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  1. Article ; Online: The epigenetic regulation of adipose tissue plasticity.

    Kajimura, Shingo

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 15

    MeSH term(s) Adipose Tissue ; Epigenesis, Genetic ; Humans ; Obesity/genetics
    Language English
    Publishing date 2021-03-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2102944118
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  2. Article ; Online: Bioenergetics matter to metabolic health-from a fat progenitor view.

    Kajimura, Shingo

    Cell stem cell

    2021  Volume 28, Issue 4, Page(s) 589–591

    Abstract: The response of adipose progenitors to metabolic states is a crucial, but poorly understood, determinant of metabolic health. The back-to-back papers by Joffin et al. (2021) and Shao et al. (2021) in this issue of Cell Stem Cell reveal how adipose-tissue- ...

    Abstract The response of adipose progenitors to metabolic states is a crucial, but poorly understood, determinant of metabolic health. The back-to-back papers by Joffin et al. (2021) and Shao et al. (2021) in this issue of Cell Stem Cell reveal how adipose-tissue-resident PDGFRβ
    MeSH term(s) Adipogenesis ; Adipose Tissue/metabolism ; Adipose Tissue, White/metabolism ; Cell Differentiation ; Energy Metabolism
    Language English
    Publishing date 2021-04-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2021.03.008
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  3. Article ; Online: Is thermogenesis really needed for brown adipose tissue-mediated metabolic benefit?

    Yook, Jin-Seon / Kajimura, Shingo

    The Journal of clinical investigation

    2022  Volume 132, Issue 9

    Abstract: Brown adipose tissue (BAT) dissipates energy in the form of heat and functions as a metabolic sink for lipids, glucose, and branched-chain amino acids. Enhanced BAT thermogenesis is thought to tightly couple with beneficial energy metabolism. However, in ...

    Abstract Brown adipose tissue (BAT) dissipates energy in the form of heat and functions as a metabolic sink for lipids, glucose, and branched-chain amino acids. Enhanced BAT thermogenesis is thought to tightly couple with beneficial energy metabolism. However, in this issue of the JCI, Huang et al. report a mouse model in which BAT thermogenesis was impaired, yet systemic glucose and lipid homeostasis were improved, on a high-fat diet compared with what occurred in control mice. The authors showed that BAT-specific deletion of mitochondrial thioredoxin-2 (TRX2) impaired adaptive thermogenesis through elevated mitochondrial reactive oxygen species (ROS) and cytosolic efflux of mitochondrial DNA. On the other hand, TRX2 loss enhanced lipid uptake in the BAT and protected mice from obesity, hypertriglyceridemia, and insulin resistance. This study provides a unique model in which BAT does not require thermogenesis per se to function as a lipid sink that leads to metabolic benefits in vivo.
    MeSH term(s) Adipose Tissue, Brown/metabolism ; Animals ; Diet, High-Fat ; Glucose/metabolism ; Lipids ; Mice ; Thermogenesis/genetics
    Chemical Substances Lipids ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-04-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI159296
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  4. Article ; Online: Adipose Tissue Remodeling in Pathophysiology.

    Auger, Christopher / Kajimura, Shingo

    Annual review of pathology

    2022  Volume 18, Page(s) 71–93

    Abstract: Rather than serving as a mere onlooker, adipose tissue is a complex endocrine organ and active participant in disease initiation and progression. Disruptions of biological processes operating within adipose can disturb healthy systemic physiology, the ... ...

    Abstract Rather than serving as a mere onlooker, adipose tissue is a complex endocrine organ and active participant in disease initiation and progression. Disruptions of biological processes operating within adipose can disturb healthy systemic physiology, the sequelae of which include metabolic disorders such as obesity and type 2 diabetes. A burgeoning interest in the field of adipose research has allowed for the elucidation of regulatory networks underlying both adipose tissue function and dysfunction. Despite this progress, few diseases are treated by targeting maladaptation in the adipose, an oft-overlooked organ. In this review, we elaborate on the distinct subtypes of adipocytes, their developmental origins and secretory roles, and the dynamic interplay at work within the tissue itself. Central to this discussion is the relationship between adipose and disease states, including obesity, cachexia, and infectious diseases, as we aim to leverage our wealth of knowledge for the development of novel and targeted therapeutics.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/metabolism ; Adipose Tissue/metabolism ; Adipocytes/metabolism ; Obesity/metabolism ; Cachexia/metabolism
    Language English
    Publishing date 2022-09-07
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2227429-7
    ISSN 1553-4014 ; 1553-4006
    ISSN (online) 1553-4014
    ISSN 1553-4006
    DOI 10.1146/annurev-pathol-042220-023633
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  5. Article ; Online: On the cutting edge: perspectives in bioenergetics.

    Granath-Panelo, Melia / Krook, Anna / Rutter, Jared / Kajimura, Shingo

    Nature reviews. Endocrinology

    2023  Volume 19, Issue 5, Page(s) 250–251

    MeSH term(s) Humans ; Energy Metabolism
    Language English
    Publishing date 2023-01-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/s41574-023-00820-9
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  6. Article ; Online: Detouring adrenergic stimulation to induce adipose thermogenesis.

    Auger, Christopher / Kajimura, Shingo

    Nature reviews. Endocrinology

    2021  Volume 17, Issue 10, Page(s) 579–580

    MeSH term(s) Adipose Tissue, Brown ; Adrenergic Agents ; Humans ; Thermogenesis
    Chemical Substances Adrenergic Agents
    Language English
    Publishing date 2021-07-29
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/s41574-021-00546-6
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  7. Article: Mitochondrial choline import regulates purine nucleotide pools via SLC25A48.

    Verkerke, Anthony R P / Shi, Xu / Abe, Ichitaro / Gerszten, Robert E / Kajimura, Shingo

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Choline is an essential nutrient for cellular metabolism, including the biosynthesis of phospholipids, neurotransmitters, and one-carbon metabolism. A critical step of choline catabolism is the mitochondrial import and synthesis of chorine-derived methyl ...

    Abstract Choline is an essential nutrient for cellular metabolism, including the biosynthesis of phospholipids, neurotransmitters, and one-carbon metabolism. A critical step of choline catabolism is the mitochondrial import and synthesis of chorine-derived methyl donors, such as betaine. However, the underlying mechanisms and the biological significance of mitochondrial choline catabolism remain insufficiently understood. Here, we report that a mitochondrial inner-membrane protein SLC25A48 controls mitochondrial choline transport and catabolism
    Language English
    Publishing date 2024-01-01
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.12.31.573776
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  8. Article ; Online: Adipose tissue in 2016: Advances in the understanding of adipose tissue biology.

    Kajimura, Shingo

    Nature reviews. Endocrinology

    2017  Volume 13, Issue 2, Page(s) 69–70

    MeSH term(s) Adipocytes/metabolism ; Adipokines/metabolism ; Adipose Tissue/metabolism ; Adipose Tissue/physiology ; Amidohydrolases/metabolism ; Animals ; Energy Metabolism/physiology ; Glucose/metabolism ; Humans ; Hyperinsulinism/metabolism ; Intercellular Signaling Peptides and Proteins/metabolism ; Liver/metabolism ; Mice ; Microfilament Proteins/metabolism ; Nerve Tissue Proteins/metabolism ; Obesity/metabolism ; Peptide Fragments/metabolism ; Peptide Hormones/metabolism
    Chemical Substances Adipokines ; FBN1 protein, human ; Intercellular Signaling Peptides and Proteins ; Microfilament Proteins ; Nerve Tissue Proteins ; Peptide Fragments ; Peptide Hormones ; Amidohydrolases (EC 3.5.-) ; Glucose (IY9XDZ35W2) ; Slit homolog 2 protein (R6FXH13RRC)
    Language English
    Publishing date 2017-01-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/nrendo.2016.211
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  9. Article ; Online: Oil does more than light the lamp: The multifaceted role of lipids in thermogenic fat.

    Verkerke, Anthony R P / Kajimura, Shingo

    Developmental cell

    2021  Volume 56, Issue 10, Page(s) 1408–1416

    Abstract: Brown and beige adipocytes, or thermogenic fat, were initially thought to be merely a thermogenic organ. However, emerging evidence suggests its multifaceted roles in the regulation of systemic glucose and lipid homeostasis that go beyond enhancing ... ...

    Abstract Brown and beige adipocytes, or thermogenic fat, were initially thought to be merely a thermogenic organ. However, emerging evidence suggests its multifaceted roles in the regulation of systemic glucose and lipid homeostasis that go beyond enhancing thermogenesis. One of the important functions of thermogenic fat is as a "metabolic sink" for glucose, fatty acids, and amino acids, which profoundly impacts metabolite clearance and oxidation. Importantly, lipids are not only the predominant fuel source used for thermogenesis but are also essential molecules for development, cellular signaling, and structural components. Here, we review the multifaceted role of lipids in thermogenic adipocytes.
    MeSH term(s) Adiposity ; Animals ; Cell Membrane/metabolism ; Humans ; Lipids/chemistry ; Models, Biological ; Signal Transduction ; Thermogenesis
    Chemical Substances Lipids
    Language English
    Publishing date 2021-06-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2021.04.018
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  10. Article ; Online: The cellular and functional complexity of thermogenic fat.

    Cohen, Paul / Kajimura, Shingo

    Nature reviews. Molecular cell biology

    2021  Volume 22, Issue 6, Page(s) 393–409

    Abstract: Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy in the form of heat. These thermogenic fat cells were originally considered to function solely in heat generation through the action of the mitochondrial protein ... ...

    Abstract Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy in the form of heat. These thermogenic fat cells were originally considered to function solely in heat generation through the action of the mitochondrial protein uncoupling protein 1 (UCP1). In recent years, significant advances have been made in our understanding of the ontogeny, bioenergetics and physiological functions of thermogenic fat. Distinct subtypes of thermogenic adipocytes have been identified with unique developmental origins, which have been increasingly dissected in cellular and molecular detail. Moreover, several UCP1-independent thermogenic mechanisms have been described, expanding the role of these cells in energy homeostasis. Recent studies have also delineated roles for these cells beyond the regulation of thermogenesis, including as dynamic secretory cells and as a metabolic sink. This Review presents our current understanding of thermogenic adipocytes with an emphasis on their development, biological functions and roles in systemic physiology.
    MeSH term(s) Adipocytes, Beige/metabolism ; Adipocytes, Brown/metabolism ; Animals ; Energy Metabolism ; Humans ; Lipid Metabolism ; Thermogenesis/genetics ; Thermogenesis/physiology ; Uncoupling Protein 1/genetics ; Uncoupling Protein 1/metabolism
    Chemical Substances Uncoupling Protein 1
    Language English
    Publishing date 2021-03-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/s41580-021-00350-0
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