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  1. Article: Correction to: Exosomes in Cardiovascular Medicine.

    Dykes, Iain M

    Cardiology and therapy

    2018  Volume 7, Issue 1, Page(s) 125

    Abstract: This article was originally published under a [CC BY-NC-SA 4.0/CC BY-NC-ND 4.0] license, but has now been made available under a CC BY 4.0 license. ...

    Abstract This article was originally published under a [CC BY-NC-SA 4.0/CC BY-NC-ND 4.0] license, but has now been made available under a CC BY 4.0 license.
    Language English
    Publishing date 2018-03-08
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 2700626-8
    ISSN 2193-6544 ; 2193-8261
    ISSN (online) 2193-6544
    ISSN 2193-8261
    DOI 10.1007/s40119-018-0105-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Corrigendum to "HIC2 regulates isoform switching during maturation of the cardiovascular system" [Journal of Molecular and Cellular Cardiology volume 114 (2018) P29-37/ https://doi.org/10.1016/j.yjmcc.2017.10.007].

    Dykes, Iain M / van Bueren, Kelly Lammerts / Scambler, Peter J

    Journal of molecular and cellular cardiology

    2023  Volume 183, Page(s) 102

    Language English
    Publishing date 2023-07-28
    Publishing country England
    Document type Published Erratum
    ZDB-ID 80157-4
    ISSN 1095-8584 ; 0022-2828
    ISSN (online) 1095-8584
    ISSN 0022-2828
    DOI 10.1016/j.yjmcc.2023.07.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 426: Show issues Location:
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  3. Article ; Online: Left Right Patterning, Evolution and Cardiac Development.

    Dykes, Iain M

    Journal of cardiovascular development and disease

    2018  Volume 1, Issue 1, Page(s) 52–72

    Abstract: Many aspects of heart development are determined by the left right axis and as a result several congenital diseases have their origins in aberrant left-right patterning. Establishment of this axis occurs early in embryogenesis before formation of the ... ...

    Abstract Many aspects of heart development are determined by the left right axis and as a result several congenital diseases have their origins in aberrant left-right patterning. Establishment of this axis occurs early in embryogenesis before formation of the linear heart tube yet impacts upon much later morphogenetic events. In this review I discuss the differing mechanisms by which left-right polarity is achieved in the mouse and chick embryos and comment on the evolution of this system. I then discus three major classes of cardiovascular defect associated with aberrant left-right patterning seen in mouse mutants and human disease. I describe phenotypes associated with the determination of atrial identity and venous connections, looping morphogenesis of the heart tube and finally the asymmetric remodelling of the embryonic branchial arch arterial system to form the leftward looped arch of aorta and associated great arteries. Where appropriate, I consider left right patterning defects from an evolutionary perspective, demonstrating how developmental processes have been modified in species over time and illustrating how comparative embryology can aide in our understanding of congenital heart disease.
    Language English
    Publishing date 2018-02-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd1010052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Exosomes in Cardiovascular Medicine.

    Dykes, Iain M

    Cardiology and therapy

    2017  Volume 6, Issue 2, Page(s) 225–237

    Abstract: Exosomes are small, extracellular membrane-bound particles that mediate intercellular transport of a cytosolic cargo. Exosomal transfer of micro-RNA can modify gene expression in targeted cells. Exosome-based endocrine/paracrine signaling has been shown ... ...

    Abstract Exosomes are small, extracellular membrane-bound particles that mediate intercellular transport of a cytosolic cargo. Exosomal transfer of micro-RNA can modify gene expression in targeted cells. Exosome-based endocrine/paracrine signaling has been shown to be involved in a wide range of physiological processes including those associated with cardiovascular injury and disease, but remains relatively poorly understood. Exosomes offer great potential to the clinical field, with applications in both diagnostics and therapeutics. A stable, circulating form of micro-RNA exists in blood protected from endogenous nucleases. This population of micro-RNA, which includes both exosomal and non-exosomal fractions, may be isolated from blood and exploited as a novel disease biomarker with the potential to deliver increased specificity and rapid diagnosis compared to conventional biomarkers. Exosomes also offer a natural drug-delivery vehicle, providing immune evasion and specific targeting through engineering of surface-displayed ligands. Much of the cardioprotective and regenerative benefits of stem-cell grafts are now thought to derive from paracrine signaling rather than direct tissue incorporation and therefore stem cell-derived exosomes offer the potential for a convenient cell-free therapeutic option, eliminating many of the risks and variability associated with stem-cell therapy. In this review, we consider the potential applications of this emerging field to cardiovascular medicine, taking myocardial infarction as our primary example.
    Language English
    Publishing date 2017-05-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2700626-8
    ISSN 2193-6544 ; 2193-8261
    ISSN (online) 2193-6544
    ISSN 2193-8261
    DOI 10.1007/s40119-017-0091-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Are there foetal extracellular vesicles in maternal blood? Prospects for diagnostic biomarker discovery.

    Adamova, Petra / Lotto, Robyn R / Powell, Andrew K / Dykes, Iain M

    Journal of molecular medicine (Berlin, Germany)

    2022  Volume 101, Issue 1-2, Page(s) 65–81

    Abstract: Prenatal diagnosis of congenital disease improves clinical outcomes; however, as many as 50% of congenital heart disease cases are missed by current ultrasound screening methods. This indicates a need for improved screening technology. Extracellular ... ...

    Abstract Prenatal diagnosis of congenital disease improves clinical outcomes; however, as many as 50% of congenital heart disease cases are missed by current ultrasound screening methods. This indicates a need for improved screening technology. Extracellular vesicles (EVs) have attracted enormous interest in recent years for their potential in diagnostics. EVs mediate endocrine signalling in health and disease and are known to regulate aspects of embryonic development. Here, we critically evaluate recent evidence suggesting that EVs released from the foetus are able to cross the placenta and enter the maternal circulation. Furthermore, EVs from the mother appear to be transported in the reverse direction, whilst the placenta itself acts as a source of EVs. Experimental work utilising rodent models employing either transgenically encoded reporters or application of fluorescent tracking dyes provide convincing evidence of foetal-maternal crosstalk. This is supported by clinical data demonstrating expression of placental-origin EVs in maternal blood, as well as limited evidence for the presence of foetal-origin EVs. Together, this work raises the possibility that foetal EVs present in maternal blood could be used for the diagnosis of congenital disease. We discuss the challenges faced by researchers in translating these basic science findings into a clinical non-invasive prenatal test.
    MeSH term(s) Pregnancy ; Female ; Humans ; Placenta/metabolism ; Extracellular Vesicles/metabolism ; Fetus ; Biomarkers/metabolism
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-12-20
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1223802-8
    ISSN 1432-1440 ; 0946-2716
    ISSN (online) 1432-1440
    ISSN 0946-2716
    DOI 10.1007/s00109-022-02278-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.36: Show issues Location:
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  6. Article ; Online: Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA.

    Dykes, Iain M / Emanueli, Costanza

    Genomics, proteomics & bioinformatics

    2017  Volume 15, Issue 3, Page(s) 177–186

    Abstract: Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated. Much of the newly-discovered transcriptome appears to represent long non-coding ... ...

    Abstract Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated. Much of the newly-discovered transcriptome appears to represent long non-coding RNA (lncRNA), a heterogeneous group of largely uncharacterised transcripts. Understanding the biological function of these molecules represents a major challenge and in this review we discuss some of the progress made to date. One major theme of lncRNA biology seems to be the existence of a network of interactions with microRNA (miRNA) pathways. lncRNA has been shown to act as both a source and an inhibitory regulator of miRNA. At the transcriptional level, a model is emerging whereby lncRNA bridges DNA and protein by binding to chromatin and serving as a scaffold for modifying protein complexes. Such a mechanism can bridge promoters to enhancers or enhancer-like non-coding genes by regulating chromatin looping, as well as conferring specificity on histone modifying complexes by directing them to specific loci.
    MeSH term(s) Animals ; Chromatin/chemistry ; Chromatin/metabolism ; Gene Expression Regulation ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA Processing, Post-Transcriptional ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcription, Genetic
    Chemical Substances Chromatin ; MicroRNAs ; RNA, Long Noncoding ; Transcription Factors
    Language English
    Publishing date 2017-06
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2240213-5
    ISSN 2210-3244 ; 1672-0229
    ISSN (online) 2210-3244
    ISSN 1672-0229
    DOI 10.1016/j.gpb.2016.12.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6438: Show issues Location:
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  7. Article ; Online: Direct Reprogramming of Cardiac Fibroblasts to Repair the Injured Heart.

    Adams, Emma / McCloy, Rachel / Jordan, Ashley / Falconer, Kaitlin / Dykes, Iain M

    Journal of cardiovascular development and disease

    2021  Volume 8, Issue 7

    Abstract: Coronary heart disease is a leading cause of mortality and morbidity. Those that survive acute myocardial infarction are at significant risk of subsequent heart failure due to fibrotic remodelling of the infarcted myocardium. By applying knowledge from ... ...

    Abstract Coronary heart disease is a leading cause of mortality and morbidity. Those that survive acute myocardial infarction are at significant risk of subsequent heart failure due to fibrotic remodelling of the infarcted myocardium. By applying knowledge from the study of embryonic cardiovascular development, modern medicine offers hope for treatment of this condition through regeneration of the myocardium by direct reprogramming of fibrotic scar tissue. Here, we will review mechanisms of cell fate specification leading to the generation of cardiovascular cell types in the embryo and use this as a framework in which to understand direct reprogramming. Driving expression of a network of transcription factors, micro RNA or small molecule epigenetic modifiers can reverse epigenetic silencing, reverting differentiated cells to a state of induced pluripotency. The pluripotent state can be bypassed by direct reprogramming in which one differentiated cell type can be transdifferentiated into another. Transdifferentiating cardiac fibroblasts to cardiomyocytes requires a network of transcription factors similar to that observed in embryonic multipotent cardiac progenitors. There is some flexibility in the composition of this network. These studies raise the possibility that the failing heart could one day be regenerated by directly reprogramming cardiac fibroblasts within post-infarct scar tissue.
    Language English
    Publishing date 2021-06-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd8070072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA

    Iain M. Dykes / Costanza Emanueli

    Genomics, Proteomics & Bioinformatics, Vol 15, Iss 3, Pp 177-

    2017  Volume 186

    Abstract: Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated. Much of the newly-discovered transcriptome appears to represent long non-coding ... ...

    Abstract Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated. Much of the newly-discovered transcriptome appears to represent long non-coding RNA (lncRNA), a heterogeneous group of largely uncharacterised transcripts. Understanding the biological function of these molecules represents a major challenge and in this review we discuss some of the progress made to date. One major theme of lncRNA biology seems to be the existence of a network of interactions with microRNA (miRNA) pathways. lncRNA has been shown to act as both a source and an inhibitory regulator of miRNA. At the transcriptional level, a model is emerging whereby lncRNA bridges DNA and protein by binding to chromatin and serving as a scaffold for modifying protein complexes. Such a mechanism can bridge promoters to enhancers or enhancer-like non-coding genes by regulating chromatin looping, as well as conferring specificity on histone modifying complexes by directing them to specific loci.
    Keywords Long non-coding RNA ; MicroRNA ; Transcriptional regulation ; Epigenetics ; Post-transcriptional regulation ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2017-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA

    Dykes, Iain M / Costanza Emanueli

    Genomics, proteomics & bioinformatics. 2017 June, v. 15, no. 3

    2017  

    Abstract: Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated. Much of the newly-discovered transcriptome appears to represent long non-coding ... ...

    Abstract Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated. Much of the newly-discovered transcriptome appears to represent long non-coding RNA (lncRNA), a heterogeneous group of largely uncharacterised transcripts. Understanding the biological function of these molecules represents a major challenge and in this review we discuss some of the progress made to date. One major theme of lncRNA biology seems to be the existence of a network of interactions with microRNA (miRNA) pathways. lncRNA has been shown to act as both a source and an inhibitory regulator of miRNA. At the transcriptional level, a model is emerging whereby lncRNA bridges DNA and protein by binding to chromatin and serving as a scaffold for modifying protein complexes. Such a mechanism can bridge promoters to enhancers or enhancer-like non-coding genes by regulating chromatin looping, as well as conferring specificity on histone modifying complexes by directing them to specific loci.
    Keywords chromatin ; DNA ; genes ; genomics ; histones ; loci ; microRNA ; models ; non-coding RNA ; transcription (genetics) ; transcriptome
    Language English
    Dates of publication 2017-06
    Size p. 177-186.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2240213-5
    ISSN 2210-3244 ; 1672-0229
    ISSN (online) 2210-3244
    ISSN 1672-0229
    DOI 10.1016/j.gpb.2016.12.005
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: A time to heal: microRNA and circadian dynamics in cutaneous wound repair.

    Fawcett, Sandra / Al Kassas, Raida / M Dykes, Iain / Hughes, Alun Tl / Ghali, Fawaz / Ross, Kehinde

    Clinical science (London, England : 1979)

    2022  Volume 136, Issue 8, Page(s) 579–597

    Abstract: Many biological systems have evolved circadian rhythms based on the daily cycles of daylight and darkness on Earth. Such rhythms are synchronised or entrained to 24-h cycles, predominantly by light, and disruption of the normal circadian rhythms has been ...

    Abstract Many biological systems have evolved circadian rhythms based on the daily cycles of daylight and darkness on Earth. Such rhythms are synchronised or entrained to 24-h cycles, predominantly by light, and disruption of the normal circadian rhythms has been linked to elevation of multiple health risks. The skin serves as a protective barrier to prevent microbial infection and maintain homoeostasis of the underlying tissue and the whole organism. However, in chronic non-healing wounds such as diabetic foot ulcers (DFUs), pressure sores, venous and arterial ulcers, a variety of factors conspire to prevent wound repair. On the other hand, keloids and hypertrophic scars arise from overactive repair mechanisms that fail to cease in a timely fashion, leading to excessive production of extracellular matrix (ECM) components such as such as collagen. Recent years have seen huge increases in our understanding of the functions of microRNAs (miRNAs) in wound repair. Concomitantly, there has been growing recognition of miRNA roles in circadian processes, either as regulators or targets of clock activity or direct responders to external circadian stimuli. In addition, miRNAs are now known to function as intercellular signalling mediators through extracellular vesicles (EVs). In this review, we explore the intersection of mechanisms by which circadian and miRNA responses interact with each other in relation to wound repair in the skin, using keratinocytes, macrophages and fibroblasts as exemplars. We highlight areas for further investigation to support the development of translational insights to support circadian medicine in the context of these cells.
    MeSH term(s) Circadian Rhythm/genetics ; Diabetic Foot ; Humans ; Keratinocytes ; MicroRNAs/genetics ; Skin ; Wound Healing/physiology
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2022-03-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 206835-7
    ISSN 1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
    ISSN (online) 1470-8736
    ISSN 0301-0538 ; 0009-0360 ; 0143-5221
    DOI 10.1042/CS20220011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.220: Show issues Location:
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