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Article: Spontaneous Ventilation Thoracoscopic Lung Biopsy in Undetermined Interstitial Lung Disease: Systematic Review and Meta-Analysis.

Patirelis, Alexandro / Elia, Stefano / Cristino, Benedetto / Puxeddu, Ermanno / Cavalli, Francesco / Rogliani, Paola / Pompeo, Eugenio

Journal of clinical medicine

2024 Volume 13, Issue 2

Abstract: Thoracoscopic surgical biopsy has shown excellent histological characterization of undetermined interstitial lung diseases, although the morbidity rates reported are not negligible. In delicate patients, interstitial lung disease and restrictive ... ...

Abstract	Thoracoscopic surgical biopsy has shown excellent histological characterization of undetermined interstitial lung diseases, although the morbidity rates reported are not negligible. In delicate patients, interstitial lung disease and restrictive ventilatory impairment morbidity are thought to be due at least in part to tracheal intubation with single-lung mechanical ventilation; therefore, spontaneous ventilation thoracoscopic lung biopsy (SVTLB) has been proposed as a potentially less invasive surgical option. This systematic review summarizes the results of SVTLB, focusing on diagnostic yield and operative morbidity. A systematic search for original studies regarding SVTLB published between 2010 to 2023 was performed. In addition, articles comparing SVTLB to mechanical ventilation thoracoscopic lung biopsy (MVTLB) were selected for a meta-analysis. Overall, 13 studies (two before 2017 and eleven between 2018 and 2023) entailing 675 patients were included. Diagnostic yield ranged from 84.6% to 100%. There were 64 (9.5%) complications, most of which were minor. There was no 30-day operative mortality. When comparing SVTLB to MVTLB, the former group showed a significantly lower risk of complications (
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13020374
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Immediate Soft Tissue Reconstruction in Lower Limb Traumas Using Propeller Perforator Flaps.

Gatto, Arianna / Giacomini, Giorgio / Cavalli, Erica Michela / Pajardi, Giorgio Eugenio / Marchesi, Andrea

Annals of plastic surgery

2023 Volume 91, Issue 5, Page(s) 590–596

Abstract: Background: Open bone fractures represent a demanding clinical condition that can be life- or limb-threatening. For small- to medium-size soft tissue defects of the lower extremity, propeller perforator flaps are a viable option for reconstruction. We ... ...

Abstract	Background: Open bone fractures represent a demanding clinical condition that can be life- or limb-threatening. For small- to medium-size soft tissue defects of the lower extremity, propeller perforator flaps are a viable option for reconstruction. We report our experience in Gustilo IIIB open fractures treatment with immediate coverage through propeller-based perforator flaps performed in acute setting. Methods: Between 2019 and 2022, 94 Gustilo III fractures were admitted to our trauma center, and 28 were Gustilo IIIB fractures. Five patients were eligible for an immediate perforator-based propeller flaps reconstruction. The mean age of the patients was 33.8 years. All of them were male. One of them was a heavy smoker (15 cigarettes per day). No other comorbidities were present. Results: The mean operating time, including fracture reduction and fixation time, was 106 minutes. The length of the defect varied between 5 and 7 cm and the width between 3 and 4 cm. We reported no major complications, and none of the patients required a surgical revision of the flap. A patient with smoking habit reported a superficial flap necrosis. The mean follow-up was 5.5 months. No cases of nonunion or osteomyelitis have developed so far. Conclusions: The use of perforator-based propeller flaps, in acute trauma setting, has not been reported in literature so far. In our experience, propeller perforator flaps are a viable reconstructive option in immediate reconstruction during the acute management of open fractures.
MeSH term(s)	Humans ; Male ; Adult ; Female ; Perforator Flap/surgery ; Plastic Surgery Procedures ; Fractures, Open/surgery ; Lower Extremity/surgery ; Leg Injuries/surgery ; Soft Tissue Injuries/surgery ; Treatment Outcome ; Retrospective Studies
Language	English
Publishing date	2023-09-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	423835-7
ISSN	1536-3708 ; 0148-7043
ISSN (online)	1536-3708
ISSN	0148-7043
DOI	10.1097/SAP.0000000000003696
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Zs.A 1419: Show issues

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Article: Autism Spectrum Disorder and miRNA: An Overview of Experimental Models.

Schepici, Giovanni / Cavalli, Eugenio / Bramanti, Placido / Mazzon, Emanuela

Brain sciences

2019 Volume 9, Issue 10

Abstract: Autism spectrum disorder (ASD) is a complex neuropsychiatric disorder characterized by deficits in social interactions, communication, language, and in a limited repertoire of activities and interests. The etiology of ASD is very complex. Genetic, ... ...

Abstract	Autism spectrum disorder (ASD) is a complex neuropsychiatric disorder characterized by deficits in social interactions, communication, language, and in a limited repertoire of activities and interests. The etiology of ASD is very complex. Genetic, epigenetic, and environmental factors contribute to the onset of ASD. Researchers have shown that microRNAs (miRNAs) could be one of the possible causes associated with ASD. miRNAs are small noncoding mRNAs that regulate gene expression, and they are often linked to biological processes and implicated in neurodevelopment. This review aims to provide an overview of the animal models and the role of the different miRNAs involved in ASD. Therefore, the use of animal models that reproduce the ASD and the identification of miRNAs could be a useful predictive tool to study this disorder.
Language	English
Publishing date	2019-10-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci9100265
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Article ; Online: Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials.

Silvestro, Serena / Mammana, Santa / Cavalli, Eugenio / Bramanti, Placido / Mazzon, Emanuela

Molecules (Basel, Switzerland)

2019 Volume 24, Issue 8

Abstract: Cannabidiol (CBD) is one of the cannabinoids with non-psychotropic action, extracted ... ...

Abstract	Cannabidiol (CBD) is one of the cannabinoids with non-psychotropic action, extracted from
MeSH term(s)	Anti-Anxiety Agents/adverse effects ; Anti-Anxiety Agents/chemistry ; Anti-Anxiety Agents/therapeutic use ; Anticonvulsants/adverse effects ; Anticonvulsants/chemistry ; Anticonvulsants/therapeutic use ; Antipsychotic Agents/adverse effects ; Antipsychotic Agents/chemistry ; Antipsychotic Agents/therapeutic use ; Cannabidiol/adverse effects ; Cannabidiol/chemistry ; Cannabidiol/therapeutic use ; Cannabis/chemistry ; Clinical Trials as Topic ; Epilepsy/drug therapy ; Epilepsy/pathology ; Epilepsy/physiopathology ; Humans ; Seizures/drug therapy ; Seizures/pathology ; Seizures/physiopathology
Chemical Substances	Anti-Anxiety Agents ; Anticonvulsants ; Antipsychotic Agents ; Cannabidiol (19GBJ60SN5)
Language	English
Publishing date	2019-04-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules24081459
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Article ; Online: The neuropathic pain: An overview of the current treatment and future therapeutic approaches.

Cavalli, Eugenio / Mammana, Santa / Nicoletti, Ferdinando / Bramanti, Placido / Mazzon, Emanuela

International journal of immunopathology and pharmacology

2019 Volume 33, Page(s) 2058738419838383

Abstract: Neuropathic pain is characterized by abnormal hypersensitivity to stimuli (hyperalgesia) and nociceptive responses to non-noxious stimuli (allodynia). The conditions and the pathophysiological states that determine the onset of neuropathic pain are ... ...

Abstract	Neuropathic pain is characterized by abnormal hypersensitivity to stimuli (hyperalgesia) and nociceptive responses to non-noxious stimuli (allodynia). The conditions and the pathophysiological states that determine the onset of neuropathic pain are heterogeneous, such as metabolic disorders, neuropathy caused by viral infections, and autoimmune diseases affecting the central nervous system (CNS). Neuropathic pain in the general population is estimated to have a prevalence ranging between 3% and 17%. Most of the available treatments for neuropathic pain have moderate efficacy and present side effects that limit their use; therefore, other therapeutic approaches are needed for patients. In this article, the current standard of care treatment, the emerging pharmacological approaches from the completed phase III clinical trials, and the preclinical studies on novel promising therapeutic options will be reviewed.
MeSH term(s)	Analgesics/pharmacology ; Analgesics/therapeutic use ; Animals ; Clinical Trials, Phase I as Topic/methods ; Drug Evaluation, Preclinical/methods ; Forecasting ; Humans ; Neuralgia/diagnosis ; Neuralgia/drug therapy ; Neuralgia/epidemiology ; Pain Measurement/drug effects ; Pain Measurement/methods ; Treatment Outcome
Chemical Substances	Analgesics
Language	English
Publishing date	2019-03-21
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	645171-8
ISSN	2058-7384 ; 0394-6320
ISSN (online)	2058-7384
ISSN	0394-6320
DOI	10.1177/2058738419838383
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Zs.A 2537: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
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Article ; Online: Use of Cannabidiol in the Treatment of Epilepsy

Serena Silvestro / Santa Mammana / Eugenio Cavalli / Placido Bramanti / Emanuela Mazzon

Molecules, Vol 24, Iss 8, p

Efficacy and Security in Clinical Trials

2019 Volume 1459

Abstract: Cannabidiol (CBD) is one of the cannabinoids with non-psychotropic action, extracted from Cannabis sativa . CBD is a terpenophenol and it has received a great scientific interest thanks to its medical applications. This compound showed efficacy as anti- ... ...

Abstract	Cannabidiol (CBD) is one of the cannabinoids with non-psychotropic action, extracted from Cannabis sativa . CBD is a terpenophenol and it has received a great scientific interest thanks to its medical applications. This compound showed efficacy as anti-seizure, antipsychotic, neuroprotective, antidepressant and anxiolytic. The neuroprotective activity appears linked to its excellent anti-inflammatory and antioxidant properties. The purpose of this paper is to evaluate the use of CBD, in addition to common anti-epileptic drugs, in the severe treatment-resistant epilepsy through an overview of recent literature and clinical trials aimed to study the effects of the CBD treatment in different forms of epilepsy. The results of scientific studies obtained so far the use of CBD in clinical applications could represent hope for patients who are resistant to all conventional anti-epileptic drugs.
Keywords	cannabidiol ; treatment-resistant epilepsy ; clinical trials ; Organic chemistry ; QD241-441
Subject code	616
Language	English
Publishing date	2019-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Could the Combination of Two Non-Psychotropic Cannabinoids Counteract Neuroinflammation? Effectiveness of Cannabidiol Associated with Cannabigerol.

Mammana, Santa / Cavalli, Eugenio / Gugliandolo, Agnese / Silvestro, Serena / Pollastro, Federica / Bramanti, Placido / Mazzon, Emanuela

Medicina (Kaunas, Lithuania)

2019 Volume 55, Issue 11

Abstract: Background ... ...

Abstract	Background and
MeSH term(s)	Cannabidiol/standards ; Cannabidiol/therapeutic use ; Cannabinoids/standards ; Cannabinoids/therapeutic use ; Cell Culture Techniques/methods ; Drug Therapy, Combination/methods ; Drug Therapy, Combination/standards ; Drug Therapy, Combination/statistics & numerical data ; Humans ; Inflammation/prevention & control ; Neurons/drug effects ; Protective Factors
Chemical Substances	Cannabinoids ; Cannabidiol (19GBJ60SN5) ; cannabigerol (J1K406072N)
Language	English
Publishing date	2019-11-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina55110747
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Zs.A 6270: Show issues

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Article ; Online: Cognitive Decline in Rheumatoid Arthritis: Insight into the Molecular Pathogenetic Mechanisms.

Basile, Maria Sofia / Ciurleo, Rosella / Bramanti, Alessia / Petralia, Maria Cristina / Fagone, Paolo / Nicoletti, Ferdinando / Cavalli, Eugenio

International journal of molecular sciences

2021 Volume 22, Issue 3

Abstract: Cognitive decline refers to a deterioration of intellectual and learning abilities and related memory problems, and is often associated with behavioral alterations, which prevents sufferers from carrying out the most common daily activities, such as ... ...

Abstract	Cognitive decline refers to a deterioration of intellectual and learning abilities and related memory problems, and is often associated with behavioral alterations, which prevents sufferers from carrying out the most common daily activities, such as maintaining normal productive interpersonal relationships, communicating, and leading an autonomous life. Numerous studies have highlighted the association between cognitive decline and autoimmune disorders, including rheumatoid arthritis (RA). RA is a chronic, inflammatory, autoimmune disease that involves systems and organs other than the bones and joints, with varying severity among patients. Here, we review the studies investigating the link between cognitive decline and RA, focusing on the main molecular pathogenetic mechanisms involved. The emerging body of data suggests that clinical, psychological, and biological factors may contribute to the pathogenesis of cognitive decline in RA, including cardiovascular complications, chronic pain, depression, inflammatory factors, changes in hormone levels, drug side effects, and genetics. Further studies are warranted in order to fully clarify the basis underlying the association between cognitive decline and RA and to find new possible diagnostic strategies and therapeutic targets for RA patients.
MeSH term(s)	Animals ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/metabolism ; Arthritis, Rheumatoid/therapy ; Autoimmunity ; Biomarkers ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/etiology ; Cytokines/metabolism ; Disease Management ; Disease Progression ; Disease Susceptibility ; Genetic Predisposition to Disease ; Humans ; Inflammation Mediators/metabolism ; Risk Factors
Chemical Substances	Biomarkers ; Cytokines ; Inflammation Mediators
Language	English
Publishing date	2021-01-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22031185
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Article ; Online: The PI3K/Akt/mTOR pathway: A potential pharmacological target in COVID-19.

Basile, Maria Sofia / Cavalli, Eugenio / McCubrey, James / Hernández-Bello, Jorge / Muñoz-Valle, José Francisco / Fagone, Paolo / Nicoletti, Ferdinando

Drug discovery today

2021 Volume 27, Issue 3, Page(s) 848–856

Abstract: Coronavirus disease 2019 (COVID-19) has emerged as a serious threat to global health. The disregulation of the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) cell signaling pathway observed in patients with ... ...

Abstract	Coronavirus disease 2019 (COVID-19) has emerged as a serious threat to global health. The disregulation of the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) cell signaling pathway observed in patients with COVID-19 has attracted attention for the possible use of specific inhibitors of this pathway for the treatment of the disease. Here, we review emerging data on the involvement of the PI3K/Akt/mTOR pathway in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the clinical studies investigating its tailored inhibition in COVID-19. Current in silico, in vitro, and in vivo data convergently support a role for the PI3K/Akt/mTOR pathway in COVID-19 and suggest the use of specific inhibitors of this pathway that, by a combined mechanism entailing downregulation of excessive inflammatory reactions, cell protection, and antiviral effects, could ameliorate the course of COVID-19.
MeSH term(s)	Animals ; Antiviral Agents/pharmacology ; COVID-19/metabolism ; Humans ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/metabolism ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents ; Protein Kinase Inhibitors ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2021-11-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1324988-5
ISSN	1878-5832 ; 1359-6446
ISSN (online)	1878-5832
ISSN	1359-6446
DOI	10.1016/j.drudis.2021.11.002
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Zs.A 4725: Show issues

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Article ; Online: Macrophage Migration Inhibitory Factor (MIF) and Its Homologue d-Dopachrome Tautomerase (DDT) Inversely Correlate with Inflammation in Discoid Lupus Erythematosus.

Caltabiano, Rosario / De Pasquale, Rocco / Piombino, Eliana / Campo, Giorgia / Nicoletti, Ferdinando / Cavalli, Eugenio / Mangano, Katia / Fagone, Paolo

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 1

Abstract: Discoid Lupus Erythematosus (DLE) is a chronic cutaneous disease of unknown etiology and of immunoinflammatory origin that is characterized by inflammatory plaques and may lead to disfiguring scarring and skin atrophy. Current treatments are limited, ... ...

Abstract	Discoid Lupus Erythematosus (DLE) is a chronic cutaneous disease of unknown etiology and of immunoinflammatory origin that is characterized by inflammatory plaques and may lead to disfiguring scarring and skin atrophy. Current treatments are limited, with a large proportion of patients either poorly or not responsive, which makes DLE an unmet medical need. Macrophage migration inhibitory factor (MIF) is the prototype of a pleiotropic family of cytokine that also includes the recently discovered homologue D-dopachrome tautomerase (DDT) or MIF2. MIF and DDT/MIF-2 exert several biological properties, primarily, but not exclusively of a proinflammatory nature. MIF and DDT have been suggested to play a key role in the pathogenesis of several autoimmune diseases, such as multiple sclerosis and type 1 diabetes, as well as in the development and progression of certain forms of cancers. In the present study, we have performed an immunohistochemistry analysis for the evaluation of MIF in DLE lesions and normal skin. We found high levels of MIF in the basal layer of the epidermis as well as in the cutaneous appendage (eccrine glands and sebocytes) of normal skin. In DLE lesions, we observed a significant negative correlation between the expression of MIF and the severity of inflammation. In addition, we performed an analysis of MIF and DDT expression levels in the skin of DLE patients in a publicly available microarray dataset. Interestingly, while these in silico data only evidenced a trend toward reduced levels of MIF, they demonstrated a significant pattern of expression and correlation of DDT with inflammatory infiltrates in DLE skins. Overall, our data support a protective role for endogenous MIF and possibly DDT in the regulation of homeostasis and inflammation in the skin and open up novel avenues for the treatment of DLE.
MeSH term(s)	Adult ; Aged ; Biomarkers/metabolism ; Epidermis/metabolism ; Epidermis/pathology ; Female ; Humans ; Inflammation/metabolism ; Inflammation/pathology ; Intramolecular Oxidoreductases/metabolism ; Lupus Erythematosus, Discoid/metabolism ; Lupus Erythematosus, Discoid/pathology ; Macrophage Migration-Inhibitory Factors/metabolism ; Male ; Middle Aged
Chemical Substances	Biomarkers ; Macrophage Migration-Inhibitory Factors ; Intramolecular Oxidoreductases (EC 5.3.-) ; MIF protein, human (EC 5.3.2.1) ; dopachrome isomerase (EC 5.3.3.12)
Language	English
Publishing date	2021-01-01
Publishing country	Switzerland
Document type	Clinical Trial ; Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26010184
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