Article ; Online: Sanhuang Shu'ai decoction alleviates DSS-induced ulcerative colitis via regulation of gut microbiota, inflammatory mediators and cytokines.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2020 Volume 125, Page(s) 109934
Abstract: Background: Sanhuangshu'ai decoction (SH), a traditional Chinese medicine (TCM) prescription, has been safely used to treat diarrhea, dysentery and other inflammatory diseases with little side effect and low cost for thousands of years. However, its ... ...
| Abstract | Background: Sanhuangshu'ai decoction (SH), a traditional Chinese medicine (TCM) prescription, has been safely used to treat diarrhea, dysentery and other inflammatory diseases with little side effect and low cost for thousands of years. However, its mechanism remains elusive. This study was designed to investigate the anti-ulcerative colitis (UC) activity of SH and mechanism by detecting its anti-inflammatory, anti-oxidative, and intervention effects of intestinal flora with the dextran sodium sulfate (DSS)-induced colitis mice. Methods: The DSS-induced colitis mice was orally administered SH for 1 week with 0.8 or 1.6 g kg Results: Oral administration of SH significantly prevented the development of colitis. It reduced the expression of interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)-α in the colon. Moreover, SH administration alleviated the oxidative stress in the colon of DSS-induced colitis mice, evidenced by the decrease of myeloperoxidase (MPO) activity and malondialdehyde (MDA) level, and increase of ROS level. Furthermore, SH can prevent the decrease ofLactobacillus sp. and population abundance of intestinal flora caused by DSS. Conclusion: SH significantly ameliorates the symptoms of DSS-induced colitis mice and the potential mechanism of SH may involve in multiple kinds of metabolic pathway including the regulation of gut microbiota, inflammatory mediators and cytokines. |
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| MeSH term(s) | Animals ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/administration & dosage ; Antioxidants/pharmacology ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/physiopathology ; Cytokines/metabolism ; Dextran Sulfate ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Gastrointestinal Microbiome/drug effects ; Inflammation Mediators/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Oxidative Stress/drug effects |
| Chemical Substances | Anti-Inflammatory Agents ; Antioxidants ; Cytokines ; Drugs, Chinese Herbal ; Inflammation Mediators ; sanhuang ; Dextran Sulfate (9042-14-2) |
| Language | English |
| Publishing date | 2020-02-12 |
| Publishing country | France |
| Document type | Journal Article |
| ZDB-ID | 392415-4 |
| ISSN | 1950-6007 ; 0753-3322 ; 0300-0893 |
| ISSN (online) | 1950-6007 |
| ISSN | 0753-3322 ; 0300-0893 |
| DOI | 10.1016/j.biopha.2020.109934 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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