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Article ; Online: Eric Harris Davidson: A systems biologist who studied how genomes function.

Cameron, Andy / Klein, Bill

2015 Volume 82, Issue 11, Page(s) fmi–v

MeSH term(s)	Embryology/history ; Genome ; History, 20th Century ; History, 21st Century ; Humans ; Portraits as Topic ; Systems Biology/history
Language	English
Publishing date	2015-11
Publishing country	United States
Document type	Biography ; Editorial ; Historical Article
ZDB-ID	20321-x
ISSN	1098-2795 ; 1040-452X
ISSN (online)	1098-2795
ISSN	1040-452X
DOI	10.1002/mrd.22592
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Article ; Online: Reply to Parham Habibzadeh and Farrokh Habibzadeh's Letter to the Editor re: Eric A. Klein, Arnon Chait, Jason M. Hafron, et al. The Single-parameter, Structure-based IsoPSA Assay Demonstrates Improved Diagnostic Accuracy for Detection of Any Prostate Cancer and High-grade Prostate Cancer Compared to a Concentration-based Assay of Total Prostate-specific Antigen: A Preliminary Report. Eur Urol 2017;72:942-9. The Most Appropriate IsoPSA Cutoff for Diagnosis of Prostate Cancer.

Klein, Eric A

European urology

2017 Volume 72, Issue 6, Page(s) e174

MeSH term(s)	Humans ; Male ; Prostate-Specific Antigen ; Prostatic Neoplasms
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2017
Publishing country	Switzerland
Document type	Letter ; Comment
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2017.07.020
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Reply to Lars Egevad, Hemamali Samaratunga, John R. Srigley, Brett Delahunt's Letter to the Editor re: Anthony Zietman, Joseph Smith, Eric Klein, Michael Droller, Prokar Dasgupta, James Catto. Describing the Grade of Prostate Cancer: Consistent Use of Contemporary Terminology Is Now Required. Eur Urol 2016;70:1.

Zietman, Anthony / Smith, Joseph / Klein, Eric / Droller, Michael / Dasgupta, Prokar / Catto, James

European urology

2017 Volume 71, Issue 2, Page(s) e54

Language	English
Publishing date	2017-02
Publishing country	Switzerland
Document type	Letter
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2016.07.020
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Article ; Online: Reply to Yuri Tolkach, Markus Kuczyk, Florian Imkamp's letter to the editor re: Eric A. Klein, Matthew R. Cooperberg, Cristina Magi-Galluzzi, et al. A 17-gene assay to predict prostate cancer aggressiveness in the context of gleason grade heterogeneity, tumor multifocality, and biopsy undersampling. Eur urol 2014;66:550-60.

Klein, Eric A / Cooperberg, Matthew R / Carroll, Peter R

European urology

2014 Volume 66, Issue 6, Page(s) e117–8

MeSH term(s)	Gene Expression ; Humans ; Male ; Neoplasm Recurrence, Local/genetics ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Transcriptome
Language	English
Publishing date	2014-12
Publishing country	Switzerland
Document type	Comment ; Letter
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2014.08.001
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Article ; Online: ERICA

Revista de Saúde Pública, Vol 50, Iss suppl

prevalence of metabolic syndrome in Brazilian adolescents

2016 Volume 1

Abstract: ... of Cardiovascular Risks in Adolescents (ERICA), a cross-sectional, school-based, national study. The adolescents ... triglycerides. CONCLUSIONS ERICA is the first Brazilian nation-wide study to present the prevalence of metabolic ...

Abstract	ABSTRACT OBJECTIVE To determine the prevalence of metabolic syndrome and its components in Brazilian adolescents. METHODS We evaluated 37,504 adolescents who were participants in the Study of Cardiovascular Risks in Adolescents (ERICA), a cross-sectional, school-based, national study. The adolescents, aged from 12 to 17 years, lived in cities with populations greater than 100,000 inhabitants. The sample was stratified and clustered into schools and classes. The criteria set out by the International Diabetes Federation were used to define metabolic syndrome. Prevalences of metabolic syndrome were estimated according to sex, age group, school type and nutritional status. RESULTS Of the 37,504 adolescents who were evaluated: 50.2% were female; 54.3% were aged from 15 to 17 years, and 73.3% were from public schools. The prevalence of metabolic syndrome was 2.6% (95%CI 2.3-2.9), slightly higher in males and in those aged from 15 to 17 years in most macro-regions. The prevalence was the highest in residents from the South macro-region, in the younger female adolescents and in the older male adolescents. The prevalence was higher in public schools (2.8% [95%CI 2.4-3.2]), when compared with private schools (1.9% [95%CI 1.4-2.4]) and higher in obese adolescents when compared with nonobese ones. The most common combinations of components, referring to 3/4 of combinations, were: enlarged waist circumference (WC), low HDL-cholesterol (HDL-c) and high blood pressure; followed by enlarged WC, low HDL-c and high triglycerides; and enlarged WC, low HDL-c, high triglycerides and blood pressure. Low HDL was the second most frequent component, but the highest prevalence of metabolic syndrome (26.8%) was observed in the presence of high triglycerides. CONCLUSIONS ERICA is the first Brazilian nation-wide study to present the prevalence of metabolic syndrome and describe the role of its components. Despite the prevalence of Metabolic Syndrome being low, the high prevalences of some components and participation of others in the ...
Keywords	Adolescente ; Síndrome Metabólica ; epidemiologia ; Fatores de Risco ; Doenças Cardiovasculares ; Estudos Transversais ; Public aspects of medicine ; RA1-1270
Subject code	370
Language	English
Publishing date	2016-02-01T00:00:00Z
Publisher	Universidade de São Paulo
Document type	Article ; Online
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Article ; Online: ERICA

Revista de Saúde Pública, Vol 50, Iss suppl

prevalences of hypertension and obesity in Brazilian adolescents

2016 Volume 1

Abstract: ... Data from participants in the Brazilian Study of Cardiovascular Risks in Adolescents (ERICA), which was ... of hypertension attributable to obesity was 17.8%. CONCLUSIONS ERICA was the first nationally representative ...

Abstract	ABSTRACT OBJECTIVE To estimate the prevalence of arterial hypertension and obesity and the population attributable fraction of hypertension that is due to obesity in Brazilian adolescents. METHODS Data from participants in the Brazilian Study of Cardiovascular Risks in Adolescents (ERICA), which was the first national school-based, cross-section study performed in Brazil were evaluated. The sample was divided into 32 geographical strata and clusters from 32 schools and classes, with regional and national representation. Obesity was classified using the body mass index according to age and sex. Arterial hypertension was defined when the average systolic or diastolic blood pressure was greater than or equal to the 95th percentile of the reference curve. Prevalences and 95% confidence intervals (95%CI) of arterial hypertension and obesity, both on a national basis and in the macro-regions of Brazil, were estimated by sex and age group, as were the fractions of hypertension attributable to obesity in the population. RESULTS We evaluated 73,399 students, 55.4% female, with an average age of 14.7 years (SD = 1.6). The prevalence of hypertension was 9.6% (95%CI 9.0-10.3); with the lowest being in the North, 8.4% (95%CI 7.7-9.2) and Northeast regions, 8.4% (95%CI 7.6-9.2), and the highest being in the South, 12.5% (95%CI 11.0-14.2). The prevalence of obesity was 8.4% (95%CI 7.9-8.9), which was lower in the North region and higher in the South region. The prevalences of arterial hypertension and obesity were higher in males. Obese adolescents presented a higher prevalence of hypertension, 28.4% (95%CI 25.5-31.2), than overweight adolescents, 15.4% (95%CI 17.0-13.8), or eutrophic adolescents, 6.3% (95%CI 5.6-7.0). The fraction of hypertension attributable to obesity was 17.8%. CONCLUSIONS ERICA was the first nationally representative Brazilian study providing prevalence estimates of hypertension in adolescents. Regional and sex differences were observed. The study indicates that the control of obesity would lower the ...
Keywords	Adolescente ; Obesidade ; epidemiologia ; Hipertensão ; Prevalência ; Estudo Transversal ; Public aspects of medicine ; RA1-1270
Subject code	796
Language	English
Publishing date	2016-02-01T00:00:00Z
Publisher	Universidade de São Paulo
Document type	Article ; Online
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Article ; Online: ERICA

Katia Vergetti Bloch / Carlos Henrique Klein / Moyses Szklo / Maria Cristina C Kuschnir / Gabriela de Azevedo Abreu / Laura Augusta Barufaldi / Gloria Valeria da Veiga / Beatriz Schaan / Thiago Luiz Nogueira da Silva / Ana Julia Pantoja Moraes / Ana Mayra Andrade de Oliveira / Bruno Mendes Tavares / Erika da Silva Magliano / Cecília Lacroix de Oliveira / Cristiane de Freitas Cunha / Denise Tavares Giannini / Dilson Rodrigues Belfort / Eduardo Lima Santos / Elisa Brosina de Leon /

Elizabete Regina Araújo Oliveira / Elizabeth Fujimori / Ana Luíza Borges / Francisco de Assis Guedes Vasconcelos / George Dantas Azevedo / Gisela Soares Brunken / Isabel Cristina Britto Guimarães / José Rocha Faria Neto / Juliana Souza Oliveira / Kenia Mara B. de Carvalho / Luis Gonzaga de Oliveira Gonçalves / Maria Inês Monteiro / Marize M. Santos / Paulo César B. Veiga Jardim / Pedro Antônio Muniz Ferreira / Renan Magalhães Montenegro Jr. / Ricardo Queiroz Gurgel / Rodrigo Pinheiro Vianna / Sandra Mary Vasconcelos / Tamara Beres Lederer Goldberg

Revista de Saúde Pública, Vol 50, Iss suppl

prevalences of hypertension and obesity in Brazilian adolescents

2016 Volume 1

Abstract	ABSTRACT OBJECTIVE To estimate the prevalence of arterial hypertension and obesity and the population attributable fraction of hypertension that is due to obesity in Brazilian adolescents. METHODS Data from participants in the Brazilian Study of Cardiovascular Risks in Adolescents (ERICA), which was the first national school-based, cross-section study performed in Brazil were evaluated. The sample was divided into 32 geographical strata and clusters from 32 schools and classes, with regional and national representation. Obesity was classified using the body mass index according to age and sex. Arterial hypertension was defined when the average systolic or diastolic blood pressure was greater than or equal to the 95th percentile of the reference curve. Prevalences and 95% confidence intervals (95%CI) of arterial hypertension and obesity, both on a national basis and in the macro-regions of Brazil, were estimated by sex and age group, as were the fractions of hypertension attributable to obesity in the population. RESULTS We evaluated 73,399 students, 55.4% female, with an average age of 14.7 years (SD = 1.6). The prevalence of hypertension was 9.6% (95%CI 9.0-10.3); with the lowest being in the North, 8.4% (95%CI 7.7-9.2) and Northeast regions, 8.4% (95%CI 7.6-9.2), and the highest being in the South, 12.5% (95%CI 11.0-14.2). The prevalence of obesity was 8.4% (95%CI 7.9-8.9), which was lower in the North region and higher in the South region. The prevalences of arterial hypertension and obesity were higher in males. Obese adolescents presented a higher prevalence of hypertension, 28.4% (95%CI 25.5-31.2), than overweight adolescents, 15.4% (95%CI 17.0-13.8), or eutrophic adolescents, 6.3% (95%CI 5.6-7.0). The fraction of hypertension attributable to obesity was 17.8%. CONCLUSIONS ERICA was the first nationally representative Brazilian study providing prevalence estimates of hypertension in adolescents. Regional and sex differences were observed. The study indicates that the control of obesity would lower the ...
Keywords	Adolescent ; Obesity ; epidemiology ; Hypertension ; Cross-Sectional Studies ; Public aspects of medicine ; RA1-1270
Subject code	796
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Universidade de São Paulo
Document type	Article ; Online
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Article ; Online: ERICA

Maria Cristina C Kuschnir / Katia Vergetti Bloch / Moyses Szklo / Carlos Henrique Klein / Laura Augusta Barufaldi / Gabriela de Azevedo Abreu / Beatriz Schaan / Gloria Valeria da Veiga / Thiago Luiz Nogueira da Silva / Maurício T L de Vasconcellos / Ana Júlia Pantoja de Moraes / Ana Mayra Andrade de Oliveira / Bruno Mendes Tavares / Cecília Lacroix de Oliveira / Cristiane de Freitas Cunha / Denise Tavares Giannini / Dilson Rodrigues Belfort / Eduardo Lima Santos / Elisa Brosina de Leon /

Elizabete Regina Araújo Oliveira / Elizabeth Fujimori / Ana Luíza Borges / Erika da Silva Magliano / Francisco de Assis Guedes Vasconcelos / George Dantas Azevedo / Gisela Soares Brunken / Isabel Cristina Britto Guimarães / José Rocha Faria Neto / Juliana Souza Oliveira / Kenia Mara B de Carvalho / Luis Gonzaga de Oliveira Gonçalves / Maria Inês Monteiro / Marize M Santos / Pascoal Torres Muniz / Paulo César B Veiga Jardim / Pedro Antônio Muniz Ferreira / Renan Magalhães Montenegro Jr / Ricardo Queiroz Gurgel / Rodrigo Pinheiro Vianna / Sandra Mary Vasconcelos / Stella Maris Seixas Martins / Tamara Beres Lederer Goldberg

Revista de Saúde Pública, Vol 50, Iss suppl

prevalence of metabolic syndrome in Brazilian adolescents

2016 Volume 1

Abstract	ABSTRACT OBJECTIVE To determine the prevalence of metabolic syndrome and its components in Brazilian adolescents. METHODS We evaluated 37,504 adolescents who were participants in the Study of Cardiovascular Risks in Adolescents (ERICA), a cross-sectional, school-based, national study. The adolescents, aged from 12 to 17 years, lived in cities with populations greater than 100,000 inhabitants. The sample was stratified and clustered into schools and classes. The criteria set out by the International Diabetes Federation were used to define metabolic syndrome. Prevalences of metabolic syndrome were estimated according to sex, age group, school type and nutritional status. RESULTS Of the 37,504 adolescents who were evaluated: 50.2% were female; 54.3% were aged from 15 to 17 years, and 73.3% were from public schools. The prevalence of metabolic syndrome was 2.6% (95%CI 2.3-2.9), slightly higher in males and in those aged from 15 to 17 years in most macro-regions. The prevalence was the highest in residents from the South macro-region, in the younger female adolescents and in the older male adolescents. The prevalence was higher in public schools (2.8% [95%CI 2.4-3.2]), when compared with private schools (1.9% [95%CI 1.4-2.4]) and higher in obese adolescents when compared with nonobese ones. The most common combinations of components, referring to 3/4 of combinations, were: enlarged waist circumference (WC), low HDL-cholesterol (HDL-c) and high blood pressure; followed by enlarged WC, low HDL-c and high triglycerides; and enlarged WC, low HDL-c, high triglycerides and blood pressure. Low HDL was the second most frequent component, but the highest prevalence of metabolic syndrome (26.8%) was observed in the presence of high triglycerides. CONCLUSIONS ERICA is the first Brazilian nation-wide study to present the prevalence of metabolic syndrome and describe the role of its components. Despite the prevalence of Metabolic Syndrome being low, the high prevalences of some components and participation of others in the ...
Keywords	Adolescent ; Metabolic Syndrome ; epidemiology ; Risk Factors ; Cardiovascular Diseases ; Cross-Sectional Studies ; Public aspects of medicine ; RA1-1270
Subject code	370
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Universidade de São Paulo
Document type	Article ; Online
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Article ; Online: Response rate in the Study of Cardiovascular Risks in Adolescents - ERICA.

da Silva, Thiago Luiz Nogueira / Klein, Carlos Henrique / Souza, Amanda de Moura / Barufaldi, Laura Augusta / Abreu, Gabriela de Azevedo / Kuschnir, Maria Cristina Caetano / de Vasconcellos, Mauricio Teixeira Leite / Bloch, Katia Vergetti

Revista de saude publica

2016 Volume 50 Suppl 1, Page(s) 3s

Abstract: ... in from the Study of Cardiovascular Risks in Adolescents (ERICA) , according to information subsets. METHODS ERICA ...

Abstract	OBJECTIVE To describe the response rate and characteristics of people who either took part or not in from the Study of Cardiovascular Risks in Adolescents (ERICA) , according to information subsets. METHODS ERICA is a school-based, nation-wide investigation with a representative sample of 12 to 17-year-old adolescents attending public or private schools in municipalities with over 100,000 inhabitants in Brazil. Response rate of eligible subjects were calculated according to macro-regions, sex, age, and type of school (public or private). We also calculated the percentages of replacement schools in comparison with the ones originally selected as per the sample design, according to the types of schools in the macro-regions. The subjects and non-subjects were compared according to sex, age, and average body mass indices (kg/m2). RESULTS We had 102,327 eligible adolescents enrolled in the groups drawn. The highest percentage of complete information was obtained for the subset of the questionnaire (72.9%). Complete information regarding anthropometric measurements and the ones from the questionnaire were obtained for 72.0% of the adolescents, and the combination of these data with the 24-hour dietary recall were obtained for 70.3% of the adolescents. Complete information from the questionnaire plus biochemical blood evaluation data were obtained for 52.5% of the morning session adolescents (selected for blood tests). The response percentage in private schools was higher than the one in public schools for most of the combination of information. The ratio of older and male adolescents non-participants was higher than the ratio among participants. CONCLUSIONS The response rate for non-invasive procedures was high. The response rate for blood collection - an invasive procedure that requires a 12-hour fasting period and the informed consent form from legal guardians - was lower. The response rate observed in public schools was lower than in the private ones, and that may reflect lower school frequency of registered students.
MeSH term(s)	Adolescent ; Anthropometry ; Brazil/epidemiology ; Cardiovascular Diseases/epidemiology ; Female ; Health Surveys ; Humans ; Male ; Risk Factors ; Schools/statistics & numerical data ; Socioeconomic Factors ; Students/statistics & numerical data ; Surveys and Questionnaires
Language	Portuguese
Publishing date	2016-02
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	732179-x
ISSN	1518-8787 ; 0034-8910
ISSN (online)	1518-8787
ISSN	0034-8910
DOI	10.1590/S01518-8787.2016050006730
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Article ; Online: ERICA: prevalence of metabolic syndrome in Brazilian adolescents.

Kuschnir, Maria Cristina C / Bloch, Katia Vergetti / Szklo, Moyses / Klein, Carlos Henrique / Barufaldi, Laura Augusta / Abreu, Gabriela de Azevedo / Schaan, Beatriz / da Veiga, Gloria Valeria / da Silva, Thiago Luiz Nogueira / de Vasconcellos, Maurício T L / de Moraes, Ana Júlia Pantoja / Borges, Ana Luíza / de Oliveira, Ana Mayra Andrade / Tavares, Bruno Mendes / de Oliveira, Cecília Lacroix / Cunha, Cristiane de Freitas / Giannini, Denise Tavares / Belfort, Dilson Rodrigues / Santos, Eduardo Lima /

de Leon, Elisa Brosina / Fujimori, Elizabeth / Oliveira, Elizabete Regina Araújo / Magliano, Erika da Silva / Vasconcelos, Francisco de Assis Guedes / Azevedo, George Dantas / Brunken, Gisela Soares / Guimarães, Isabel Cristina Britto / Faria Neto, José Rocha / Oliveira, Juliana Souza / de Carvalho, Kenia Mara B / Gonçalves, Luis Gonzaga de Oliveira / Monteiro, Maria Inês / Santos, Marize M / Muniz, Pascoal Torres / Jardim, Paulo César B Veiga / Ferreira, Pedro Antônio Muniz / Montenegro, Renan Magalhães / Gurgel, Ricardo Queiroz / Vianna, Rodrigo Pinheiro / Vasconcelos, Sandra Mary / Martins, Stella Maris Seixas / Goldberg, Tamara Beres Lederer

Revista de saude publica

2016 Volume 50 Suppl 1, Page(s) 11s

Abstract: ... Risks in Adolescents (ERICA), a cross-sectional, school-based, national study. The adolescents, aged ... CONCLUSIONS ERICA is the first Brazilian nation-wide study to present the prevalence of metabolic syndrome and ...

Abstract	OBJECTIVE To determine the prevalence of metabolic syndrome and its components in Brazilian adolescents. METHODS We evaluated 37,504 adolescents who were participants in the Study of Cardiovascular Risks in Adolescents (ERICA), a cross-sectional, school-based, national study. The adolescents, aged from 12 to 17 years, lived in cities with populations greater than 100,000 inhabitants. The sample was stratified and clustered into schools and classes. The criteria set out by the International Diabetes Federation were used to define metabolic syndrome. Prevalences of metabolic syndrome were estimated according to sex, age group, school type and nutritional status. RESULTS Of the 37,504 adolescents who were evaluated: 50.2% were female; 54.3% were aged from 15 to 17 years, and 73.3% were from public schools. The prevalence of metabolic syndrome was 2.6% (95%CI 2.3-2.9), slightly higher in males and in those aged from 15 to 17 years in most macro-regions. The prevalence was the highest in residents from the South macro-region, in the younger female adolescents and in the older male adolescents. The prevalence was higher in public schools (2.8% [95%CI 2.4-3.2]), when compared with private schools (1.9% [95%CI 1.4-2.4]) and higher in obese adolescents when compared with nonobese ones. The most common combinations of components, referring to 3/4 of combinations, were: enlarged waist circumference (WC), low HDL-cholesterol (HDL-c) and high blood pressure; followed by enlarged WC, low HDL-c and high triglycerides; and enlarged WC, low HDL-c, high triglycerides and blood pressure. Low HDL was the second most frequent component, but the highest prevalence of metabolic syndrome (26.8%) was observed in the presence of high triglycerides. CONCLUSIONS ERICA is the first Brazilian nation-wide study to present the prevalence of metabolic syndrome and describe the role of its components. Despite the prevalence of Metabolic Syndrome being low, the high prevalences of some components and participation of others in the syndrome composition shows the importance of early diagnosis of this changes, even if not grouped within the metabolic syndrome.
MeSH term(s)	Adolescent ; Brazil/epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Hypertension/epidemiology ; Male ; Metabolic Syndrome/epidemiology ; Obesity/epidemiology ; Prevalence ; Residence Characteristics ; Risk Factors ; Triglycerides/blood
Chemical Substances	Triglycerides
Language	Portuguese
Publishing date	2016-02
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	732179-x
ISSN	1518-8787 ; 0034-8910
ISSN (online)	1518-8787
ISSN	0034-8910
DOI	10.1590/S01518-8787.2016050006701
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