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Article ; Online: Targeting the m

Burgess, Hannah M / Depledge, Daniel P / Thompson, Letitia / Srinivas, Kalanghad Puthankalam / Grande, Rebecca C / Vink, Elizabeth I / Abebe, Jonathan S / Blackaby, Wesley P / Hendrick, Alan / Albertella, Mark R / Kouzarides, Tony / Stapleford, Kenneth A / Wilson, Angus C / Mohr, Ian

Genes & development

2021 Volume 35, Issue 13-14, Page(s) 1005–1019

Abstract: ... ...

Abstract	N
MeSH term(s)	Adenosine/analogs & derivatives ; Adenosine/genetics ; Adenosine/metabolism ; Cell Line ; Coronavirus Infections/metabolism ; Coronavirus Infections/virology ; Coronavirus OC43, Human/physiology ; Gene Expression Regulation/drug effects ; Host-Pathogen Interactions/drug effects ; Humans ; Methyltransferases/antagonists & inhibitors ; Methyltransferases/metabolism ; Nucleocapsid Proteins ; RNA Processing, Post-Transcriptional/genetics ; RNA, Viral/metabolism ; RNA-Binding Proteins/metabolism ; SARS-CoV-2/physiology ; Virus Replication/drug effects ; Virus Replication/genetics
Chemical Substances	Nucleocapsid Proteins ; RNA, Viral ; RNA-Binding Proteins ; YTHDF1 protein, human ; YTHDF3 protein, human ; N-methyladenosine (CLE6G00625) ; Methyltransferases (EC 2.1.1.-) ; METTL3 protein, human (EC 2.1.1.62) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2021-06-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	806684-x
ISSN	1549-5477 ; 0890-9369
ISSN (online)	1549-5477
ISSN	0890-9369
DOI	10.1101/gad.348320.121
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Zs.A 2292: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 54: Show issues

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Article ; Online: Determinants of above-ground carbon stocks and productivity in secondary forests along a 3000-m elevation gradient in the Ecuadorian Andes

Pinto, Esteban / Cuesta, Francisco / Bernardi, Antonella / Llerena-Zambrano, Mellisa / Pérez, Álvaro / van der Sande, Masha / Gosling, William / Burgess, Kevin

Plant Ecology & Diversity

2023 Volume 16, Issue 3-4

Abstract: ... the determinants of above-ground carbon (AGC) dynamics in secondary forests along a 3000-m elevational gradient ...

Abstract	BackgroundSecondary montane forests, covering 30% of forested lands in the Andes, play a crucial role in mitigating the impact of carbon release. However, the mechanisms responsible for carbon sequestration in the above-ground biomass of these forests are not well quantified.AimsUnderstanding the determinants of above-ground carbon (AGC) dynamics in secondary forests along a 3000-m elevational gradient in the Andes to assess their mitigation potential.MethodsWe assessed how abiotic and biotic conditions and past human disturbances were related to forest structure and composition, AGC stocks and productivity within sixteen 0.36-ha plots established in secondary forest stands of 30–35 years of age.ResultsStructural equation models revealed that changes in temperature conditions along the elevation gradient shaped leaf functional composition, which in turn controlled AGC dynamics. Productivity and temperature decreased with increasing elevation and decreased tree community leaf area. Disturbance legacy (Tree mortality) increased with competitive thinning and low soil fertility.ConclusionsWe show that temperature drives AGC dynamics by changing the functional trait composition. This highlights the importance of preserving these forests along elevation gradients and implies potentially strong future changes due to global warming.
Keywords	Life Science
Subject code	550
Language	English
Publishing country	nl
Document type	Article ; Online
ZDB-ID	2451208-4
ISSN	1755-1668 ; 1755-0874
ISSN (online)	1755-1668
ISSN	1755-0874
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: PEPCK-M recoups tumor cell anabolic potential in a PKC-ζ-dependent manner.

Hyroššová, Petra / Aragó, Marc / Moreno-Felici, Juan / Fu, Xiarong / Mendez-Lucas, Andrés / García-Rovés, Pablo M / Burgess, Shawn / Figueras, Agnès / Viñals, Francesc / Perales, Jose C

Cancer & metabolism

2021 Volume 9, Issue 1, Page(s) 1

Abstract: Background: Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M; PCK2) is expressed ... Results: PEPCK-M levels linearly correlated with [U-: Conclusions: All in all, our data suggest ... that PEPCK-M might participate in the mechanisms to regulate proteostasis in the anabolic and stalling phases ...

Abstract	Background: Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M; PCK2) is expressed in all cancer types examined and in neuroprogenitor cells. The gene is upregulated by amino acid limitation and ER-stress in an ATF4-dependent manner, and its activity modulates the PEP/Ca Methods: [U- Results: PEPCK-M levels linearly correlated with [U- Conclusions: All in all, our data suggest that PEPCK-M might participate in the mechanisms to regulate proteostasis in the anabolic and stalling phases of tumor growth. We provide molecular clues into the clinical relevance of PEPCK-M as a mechanism of evasion of cancer cells in conditions of nutrient stress.
Language	English
Publishing date	2021-01-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2700141-6
ISSN	2049-3002
ISSN	2049-3002
DOI	10.1186/s40170-020-00236-3
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Article: Vegetative reproduction and root anatomy of Solanum centrale J.M.Black (Australian bush tomato)

Pattison, A. L / Bell, T. L / Burgess, L. W / Ryder, M. H

Rangeland journal. 2019, v. 41, no. 4

2019

Abstract: ... structures associated with colonies of Solanum centrale J.M.Black (Australian bush tomato), a perennial sub ...

Abstract	The aim of this study was to describe the morphology, anatomy and function of underground structures associated with colonies of Solanum centrale J.M.Black (Australian bush tomato), a perennial sub-shrub found in arid areas of Australia and an important traditional staple food for Aboriginal people. It is known that this species forms clonal communities, but there is little understanding of the mechanisms of formation in either natural or cultivated situations. The underground connections within seven clonal communities from Central and South Australia were documented and samples of secondary roots, thick lateral roots and stems were examined under both laboratory and glasshouse conditions. Clonal communities were observed at all sites with individual ramets arising from lateral roots (root-suckers) that ranged from 2–10 mm in diameter growing in a network 5–15 cm below the soil surface. Lateral roots have dicotyledonous root anatomy and rapidly resprout to form new clonal ramets. They also have the capacity to accumulate starch in parenchyma cells. The morphology and root-suckering ability resemble those of weedy Solanum spp. from other parts of the world, as well as species from a variety of genera adapted to arid climates. Methods to capitalise on the ability of lateral roots to form clonal ramets in cultivated situations, particularly given the difficulties in establishing crops from seed, are discussed.
Keywords	asexual reproduction ; climate ; clones ; crops ; greenhouses ; indigenous peoples ; roots ; soil ; Solanum ; staple foods ; starch ; stems ; tomatoes ; South Australia
Language	English
Size	p. 345-354.
Publishing place	CSIRO Publishing
Document type	Article
ZDB-ID	1082716-x
ISSN	1036-9872
ISSN	1036-9872
DOI	10.1071/RJ19011
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Article: Asymmetrical introgression between two Morus species (M. alba, M. rubra) that differ in abundance.

Burgess, K S / Morgan, M / Deverno, L / Husband, B C

Molecular ecology

2005 Volume 14, Issue 11, Page(s) 3471–3483

Abstract: ... of all hybrids contained more nuclear markers from M. alba than M. rubra (hybrid index x = 0.46 ... among populations, the degree of M. alba bias was correlated with the frequency of M. alba. In addition ...

Abstract	Asymmetrical introgression is an expected genetic consequence of hybridization when parental taxa differ in abundance; however, evidence for such effects in small populations is scarce. To test this prediction, we estimated the magnitude and direction of hybridization between red mulberry (Morus rubra L.), an endangered species in Canada, and the introduced and more abundant white mulberry (Morus alba L.) using nuclear (randomly amplified polymorphic DNA) and cytoplasmic (chloroplast DNA sequence) markers. Parentage of 184 trees (n = 42 using cpDNA) from four sympatric populations was estimated using a hybrid index and related to six morphological characters and population frequencies of the parental classes. Overall, the frequency of nuclear hybrids was 53.7% (n = 99) and ranged from 43% to 67% among populations. The parental and hybrid taxa differed with respect to all of the morphological traits. Sixty-seven percent of all hybrids contained more nuclear markers from M. alba than M. rubra (hybrid index x = 0.46); among populations, the degree of M. alba bias was correlated with the frequency of M. alba. In addition, the majority of hybrids (68%) contained the chloroplast genome of white mulberry. These results suggest that introgression is bidirectional but asymmetrical and is related, in part, to the relative frequency of parental taxa.
MeSH term(s)	Analysis of Variance ; Base Sequence ; DNA Primers ; DNA, Chloroplast/genetics ; Genetics, Population ; Hybridization, Genetic ; Molecular Sequence Data ; Morus/anatomy & histology ; Morus/genetics ; Ontario ; Plant Leaves/anatomy & histology ; Population Density ; Random Amplified Polymorphic DNA Technique ; Sequence Analysis, DNA
Chemical Substances	DNA Primers ; DNA, Chloroplast
Language	English
Publishing date	2005-10
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1126687-9
ISSN	1365-294X ; 0962-1083
ISSN (online)	1365-294X
ISSN	0962-1083
DOI	10.1111/j.1365-294X.2005.02670.x
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Article ; Online: Effects of acetazolamide on cerebrovascular function and breathing stability at 5050 m.

Fan, Jui-Lin / Burgess, Keith R / Thomas, Kate N / Lucas, Samuel J E / Cotter, James D / Kayser, Bengt / Peebles, Karen C / Ainslie, Philip N

The Journal of physiology

2012 Volume 590, Issue 5, Page(s) 1213–1225

Abstract: ... healthy participants at sea level and following partial acclimatisation to altitude (5050 m).Measures were ...

Abstract	One of the many actions of the carbonic anhydrase inhibitor, acetazolamide (ACZ), is to accelerate acclimatisation and reduce periodic breathing during sleep. The mechanism(s) by which ACZ may improve breathing stability, especially at high altitude, remain unclear. We tested the hypothesis that acute I.V. ACZ would enhance cerebrovascular reactivity to CO₂ at altitude, and thereby lower ventilatory drive and improve breathing stability during wakefulness. We measured arterial blood gases, minute ventilation (˙VE) and middle cerebral artery blood flow velocity (MCAv) before and 30 min following ACZ administration (I.V. 10 mg kg⁻¹) in 12 healthy participants at sea level and following partial acclimatisation to altitude (5050 m).Measures were made at rest and during changes in end-tidal PCO₂ and PO₂ (isocapnic hypoxia). At sea level, ACZ increased resting MCAv and its reactivity to both hypocapnia and hypercapnia (P < 0.05), and lowered resting VE, arterial O₂ saturation (Sa,O₂ ) and arterial PO₂ (Pa,O₂) (P < 0.05); arterial PCO₂ (Pa,CO₂ ) was unaltered (P > 0.05). At altitude, ACZ also increased resting MCAv and its reactivity to both hypocapnia and hypercapnia (resting MCAv and hypocapnia reactivity to a greater extent than at sea level). Moreover, ACZ at altitude elevated Pa,CO₂ and again lowered resting Pa,O₂ and Sa,O₂ (P <0.05). Although the ˙VE sensitivity to hypercapnia or isocapnic hypoxia was unaltered following ACZ at both sea level and altitude (P > 0.05), breathing stability at altitude was improved (e.g. lower incidence of ventilatory oscillations and variability of tidal volume; P < 0.05). Our data indicate that I.V. ACZ elevates cerebrovascular reactivity and improves breathing stability at altitude, independent of changes in peripheral or central chemoreflex sensitivities. We speculate that Pa,CO₂-mediated elevations in cerebral perfusion and an enhanced cerebrovascular reactivity may partly account for the improved breathing stability following ACZ at high altitude.
MeSH term(s)	Acetazolamide/pharmacology ; Adult ; Altitude ; Blood Gas Analysis ; Brain/blood supply ; Brain/drug effects ; Brain/physiology ; Carbon Dioxide/physiology ; Carbonic Anhydrase Inhibitors/pharmacology ; Cerebral Arteries/drug effects ; Cerebral Arteries/physiology ; Cerebrovascular Circulation/drug effects ; Female ; Humans ; Male ; Pulmonary Ventilation/drug effects ; Regional Blood Flow/drug effects ; Respiration/drug effects ; Young Adult
Chemical Substances	Carbonic Anhydrase Inhibitors ; Carbon Dioxide (142M471B3J) ; Acetazolamide (O3FX965V0I)
Language	English
Publishing date	2012-01-04
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	3115-x
ISSN	1469-7793 ; 0022-3751
ISSN (online)	1469-7793
ISSN	0022-3751
DOI	10.1113/jphysiol.2011.219923
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Article ; Online: Sleep architecture changes during a trek from 1400 to 5000 m in the Nepal Himalaya.

Johnson, Pamela L / Edwards, Natalie / Burgess, Keith R / Sullivan, Colin E

Journal of sleep research

2010 Volume 19, Issue 1 Pt 2, Page(s) 148–156

Abstract: ... overnight polysomnography were performed in 14 subjects at altitudes: 0, 1400, 3500, 3900, 4200 and 5000 m ... non-rapid eye movement sleep increased at 3500 m and higher (P < 0.001), time spent in slow-wave sleep ... progressively more disturbed, with Stage 1 and SWS being affected from 3500 m, while REM sleep was well ...

Abstract	The aim of this study was to examine sleep architecture at high altitude and its relationship to periodic breathing during incremental increases in altitude. Nineteen normal, sea level-dwelling volunteers were studied at sea level and five altitudes in the Nepal Himalaya. Morning arterial blood gases and overnight polysomnography were performed in 14 subjects at altitudes: 0, 1400, 3500, 3900, 4200 and 5000 m above sea level. Subjects became progressively more hypoxic, hypocapnic and alkalinic with increasing altitude. As expected, sleep architecture was affected by increasing altitude. While time spent in Stage 1 non-rapid eye movement sleep increased at 3500 m and higher (P < 0.001), time spent in slow-wave sleep (SWS) decreased as altitude increased. Time spent in rapid eye movement (REM) sleep was well preserved. In subjects who developed periodic breathing during sleep at one or more altitudes (16 of 19), arousals because of periodic breathing predominated, contributing to an increase in the total arousal index. However, there were no differences in sleep architecture or sleeping oxyhaemoglobin saturation between subjects who developed periodic breathing and those who did not. As altitude increased, sleep architecture became progressively more disturbed, with Stage 1 and SWS being affected from 3500 m, while REM sleep was well preserved. Periodic breathing was commonplace at all altitudes, and while associated with increases in arousal indices, did not have any apparent effect on sleep architecture.
MeSH term(s)	Acclimatization/physiology ; Adult ; Altitude ; Altitude Sickness/diagnosis ; Altitude Sickness/physiopathology ; Arteries ; Blood Gas Analysis ; Circadian Rhythm/physiology ; Competitive Behavior ; Electroencephalography ; Female ; Humans ; Male ; Middle Aged ; Mountaineering ; Nepal ; Oxygen Consumption/physiology ; Polysomnography ; Respiration ; Sleep/physiology ; Sleep Stages/physiology ; Surveys and Questionnaires ; Young Adult
Language	English
Publishing date	2010-03
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1122722-9
ISSN	1365-2869 ; 0962-1105
ISSN (online)	1365-2869
ISSN	0962-1105
DOI	10.1111/j.1365-2869.2009.00745.x
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Zs.A 3464: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: The EBNA-3 gene family proteins disrupt the G2/M checkpoint.

Krauer, Kenia G / Burgess, Andrew / Buck, Marion / Flanagan, James / Sculley, Tom B / Gabrielli, Brian

Oncogene

2004 Volume 23, Issue 7, Page(s) 1342–1353

Abstract: ... of the G2/M checkpoint. Lymphoblastoid cell lines (LCLs) treated with a G2/M initiating drug azelaic ... bishydroxamine (ABHA) did not show a G2/M checkpoint response, but rather they display an increase in cell death ... that the individual expression of EBNA-3, -4 or -6 are capable of disrupting the G2/M checkpoint response induced ...

Abstract	The Epstein-Barr nuclear antigens (EBNA), EBNA-3, -4 and -6, have previously been shown to act as transcriptional regulators, however, this study identifies another function for these proteins, disruption of the G2/M checkpoint. Lymphoblastoid cell lines (LCLs) treated with a G2/M initiating drug azelaic bishydroxamine (ABHA) did not show a G2/M checkpoint response, but rather they display an increase in cell death, a characteristic of sensitivity to the cytotoxic effects of the drug. Cell cycle analysis demonstrated that the individual expression of EBNA-3, -4 or -6 are capable of disrupting the G2/M checkpoint response induced by ABHA resulting in increased toxicity, whereas EBNA-2, and -5 were not. EBNA-3 gene family protein expression also disrupted the G2/M checkpoint initiated in response to the genotoxin etoposide and the S phase inhibitor hydroxyurea. The G2 arrest in response to these drugs were sensitive to caffeine, suggesting that ATM/ATR signalling in these checkpoint responses may be blocked by the EBNA-3 family proteins. The function of EBNA-3, -4 and -6 proteins appears to be more complex than anticipated and these data suggest a role for these proteins in disrupting the host cell cycle machinery.
MeSH term(s)	Ataxia Telangiectasia Mutated Proteins ; Cell Cycle Proteins ; Checkpoint Kinase 2 ; DNA Damage/physiology ; DNA-Binding Proteins ; Epstein-Barr Virus Nuclear Antigens/immunology ; Epstein-Barr Virus Nuclear Antigens/metabolism ; G2 Phase/drug effects ; G2 Phase/physiology ; Histone Deacetylase Inhibitors ; Humans ; Hydroxamic Acids/pharmacology ; Mitosis/drug effects ; Mitosis/physiology ; Precipitin Tests ; Protein-Serine-Threonine Kinases/immunology ; Protein-Serine-Threonine Kinases/metabolism ; Signal Transduction/physiology ; Tumor Suppressor Proteins
Chemical Substances	Cell Cycle Proteins ; DNA-Binding Proteins ; Epstein-Barr Virus Nuclear Antigens ; Histone Deacetylase Inhibitors ; Hydroxamic Acids ; Tumor Suppressor Proteins ; azelaic bishydroxamic acid (18992-11-5) ; Checkpoint Kinase 2 (EC 2.7.1.11) ; ATM protein, human (EC 2.7.11.1) ; ATR protein, human (EC 2.7.11.1) ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1) ; CHEK2 protein, human (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2004-02-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639046-8
ISSN	1476-5594 ; 0950-9232
ISSN (online)	1476-5594
ISSN	0950-9232
DOI	10.1038/sj.onc.1207253
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Article: Asymmetrical introgression between two Morus species (M. alba, M. rubra) that differ in abundance

Burgess, K.S / Morgan, M / Deverno, L / Husband, B.C

Molecular ecology. 2005 Oct., v. 14, no. 11

2005

Keywords	Morus alba ; Morus rubra ; introgression ; interspecific hybridization ; gene flow ; genetic markers ; chloroplast DNA ; random amplified polymorphic DNA technique ; hybrids ; nucleotide sequences ; genes ; ribulose-bisphosphate carboxylase ; Canada ; Eastern United States
Language	English
Dates of publication	2005-10
Size	p. 3471-3483.
Document type	Article
ZDB-ID	1126687-9
ISSN	1365-294X ; 0962-1083
ISSN (online)	1365-294X
ISSN	0962-1083
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Nees-Institut: Meckenheimer Allee: Show issues

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Article ; Online: PEPCK-M expression in mouse liver potentiates, not replaces, PEPCK-C mediated gluconeogenesis.

Méndez-Lucas, Andrés / Duarte, João André Gonçalves / Sunny, Nishanth E / Satapati, Santhosh / He, TianTeng / Fu, Xiaorong / Bermúdez, Jordi / Burgess, Shawn C / Perales, Jose C

Journal of hepatology

2013 Volume 59, Issue 1, Page(s) 105–113

Abstract: ... present a mitochondrial isozyme (PEPCK-M). Despite clear relevance to human physiology, the role of PEPCK ... M and its gluconeogenic potential remain unknown. Here, we test the significance of PEPCK-M ... of the overexpression of PEPCK-M were examined by a combination of tracer studies and molecular biology techniques ...

Abstract	Background & aims: Hepatic gluconeogenesis helps maintain systemic energy homeostasis by compensating for discontinuities in nutrient supply. Liver-specific deletion of cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) abolishes gluconeogenesis from mitochondrial substrates, deregulates lipid metabolism and affects TCA cycle. While the mouse liver almost exclusively expresses PEPCK-C, humans equally present a mitochondrial isozyme (PEPCK-M). Despite clear relevance to human physiology, the role of PEPCK-M and its gluconeogenic potential remain unknown. Here, we test the significance of PEPCK-M in gluconeogenesis and TCA cycle function in liver-specific PEPCK-C knockout and WT mice. Methods: The effects of the overexpression of PEPCK-M were examined by a combination of tracer studies and molecular biology techniques. Partial PEPCK-C re-expression was used as a positive control. Metabolic fluxes were evaluated in isolated livers by NMR using (2)H and (13)C tracers. Gluconeogenic potential, together with metabolic profiling, was investigated in vivo and in primary hepatocytes. Results: PEPCK-M expression partially rescued defects in lipid metabolism, gluconeogenesis and TCA cycle function impaired by PEPCK-C deletion, while ∼10% re-expression of PEPCK-C normalized most parameters. When PEPCK-M was expressed in the presence of PEPCK-C, the mitochondrial isozyme amplified total gluconeogenic capacity, suggesting autonomous regulation of oxaloacetate to phosphoenolpyruvate fluxes by the individual isoforms. Conclusions: We conclude that PEPCK-M has gluconeogenic potential per se, and cooperates with PEPCK-C to adjust gluconeogenic/TCA flux to changes in substrate or energy availability, hinting at a role in the regulation of glucose and lipid metabolism in the human liver.
MeSH term(s)	Animals ; Citric Acid Cycle ; Cytosol/metabolism ; Gene Expression ; Gluconeogenesis/genetics ; Gluconeogenesis/physiology ; Glucose/metabolism ; Hepatocytes/metabolism ; Humans ; Lipid Metabolism ; Liver/metabolism ; Mice ; Mice, Knockout ; Mitochondria, Liver/metabolism ; Phosphoenolpyruvate Carboxykinase (ATP)/genetics ; Phosphoenolpyruvate Carboxykinase (ATP)/metabolism ; Phosphoenolpyruvate Carboxykinase (GTP)/deficiency ; Phosphoenolpyruvate Carboxykinase (GTP)/genetics ; Phosphoenolpyruvate Carboxykinase (GTP)/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Chemical Substances	RNA, Messenger ; Phosphoenolpyruvate Carboxykinase (GTP) (EC 4.1.1.32) ; Phosphoenolpyruvate Carboxykinase (ATP) (EC 4.1.1.49) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2013-03-04
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2013.02.020
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