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Book ; Online ; E-Book: Clinical applications of optical coherence tomography angiography

Bandello, Francesco / Mastropasqua, Leonardo / Querques, Giuseppe / Bandello, F. / Corcóstegui, B.

(ESASO Course Series ; 11)

2020

Series title	ESASO Course Series ; 11 ESASO course series
Collection	ESASO course series
Keywords	Ophthalmology ; Internal Medicine ; Diabetes
Language	English
Size	1 Online-Ressource (x, 134 Seiten), Illustrationen
Edition	1. Auflage
Publisher	S. Karger
Publishing place	Basel
Publishing country	Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT020689240
ISBN	978-3-318-06643-2 ; 9783318066425 ; 3-318-06643-5 ; 3318066427
DOI	10.1159/isbn.978-3-318-06643-2
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Bilateral ectasia after femtosecond laser-assisted small-incision lenticule extraction.

Mastropasqua, Leonardo

Journal of cataract and refractive surgery

2015 Volume 41, Issue 6, Page(s) 1338–1339

MeSH term(s)	Corneal Stroma/surgery ; Corneal Surgery, Laser/adverse effects ; Humans ; Keratoconus/etiology ; Male
Language	English
Publishing date	2015-06
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	632744-8
ISSN	1873-4502 ; 0886-3350
ISSN (online)	1873-4502
ISSN	0886-3350
DOI	10.1016/j.jcrs.2015.05.013
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Article: Collagen cross-linking: when and how? A review of the state of the art of the technique and new perspectives.

Mastropasqua, Leonardo

Eye and vision (London, England)

2015 Volume 2, Page(s) 19

Abstract: Since the late 1990s corneal crosslinking (CXL) has been proposed as a new possibility to stop progression of keratoconus or secondary corneal ectasia, with the promising aim to prevent progressive visual loss due to the evolution of the pathology and to ...

Abstract	Since the late 1990s corneal crosslinking (CXL) has been proposed as a new possibility to stop progression of keratoconus or secondary corneal ectasia, with the promising aim to prevent progressive visual loss due to the evolution of the pathology and to delay or avoid invasive surgical procedures such as corneal transplantation. The possibility of strengthening corneal tissue by means of a photochemical reaction of corneal collagen by the combined action of Riboflavin and ultraviolet A irradiation (UVA), radically modified the conservative management of progressive corneal ectasia. This is a review of the state of the art of CXL, reporting basic and clinical evidence. The paper describes basic principles, advantages and limits of different CXL techniques and possible future evolution of the procedure.
Language	English
Publishing date	2015-11-29
Publishing country	England
Document type	Journal Article ; Review
ISSN	2326-0254
ISSN	2326-0254
DOI	10.1186/s40662-015-0030-6
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Article: Innovation in the Development of Synthetic and Natural Ocular Drug Delivery Systems for Eye Diseases Treatment: Focusing on Drug-Loaded Ocular Inserts, Contacts, and Intraocular Lenses.

Pelusi, Letizia / Mandatori, Domitilla / Mastropasqua, Leonardo / Agnifili, Luca / Allegretti, Marcello / Nubile, Mario / Pandolfi, Assunta

Pharmaceutics

2023 Volume 15, Issue 2

Abstract: Nowadays, ocular drug delivery still remains a challenge, since the conventional dosage forms used for anterior and posterior ocular disease treatments, such as topical, systemic, and intraocular administration methods, present important limitations ... ...

Abstract	Nowadays, ocular drug delivery still remains a challenge, since the conventional dosage forms used for anterior and posterior ocular disease treatments, such as topical, systemic, and intraocular administration methods, present important limitations mainly related to the anatomical complexity of the eye. In particular, the blood-ocular barrier along with the corneal barrier, ocular surface, and lacrimal fluid secretion reduce the availability of the administered active compounds and their efficacy. These limitations have increased the need to develop safe and effective ocular delivery systems able to sustain the drug release in the interested ocular segment over time. In the last few years, thanks to the innovations in the materials and technologies employed, different ocular drug delivery systems have been developed. Therefore, this review aims to summarize the synthetic and natural drug-loaded ocular inserts, contacts, and intraocular lenses that have been recently developed, emphasizing the characteristics that make them promising for future ocular clinical applications.
Language	English
Publishing date	2023-02-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15020625
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Article ; Online: Response to Letter to the Editor: Tear Meniscus Imaging by Anterior Segment-Optical Coherence Tomography in Medically Controlled Glaucoma.

Brescia, Lorenza / Agnifili, Luca / Mastropasqua, Leonardo

Journal of glaucoma

2020 Volume 30, Issue 3, Page(s) e106–e107

MeSH term(s)	Anterior Eye Segment/diagnostic imaging ; Glaucoma/diagnosis ; Humans ; Intraocular Pressure ; Meniscus ; Tears ; Tomography, Optical Coherence
Language	English
Publishing date	2020-12-09
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	913494-3
ISSN	1536-481X ; 1057-0829
ISSN (online)	1536-481X
ISSN	1057-0829
DOI	10.1097/IJG.0000000000001665
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Article ; Online: Structural and Molecular Tear Film Changes in Glaucoma.

Mastropasqua, Rodolfo / Agnifili, Luca / Mastropasqua, Leonardo

Current medicinal chemistry

2018 Volume 26, Issue 22, Page(s) 4225–4240

Abstract: The Tear Film (TF) is a trilaminar and dynamic fluid covering the entire Ocular Surface (OS), consisting of a mucus, aqueous, and lipid layer deeply interacting between them. Because of its structure and functions, TF plays a pivotal role in the ... ...

Abstract	The Tear Film (TF) is a trilaminar and dynamic fluid covering the entire Ocular Surface (OS), consisting of a mucus, aqueous, and lipid layer deeply interacting between them. Because of its structure and functions, TF plays a pivotal role in the preservation of the OS integrity and the quality of vision. Medical therapy for glaucoma is recognized to profoundly disturb the OS homeostasis by altering all components of the ocular surface unit, including TF. The presence of preservatives, the number of daily eye drops instillations, and the duration of therapy are the main contributors to TF changes. From the physio-pathological side, TF alterations are induced by toxic and allergic mechanisms and result from goblet cell and Meibomian gland loss, dysfunction of accessory lacrimal glands, and epithelial disruption. In detail, TF changes are represented by mucus layer thinning, reduced mucin concentration, aqueous layer volume reduction, and lipid layer thinning with increased tear evaporation. Hyper- osmolarity and instability represent the main hallmarks of these changes and are an expression of a iatrogenic form of dry eye. TF undergoes also molecular modifications that primarily reflect a therapy- or disease-induced inflammatory status of the OS. Over the last years, this field of research aimed a progressively growing interest since molecular variations may be considered as potential candidate biomarkers of glaucoma. The aim of this review is to report the main TF changes occurring during glaucoma, exploring the relationship they may have with the glaucoma-related ocular surface disease and the patient quality of life, and their utility as potential biomarkers of disease.
MeSH term(s)	Animals ; Antihypertensive Agents/chemistry ; Antihypertensive Agents/pharmacology ; Corneal Diseases/drug therapy ; Glaucoma/drug therapy ; Humans ; Molecular Structure ; Preservatives, Pharmaceutical/chemistry ; Preservatives, Pharmaceutical/pharmacology ; Tears/drug effects
Chemical Substances	Antihypertensive Agents ; Preservatives, Pharmaceutical
Language	English
Publishing date	2018-10-10
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0929867325666181009153212
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Article: Femtosecond Laser-Assisted Stromal Lenticule Addition Keratoplasty for the Treatment of Advanced Keratoconus: A Preliminary Study.

Mastropasqua, Leonardo / Nubile, Mario / Salgari, Niccolò / Mastropasqua, Rodolfo

Journal of refractive surgery (Thorofare, N.J. : 1995)

2018 Volume 34, Issue 1, Page(s) 36–44

Abstract: Purpose: To investigate the in vivo effect of a novel femtosecond laser-assisted procedure termed stromal lenticule addition keratoplasty for advanced keratoconus.: Methods: Ten patients with stage III and IV stable keratoconus were included. ... ...

Abstract	Purpose: To investigate the in vivo effect of a novel femtosecond laser-assisted procedure termed stromal lenticule addition keratoplasty for advanced keratoconus. Methods: Ten patients with stage III and IV stable keratoconus were included. Negative meniscus-shaped stromal lenticules were produced from corneoscleral eye bank buttons with a refractive lenticule extraction procedure with a 500-kHz VisuMax femtosecond laser (Carl Zeiss Meditec, Jena, Germany). Recipient corneas underwent a modified femtosecond laser flap-cut procedure to produce an intrastromal pocket and lenticules were implanted. Patients were followed up for 6 months after surgery with determination of uncorrected (UDVA) and corrected (CDVA) distance visual acuity, subjective refraction and topographic corneal curvature changes, anterior segment optical coherence tomography (AS-OCT), and in vivo confocal microscopy. Results: Comparison of preoperative and 6-month postoperative UDVA and CDVA showed statistically significant improvements (P = .024 and .007, respectively) from 1.58 ± 0.36 to 1.22 ± 0.37 and from 1.07 ± 0.17 to 0.70 ± 0.23 logMAR. Eight of 10 eyes showed an improvement in UDVA (P < .001) that ranged between one and three lines, whereas all but one eye presented improved CDVA. Corneal topography documented a decrease between preoperative and 6-month postoperative anterior mean curvature (AVG-K at 3 mm) and anterior Q values (P = .005). AS-OCT showed a significant increase in thickness of the central and mid-peripheral cornea produced by the lenticule implantation (P = .005). Conclusions: The stromal lenticule addition keratoplasty procedure was clinically efficient in improving the corneal shape and vision in patients with keratoconus. Negative meniscus-shaped lenticule addition induced a flattening of the cone while increasing corneal thickness. [J Refract Surg. 2018;34(1):36-44.].
MeSH term(s)	Adult ; Corneal Stroma/transplantation ; Corneal Surgery, Laser/methods ; Corneal Topography ; Corneal Transplantation/methods ; Female ; Humans ; Keratoconus/physiopathology ; Keratoconus/surgery ; Male ; Middle Aged ; Pilot Projects ; Refraction, Ocular/physiology ; Tissue Donors ; Tissue Preservation ; Tomography, Optical Coherence ; Visual Acuity/physiology
Language	English
Publishing date	2018-01-01
Publishing country	United States
Document type	Journal Article
ISSN	1081-597X
ISSN	1081-597X
DOI	10.3928/1081597X-20171004-04
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Article ; Online: Pushing Retinal Imaging Forward: Innovations and Their Clinical Meaning - The 2022 Ophthalmologica Lecture.

Borrelli, Enrico / Berni, Alessandro / Mastropasqua, Leonardo / Querques, Giuseppe / Sadda, Srinivas R / Sarraf, David / Bandello, Francesco

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde

2023 Volume 246, Issue 5-6, Page(s) 278–294

Abstract: Retinal imaging has greatly expanded our understanding of various pathological conditions. This article presents a summary of the key points covered during the 2022 Ophthalmologica Lecture held at the Euretina Congress in Hamburg. The first part of the ... ...

Abstract	Retinal imaging has greatly expanded our understanding of various pathological conditions. This article presents a summary of the key points covered during the 2022 Ophthalmologica Lecture held at the Euretina Congress in Hamburg. The first part of the article focuses on the use of optical coherence tomography angiography to examine and comprehend the choroid in age-related macular degeneration (AMD). Subsequently, we delve into the discussion of the "postreceptor neuronal loss" theory in AMD, which was studied using en face structural optical coherence tomography (OCT). Following that, we explore pertinent findings obtained through cross-sectional OCT in retinal and optic nerve diseases, such as AMD, diabetic macular edema, pathologic myopia, central serous chorioretinopathy, and Leber's hereditary optic neuropathy.
MeSH term(s)	Humans ; Diabetic Retinopathy/diagnosis ; Cross-Sectional Studies ; Macular Edema/pathology ; Retina/pathology ; Central Serous Chorioretinopathy ; Macular Degeneration/pathology ; Tomography, Optical Coherence/methods ; Fluorescein Angiography/methods
Language	English
Publishing date	2023-09-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	209735-7
ISSN	1423-0267 ; 0030-3755
ISSN (online)	1423-0267
ISSN	0030-3755
DOI	10.1159/000533910
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Article ; Online: A machine learning approach to predict the glaucoma filtration surgery outcome.

Agnifili, Luca / Figus, Michele / Porreca, Annamaria / Brescia, Lorenza / Sacchi, Matteo / Covello, Giuseppe / Posarelli, Chiara / Di Nicola, Marta / Mastropasqua, Rodolfo / Nucci, Paolo / Mastropasqua, Leonardo

Scientific reports

2023 Volume 13, Issue 1, Page(s) 18157

Abstract: This study aimed at predicting the filtration surgery (FS) outcome using a machine learning (ML) approach. 102 glaucomatous patients undergoing FS were enrolled and underwent ocular surface clinical tests (OSCTs), determination of surgical site-related ... ...

Abstract	This study aimed at predicting the filtration surgery (FS) outcome using a machine learning (ML) approach. 102 glaucomatous patients undergoing FS were enrolled and underwent ocular surface clinical tests (OSCTs), determination of surgical site-related biometric parameters (SSPs) and conjunctival vascularization. Break-up-time, Schirmer test I, corneal fluorescein staining, Meibomian gland expressibility; conjunctival hyperemia, upper bulbar conjunctiva area of exposure, limbus to superior eyelid distance; and conjunctival epithelial and stromal (CET, CST) thickness and reflectivity (ECR, SCR) at AS-OCT were considered. Successful FS required a 30% baseline intraocular pressure reduction, with values ≤ 18 mmHg with or without medications. The classification tree (CT) was the ML algorithm used to analyze data. At the twelfth month, FS was successful in 60.8% of cases, whereas failed in 39.2%. At the variable importance ranking, CST and SCR were the predictors with the greater relative importance to the CART tree construction, followed by age. CET and ECR showed less relative importance, whereas OSCTs and SSPs were not important features. Within the CT, CST turned out the most important variable for discriminating success from failure, followed by SCR and age, with cut-off values of 75 µm, 169 on gray scale, and 62 years, respectively. The ROC curve for the classifier showed an AUC of 0.784 (0.692-0.860). In this ML approach, CT analysis found that conjunctival stroma thickness and reflectivity, along with age, can predict the FS outcome with good accuracy. A pre-operative thick and hyper-reflective stroma, and a younger age increase the risk of FS failure.
MeSH term(s)	Humans ; Glaucoma/surgery ; Meibomian Glands ; Filtering Surgery ; Conjunctiva/surgery ; Fluorescein
Chemical Substances	Fluorescein (TPY09G7XIR)
Language	English
Publishing date	2023-10-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-44659-6
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Article ; Online: The Effect of Varied Microperimetric Biofeedback Training in Central Vision Loss: A Randomized Trial.

Silvestri, Valeria / De Rossi, Francesca / Piscopo, Paola / Perna, Fabiana / Mastropasqua, Leonardo / Turco, Simona / Rizzo, Stanislao / Mariotti, Silvio Paolo / Amore, Filippo

Optometry and vision science : official publication of the American Academy of Optometry

2023 Volume 100, Issue 11, Page(s) 737–744

Abstract: Significance: This investigation reports for the first time the effects of different microperimetric biofeedback strategies in visually impaired subjects with central field loss.: Purpose: This study aimed to evaluate the effects of two MP-3 ... ...

Abstract	Significance: This investigation reports for the first time the effects of different microperimetric biofeedback strategies in visually impaired subjects with central field loss. Purpose: This study aimed to evaluate the effects of two MP-3 microperimeter biofeedback strategies on the visual performance of subjects with central vision loss. Moreover, changes between the groups were compared to provide indications of practice with biofeedback stimulation in subjects with central vision loss. Methods: Using simple randomization, 19 participants were trained according to two different biofeedback stimulation approaches using the MP-3 microperimeter. Patients were assigned to two different groups: subjects trained for 2 days a week (group A) and 3 days a week (group B). The patients in each group were randomized to perform a total of 10 or 15 sessions. Results: Fixation stability increased from 4.5 ± 2.8 to 2.3 ± 2.2° 2 and from 8.2 ± 6.9 to 1.4 ± 1° 2 after 2 and 3 weekly biofeedback training sessions, respectively ( P < .05). Biofeedback training induced a significant improvement of 40.7 and 29.4% in reading speed for groups A and B, respectively ( P < .05). A comparison of two weekly biofeedback training sessions with three weekly biofeedback sessions demonstrated greater fixation stability in group B ( P < .05). Conclusions: This study concludes that a biofeedback intervention is effective in enhancing oculomotor control in patients with central vision loss. In our study, a more intensive biofeedback strategy seemed to produce significantly better results in terms of functional vision parameters.
MeSH term(s)	Humans ; Retina ; Vision, Low/therapy ; Visual Acuity ; Scotoma ; Biofeedback, Psychology/methods
Language	English
Publishing date	2023-09-25
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1001706-9
ISSN	1538-9235 ; 1040-5488
ISSN (online)	1538-9235
ISSN	1040-5488
DOI	10.1097/OPX.0000000000002073
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