and male floral buds. On the contrary, in both single- and co-sexual plants, female function was expressed in the presence of a genome-wide decrease in methylation levels, along with sexually distinct regulatory networks of smRNAs and their targets. Furthermore, a genome-wide association study (GWAS) identified a genomic region and a DUF247 gene cluster strongly associated with the monoecious phenotype and several regions that may contribute to andromonoecy. Conclusions: Collectively, our findings demonstrate stable breakdown of the dioecious system in D. oleifera, presumably also a result of genomic features of the Y-linked region.
MeSH term(s)	Diospyros/genetics ; Diploidy ; Genome-Wide Association Study ; Genomics ; Polyploidy
Language	English
Publishing date	2023-11-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2059868-3
ISSN	1471-2229 ; 1471-2229
ISSN (online)	1471-2229
ISSN	1471-2229
DOI	10.1186/s12870-023-04610-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of Ficus pandurata Hance var. angustifolia Cheng Flavonoids on Intestinal Barrier and Cognitive Function by Regulating Intestinal Microbiota

Zhang, Yuting / Pan, Junjie / Liu, Yanan / Zhang, Xin / Cheng, Kejun

Foods. 2023 Apr. 18, v. 12, no. 8

2023

Abstract: ... showed that Ficus pandurata Hance var. angustifolia Cheng flavonoids (FCF) ameliorated the pathological ...

Abstract	More and more evidence has supported the interaction between circadian rhythms and intestinal microbes, which provides new insights into how dietary nutrition can improve host health. Our research showed that Ficus pandurata Hance var. angustifolia Cheng flavonoids (FCF) ameliorated the pathological damage of colon and abnormal intestinal microflora structure in mice with circadian clock disorder and improved their exploration and memory behaviors. Mechanism studies have shown that FCF is involved in regulating metabolic pathways and related metabolites, regulating the expression of related tight junction proteins in the colon and the levels of Aβ and inflammatory factors in the hippocampus. Further analysis found that these metabolites showed a certain correlation with intestinal flora and played a certain role in alleviating intestinal physiological damage and cognitive decline.
Keywords	Ficus pandurata ; circadian clocks ; cognition ; cognitive disorders ; colon ; flavonoids ; hippocampus ; intestinal microorganisms ; memory ; metabolites ; nutrition ; tight junctions
Language	English
Dates of publication	2023-0418
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12081682
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Correction: Cheng et al. Glutathione S-Transferases S1, Z1 and A1 Serve as Prognostic Factors in Glioblastoma and Promote Drug Resistance through Antioxidant Pathways.

Cheng, Bo / Wang, Yu / Ayanlaja, Abiola Abdulrahman / Zhu, Jing / Kambey, Piniel Alphayo / Qiu, Ziqiang / Zhang, Caiyi / Hu, Wei

Cells

2023 Volume 12, Issue 14

Abstract: The authors wish to make the following change to their paper [ ... ]. ...

Abstract	The authors wish to make the following change to their paper [...].
Language	English
Publishing date	2023-07-21
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12141908
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Article: Anticolon Cancer Targets and Molecular Mechanisms of Tao-He-Cheng-Qi Formula.

Zhang, Zexin / Lin, Siqi / Liu, Zifeng / Han, Jun / Li, Jing / Yu, Yi

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 7998664

Abstract: Background: Tao-He-Cheng-Qi Formula (THCQF) is a traditional Chinese medicine that has been proven ...

Abstract	Background: Tao-He-Cheng-Qi Formula (THCQF) is a traditional Chinese medicine that has been proven to have antitumor effects. The aim of this study was to elucidate the molecular targets and mechanisms of THCQF against colon cancer and construct a prognostic model based on network pharmacology, bioinformatics analysis, and in vitro experiments. Methods: Potential THCQF compounds and targets were retrieved from the Traditional Chinese Medicine Systems Pharmacology and Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine databases. Differentially expressed genes for colon cancer were screened in The Cancer Genome Atlas and Gene Expression Omnibus databases. The anticolon cancer mechanisms of THCQF were explored using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. Molecular docking simulations and molecular dynamics analysis were used to evaluate the binding between target proteins and active compounds. Finally, the identified compounds were used to treat colon cancer cells from the HCT116 cell line, and expression of mRNA and protein after relevant posttreatment were tested using real-time polymerase chain reaction and western blotting. Results: A total of 27 anticolon cancer targets of THCQF were selected, among which four genes ( Conclusions: Taken together, the results indicate that AE and QR are the pivotal active compounds of THCQF, and
Language	English
Publishing date	2022-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/7998664
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Article ; Online: Protective effects of Da-cheng-qi decoction in rats with intracerebral hemorrhage.

Zeng, Peng / Wang, Xiao-Ming / Su, Hong-Fei / Zhang, Teng / Ning, Lin-Na / Shi, Yan / Yang, Shu-Sheng / Lin, Li / Tian, Qing

Phytomedicine : international journal of phytotherapy and phytopharmacology

2021 Volume 90, Page(s) 153630

Abstract: ... modifying treatment. Da-cheng-qi decoction (DCQ), composed of rhubarb, is one of the most commonly used ...

Abstract	Background: Intracerebral hemorrhage (ICH), the most fatal subtype of stroke, has no disease-modifying treatment. Da-cheng-qi decoction (DCQ), composed of rhubarb, is one of the most commonly used Chinese traditional decoctions in ICH treatment. But the mechanism is not clear. Emodin is an active compound found in rhubarb. Purpose: To study the protective effects of DCQ on ICH and its possible mechanisms of action. Methods: The ICH model was reproduced by injecting collagenase-VII into the left caudate putamen (CPu) of rats. DCQ and emodin were used to treat the ICH rats for 7 days. Behavior tests, proteomic analysis, morphological studies, and western blotting were performed. Results: The neurological deficits in the ICH rats recovered with DCQ and emodin on the 14 Conclusion: The protective effects of DCQ on ICH were confirmed in this study, and its mechanism may be related to the inhibition of MAPK and activation of M2 microglia. These results are beneficial to the development of ICH therapeutic targets.
MeSH term(s)	Animals ; Cerebral Hemorrhage/drug therapy ; Drugs, Chinese Herbal/pharmacology ; Emodin/pharmacology ; Hippocampus/drug effects ; Proteomics ; Rats ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
Chemical Substances	Da-Cheng-Qi ; Drugs, Chinese Herbal ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Emodin (KA46RNI6HN)
Language	English
Publishing date	2021-06-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2021.153630
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Article ; Online: Enhancing β-cell function and identity in type 2 diabetes: The protective role of Coptis deltoidea C. Y. Cheng et Hsiao via glucose metabolism modulation and AMPK signaling activation.

Zhang, Shan / Zhang, Yueying / Wen, Zhige / Chen, Yupeng / Bu, Tianjie / Yang, Yanan / Ni, Qing

Phytomedicine : international journal of phytotherapy and phytopharmacology

2024 Volume 128, Page(s) 155396

Abstract: ... and identity impairment resulting from high glucose exposure. In China, Coptis deltoidea C. Y. Cheng ...

Abstract	Background: Abnormalities in glucose metabolism may be the underlying cause of β-cell dysfunction and identity impairment resulting from high glucose exposure. In China, Coptis deltoidea C. Y. Cheng et Hsiao (YL) has demonstrated remarkable hypoglycemic effects. Hypothesis/purpose: To investigate the hypoglycemic effect of YL and determine the mechanism of YL in treating diabetes. Methods: A type 2 diabetes mouse model was used to investigate the pharmacodynamics of YL. YL was administrated once daily for 8 weeks. The hypoglycemic effect of YL was assessed by fasting blood glucose, an oral glucose tolerance test, insulin levels, and other indexes. The underlying mechanism of YL was examined by targeting glucose metabolomics, western blotting, and qRT-PCR. Subsequently, the binding capacity between predicted AMP-activated protein kinase (AMPK) and important components of YL (Cop, Ber, and Epi) were validated by molecular docking and surface plasmon resonance. Then, in AMPK knockdown MIN6 cells, the mechanisms of Cop, Ber, and Epi were inversely confirmed through evaluations encompassing glucose-stimulated insulin secretion, markers indicative of β-cell identity, and the examination of glycolytic genes and products. Results: YL (0.9 g/kg) treatment exerted notable hypoglycemic effects and protected the structural integrity and identity of pancreatic β-cells. Metabolomic analysis revealed that YL inhibited the hyperactivated glycolysis pathway in diabetic mice, thereby regulating the products of the tricarboxylic acid cycle. KEGG enrichment revealed the intimate relationship of this process with the AMPK signaling pathway. Cop, Ber, and Epi in YL displayed high binding affinities for AMPK protein. These compounds played a pivotal role in preserving the identity of pancreatic β-cells and amplifying insulin secretion. The mechanism underlying this process involved inhibition of glucose uptake, lowering intracellular lactate levels, and elevating acetyl coenzyme A and ATP levels through AMPK signaling. The use of a glycolytic inhibitor corroborated that attenuation of glycolysis restored β-cell identity and function. Conclusion: YL demonstrates significant hypoglycemic efficacy. We elucidated the potential mechanisms underlying the protective effects of YL and its active constituents on β-cell function and identity by observing glucose metabolism processes in pancreatic tissue and cells. In this intricate process, AMPK plays a pivotal regulatory role.
Language	English
Publishing date	2024-01-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2024.155396
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Article: Improvement of inflammatory response and gastrointestinal function in perioperative of cholelithiasis by Modified Xiao-Cheng-Qi decoction.

Sun, Bao-Fang / Zhang, Fan / Chen, Qiang-Pu / Wei, Qiang / Zhu, Wen-Tao / Ji, Hai-Bin / Zhang, Xing-Yuan

World journal of clinical cases

2022 Volume 11, Issue 4, Page(s) 830–843

Abstract: ... the effects of Modified Xiao-Cheng-Qi decoction (MXD) on inflammatory response and GI function ...

Abstract	Background: In the perioperative period of biliary surgery, various factors can induce the release of a large number of inflammatory factors, leading to an imbalance in pro-inflammatory and anti-inflammatory responses and resulting in gastrointestinal (GI) dysfunction. Enhanced Recovery After Surgery protocols in biliary surgery have been shown to reduce the stress response and accelerate postoperative recovery. It is crucial to reduce the inflammatory response and promote the recovery of GI function after biliary surgery, both of which are the basis and key for perioperative care and postoperative recovery. Aim: To better understand the effects of Modified Xiao-Cheng-Qi decoction (MXD) on inflammatory response and GI function in the perioperative management of cholelithiasis and their correlation. Methods: This was a prospective randomized placebo-controlled trial, in which 162 patients who received biliary tract surgery were randomly assigned to three groups: MXD group, XD group, and placebo-control group. The observed parameters included frequency of bowel sounds, time of first flatus and defecation, time of diet, and amount of activity after surgery. The serum levels of C-reactive protein (CRP), interleukin (IL)-6, IL-10, serum amyloid A protein (SAA), and substance P were measured by the enzyme-linked immunosorbent assay. Then, the spearman correlation coefficient was used to analyze the relationship between the indicators of GI function and inflammation. Results: Compared to the placebo-control, improvements in GI function were observed in the MXD groups including reduced incidence of nausea, vomiting, and bloating; and earlier first exhaust time, first defecation time, and feeding time after surgery ( Conclusion: Treatment with MXD can relieve inflammatory response and improve GI function after surgery. Moreover, there are significant correlations between them. Furthermore, it does not cause serious adverse reactions.
Language	English
Publishing date	2022-12-04
Publishing country	United States
Document type	Clinical Trial
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i4.830
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Article ; Online: Anticolon Cancer Targets and Molecular Mechanisms of Tao-He-Cheng-Qi Formula

Zexin Zhang / Siqi Lin / Zifeng Liu / Jun Han / Jing Li / Yi Yu

Evidence-Based Complementary and Alternative Medicine, Vol

2022 Volume 2022

Abstract: Background. Tao-He-Cheng-Qi Formula (THCQF) is a traditional Chinese medicine that has been proven ...

Abstract	Background. Tao-He-Cheng-Qi Formula (THCQF) is a traditional Chinese medicine that has been proven to have antitumor effects. The aim of this study was to elucidate the molecular targets and mechanisms of THCQF against colon cancer and construct a prognostic model based on network pharmacology, bioinformatics analysis, and in vitro experiments. Methods. Potential THCQF compounds and targets were retrieved from the Traditional Chinese Medicine Systems Pharmacology and Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine databases. Differentially expressed genes for colon cancer were screened in The Cancer Genome Atlas and Gene Expression Omnibus databases. The anticolon cancer mechanisms of THCQF were explored using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. Molecular docking simulations and molecular dynamics analysis were used to evaluate the binding between target proteins and active compounds. Finally, the identified compounds were used to treat colon cancer cells from the HCT116 cell line, and expression of mRNA and protein after relevant posttreatment were tested using real-time polymerase chain reaction and western blotting. Results. A total of 27 anticolon cancer targets of THCQF were selected, among which four genes (CCNB1, CCNA2, IL1A, and MMP3) were shown to effectively predict patient outcomes in a prognostic colon cancer model. GO and KEGG enrichment analyses indicated that the activity against colon cancer of THCQF was associated with the interleukin (IL)-4 and IL-3 signaling pathways. Two compounds in THCQF, aloe emodin (AE) and quercetin (QR), were shown to efficiently bind to cyclin B1, the protein encoded by CCNB1. Finally, incubation of HCT116 cells with AE and QR significantly decreased CCNB1 mRNA expression and cyclin B1 levels. Conclusions. Taken together, the results indicate that AE and QR are the pivotal active compounds of THCQF, and CCNB1 is the main molecular target through which THCQF exerts its anticolon ...
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Spatial Association Effect of Haze Pollution in Cheng-Yu Urban Agglomeration.

Zhang, Degang / Lu, Yuanquan / Tian, Yuan

Scientific reports

2020 Volume 10, Issue 1, Page(s) 9753

Abstract: ... in Cheng-Yu urban agglomeration which is the fourth largest urban agglomeration and a comprehensive ... characteristics of this network. The results show that: haze pollution in Cheng-Yu urban agglomeration is ...

Abstract	This study takes a network perspective to examine the spatial spillover effects of haze pollution in Cheng-Yu urban agglomeration which is the fourth largest urban agglomeration and a comprehensive demonstration zone of new urbanization in China. Firstly, we use Granger causality test to construct haze pollution spatial association network, and then we apply social network analysis to reveal the structural characteristics of this network. The results show that: haze pollution in Cheng-Yu urban agglomeration is a complex multithreaded network. Chongqing, Chengdu, Guang'an, Luzhou, Deyang and Nanchong are the centers of the network, sending and transmitting the most relationships. The haze pollution spatial association network can be divided into net beneficiary block, net overflow block, bilateral overflow block and broker block. These four blocks present obvious geographical distribution characteristics and are partly related to the difference of urbanization. The above results contribute by illustrating the current spatial spillover situation of haze pollution and provide a theoretical foundation for the government that it should simultaneously consider cities' statues and their spatial spillover effects in the network rather than simple geographic proximity when formulating future haze pollution control policies in urban agglomeration.
Language	English
Publishing date	2020-06-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-66665-8
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Article ; Online: Retraction for Cheng et al., "Salecanase, a Novel Glycosyl Hydrolase from Paenibacillus sp. S09".

Cheng, Rui / Xu, Linxiang / Wang, Lei / Fu, Renjie / Li, Jing / Wang, Shiming / Zhang, Jianfa

Applied and environmental microbiology

2018 Volume 84, Issue 20

Language	English
Publishing date	2018-10-01
Publishing country	United States
Document type	Journal Article ; Retraction of Publication
ZDB-ID	223011-2
ISSN	1098-5336 ; 0099-2240
ISSN (online)	1098-5336
ISSN	0099-2240
DOI	10.1128/AEM.01321-18
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