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  1. Article ; Online: Erythrobacter oryzae

    Lee, Hyo-Jin / Hwang, Ji-Soo / Lee, Eun-Kyung / Whang, Kyung-Sook

    International journal of systematic and evolutionary microbiology

    2024  Volume 74, Issue 3

    Abstract: Two novel bacterial strains, designated as COR- ... ...

    Abstract Two novel bacterial strains, designated as COR-2
    MeSH term(s) Sphingomonadaceae ; Oryza ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Base Composition ; Fatty Acids/chemistry ; Sequence Analysis, DNA ; DNA, Bacterial/genetics ; Bacterial Typing Techniques
    Chemical Substances RNA, Ribosomal, 16S ; Fatty Acids ; DNA, Bacterial
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2002336-4
    ISSN 1466-5034 ; 1466-5026
    ISSN (online) 1466-5034
    ISSN 1466-5026
    DOI 10.1099/ijsem.0.006287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 409: Show issues Location:
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  2. Article ; Online: Correction: A subfamily of the small heat shock proteins of the marine red alga Neopyropia yezoensis localizes in the chloroplast.

    Wi, Jiwoong / Park, Eun-Jeong / Hwang, Mi-Sook / Choi, Dong-Woog

    Cell stress & chaperones

    2023  Volume 28, Issue 6, Page(s) 847

    Language English
    Publishing date 2023-11-15
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 1362749-1
    ISSN 1466-1268 ; 1355-8145
    ISSN (online) 1466-1268
    ISSN 1355-8145
    DOI 10.1007/s12192-023-01393-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4797: Show issues Location:
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  3. Article ; Online: A subfamily of the small heat shock proteins of the marine red alga Neopyropia yezoensis localizes in the chloroplast.

    Wi, Jiwoong / Park, Eun-Jeong / Hwang, Mi-Sook / Choi, Dong-Woog

    Cell stress & chaperones

    2023  Volume 28, Issue 6, Page(s) 835–846

    Abstract: Small heat shock proteins (sHSPs) play a crucial role under abiotic stress and are present in all organisms, from eukaryotes to prokaryotes. However, studies on the sHSP gene family in red alga are limited. In this study, we aimed to identify and ... ...

    Abstract Small heat shock proteins (sHSPs) play a crucial role under abiotic stress and are present in all organisms, from eukaryotes to prokaryotes. However, studies on the sHSP gene family in red alga are limited. In this study, we aimed to identify and characterize NysHSP genes from the genome of N. yezoensis, a marine red alga adapted to the stressful intertidal zone. We identified seven NysHSP genes distributed on all three chromosomes. Expression analysis revealed that all NysHSP genes responded to H
    MeSH term(s) Heat-Shock Proteins, Small/genetics ; Heat-Shock Proteins, Small/metabolism ; Hydrogen Peroxide/metabolism ; Chloroplasts/genetics ; Chloroplasts/metabolism ; Rhodophyta/genetics
    Chemical Substances Heat-Shock Proteins, Small ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2023-08-26
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1362749-1
    ISSN 1466-1268 ; 1355-8145
    ISSN (online) 1466-1268
    ISSN 1355-8145
    DOI 10.1007/s12192-023-01375-4
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    Zs.A 4797: Show issues Location:
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  4. Article: Diffusion-Weighted MR Imaging of the Thymus in Children with Non-Thymic Neoplasms.

    Hwang, Sook Min / Park, Ji Eun / Yoo, So-Young / Kim, Ji Hye / Baek, Sun-Young / Moon, Sung-Hoon / Jeon, Tae Yeon

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 24

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2023-12-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13243654
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  5. Article: Cydonia oblonga

    Lee, Hyun Sook / Jung, Jae In / Hwang, Jung Soon / Hwang, Myeong Oh / Kim, Eun Ji

    Nutrition research and practice

    2023  Volume 17, Issue 6, Page(s) 1043–1055

    Abstract: Background/objectives: The fruit of : Materials/methods: 3T3-L1 preadipocytes were cultured for 8 days with COM fruit extract (COME) at different concentrations (0-600 µg/mL) with adipocyte differentiation medium. The cell viability was measured ... ...

    Abstract Background/objectives: The fruit of
    Materials/methods: 3T3-L1 preadipocytes were cultured for 8 days with COM fruit extract (COME) at different concentrations (0-600 µg/mL) with adipocyte differentiation medium. The cell viability was measured using an MTT assay; triglyceride (TG) was stained with Oil Red O. The expression levels of the adipogenesis-related genes and protein expression were analyzed by reverse transcription polymerase chain reaction and Western blotting, respectively.
    Results: COME inhibited intracellular TG accumulation during adipogenesis. A COME treatment in 3T3-L1 cells induced upregulation of the adenosine monophosphate-activated protein kinase (AMPK)α phosphorylation and downregulation of the adipogenic transcription factors, such as sterol regulatory element-binding protein 1c, peroxisome proliferator-activated receptor γ, and CCAAT/enhancer binding protein α. The COME treatment reduced the mRNA expression of fatty acyl synthetase, adenosine triphosphate-citrate lyase, adipocyte protein 2, and lipoprotein lipase. It increased the mRNA expression of hormone-sensitive lipase and carnitine palmitoyltransferase I in 3T3-L1 cells.
    Conclusions: COME inhibits adipogenesis via the AMPK signaling pathways. COME may be used to prevent and treat obesity.
    Language English
    Publishing date 2023-08-21
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2387946-4
    ISSN 2005-6168 ; 1976-1457
    ISSN (online) 2005-6168
    ISSN 1976-1457
    DOI 10.4162/nrp.2023.17.6.1043
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  6. Article ; Online: Anticancer Activity of Astaxanthin-Incorporated Chitosan Nanoparticles.

    Hwang, Eun Ju / Jeong, Young-Il / Lee, Kyong-Je / Yu, Young-Bob / Ohk, Seung-Ho / Lee, Sook-Young

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 2

    Abstract: Astaxanthin (AST)-encapsulated nanoparticles were fabricated using glycol chitosan (Chito) through electrostatic interaction (abbreviated as ChitoAST) to solve the aqueous solubility of astaxanthin and improve its biological activity. AST was dissolved ... ...

    Abstract Astaxanthin (AST)-encapsulated nanoparticles were fabricated using glycol chitosan (Chito) through electrostatic interaction (abbreviated as ChitoAST) to solve the aqueous solubility of astaxanthin and improve its biological activity. AST was dissolved in organic solvents and then mixed with chitosan solution, followed by a dialysis procedure. All formulations of ChitoAST nanoparticles showed small diameters (less than 400 nm) with monomodal distributions. Analysis with Fourier transform infrared (FT-IR) spectroscopy confirmed the specific peaks of AST and Chito. Furthermore, ChitoAST nanoparticles were formed through electrostatic interactions between Chito and AST. In addition, ChitoAST nanoparticles showed superior antioxidant activity, as good as AST itself; the half maximal radical scavenging concentrations (RC
    MeSH term(s) Mice ; Animals ; Chitosan/chemistry ; Spectroscopy, Fourier Transform Infrared ; Nanoparticles/chemistry ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Xanthophylls
    Chemical Substances Chitosan (9012-76-4) ; astaxanthine (8XPW32PR7I) ; Antioxidants ; Xanthophylls
    Language English
    Publishing date 2024-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29020529
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  7. Article: Drug like HSP27 cross linkers with chromenone structure ameliorates pulmonary fibrosis.

    Yoo, Young Jo / Jeon, Seulgi / Jin, Hee / Won, Hee Yeon / Jeong, Mi Gyeong / Cho, Yeseul / Hwang, Eun Sook / Na, Younghwa / Cho, Jaeho / Lee, Yun-Sil

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1203033

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-07-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1203033
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  8. Article: The essential role of TAZ in normal tissue homeostasis.

    Jeong, Mi Gyeong / Kim, Hyo Kyeong / Hwang, Eun Sook

    Archives of pharmacal research

    2021  Volume 44, Issue 3, Page(s) 253–262

    Abstract: Transcriptional coactivator with PDZ-binding motif (TAZ) has been extensively characterized in organ development, tissue regeneration, and tumor progression. In particular, TAZ functions as a Hippo mediator that regulates organ size, tumor growth and ... ...

    Abstract Transcriptional coactivator with PDZ-binding motif (TAZ) has been extensively characterized in organ development, tissue regeneration, and tumor progression. In particular, TAZ functions as a Hippo mediator that regulates organ size, tumor growth and migration. It is highly expressed in various types of human cancer, and has been reported to be associated with tumor metastasis and poor outcomes in cancer patients, suggesting that TAZ is an oncogenic regulator. Yes-associated protein (YAP) has 60% similarity in amino acid sequence to TAZ and plays redundant roles with TAZ in the regulation of cell proliferation and migration of cancer cells. Therefore, TAZ and YAP, which are encoded by paralogous genes, are referred to as TAZ/YAP and are suggested to be functionally equivalent. Despite its similarity to YAP, TAZ can be clearly distinguished from YAP based on its genetic, structural, and functional aspects. In addition, targeting superabundant TAZ can be a promising therapeutic strategy for cancer treatment; however, persistent TAZ inactivation may cause failure of tissue homeostatic control. This review focuses primarily on TAZ, not YAP, discusses its structural features and physiological functions in the regulation of tissue homeostasis, and provides new insights into the drug development targeting TAZ to control reproductive and musculoskeletal disorders.
    MeSH term(s) Adaptor Proteins, Signal Transducing/chemistry ; Adaptor Proteins, Signal Transducing/metabolism ; Homeostasis ; Humans ; Transcription Factors/chemistry ; Transcription Factors/metabolism
    Chemical Substances Adaptor Proteins, Signal Transducing ; Transcription Factors ; YAP1 protein, human
    Language English
    Publishing date 2021-03-26
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 447623-2
    ISSN 1976-3786 ; 0253-6269
    ISSN (online) 1976-3786
    ISSN 0253-6269
    DOI 10.1007/s12272-021-01322-w
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3229: Show issues Location:
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  9. Article ; Online: Post-Translational Modifications in Transcription Factors that Determine T Helper Cell Differentiation.

    Kim, Hyo Kyeong / Jeong, Mi Gyeong / Hwang, Eun Sook

    Molecules and cells

    2021  Volume 44, Issue 5, Page(s) 318–327

    Abstract: CD4+ T helper (Th) cells play a crucial role in the modulation of innate and adaptive immune responses through the differentiation of Th precursor cells into several subsets, including Th1, Th2, Th17, and regulatory T (Treg) cells. Effector Th and Treg ... ...

    Abstract CD4+ T helper (Th) cells play a crucial role in the modulation of innate and adaptive immune responses through the differentiation of Th precursor cells into several subsets, including Th1, Th2, Th17, and regulatory T (Treg) cells. Effector Th and Treg cells are distinguished by the production of signature cytokines and are important for eliminating intracellular and extracellular pathogens and maintaining immune homeostasis. Stimulation of naïve Th cells by T cell receptor and specific cytokines activates master transcription factors and induces lineage specification during the differentiation of Th cells. The master transcription factors directly activate the transcription of signature cytokine genes and also undergo post-translational modifications to fine-tune cytokine production and maintain immune balance through cross-regulation with each other. This review highlights the post-translational modifications of master transcription factors that control the differentiation of effector Th and Treg cells and provides additional insights on the immune regulation mediated by protein arginine-modifying enzymes in effector Th cells.
    MeSH term(s) Cell Differentiation ; Humans ; Protein Processing, Post-Translational/immunology ; T-Lymphocytes, Helper-Inducer/immunology ; Transcription Factors/immunology
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2021-05-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1148964-9
    ISSN 0219-1032 ; 1016-8478
    ISSN (online) 0219-1032
    ISSN 1016-8478
    DOI 10.14348/molcells.2021.0057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4713: Show issues Location:
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  10. Article ; Online: Discovery of N-benzylbenzamide-based allosteric inhibitors of Aurora kinase A.

    Lee, Hyomin / Kim, Euijung / Hwang, Narae / Yoo, Jesik / Nam, Yunju / Hwang, Injeoung / Park, Jin-Gyeong / Park, Sang-Eun / Chung, Kyung-Sook / Won Chung, Hwan / Song, Chiman / Ji, Mi-Jung / Park, Hyun-Mee / Lee, In-Kyun / Lee, Kyung-Tae / Joo Roh, Eun / Hur, Wooyoung

    Bioorganic & medicinal chemistry

    2024  Volume 102, Page(s) 117658

    Abstract: Aurora kinases (AurkA/B/C) regulate the assembly of bipolar mitotic spindles and the fidelity of chromosome segregation during mitosis, and are attractive therapeutic targets for cancers. Numerous ATP-competitive AurkA inhibitors have been developed as ... ...

    Abstract Aurora kinases (AurkA/B/C) regulate the assembly of bipolar mitotic spindles and the fidelity of chromosome segregation during mitosis, and are attractive therapeutic targets for cancers. Numerous ATP-competitive AurkA inhibitors have been developed as potential anti-cancer agents. Recently, a few allosteric inhibitors have been reported that bind to the allosteric Y-pocket within AurkA kinase domain and disrupt the interaction between AurkA and its activator TPX2. Herein we report a novel allosteric AurkA inhibitor (6h) of N-benzylbenzamide backbone. Compound 6h suppressed the both catalytic activity and non-catalytic functions of AurkA. The inhibitory activity of 6h against AurkA (IC
    MeSH term(s) Humans ; Cell Cycle Proteins ; Aurora Kinase A ; Neoplasms/drug therapy ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; DNA Replication ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use
    Chemical Substances Cell Cycle Proteins ; Aurora Kinase A (EC 2.7.11.1) ; Antineoplastic Agents ; Protein Kinase Inhibitors
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2024.117658
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    Zs.A 3815: Show issues Location:
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