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Article ; Online: Single-cell melanoma transcriptomes depicting functional versatility and clinical implications of STIM1 in the tumor microenvironment.

Wong, Henry Sung-Ching / Chang, Wei-Chiao

2021 Volume 11, Issue 11, Page(s) 5092–5106

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	CD4-Positive T-Lymphocytes/pathology ; Cell Line, Tumor ; Cytokines/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Melanoma/genetics ; Melanoma/pathology ; Neoplasm Proteins/genetics ; Prognosis ; Signal Transduction/genetics ; Stromal Interaction Molecule 1/genetics ; T-Lymphocytes, Regulatory/pathology ; Transcriptome/genetics ; Tumor Microenvironment/genetics
Chemical Substances	Cytokines ; Neoplasm Proteins ; STIM1 protein, human ; Stromal Interaction Molecule 1
Language	English
Publishing date	2021-03-05
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.54134
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Article ; Online: The genome-wide association study of serum IgE levels demonstrated a shared genetic background in allergic diseases.

Lu, Hsing-Fang / Chou, Chen-Hsing / Lin, Ying-Ju / Uchiyama, Shunsuke / Terao, Chikashi / Wang, Yu-Wen / Yang, Jai-Sing / Liu, Ting-Yuan / Wong, Henry Sung-Ching / Chen, Sean Chun-Chang / Tsai, Fuu-Jen

Clinical immunology (Orlando, Fla.)

2024 Volume 260, Page(s) 109897

Abstract: Immunoglobulin E (IgE) synthessis is highly related to a variety of atopic diseases, and several genome-wide association studies (GWASs) have demonstrated the association between genes and IgE level. In this study, we conducted the largest genome-wide ... ...

Abstract	Immunoglobulin E (IgE) synthessis is highly related to a variety of atopic diseases, and several genome-wide association studies (GWASs) have demonstrated the association between genes and IgE level. In this study, we conducted the largest genome-wide association study of IgE involving a Taiwanese Han population. Eight independent variants exhibited genome-wide significance. Among them, an intronic SNP of CD28, rs1181388, and an intergenic SNP, rs1002957030, on 11q23.2 were identified as novel signals for IgE. Seven of the loci were replicated successfully in a meta-analysis using data on Japanese population. Among all the human leukocyte antigen (HLA) regions, HLA-DQA103:02 - HLA-DQB103:03 was the most significant haplotype (OR = 1.25, SE = 0.02, FDR = 1.6 × 10
MeSH term(s)	Humans ; Genome-Wide Association Study ; Hypersensitivity/genetics ; Asthma ; Polymorphism, Single Nucleotide ; Immunoglobulin E ; Genetic Predisposition to Disease
Chemical Substances	Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2024.109897
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Zs.A 880: Show issues

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Article ; Online: Human rs75776403 polymorphism links differential phenotypic and clinical outcomes to a CLEC18A p.T151M-driven multiomics.

Hsu, Yu-Wen / Wong, Henry Sung-Ching / Huang, Wan-Chen / Yeh, Yi-Hung / Hsiao, Chwan-Deng / Chang, Wei-Chiao / Hsieh, Shie-Liang

Journal of biomedical science

2022 Volume 29, Issue 1, Page(s) 43

Abstract: Background: Human traits, diseases susceptibility, and clinical outcomes vary hugely among individuals. Despite a fundamental understanding of genetic (or environmental) contributions, the detailed mechanisms of how genetic variation impacts molecular ... ...

Abstract	Background: Human traits, diseases susceptibility, and clinical outcomes vary hugely among individuals. Despite a fundamental understanding of genetic (or environmental) contributions, the detailed mechanisms of how genetic variation impacts molecular or cellular behaviours of a gene, and subsequently leads to such variability remain poorly understood. Methods: Here, in addition to phenome-wide correlations, we leveraged multiomics to exploit mechanistic links, from genetic polymorphism to protein structural or functional changes and a cross-omics perturbation landscape of a germline variant. Results: We identified a missense cis-acting expression quantitative trait locus in CLEC18A (rs75776403) in which the altered residue (T Conclusions: Collectively, we uncovered genetic pleiotropy in human complex traits and diseases via CLEC18A rs75776403-regulated pathways.
MeSH term(s)	Alleles ; Genetic Pleiotropy ; Genome-Wide Association Study ; Humans ; Lectins, C-Type/genetics ; Phenotype ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide
Chemical Substances	CLEC18A protein, human ; Lectins, C-Type
Language	English
Publishing date	2022-06-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1193378-1
ISSN	1423-0127 ; 1021-7770
ISSN (online)	1423-0127
ISSN	1021-7770
DOI	10.1186/s12929-022-00822-1
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Zs.A 4037: Show issues

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Article: Losses of cytokines and chemokines are common genetic features of human cancers: the somatic copy number alterations are correlated with patient prognoses and therapeutic resistance.

Wong, Henry Sung-Ching / Chang, Wei-Chiao

Oncoimmunology

2018 Volume 7, Issue 9, Page(s) e1468951

Abstract: Intricate relationships among cytokines (including chemokines) shape the tumor microenvironment (TME) and reflect cell-cell interactions between malignant cells and other cells from the TME. Although our previous study indicated the transcriptional ... ...

Abstract	Intricate relationships among cytokines (including chemokines) shape the tumor microenvironment (TME) and reflect cell-cell interactions between malignant cells and other cells from the TME. Although our previous study indicated the transcriptional landscape of cytokines in 19 cancer types, the global pattern somatic copy number (SCN) alterations and the clinical relevance of cytokines have not been systematically investigated. Here, we reported a significant negative selection on cytokine genes. We also linked the SCN losses of cytokine genes to the abundance of immune infiltrates which affects cancer progression and patient prognoses. We also demonstrated and validated the correlations between SCN alterations of cytokine-containing loci and drug sensitivity. The results indicated the genomic loss of cytokines in malignant cells as a crucial theme for interrogating cancer progression, malignant cell-TME interactions, and therapeutics.
Language	English
Publishing date	2018-07-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2645309-5
ISSN	2162-402X ; 2162-4011
ISSN (online)	2162-402X
ISSN	2162-4011
DOI	10.1080/2162402X.2018.1468951
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Article ; Online: Genome-Wide Association Study for eGFR in a Taiwanese Population.

Chen, Ying-Chun / Wong, Henry Sung-Ching / Wu, Mei-Yi / Chou, Wan-Hsuan / Kao, Chih-Chin / Chao, Ching-Hsuan / Chang, Wei-Chiao / Wu, Mai-Szu

Clinical journal of the American Society of Nephrology : CJASN

2022 Volume 17, Issue 11, Page(s) 1598–1608

Abstract: Background and objectives: Chronic kidney disease (CKD) is a global public health issue associated with large economic burdens. CKD contributes to higher risks of cardiovascular complications, kidney failure, and mortality. The incidence and prevalence ... ...

Abstract	Background and objectives: Chronic kidney disease (CKD) is a global public health issue associated with large economic burdens. CKD contributes to higher risks of cardiovascular complications, kidney failure, and mortality. The incidence and prevalence rates of kidney failure in Taiwan have remained the highest in the world. Design, setting, participants, & measurements: Assessing genetic factors that influence kidney function in specific populations has substantial clinical relevance. We investigated associations of genetic variants with eGFR. The quality control filtering and genotype imputation resulted in 10,008 Taiwan Biobank participants and 6,553,511 variants for final analyses. We examined these loci with Results: Our results revealed one significant locus (4q21.1) and three suggestive significant loci (17q23.2, 22q13.2, and 3q29) for eGFR in the Taiwanese population. In total, four conditional-independent single nucleotide polymorphisms were identified as the most important variants within these regions, including rs55948430 ( Conclusions: We identified four susceptibility loci on 4q21.1, 17q23.2, 22q13.2, and 3q29 that associated with kidney-related traits in a Taiwanese population. The 22q13.2 (
MeSH term(s)	Humans ; Asian People/genetics ; Genetic Loci ; Genome-Wide Association Study ; Kidney/physiology ; Kidney/physiopathology ; Polymorphism, Single Nucleotide ; Renal Insufficiency, Chronic ; Glomerular Filtration Rate
Language	English
Publishing date	2022-10-12
Publishing country	United States
Document type	Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2226665-3
ISSN	1555-905X ; 1555-9041
ISSN (online)	1555-905X
ISSN	1555-9041
DOI	10.2215/CJN.02180222
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Zs.A 6584: Show issues

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Article: Evaluation for the Genetic Association between Store-Operated Calcium Influx Pathway (STIM1 and ORAI1) and Human Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Infection.

Muhammad Irham, Lalu / Chou, Wan-Hsuan / Wang, Yu-Shiuan / Adikusuma, Wirawan / Sung-Ching Wong, Henry / Aryani Perwitasari, Dyah / Huang, Wan-Chen / Chen, Ben-Kuen / Yang, Hwai-I / Chang, Wei-Chiao

Biology

2020 Volume 9, Issue 11

Abstract: Hepatocellular carcinoma (HCC) often develops from chronic hepatitis B (CHB) through replication of hepatitis B virus (HBV) infection. Calcium ( ... ...

Abstract	Hepatocellular carcinoma (HCC) often develops from chronic hepatitis B (CHB) through replication of hepatitis B virus (HBV) infection. Calcium (Ca
Language	English
Publishing date	2020-11-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology9110388
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Article ; Online: Transcriptome network analyses in human coronavirus infections suggest a rational use of immunomodulatory drugs for COVID-19 therapy.

Wong, Henry Sung-Ching / Guo, Chin-Lin / Lin, Gan-Hong / Lee, Kang-Yun / Okada, Yukinori / Chang, Wei-Chiao

Genomics

2021 Volume 113, Issue 2, Page(s) 564–575

Abstract: The recent outbreak of coronavirus disease 2019 (COVID-19) by SARS-CoV-2 has led to uptodate 24.3 M cases and 0.8 M deaths. It is thus in urgent need to rationalize potential therapeutic targets against the progression of diseases. An effective, feasible ...

Abstract	The recent outbreak of coronavirus disease 2019 (COVID-19) by SARS-CoV-2 has led to uptodate 24.3 M cases and 0.8 M deaths. It is thus in urgent need to rationalize potential therapeutic targets against the progression of diseases. An effective, feasible way is to use the pre-existing ΔORF6 mutant of SARS-CoV as a surrogate for SARS-CoV-2, since both lack the moiety responsible for interferon antagonistic effects. By analyzing temporal profiles of upregulated genes in ΔORF6-infected Calu-3 cells, we prioritized 55 genes and 238 ligands to reposition currently available medications for COVID-19 therapy. Eight of them are already in clinical trials, including dexamethasone, ritonavir, baricitinib, tofacitinib, naproxen, budesonide, ciclesonide and formoterol. We also pinpointed 16 drug groups from the Anatomical Therapeutic Chemical classification system, with the potential to mitigate symptoms of SARS-CoV-2 infection and thus to be repositioned for COVID-19 therapy.
MeSH term(s)	COVID-19/immunology ; Cell Line ; Gene Expression Profiling ; Humans ; Immunologic Factors/pharmacology ; SARS-CoV-2/immunology ; Transcriptome/drug effects ; Transcriptome/immunology ; COVID-19 Drug Treatment
Chemical Substances	Immunologic Factors
Language	English
Publishing date	2021-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	356334-0
ISSN	1089-8646 ; 0888-7543
ISSN (online)	1089-8646
ISSN	0888-7543
DOI	10.1016/j.ygeno.2020.12.041
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Zs.A 2367: Show issues

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Article ; Online: The role of genetic polymorphisms in STIM1 and ORAI1 for erythropoietin resistance in patients with renal failure.

Kao, Chih-Chin / Wong, Henry Sung-Ching / Wang, Yu-Jia / Chou, Wan-Hsuan / Perwitasari, Dyah Aryani / Wu, Mai-Szu / Chang, Wei-Chiao

Medicine

2021 Volume 100, Issue 17, Page(s) e25243

Abstract: Abstract: Anemia is a common complication in patients with renal failure. While erythropoietin is commonly used to treat anemia, some patients exhibit a poor response to erythropoietin. Since store-operated calcium channel (SOC) signaling is one of the ... ...

Abstract	Abstract: Anemia is a common complication in patients with renal failure. While erythropoietin is commonly used to treat anemia, some patients exhibit a poor response to erythropoietin. Since store-operated calcium channel (SOC) signaling is one of the erythropoietin activated pathways, we aimed to investigate the association between the genetic polymorphisms of SOC signaling pathway and erythropoietin resistance in patients with renal failure.Four tagging single nucleotide polymorphisms in STIM1 and five in ORAI1 were selected in this study. Genotyping was performed with the TaqMan Allelic Discrimination assay and the association of individual tagging single nucleotide polymorphisms with erythropoietin resistance was analyzed by multivariable adjusted random intercepts model.194 patients were enrolled in this study. The mean age of participants is 68 years, and 56% were men. The mean erythropoietin resistance index was 9.04 ± 4.51 U/Kg/week/g/dL. We found that patients with the AA genotype of rs1561876 in STIM1, and the CC or CT genotypes of rs6486795 in ORAI1, were associated with increased risk of erythropoietin resistance. Functional annotation of expression quantitative trait loci revealed that the AA genotype of rs1561876 in STIM1 has a relatively lower expression of ribonucleotide reductase catalytic subunit M1 in skeletal muscle, while the CC genotype of rs6486795 in ORAI1 has a relatively higher expression of ORAI1 in the whole blood and thyroid.Overall, we demonstrate a significant association between erythropoietin resistance and genetic polymorphisms of STIM1 and ORAI1. Annotation prediction revealed the importance of SOC-mediated calcium signaling for erythropoietin resistance.
MeSH term(s)	Aged ; Calcium Signaling/genetics ; Drug Resistance/genetics ; Erythropoietin/pharmacology ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Proteins/genetics ; ORAI1 Protein/genetics ; Pharmacogenomic Variants/drug effects ; Renal Insufficiency/drug therapy ; Renal Insufficiency/genetics ; Stromal Interaction Molecule 1/genetics
Chemical Substances	Neoplasm Proteins ; ORAI1 Protein ; ORAI1 protein, human ; STIM1 protein, human ; Stromal Interaction Molecule 1 ; Erythropoietin (11096-26-7)
Language	English
Publishing date	2021-04-22
Publishing country	United States
Document type	Evaluation Study ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000025243
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Article: Germline Genetic Association between Stromal Interaction Molecule 1 (STIM1) and Clinical Outcomes in Breast Cancer Patients.

Huang, Chi-Cheng / Lin, Min-Rou / Yang, Yu-Chen / Hsu, Yu-Wen / Wong, Henry Sung-Ching / Chang, Wei-Chiao

Journal of personalized medicine

2020 Volume 10, Issue 4

Abstract: Among all cancers in women, breast cancer has the highest incidence. The mortality of breast cancer is highly associated with metastasis. Migration and malignant transformation of cancer cells have been reported to be modulated by store-operated calcium ( ...

Abstract	Among all cancers in women, breast cancer has the highest incidence. The mortality of breast cancer is highly associated with metastasis. Migration and malignant transformation of cancer cells have been reported to be modulated by store-operated calcium (SOC) channels, which control calcium signaling and cell proliferation pathways. Stromal interaction molecule 1 (
Language	English
Publishing date	2020-12-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm10040287
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Article ; Online: Germline Genetic Association between Stromal Interaction Molecule 1 (STIM1) and Clinical Outcomes in Breast Cancer Patients

Chi-Cheng Huang / Min-Rou Lin / Yu-Chen Yang / Yu-Wen Hsu / Henry Sung-Ching Wong / Wei-Chiao Chang

Journal of Personalized Medicine, Vol 10, Iss 287, p

2020 Volume 287

Abstract	Among all cancers in women, breast cancer has the highest incidence. The mortality of breast cancer is highly associated with metastasis. Migration and malignant transformation of cancer cells have been reported to be modulated by store-operated calcium (SOC) channels, which control calcium signaling and cell proliferation pathways. Stromal interaction molecule 1 ( STIM1) is a calcium sensor in the endoplasmic reticulum, triggering the activation of store-operated calcium signaling. However, the clinical relevance of STIM1 in breast cancer is still unclear. Here, we recruited 348 breast cancer patients and conducted a genetic association study to address this question. Four tagging germline single nucleotide variants (SNVs) in STIM1 were selected and RNA sequencing data of 525 breast cancer samples from The Cancer Genome Atlas (TCGA) database were evaluated. The results show that rs2304891 and rs3750996 were correlated with clinical stage of breast cancer. Expression quantitative trait loci (eQTL) analysis indicated that risk G allele of STIM1 contributed to the higher expression of STIM1 . In addition, we found an increased risk of rs2304891 G allele and rs3750996 A allele in estrogen receptor (ER) positive and progesterone receptor (PR) positive patients. In conclusion, our results suggest that germline SNV, rs2304891 and rs3750996 as well as STIM1 expression are important biomarkers for the prediction of clinical outcomes in breast cancer patients.
Keywords	breast cancer ; STIM1 ; genetic variants ; Medicine ; R
Subject code	616 ; 610
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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