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  1. Book: Surgery of the adrenal gland

    Valeri, Andrea

    2013  

    Author's details Andrea Valeri ... ed
    Keywords Adrenal glands--Surgery
    Language English
    Size XII, 193 S. : zahlr. Ill., graph. Darst., 24 cm
    Publisher Springer
    Publishing place Milan u.a.
    Publishing country Italy
    Document type Book
    HBZ-ID HT017408086
    ISBN 978-88-470-2585-1 ; 88-470-2585-0 ; 9788847025868 ; 8847025869
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 3949 order for loan Magazin

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  2. Book: What's new in surgical oncology

    Valeri, Andrea

    a guide for surgeos in training and medical/radiation oncologists

    2013  

    Author's details Andrea Valeri ... ed
    Language English
    Size VIII, 295 S. : graph. Darst.
    Publisher Springer
    Publishing place Milan u.a.)
    Publishing country Italy
    Document type Book
    HBZ-ID HT017659062
    ISBN 978-88-470-5309-0 ; 9788847053106 ; 88-470-5309-9 ; 8847053102
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 1148 available for loan (reading room) Lesesaal EG

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  3. Article: State of the Art and Future of Stem Cell Therapy in Ischemic Stroke: Why Don't We Focus on Their Administration?

    Valeri, Andrea / Mazzon, Emanuela

    Bioengineering (Basel, Switzerland)

    2023  Volume 10, Issue 1

    Abstract: Stroke is one of the leading causes of death and disability worldwide, so there is an urgent need to find a therapy for the tragic outcomes of this cerebrovascular disease. Stem cells appeared to be a good solution for many conditions, so different ... ...

    Abstract Stroke is one of the leading causes of death and disability worldwide, so there is an urgent need to find a therapy for the tragic outcomes of this cerebrovascular disease. Stem cells appeared to be a good solution for many conditions, so different experiments were made to establish stem cells as a feasible therapy for stroke. The aim of this review is to analyze the state of the art of stem cell therapy for stroke and if the route of administration could represent a valid adjusting point for ameliorating the therapy's outcome. To obtain this, we searched the scientific literature of the last 10 years for relevant in vitro and in vivo evidence regarding stem cells' potential in stroke therapy. In vitro evidence points to hypoxia, among the preconditioning strategies, as the most used and probably efficient method to enhance cells qualities, while in vivo results raise the question if it is the type of cells or how they are administrated which can make the difference in terms of efficiency. Unfortunately, despite the number of clinical trials, only a few were successfully concluded, demonstrating how urgent the necessity is to translate pre-clinical results into clinics. Since any type of stem cell seems suitable for therapy, the chosen route of administration corresponds to different engraftment rates, distribution and efficiency in terms of the beneficial effects of stem cells. Intravenous administration was widely used for delivering stem cells into the human body, but recently intranasal administration has given promising results in vivo. It allows stem cells to efficiently reach the brain that was precluded to intravenous administration, so it is worth further investigation.
    Language English
    Publishing date 2023-01-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering10010118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: State of the Art and Future of Stem Cell Therapy in Ischemic Stroke

    Andrea Valeri / Emanuela Mazzon

    Bioengineering, Vol 10, Iss 118, p

    Why Don’t We Focus on Their Administration?

    2023  Volume 118

    Abstract: Stroke is one of the leading causes of death and disability worldwide, so there is an urgent need to find a therapy for the tragic outcomes of this cerebrovascular disease. Stem cells appeared to be a good solution for many conditions, so different ... ...

    Abstract Stroke is one of the leading causes of death and disability worldwide, so there is an urgent need to find a therapy for the tragic outcomes of this cerebrovascular disease. Stem cells appeared to be a good solution for many conditions, so different experiments were made to establish stem cells as a feasible therapy for stroke. The aim of this review is to analyze the state of the art of stem cell therapy for stroke and if the route of administration could represent a valid adjusting point for ameliorating the therapy’s outcome. To obtain this, we searched the scientific literature of the last 10 years for relevant in vitro and in vivo evidence regarding stem cells’ potential in stroke therapy. In vitro evidence points to hypoxia, among the preconditioning strategies, as the most used and probably efficient method to enhance cells qualities, while in vivo results raise the question if it is the type of cells or how they are administrated which can make the difference in terms of efficiency. Unfortunately, despite the number of clinical trials, only a few were successfully concluded, demonstrating how urgent the necessity is to translate pre-clinical results into clinics. Since any type of stem cell seems suitable for therapy, the chosen route of administration corresponds to different engraftment rates, distribution and efficiency in terms of the beneficial effects of stem cells. Intravenous administration was widely used for delivering stem cells into the human body, but recently intranasal administration has given promising results in vivo. It allows stem cells to efficiently reach the brain that was precluded to intravenous administration, so it is worth further investigation.
    Keywords stem cells therapy ; stroke ; mechanism of stem cells therapy ; route of administration ; precondition ; Technology ; T ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: Sex-Specific Effects of Short-Term Oral Administration of Food-Grade Titanium Dioxide Nanoparticles in the Liver and Kidneys of Adult Rats.

    Tassinari, Roberta / Tammaro, Alessia / Martinelli, Andrea / Valeri, Mauro / Maranghi, Francesca

    Toxics

    2023  Volume 11, Issue 9

    Abstract: Titanium dioxide ( ... ...

    Abstract Titanium dioxide (TiO
    Language English
    Publishing date 2023-09-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics11090776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cannabinoids and Neurogenesis: The Promised Solution for Neurodegeneration?

    Valeri, Andrea / Mazzon, Emanuela

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 20

    Abstract: The concept of neurons as irreplaceable cells does not hold true today. Experiments and evidence of neurogenesis, also, in the adult brain give hope that some compounds or drugs can enhance this process, helping to reverse the outcomes of diseases or ... ...

    Abstract The concept of neurons as irreplaceable cells does not hold true today. Experiments and evidence of neurogenesis, also, in the adult brain give hope that some compounds or drugs can enhance this process, helping to reverse the outcomes of diseases or traumas that once were thought to be everlasting. Cannabinoids, both from natural and artificial origins, already proved to have several beneficial effects (e.g., anti-inflammatory, anti-oxidants and analgesic action), but also capacity to increase neuronal population, by replacing the cells that were lost and/or regenerate a damaged nerve cell. Neurogenesis is a process which is not highly represented in literature as neuroprotection, though it is as important as prevention of nervous system damage, because it can represent a possible solution when neuronal death is already present, such as in neurodegenerative diseases. The aim of this review is to resume the experimental evidence of phyto- and synthetic cannabinoids effects on neurogenesis, both in vitro and in vivo, in order to elucidate if they possess also neurogenetic and neurorepairing properties.
    MeSH term(s) Animals ; Brain/drug effects ; Cannabinoids/pharmacology ; Humans ; Neurodegenerative Diseases/drug therapy ; Neurogenesis/drug effects ; Neurons/drug effects ; Neuroprotection/drug effects ; Neuroprotective Agents/pharmacology
    Chemical Substances Cannabinoids ; Neuroprotective Agents
    Language English
    Publishing date 2021-10-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26206313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  7. Article ; Online: Aducanumab and Its Effects on Tau Pathology: Is This the Turning Point of Amyloid Hypothesis?

    Silvestro, Serena / Valeri, Andrea / Mazzon, Emanuela

    International journal of molecular sciences

    2022  Volume 23, Issue 4

    Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder affecting millions of people around the world. The two main pathological mechanisms underlying the disease are beta-amyloid (Aβ) plaques and intracellular neurofibrillary tangles (NFTs) of Tau ... ...

    Abstract Alzheimer's disease (AD) is a neurodegenerative disorder affecting millions of people around the world. The two main pathological mechanisms underlying the disease are beta-amyloid (Aβ) plaques and intracellular neurofibrillary tangles (NFTs) of Tau proteins in the brain. Their reduction has been associated with slowing of cognitive decline and disease progression. Several antibodies aimed to target Aβ or Tau in order to represent hope for millions of patients, but only a small number managed to be selected to participate in clinical trials. Aducanumab is a monoclonal antibody recently approved by the Food and Drug Administration (FDA), which, targeting (Aβ) oligomers and fibrils, was able to reduce Aβ accumulation and slow the progression of cognitive impairment. It was also claimed to have an effect on the second hallmark of AD, decreasing the level of phospho-Tau evaluated in cerebrospinal fluid (CSF) and by positron emission tomography (PET). This evidence may represent a turning point in the development of AD-efficient drugs.
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Amyloid/metabolism ; Amyloid beta-Peptides/metabolism ; Animals ; Antibodies, Monoclonal, Humanized/pharmacology ; Brain/drug effects ; Brain/metabolism ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/metabolism ; Humans ; Plaque, Amyloid/drug therapy ; Plaque, Amyloid/metabolism ; tau Proteins/metabolism
    Chemical Substances Amyloid ; Amyloid beta-Peptides ; Antibodies, Monoclonal, Humanized ; tau Proteins ; aducanumab (105J35OE21)
    Language English
    Publishing date 2022-02-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23042011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cannabinoids and Neurogenesis

    Andrea Valeri / Emanuela Mazzon

    Molecules, Vol 26, Iss 6313, p

    The Promised Solution for Neurodegeneration?

    2021  Volume 6313

    Abstract: The concept of neurons as irreplaceable cells does not hold true today. Experiments and evidence of neurogenesis, also, in the adult brain give hope that some compounds or drugs can enhance this process, helping to reverse the outcomes of diseases or ... ...

    Abstract The concept of neurons as irreplaceable cells does not hold true today. Experiments and evidence of neurogenesis, also, in the adult brain give hope that some compounds or drugs can enhance this process, helping to reverse the outcomes of diseases or traumas that once were thought to be everlasting. Cannabinoids, both from natural and artificial origins, already proved to have several beneficial effects (e.g., anti-inflammatory, anti-oxidants and analgesic action), but also capacity to increase neuronal population, by replacing the cells that were lost and/or regenerate a damaged nerve cell. Neurogenesis is a process which is not highly represented in literature as neuroprotection, though it is as important as prevention of nervous system damage, because it can represent a possible solution when neuronal death is already present, such as in neurodegenerative diseases. The aim of this review is to resume the experimental evidence of phyto- and synthetic cannabinoids effects on neurogenesis, both in vitro and in vivo, in order to elucidate if they possess also neurogenetic and neurorepairing properties.
    Keywords cannabinoid receptors ; neurogenesis ; neuroregeneration ; phytocannabinoids ; synthetic cannabinoids ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Book ; Online: Anisotropic Rheology and Friction of Suspended Graphene

    Mescola, Andrea / Silva, Andrea / Khosravi, Ali / Vanossi, Andrea / Tosatti, Erio / Valeri, Sergio / Paolicelli, Guido

    2023  

    Abstract: Graphene is a powerful membrane prototype for both applications and fundamental research. Rheological phenomena including indentation, twisting, and wrinkling in deposited and suspended graphene are actively investigated to unravel the mechanical laws at ...

    Abstract Graphene is a powerful membrane prototype for both applications and fundamental research. Rheological phenomena including indentation, twisting, and wrinkling in deposited and suspended graphene are actively investigated to unravel the mechanical laws at the nanoscale. Most studies focused on isotropic set-ups, while realistic graphene membranes are often subject to strongly anisotropic constraints, with important consequences for the rheology, strain, indentation, and friction in engineering conditions.
    Keywords Condensed Matter - Materials Science ; Condensed Matter - Mesoscale and Nanoscale Physics ; Physics - Applied Physics
    Publishing date 2023-06-06
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article: Cannabichromene Induces Neuronal Differentiation in NSC-34 Cells: Insights from Transcriptomic Analysis.

    Valeri, Andrea / Chiricosta, Luigi / D'Angiolini, Simone / Pollastro, Federica / Salamone, Stefano / Mazzon, Emanuela

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 3

    Abstract: Phytocannabinoids, with their variety of beneficial effects, represent a valid group of substances that could be employed as neurogenesis-enhancers or neuronal differentiation inducers. We focused our attention on the neuronal-related potential of ... ...

    Abstract Phytocannabinoids, with their variety of beneficial effects, represent a valid group of substances that could be employed as neurogenesis-enhancers or neuronal differentiation inducers. We focused our attention on the neuronal-related potential of cannabichromene (CBC) when administered to undifferentiated NSC-34 for 24 h. Transcriptomic analysis showed an upregulation of several neuronal markers, such as
    Language English
    Publishing date 2023-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13030742
    Database MEDical Literature Analysis and Retrieval System OnLINE

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