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  1. Article ; Online: Investigating Protein-Protein Interactions of Autophagy-Involved TNIP1.

    Samulevich, Michael L / Carman, Liam E / Aneskievich, Brian J

    Methods in molecular biology (Clifton, N.J.)

    2024  

    Abstract: Myriad proteins are involved in the process of autophagy, which they participate in via their protein-protein interactions (PPI). Herein we outline a methodology for examining such interactions utilizing the case of intrinsically disordered protein (IDP) ...

    Abstract Myriad proteins are involved in the process of autophagy, which they participate in via their protein-protein interactions (PPI). Herein we outline a methodology for examining such interactions utilizing the case of intrinsically disordered protein (IDP) TNIP1 and its interaction with linear M1-linked polyubiquitin. This includes methods for recombinant production, purification, immuno-identification, and analysis of an IDP associated with autophagy, its ordered binding partner, and means of quantitatively analyzing their interaction.
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/7651_2024_525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Fixed Versus Body-Sized-Based Dosing of Monoclonal Antibodies.

    Erstad, Brian L / Davis, Lisa E

    The Annals of pharmacotherapy

    2023  Volume 58, Issue 1, Page(s) 91–95

    Abstract: Monoclonal antibody products are an increasing portion of novel drug approvals. The labeling of initial drug approvals frequently involves body-size-based rather than fixed-dose administration regimens for adults without clear rationale for doing so. ... ...

    Abstract Monoclonal antibody products are an increasing portion of novel drug approvals. The labeling of initial drug approvals frequently involves body-size-based rather than fixed-dose administration regimens for adults without clear rationale for doing so. This presents challenges when prescribing these products for patients with extremes of body habitus who constitute a small portion of enrollment in pre-approval investigations. Fixed-dose regimens allow for standardized preparation with the potential to reduce the risk of calculation errors, drug waste, and make home administration more practical. Fixed-dose rather than body-size-based monoclonal antibody regimens should serve as the initial approach in early phase 1 clinical trials.
    MeSH term(s) Adult ; Humans ; Antibodies, Monoclonal/therapeutic use ; Body Weight ; Drug Approval ; Dose-Response Relationship, Drug
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1101370-9
    ISSN 1542-6270 ; 1060-0280
    ISSN (online) 1542-6270
    ISSN 1060-0280
    DOI 10.1177/10600280231170650
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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Repressive Control of Keratinocyte Cytoplasmic Inflammatory Signaling.

    Carman, Liam E / Samulevich, Michael L / Aneskievich, Brian J

    International journal of molecular sciences

    2023  Volume 24, Issue 15

    Abstract: The overactivity of keratinocyte cytoplasmic signaling contributes to several cutaneous inflammatory and immune pathologies. An important emerging complement to proteins responsible for this overactivity is signal repression brought about by several ... ...

    Abstract The overactivity of keratinocyte cytoplasmic signaling contributes to several cutaneous inflammatory and immune pathologies. An important emerging complement to proteins responsible for this overactivity is signal repression brought about by several proteins and protein complexes with the native role of limiting inflammation. The signaling repression by these proteins distinguishes them from transmembrane receptors, kinases, and inflammasomes, which drive inflammation. For these proteins, defects or deficiencies, whether naturally arising or in experimentally engineered skin inflammation models, have clearly linked them to maintaining keratinocytes in a non-activated state or returning cells to a post-inflamed state after a signaling event. Thus, together, these proteins help to resolve acute inflammatory responses or limit the development of chronic cutaneous inflammatory disease. We present here an integrated set of demonstrated or potentially inflammation-repressive proteins or protein complexes (linear ubiquitin chain assembly complex [LUBAC], cylindromatosis lysine 63 deubiquitinase [CYLD], tumor necrosis factor alpha-induced protein 3-interacting protein 1 [TNIP1], A20, and OTULIN) for a comprehensive view of cytoplasmic signaling highlighting protein players repressing inflammation as the needed counterpoints to signal activators and amplifiers. Ebb and flow of players on both sides of this inflammation equation would be of physiological advantage to allow acute response to damage or pathogens and yet guard against chronic inflammatory disease. Further investigation of the players responsible for repressing cytoplasmic signaling would be foundational to developing new chemical-entity pharmacologics to stabilize or enhance their function when clinical intervention is needed to restore balance.
    MeSH term(s) Humans ; Keratinocytes/metabolism ; Signal Transduction/physiology ; Skin/metabolism ; Cytoplasm/metabolism ; Dermatitis/metabolism ; Inflammation/metabolism ; NF-kappa B/metabolism
    Chemical Substances NF-kappa B
    Language English
    Publishing date 2023-07-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241511943
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  4. Article: SPIM-Flow: An Integrated Light Sheet and Microfluidics Platform for Hydrodynamic Studies of

    Hedde, Per Niklas / Le, Brian T / Gomez, Erika L / Duong, Leora / Steele, Robert E / Ahrar, Siavash

    Biology

    2023  Volume 12, Issue 1

    Abstract: Selective plane illumination microscopy (SPIM), or light sheet microscopy, is a powerful imaging approach. However, access to and interfacing microscopes with microfluidics have remained challenging. Complex interfacing with microfluidics has limited the ...

    Abstract Selective plane illumination microscopy (SPIM), or light sheet microscopy, is a powerful imaging approach. However, access to and interfacing microscopes with microfluidics have remained challenging. Complex interfacing with microfluidics has limited the SPIM's utility for studying the hydrodynamics of freely moving multicellular organisms. We developed SPIM-Flow, an inexpensive light sheet platform that enables easy integration with microfluidics. We used SPIM-Flow to investigate the hydrodynamics of a freely moving
    Language English
    Publishing date 2023-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12010116
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  5. Article ; Online: Enhancing oncological care: A guide to setting up a new multidisciplinary cancer cachexia clinic within a tertiary centre.

    Ko, Hyun Soo / Denehy, Linda / Edbrooke, Lara / Albarqouni, Shadi / Attenberger, Ulrike / Parker, Benjamin L / Cox, Andrew / Le, Brian / Cheng, Louise

    Journal of cachexia, sarcopenia and muscle

    2023  Volume 15, Issue 1, Page(s) 4–7

    MeSH term(s) Humans ; Cachexia/etiology ; Cachexia/therapy ; Neoplasms/complications ; Neoplasms/therapy ; Nutritional Status
    Language English
    Publishing date 2023-11-15
    Publishing country Germany
    Document type Editorial
    ZDB-ID 2586864-0
    ISSN 2190-6009 ; 2190-5991
    ISSN (online) 2190-6009
    ISSN 2190-5991
    DOI 10.1002/jcsm.13360
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  6. Article ; Online: Evaluation of CHROMagar

    Bentz, Meghan L / Le, Ngoc / Min, Brian / Nunnally, Natalie S / Sullivan, Vickie / Tran, Mike / Lockhart, Shawn R / Litvintseva, Ana / Berkow, Elizabeth L / Sexton, D Joseph

    Microbiology spectrum

    2024  Volume 12, Issue 4, Page(s) e0356423

    Abstract: ... ...

    Abstract CHROMagar
    MeSH term(s) Humans ; Candida ; Candida auris ; Candidiasis/diagnosis ; Candidiasis/microbiology ; Culture Media ; Coloring Agents ; Antifungal Agents
    Chemical Substances Culture Media ; Coloring Agents ; Antifungal Agents
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.03564-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A systematic review and meta-analysis of depression and apathy frequency in adult-onset Huntington's disease.

    Clark, Melanie L / Abimanyi-Ochom, Julie / Le, Ha / Long, Brian / Orr, Carolyn / Khanh-Dao Le, Long

    Neuroscience and biobehavioral reviews

    2023  Volume 149, Page(s) 105166

    Abstract: Depression and apathy are associated with decreased functional capacity in Huntington's disease (HD) but frequency of depression and apathy in HD is largely unknown. Systematic literature searching was conducted across 21 databases until 30 June 2021. ... ...

    Abstract Depression and apathy are associated with decreased functional capacity in Huntington's disease (HD) but frequency of depression and apathy in HD is largely unknown. Systematic literature searching was conducted across 21 databases until 30 June 2021. Inclusion criteria was limited to clinician-rated assessments of depression and apathy and adult-onset HD. Inverse-variance heterogeneity meta-analyses were conducted exploring depression and apathy frequency within individuals from families affected by HD, and within individuals with confirmed HD gene-positive status. Screening identified 289 articles for full-text review; nine remained for meta-analysis. Depression frequency in the lifetime in adults affected by or at-risk for HD was 38%, I
    MeSH term(s) Adult ; Humans ; Apathy ; Huntington Disease/complications ; Huntington Disease/epidemiology ; Depression/epidemiology
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2023.105166
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1371: Show issues Location:
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  8. Article ; Online: Genomic epidemiology and antifungal-resistant characterization of

    Misas, Elizabeth / Escandón, Patricia L / Gade, Lalitha / Caceres, Diego H / Hurst, Steve / Le, Ngoc / Min, Brian / Lyman, Meghan / Duarte, Carolina / Chow, Nancy A

    mSphere

    2024  Volume 9, Issue 2, Page(s) e0057723

    Abstract: Since 2016, in Colombia, ongoing transmission of : Importance: Candida ... ...

    Abstract Since 2016, in Colombia, ongoing transmission of
    Importance: Candida auris
    MeSH term(s) Humans ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Amphotericin B ; Candida auris ; Fluconazole ; Colombia/epidemiology ; Candida/genetics ; Candidiasis/microbiology ; Phylogeny ; Genomics
    Chemical Substances Antifungal Agents ; Amphotericin B (7XU7A7DROE) ; Fluconazole (8VZV102JFY)
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/msphere.00577-23
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  9. Article ; Online: Influence of running on femoroacetabular joint bone-to-bone distances.

    Heckelman, Lauren N / Kratzer, Avery L / Spritzer, Charles E / Soher, Brian J / Lewis, Brian D / DeFrate, Louis E

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society

    2023  Volume 42, Issue 4, Page(s) 837–842

    Abstract: There is limited data quantifying the influence of running on hip cartilage mechanics. The goal of this investigation was to quantify changes in hip joint bone-to-bone distance in response to a 3-mile treadmill run. We acquired magnetic resonance (MR) ... ...

    Abstract There is limited data quantifying the influence of running on hip cartilage mechanics. The goal of this investigation was to quantify changes in hip joint bone-to-bone distance in response to a 3-mile treadmill run. We acquired magnetic resonance (MR) images of the dominant hip of eight young, asymptomatic runners (five males, three females) before and immediately after they ran 3 miles at a self-selected pace on a level treadmill. The femoral heads and acetabula were semiautomatically segmented from the pre- and post-exercise MR images to generate three-dimensional models of each participant's hip that were used to compute changes in the bone-to-bone distances incurred by the running exercise. We observed a significant 3% decrease in bone-to-bone distance from 3.47 ± 0.20 to 3.36 ± 0.22 mm between the femoral head and acetabulum after a 3-mile treadmill run (mean ± 95% confidence interval; p = 0.03). These findings provide new baseline data describing how running impacts the hip joint in young, asymptomatic runners.
    MeSH term(s) Male ; Female ; Humans ; Hip Joint/diagnostic imaging ; Acetabulum ; Cartilage ; Femur Head/diagnostic imaging ; Knee Joint/physiology ; Magnetic Resonance Imaging/methods
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605542-4
    ISSN 1554-527X ; 0736-0266
    ISSN (online) 1554-527X
    ISSN 0736-0266
    DOI 10.1002/jor.25735
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    Zs.A 1879: Show issues Location:
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  10. Article: Osteosarcoma in Pediatric and Adult Populations: Are Adults Just Big Kids?

    Kim, Caleb / Davis, Lara E / Albert, Catherine M / Samuels, Brian / Roberts, Jesse L / Wagner, Michael J

    Cancers

    2023  Volume 15, Issue 20

    Abstract: Malignant bone tumors are commonly classified as pediatric or adolescent malignancies, and clinical trials for these diseases have generally focused on these populations. Of primary bone cancers, osteosarcoma is among the most common. Osteosarcoma has a ... ...

    Abstract Malignant bone tumors are commonly classified as pediatric or adolescent malignancies, and clinical trials for these diseases have generally focused on these populations. Of primary bone cancers, osteosarcoma is among the most common. Osteosarcoma has a bimodal age distribution, with the first peak occurring in patients from 10 to 14 years old, and the second peak occurring in patients older than 65, with about 25% of cases occurring in adults between 20 and 59 years old. Notably, adult osteosarcoma patients have worse outcomes than their pediatric counterparts. It remains unclear whether age itself is a poor prognostic factor, or if inherent differences in tumor biology exist between age groups. Despite these unknowns, current treatment strategies for adults are largely extrapolated from pediatric studies since the majority of clinical trials for osteosarcoma treatments are based on younger patient populations. In light of the different prognoses observed in pediatric and adult osteosarcoma, we summarize the current understanding of the molecular etiology of osteosarcoma and how it may differ between age groups, hypothesizing why adult patients have worse outcomes compared to children.
    Language English
    Publishing date 2023-10-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15205044
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