LIVIVO - Search results -

Search results

Result 1 - 10 of total 277

Search options

Article ; Online: Obesity-induced endothelial dysfunction is prevented by deficiency of P-selectin glycoprotein ligand-1.

Wang, Hui / Luo, Wei / Wang, Jintao / Guo, Chiao / Wang, Xiaohong / Wolffe, Stephanie L / Bodary, Peter F / Eitzman, Daniel T

Diabetes

2012 Volume 61, Issue 12, Page(s) 3219–3227

Abstract: ... the cardiovascular complications triggered by obesity. We tested the hypothesis that deficiency of P-selectin ...

Abstract	Endothelial dysfunction precedes atherosclerosis and represents an important link between obesity and cardiovascular events. Strategies designed to prevent endothelial dysfunction may therefore reduce the cardiovascular complications triggered by obesity. We tested the hypothesis that deficiency of P-selectin glycoprotein ligand-1 (Psgl-1) would improve the endothelial dysfunction associated with obesity. Psgl-1-deficient (Psgl-1(-/-)) and wild-type (Psgl-1(+/+)) mice were fed standard chow or a high-fat, high-sucrose diet (diet-induced obesity [DIO]) for 10 weeks. DIO increased mesenteric perivascular adipose tissue (mPVAT) macrophage content and vascular oxidative stress in Psgl-1(+/+) mice but not in Psgl-1(-/-) mice. Pressure myography using mesenteric arteries demonstrated that relaxation responses to acetylcholine were significantly impaired in DIO Psgl-1(+/+) mice, whereas DIO Psgl-1(-/-) mice were protected from endothelial dysfunction with similar relaxation responses to Psgl-1(+/+) or Psgl-1(-/-) mice fed standard chow. The superoxide scavenger 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy (TEMPOL) partially recovered impaired endothelial function induced by DIO. A neutralizing Psgl-1 antibody was also effective in preventing endothelial dysfunction and reducing mPVAT macrophage content induced by DIO. These results indicate that obesity in mice leads to PVAT inflammation and endothelial dysfunction that is prevented by Psgl-1 deficiency. Psgl-1 inhibition may be a useful treatment strategy for targeting vascular disease associated with obesity.
MeSH term(s)	Animals ; Antioxidants/therapeutic use ; Cyclic N-Oxides/therapeutic use ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/physiopathology ; Immunoblotting ; Immunohistochemistry ; Male ; Membrane Glycoproteins/therapeutic use ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Obesity/drug therapy ; Obesity/physiopathology ; Real-Time Polymerase Chain Reaction ; Spin Labels ; Vascular Diseases/metabolism ; Vascular Diseases/prevention & control
Chemical Substances	Antioxidants ; Cyclic N-Oxides ; Membrane Glycoproteins ; P-selectin ligand protein ; Spin Labels ; tempol (U78ZX2F65X)
Language	English
Publishing date	2012-08-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	80085-5
ISSN	1939-327X ; 0012-1797
ISSN (online)	1939-327X
ISSN	0012-1797
DOI	10.2337/db12-0162
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.175: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: The prevalence of A. actinomycetemcomitans, P. gingivalis and P. intermedia in selected subjects with periodontitis.

Van der Weijden, G A / Timmerman, M F / Reijerse, E / Wolffe, G N / Van Winkelhoff, A J / Van der Velden, U

Journal of clinical periodontology

1994 Volume 21, Issue 9, Page(s) 583–588

Abstract: ... p < 0.005) compared to older age cohorts. A. actinomycetemcomitans was found more often ... who responded poorly to scaling and rootplaning. P. gingivalis and P. intermedia were most frequently recovered ... that A. actinomycetemcomitans occurred less frequently in patients showing horizontal bone loss (p < 0.05). ...

Abstract	The present study was carried out in a private periodontal practice. 8 clinical criteria were chosen to select patients for microbiological examination. These criteria characterize prominent features of disease which at the start, during, or in the maintenance phase of treatment suggest difficulties in the progress of the periodontal therapy. Based on these clinical characteristics, an inventory was made of the prevalence of the 3 putative periodontal pathogens: Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia. Out of 320 referred patients 91 patients did meet > or = 1 of the clinical criteria and consequently were selected for microbiological examination. Results showed that young patients (19-30 years) with periodontitis demonstrated the presence of A. actinomycetemcomitans more often (69%: p < 0.005) compared to older age cohorts. A. actinomycetemcomitans was found more often when localized breakdown (in particular in the 1st molar and incisor region) was observed and in patient who responded poorly to scaling and rootplaning. P. gingivalis and P. intermedia were most frequently recovered in patients showing primarily a bone loss pattern of angular defects of > or = 5 mm. Retrospectively, these patients were further categorized, based on full mouth radiographs, in (1) patients with primarily horizontal bone loss and (2) patients with primarily angular bony defects. Results showed that A. actinomycetemcomitans occurred less frequently in patients showing horizontal bone loss (p < 0.05).
MeSH term(s)	Actinobacillus Infections ; Adult ; Age Factors ; Aggregatibacter actinomycetemcomitans/isolation & purification ; Alveolar Bone Loss/diagnostic imaging ; Alveolar Bone Loss/microbiology ; Alveolar Bone Loss/pathology ; Bacteroidaceae Infections ; Cohort Studies ; Colony Count, Microbial ; Dental Scaling ; Female ; Humans ; Incisor/microbiology ; Male ; Middle Aged ; Molar/microbiology ; Periodontitis/microbiology ; Periodontitis/therapy ; Porphyromonas gingivalis/isolation & purification ; Prevotella intermedia/isolation & purification ; Radiography ; Retrospective Studies ; Root Planing ; Sex Factors
Language	English
Publishing date	1994-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	188647-2
ISSN	1600-051X ; 0303-6979
ISSN (online)	1600-051X
ISSN	0303-6979
DOI	10.1111/j.1600-051x.1994.tb00747.x
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1003: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Temporal variability in the impacts of particulate matter on crop yields on the North China Plain.

Wolffe, Michael C / Wild, Oliver / Long, Stephen P / Ashworth, Kirsti

The Science of the total environment

2021 Volume 776, Page(s) 145135

Abstract: The North China Plain (NCP) is a major agricultural region, producing 45% of China's maize. It is also vital to the Chinese economy, encompassing the Beijing-Tianjin-Hebei megacity region. Anthropogenic factors increasingly impact crop yields on the NCP, ...

Abstract	The North China Plain (NCP) is a major agricultural region, producing 45% of China's maize. It is also vital to the Chinese economy, encompassing the Beijing-Tianjin-Hebei megacity region. Anthropogenic factors increasingly impact crop yields on the NCP, and globally. Particulate matter (PM) pollution is a significant problem in this region, where annual average PM concentrations over three times the Chinese national air quality standard were recorded for the Beijing-Tianjin-Hebei megacity region between 2013 and 18. PM absorbs light, reducing total shortwave radiation (SW), thereby limiting plant productivity. However, PM also scatters incoming SW, increasing the diffuse fraction, which has been shown to increase growth and biomass assimilation. The Joint UK Land Environment Simulator (JULES) crop model was used to assess the net impact of these competing changes in light on NCP maize yields. In contrast to some previous analyses, we find that PM-associated decreases in SW outweigh any positive impact on yield from an increasing proportion of diffuse radiation. Furthermore, carbon allocation to different portions of the growing cropchanges during the development cycle. We find significant differences between the effect on final yield of identical changes to diffuse fraction and total SW occurring during different development stages. The greatest simulated yield gains from increased SW and reduced diffuse fraction, consistent with reductions in PM, are observed during the early reproductive stage of development (July-August), when the simulated gain of yield is as much as 12.9% more than in other periods. To further assess the impact of PM-linked changes in SW and diffuse fraction on NCP crop yields, radiation profiles from different city regions were then applied across the NCP. The changes in SW associated with these city regions could increase maize yields across China by ~8 Mt. This would completely offset China's annual maize imports, increasing both national and global food security.
Language	English
Publishing date	2021-02-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2021.145135
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 949: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Temporal variability in the impacts of particulate matter on crop yields on the North China Plain

Wolffe, Michael C / Wild, Oliver / Long, Stephen P / Ashworth, Kirsti

Science of the total environment. 2021 July 01, v. 776

2021

Abstract	The North China Plain (NCP) is a major agricultural region, producing 45% of China's maize. It is also vital to the Chinese economy, encompassing the Beijing-Tianjin-Hebei megacity region. Anthropogenic factors increasingly impact crop yields on the NCP, and globally. Particulate matter (PM) pollution is a significant problem in this region, where annual average PM concentrations over three times the Chinese national air quality standard were recorded for the Beijing-Tianjin-Hebei megacity region between 2013 and 18. PM absorbs light, reducing total shortwave radiation (SW), thereby limiting plant productivity. However, PM also scatters incoming SW, increasing the diffuse fraction, which has been shown to increase growth and biomass assimilation.The Joint UK Land Environment Simulator (JULES) crop model was used to assess the net impact of these competing changes in light on NCP maize yields. In contrast to some previous analyses, we find that PM-associated decreases in SW outweigh any positive impact on yield from an increasing proportion of diffuse radiation.Furthermore, carbon allocation to different portions of the growing cropchanges during the development cycle. We find significant differences between the effect on final yield of identical changes to diffuse fraction and total SW occurring during different development stages. The greatest simulated yield gains from increased SW and reduced diffuse fraction, consistent with reductions in PM, are observed during the early reproductive stage of development (July–August), when the simulated gain of yield is as much as 12.9% more than in other periods.To further assess the impact of PM-linked changes in SW and diffuse fraction on NCP crop yields, radiation profiles from different city regions were then applied across the NCP. The changes in SW associated with these city regions could increase maize yields across China by ~8 Mt. This would completely offset China's annual maize imports, increasing both national and global food security.
Keywords	air quality ; biomass ; carbon ; cities ; corn ; crop models ; developmental stages ; environment ; food security ; particulates ; pollution ; shortwave radiation ; temporal variation ; China
Language	English
Dates of publication	2021-0701
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2021.145135
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 74/341: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A Survey of Systematic Evidence Mapping Practice and the Case for Knowledge Graphs in Environmental Health and Toxicology.

Wolffe, Taylor A M / Vidler, John / Halsall, Crispin / Hunt, Neil / Whaley, Paul

Toxicological sciences : an official journal of the Society of Toxicology

2020 Volume 175, Issue 1, Page(s) 35–49

Abstract: Systematic evidence mapping offers a robust and transparent methodology for facilitating evidence-based approaches to decision-making in chemicals policy and wider environmental health (EH). Interest in the methodology is growing; however, its ... ...

Abstract	Systematic evidence mapping offers a robust and transparent methodology for facilitating evidence-based approaches to decision-making in chemicals policy and wider environmental health (EH). Interest in the methodology is growing; however, its application in EH is still novel. To facilitate the production of effective systematic evidence maps for EH use cases, we survey the successful application of evidence mapping in other fields where the methodology is more established. Focusing on issues of "data storage technology," "data integrity," "data accessibility," and "transparency," we characterize current evidence mapping practice and critically review its potential value for EH contexts. We note that rigid, flat data tables and schema-first approaches dominate current mapping methods and highlight how this practice is ill-suited to the highly connected, heterogeneous, and complex nature of EH data. We propose this challenge is overcome by storing and structuring data as "knowledge graphs." Knowledge graphs offer a flexible, schemaless, and scalable model for systematically mapping the EH literature. Associated technologies, such as ontologies, are well-suited to the long-term goals of systematic mapping methodology in promoting resource-efficient access to the wider EH evidence base. Several graph storage implementations are readily available, with a variety of proven use cases in other fields. Thus, developing and adapting systematic evidence mapping for EH should utilize these graph-based resources to ensure the production of scalable, interoperable, and robust maps to aid decision-making processes in chemicals policy and wider EH.
MeSH term(s)	Data Accuracy ; Data Management ; Databases, Factual ; Decision Making ; Decision Support Techniques ; Environmental Health ; Evidence-Based Practice ; Humans ; Information Storage and Retrieval ; Knowledge Management ; Toxicology
Language	English
Publishing date	2020-02-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1420885-4
ISSN	1096-0929 ; 1096-6080
ISSN (online)	1096-0929
ISSN	1096-6080
DOI	10.1093/toxsci/kfaa025
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1709: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Transformative experiences at art museums to support flourishing in medicine.

Tackett, Sean / Eller, Lauren / Scharff, Samuel / Balhara, Kamna S / Stouffer, Kaitlin M / Suchanek, Melissa / Clever, Sarah L / Yenawine, Philip / Wolffe, Suzy / Chisolm, Margaret S

Medical education online

2023 Volume 28, Issue 1, Page(s) 2202914

Abstract: ... Quantitatively, pre-post mean totals increased for the CfW (32.0 [SD 6.8] vs 44.0 [SD 5.7], p=.006) and TFA ... scales (16.4 [SD 5.2] vs 24.2 [SD 6.9], p=.033).: Conclusions: This elective facilitated learners' ...

Abstract	Purpose: We implemented and evaluated a hybrid 4-week arts-based elective for clinical medical students to support flourishing. Materials and methods: Five students participated in early 2022. Twelve sessions occurred in-person at art museums and other cultural centers, and five occurred online. Sessions incorporated varied arts-based learning activities, including Visual Thinking Strategies, a jazz seminar, and a mask-making workshop. We evaluated the course via weekly reflective essays, interviews 6 weeks after the course, and pre-post surveys that included four scales with clinical relevance: capacity for wonder (CfW), tolerance for ambiguity (TFA), interpersonal reactivity index, and openness to diversity. Results: Qualitatively, the course helped learners: 1) reconnect with individual characteristics and interests that had been neglected during medical education; 2) better appreciate others' perspectives; 3) develop identities as physicians; and 4) engage in quiet reflection, renewing their sense of purpose. Quantitatively, pre-post mean totals increased for the CfW (32.0 [SD 6.8] vs 44.0 [SD 5.7], p=.006) and TFA scales (16.4 [SD 5.2] vs 24.2 [SD 6.9], p=.033). Conclusions: This elective facilitated learners' connecting with themselves, others, and their profession with improvement in clinically-relevant measures. This provides further evidence that arts-based education can foster professional identity formation and be transformative for students.
MeSH term(s)	Humans ; Art ; Museums ; Education, Medical ; Learning ; Students, Medical ; Curriculum
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2052877-2
ISSN	1087-2981 ; 1087-2981
ISSN (online)	1087-2981
ISSN	1087-2981
DOI	10.1080/10872981.2023.2202914
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Systematic evidence maps as a novel tool to support evidence-based decision-making in chemicals policy and risk management.

Wolffe, Taylor A M / Whaley, Paul / Halsall, Crispin / Rooney, Andrew A / Walker, Vickie R

Environment international

2019 Volume 130, Page(s) 104871

Abstract: Background: While systematic review (SR) methods are gaining traction as a method for providing a reliable summary of existing evidence for health risks posed by exposure to chemical substances, it is becoming clear that their value is restricted to a ... ...

Abstract	Background: While systematic review (SR) methods are gaining traction as a method for providing a reliable summary of existing evidence for health risks posed by exposure to chemical substances, it is becoming clear that their value is restricted to a specific range of risk management scenarios - in particular, those which can be addressed with tightly focused questions and can accommodate the time and resource requirements of a systematic evidence synthesis. Methods: The concept of a systematic evidence map (SEM) is defined and contrasted to the function and limitations of systematic review (SR) in the context of risk management decision-making. The potential for SEMs to facilitate evidence-based decision-making are explored using a hypothetical example in risk management priority-setting. The potential role of SEMs in reference to broader risk management workflows is characterised. Results: SEMs are databases of systematically gathered research which characterise broad features of the evidence base. Although not intended to substitute for the evidence synthesis element of systematic reviews, SEMs provide a comprehensive, queryable summary of a large body of policy relevant research. They provide an evidence-based approach to characterising the extent of available evidence and support forward looking predictions or trendspotting in the chemical risk sciences. In particular, SEMs facilitate the identification of related bodies of decision critical chemical risk information which could be further analysed using SR methods, and highlight gaps in the evidence which could be addressed with additional primary studies to reduce uncertainties in decision-making. Conclusions: SEMs have strong and growing potential as a high value tool in resource efficient use of existing research in chemical risk management. They can be used as a critical precursor to efficient deployment of high quality SR methods for characterising chemical health risks. Furthermore, SEMs have potential, at a large scale, to support the sort of evidence summarisation and surveillance methods which would greatly increase the resource efficiency, transparency and effectiveness of regulatory initiatives such as EU REACH and US TSCA.
MeSH term(s)	Decision Making ; Hazardous Substances ; Humans ; Public Policy ; Research Design ; Risk Assessment
Chemical Substances	Hazardous Substances
Keywords	covid19
Language	English
Publishing date	2019-06-26
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2019.05.065
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3131: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Developmental regulation of chromatin structure and function.

Wolffe, A P

Trends in cell biology

2004 Volume 1, Issue 2-3, Page(s) 61–66

Language	English
Publishing date	2004-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	30122-x
ISSN	1879-3088 ; 0962-8924
ISSN (online)	1879-3088
ISSN	0962-8924
DOI	10.1016/0962-8924(91)90091-m
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.MG 25: Show issues
Zs.MO 113: Show issues
Zs.A 3410: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Knowledge Organization Systems for Systematic Chemical Assessments.

Whaley, Paul / Edwards, Stephen W / Kraft, Andrew / Nyhan, Kate / Shapiro, Andrew / Watford, Sean / Wattam, Steve / Wolffe, Taylor / Angrish, Michelle

Environmental health perspectives

2020 Volume 128, Issue 12, Page(s) 125001

Abstract: Background: Although the implementation of systematic review and evidence mapping methods stands to improve the transparency and accuracy of chemical assessments, they also accentuate the challenges that assessors face in ensuring they have located and ... ...

Abstract	Background: Although the implementation of systematic review and evidence mapping methods stands to improve the transparency and accuracy of chemical assessments, they also accentuate the challenges that assessors face in ensuring they have located and included all the evidence that is relevant to evaluating the potential health effects an exposure might be causing. This challenge of information retrieval can be characterized in terms of "semantic" and "conceptual" factors that render chemical assessments vulnerable to the streetlight effect. Objectives: This commentary presents how controlled vocabularies, thesauruses, and ontologies contribute to overcoming the streetlight effect in information retrieval, making up the key components of Knowledge Organization Systems (KOSs) that enable more systematic access to assessment-relevant information than is currently achievable. The concept of Adverse Outcome Pathways is used to illustrate what a general KOS for use in chemical assessment could look like. Discussion: Ontologies are an underexploited element of effective knowledge organization in the environmental health sciences. Agreeing on and implementing ontologies in chemical assessment is a complex but tractable process with four fundamental steps. Successful implementation of ontologies would not only make currently fragmented information about health risks from chemical exposures vastly more accessible, it could ultimately enable computational methods for chemical assessment that can take advantage of the full richness of data described in natural language in primary studies. https://doi.org/10.1289/EHP6994.
MeSH term(s)	Artificial Intelligence ; Environmental Exposure/statistics & numerical data ; Environmental Health ; Environmental Pollutants ; Humans
Chemical Substances	Environmental Pollutants
Language	English
Publishing date	2020-12-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/EHP6994
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1360: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 379: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Chromatin remodeling: why it is important in cancer.

Wolffe, A P

Oncogene

2001 Volume 20, Issue 24, Page(s) 2988–2990

Abstract: A typical human cell expresses only a few thousand of the more than 30 000 genes contained within our chromosomes. The chromosomal infrastructure is essential for gene control, determining both active and repressed states. It is important not only to ... ...

Abstract	A typical human cell expresses only a few thousand of the more than 30 000 genes contained within our chromosomes. The chromosomal infrastructure is essential for gene control, determining both active and repressed states. It is important not only to turn the right genes on but also to turn the right genes off. Histones and chromatin components have key roles in this decision making process. Mistakes have severe consequences. If as few as three inappropriate genes are turned off, a normal cell can be converted into a cancer cell. This epigenetic silencing of genes underlies a new approach to cancer therapy. Advances in the biochemistry and genetics of chromatin remodeling reveal that gene inactivation depends on the recruitment of enzymes that control the display of DNA within the chromosome. Mistargeting of these enzymes leads to tumorigenesis, but inhibition of their activity presents a novel approach to therapy.
MeSH term(s)	Animals ; Chromatin/genetics ; Chromatin/metabolism ; Gene Expression Regulation ; Humans ; Neoplasms/genetics
Chemical Substances	Chromatin
Language	English
Publishing date	2001-05-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639046-8
ISSN	1476-5594 ; 0950-9232
ISSN (online)	1476-5594
ISSN	0950-9232
DOI	10.1038/sj.onc.1204322
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2218: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito