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Article: Spindle cell oncocytoma of the pituitary tumor: A rare case report and literature reviews.

Chang, Chia Ning / Shen, Chiung Chyi

2023 Volume 9, Page(s) 1021680

Abstract: Introduction: Spindle cell oncocytoma (SCO) of the pituitary gland is increasingly established with improvements in histological and immunohistochemical examination. However, the diagnosis was often mistaken based on imaging studies and nonspecific ... ...

Abstract	Introduction: Spindle cell oncocytoma (SCO) of the pituitary gland is increasingly established with improvements in histological and immunohistochemical examination. However, the diagnosis was often mistaken based on imaging studies and nonspecific clinical manifestations. Purpose: This case is presented to provide an overview of the characteristics of the rare tumor as well as to demonstrate the difficulties in diagnosis and current treatments. Clinical discussion: The pathogenesis of SCO remains unclear, and a possible origin was described. Further research is needed to optimize pre-operative diagnosis and surgical strategy. Conclusion: SCO should be considered when images indicate some features. Gross total resection (GTR) after surgery seems to have better long-term tumor control, and radiotherapy may help decrease tumor progression in patients with non-GTR. Regular follow-up is advised because of the higher recurrence rate.
Language	English
Publishing date	2023-01-30
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2022.1021680
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: An Alternative Cell Therapy for Cancers: Induced Pluripotent Stem Cell (iPSC)-Derived Natural Killer Cells.

Hsu, Li-Jie / Liu, Chao-Lin / Kuo, Ming-Ling / Shen, Chia-Ning / Shen, Chia-Rui

Biomedicines

2021 Volume 9, Issue 10

Abstract: Cell therapy is usually defined as the treatment or prevention of human disease by supplementation with cells that have been selected, manipulated, and pharmacologically treated or altered outside the body (ex vivo). Induced pluripotent stem cells (iPSCs) ...

Abstract	Cell therapy is usually defined as the treatment or prevention of human disease by supplementation with cells that have been selected, manipulated, and pharmacologically treated or altered outside the body (ex vivo). Induced pluripotent stem cells (iPSCs), with their unique characteristics of indefinite expansion in cultures and genetic modifications, represent an ideal cell source for differentiation into specialized cell types. Cell therapy has recently become one of the most promising therapeutic approaches for cancers, and different immune cell types are selected as therapeutic platforms. Natural killer (NK) cells are shown to be effective tumor cell killers and do not cause graft-vs-host disease (GVHD), making them excellent candidates for, and facilitating the development of, "off-the-shelf" cell therapies. In this review, we summarize the progress in the past decade in the advent of iPSC technology and review recent developments in gene-modified iPSC-NK cells as readily available "off-the-shelf" cellular therapies.
Language	English
Publishing date	2021-09-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines9101323
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Article ; Online: Effects of the media conditioned by various macrophage subtypes derived from THP-1 cells on tunneling nanotube formation in pancreatic cancer cells.

Lee, Chia-Wei / Kuo, Chia-Chen / Liang, Chi-Jung / Pan, Huei-Jyuan / Shen, Chia-Ning / Lee, Chau-Hwang

BMC molecular and cell biology

2022 Volume 23, Issue 1, Page(s) 26

Abstract: Background: Tunneling nanotubes (TNTs) are special membrane structures for intercellular communications. Vital cargoes (such as mitochondria) could be delivered from healthy cells to rescue damaged ones through TNTs. The TNTs could be utilized for the ... ...

Abstract	Background: Tunneling nanotubes (TNTs) are special membrane structures for intercellular communications. Vital cargoes (such as mitochondria) could be delivered from healthy cells to rescue damaged ones through TNTs. The TNTs could be utilized for the purpose of systematic delivery of therapeutic agents between cells. However, there are insufficient studies on the controlled enhancement of TNT formations. The purpose of this study is to understand how macrophages influence the TNT formation in cancer cells. Results: Here we compared the capabilities of inducing TNTs in human pancreatic cancer cells (PANC-1) of the media conditioned by M0, M1 and M2 macrophages derived from THP-1 cells. The M0 and M1 macrophage conditioned media promoted TNT formation. Using a focused ion beam to cut through a TNT, we observed tunnel-like structures inside dense cytoskeletons with scanning electron microscopy. The TNT formation correlated with raised motility, invasion, and epithelial-mesenchymal transition in the PANC-1 cells. Mitochondria and lysosomes were also found to be transported in the TNTs. Conclusions: These results suggest that TNT formation could be one of the responses to the immune stress in pancreatic cancer cells caused by M0 and M1 macrophages. This finding is valuable for the development of macrophage-targeting cancer therapy.
MeSH term(s)	Cell Membrane Structures ; Culture Media, Conditioned ; Humans ; Macrophages ; Nanotubes/chemistry ; Pancreatic Neoplasms ; THP-1 Cells
Chemical Substances	Culture Media, Conditioned ; Tunneling Nanotubes
Language	English
Publishing date	2022-07-06
Publishing country	England
Document type	Journal Article
ISSN	2661-8850
ISSN (online)	2661-8850
DOI	10.1186/s12860-022-00428-3
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Article ; Online: Inhibiting TLR7 Expression in the Retinal Pigment Epithelium Suppresses Experimental Autoimmune Uveitis.

Lo, Sheng-Min / Hwang, Yih-Shiou / Liu, Chao-Lin / Shen, Chia-Ning / Hong, Wei-Hsin / Yang, Wei-Cheng / Lee, Meng-Hua / Shen, Chia-Rui

Frontiers in immunology

2022 Volume 12, Page(s) 736261

Abstract: Experimental autoimmune uveitis (EAU), a model of human uveitis, is an organ-specific, T cell-mediated autoimmune disease. Autoreactive T cells can penetrate the blood-retinal barrier, which is a physical defense composed of tight junction-linked retinal ...

Abstract	Experimental autoimmune uveitis (EAU), a model of human uveitis, is an organ-specific, T cell-mediated autoimmune disease. Autoreactive T cells can penetrate the blood-retinal barrier, which is a physical defense composed of tight junction-linked retinal pigment epithelial (RPE) cells. RPE cells serve as antigen-presenting cells (APCs) in the eye since they express MHC class I and II and Toll-like receptors (TLRs). Although previous studies have shown that supplementation with TLR agonists exacerbates uveitis, little is known about how TLR signaling in the RPE contributes to the development of uveitis. In this study, we isolated the RPE from EAU mice, which were induced by active immunization (aEAU) or adoptive transfer of antigen-specific T cells (tEAU). The expression of TLRs on RPE was determined, and both aEAU and tEAU mice exhibited induced
MeSH term(s)	Animals ; Autoimmune Diseases/genetics ; Autoimmune Diseases/immunology ; Disease Models, Animal ; Gene Expression Regulation/immunology ; Imidazoles/pharmacology ; Membrane Glycoproteins/agonists ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/immunology ; Mice ; Retinal Pigment Epithelium/immunology ; Signal Transduction/genetics ; Signal Transduction/immunology ; Toll-Like Receptor 7/agonists ; Toll-Like Receptor 7/genetics ; Toll-Like Receptor 7/immunology ; Uveitis/genetics ; Uveitis/immunology
Chemical Substances	Imidazoles ; Membrane Glycoproteins ; Tlr7 protein, mouse ; Toll-Like Receptor 7 ; resiquimod (V3DMU7PVXF)
Language	English
Publishing date	2022-01-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.736261
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Article ; Online: Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy.

Huang, Yu-Kai / Cheng, Wei-Chung / Kuo, Ting-Ting / Yang, Juan-Cheng / Wu, Yang-Chang / Wu, Heng-Hsiung / Lo, Chia-Chien / Hsieh, Chih-Ying / Wong, Sze-Ching / Lu, Chih-Hao / Wu, Wan-Ling / Liu, Shih-Jen / Li, Yi-Chuan / Lin, Ching-Chan / Shen, Chia-Ning / Hung, Mien-Chie / Lin, Jaw-Town / Yeh, Chun-Chieh / Sher, Yuh-Pyng

Nature cancer

2024 Volume 5, Issue 3, Page(s) 400–419

Abstract: Kirsten rat sarcoma virus (KRAS) signaling drives pancreatic ductal adenocarcinoma (PDAC) malignancy, which is an unmet clinical need. Here, we identify a disintegrin and metalloproteinase domain (ADAM)9 as a modulator of PDAC progression via ... ...

Abstract	Kirsten rat sarcoma virus (KRAS) signaling drives pancreatic ductal adenocarcinoma (PDAC) malignancy, which is an unmet clinical need. Here, we identify a disintegrin and metalloproteinase domain (ADAM)9 as a modulator of PDAC progression via stabilization of wild-type and mutant KRAS proteins. Mechanistically, ADAM9 loss increases the interaction of KRAS with plasminogen activator inhibitor 1 (PAI-1), which functions as a selective autophagy receptor in conjunction with light chain 3 (LC3), triggering lysosomal degradation of KRAS. Suppression of ADAM9 by a small-molecule inhibitor restricts disease progression in spontaneous models, and combination with gemcitabine elicits dramatic regression of patient-derived tumors. Our findings provide a promising strategy to target the KRAS signaling cascade and demonstrate a potential modality to enhance sensitivity to chemotherapy in PDAC.
MeSH term(s)	Humans ; Proto-Oncogene Proteins p21(ras) ; Cell Proliferation ; Pancreatic Neoplasms/drug therapy ; Carcinoma, Pancreatic Ductal/drug therapy ; Gemcitabine ; Membrane Proteins/metabolism ; ADAM Proteins/metabolism ; ADAM Proteins/therapeutic use
Chemical Substances	Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; Gemcitabine ; KRAS protein, human ; ADAM9 protein, human (EC 3.4.24.-) ; Membrane Proteins ; ADAM Proteins (EC 3.4.24.-)
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article
ISSN	2662-1347
ISSN (online)	2662-1347
DOI	10.1038/s43018-023-00720-x
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Article ; Online: An Alternative Cell Therapy for Cancers

Li-Jie Hsu / Chao-Lin Liu / Ming-Ling Kuo / Chia-Ning Shen / Chia-Rui Shen

Biomedicines, Vol 9, Iss 1323, p

Induced Pluripotent Stem Cell (iPSC)-Derived Natural Killer Cells

2021 Volume 1323

Abstract	Cell therapy is usually defined as the treatment or prevention of human disease by supplementation with cells that have been selected, manipulated, and pharmacologically treated or altered outside the body (ex vivo). Induced pluripotent stem cells (iPSCs), with their unique characteristics of indefinite expansion in cultures and genetic modifications, represent an ideal cell source for differentiation into specialized cell types. Cell therapy has recently become one of the most promising therapeutic approaches for cancers, and different immune cell types are selected as therapeutic platforms. Natural killer (NK) cells are shown to be effective tumor cell killers and do not cause graft-vs-host disease (GVHD), making them excellent candidates for, and facilitating the development of, “off-the-shelf” cell therapies. In this review, we summarize the progress in the past decade in the advent of iPSC technology and review recent developments in gene-modified iPSC-NK cells as readily available “off-the-shelf” cellular therapies.
Keywords	induced pluripotent stem cells (iPSCs) ; natural killer cells (NK cells) ; cell therapy ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Harnessing natural-product-inspired combinatorial chemistry and computation-guided synthesis to develop

Chen, Wei-An / Chen, Yu-Hsin / Hsieh, Chiao-Yun / Hung, Pi-Fang / Chen, Chiao-Wen / Chen, Chien-Hung / Lin, Jung-Lee / Cheng, Ting-Jen R / Hsu, Tsui-Ling / Wu, Ying-Ta / Shen, Chia-Ning / Cheng, Wei-Chieh

Chemical science

2022 Volume 13, Issue 21, Page(s) 6233–6243

Abstract: Modulation ... ...

Abstract	Modulation of
Language	English
Publishing date	2022-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d1sc05894k
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Article: A Few-Shot Learning Approach Assists in the Prognosis Prediction of Magnetic Resonance-Guided Focused Ultrasound for the Local Control of Bone Metastatic Lesions.

Hsu, Fang-Chi / Lee, Hsin-Lun / Chen, Yin-Ju / Shen, Yao-An / Tsai, Yi-Chieh / Wu, Meng-Huang / Kuo, Chia-Chun / Lu, Long-Sheng / Yeh, Shauh-Der / Huang, Wen-Sheng / Shen, Chia-Ning / Chiou, Jeng-Fong

Cancers

2022 Volume 14, Issue 2

Abstract: Magnetic resonance-guided focused ultrasound surgery (MRgFUS) constitutes a noninvasive treatment strategy to ablate deep-seated bone metastases. However, limited evidence suggests that, although cytokines are influenced by thermal necrosis, there is ... ...

Abstract	Magnetic resonance-guided focused ultrasound surgery (MRgFUS) constitutes a noninvasive treatment strategy to ablate deep-seated bone metastases. However, limited evidence suggests that, although cytokines are influenced by thermal necrosis, there is still no cytokine threshold for clinical responses. A prediction model to approximate the postablation immune status on the basis of circulating cytokine activation is thus needed. IL-6 and IP-10, which are proinflammatory cytokines, decreased significantly during the acute phase. Wound-healing cytokines such as VEGF and PDGF increased after ablation, but the increase was not statistically significant. In this phase, IL-6, IL-13, IP-10, and eotaxin expression levels diminished the ongoing inflammatory progression in the treated sites. These cytokine changes also correlated with the response rate of primary tumor control after acute periods. The few-shot learning algorithm was applied to test the correlation between cytokine levels and local control (
Language	English
Publishing date	2022-01-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14020445
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Article ; Online: Transparent tissue in solid state for solvent-free and antifade 3D imaging.

Hsiao, Fu-Ting / Chien, Hung-Jen / Chou, Ya-Hsien / Peng, Shih-Jung / Chung, Mei-Hsin / Huang, Tzu-Hui / Lo, Li-Wen / Shen, Chia-Ning / Chang, Hsiu-Pi / Lee, Chih-Yuan / Chen, Chien-Chia / Jeng, Yung-Ming / Tien, Yu-Wen / Tang, Shiue-Cheng

Nature communications

2023 Volume 14, Issue 1, Page(s) 3395

Abstract: Optical clearing with high-refractive-index (high-n) reagents is essential for 3D tissue imaging. However, the current liquid-based clearing condition and dye environment suffer from solvent evaporation and photobleaching, causing difficulties in ... ...

Abstract	Optical clearing with high-refractive-index (high-n) reagents is essential for 3D tissue imaging. However, the current liquid-based clearing condition and dye environment suffer from solvent evaporation and photobleaching, causing difficulties in maintaining the tissue optical and fluorescent features. Here, using the Gladstone-Dale equation [(n-1)/density=constant] as a design concept, we develop a solid (solvent-free) high-n acrylamide-based copolymer to embed mouse and human tissues for clearing and imaging. In the solid state, the fluorescent dye-labeled tissue matrices are filled and packed with the high-n copolymer, minimizing scattering in in-depth imaging and dye fading. This transparent, liquid-free condition provides a friendly tissue and cellular environment to facilitate high/super-resolution 3D imaging, preservation, transfer, and sharing among laboratories to investigate the morphologies of interest in experimental and clinical conditions.
MeSH term(s)	Mice ; Humans ; Animals ; Imaging, Three-Dimensional/methods ; Solvents ; Fluorescent Dyes ; Acrylamide ; Optical Imaging
Chemical Substances	Solvents ; Fluorescent Dyes ; Acrylamide (20R035KLCI)
Language	English
Publishing date	2023-06-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-39082-4
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Article ; Online: Effect of species, muscle location, food processing and refrigerated storage on the fish allergens, tropomyosin and parvalbumin.

Tsai, Chia-Lin / Perng, Kristy / Hou, Yu-Chen / Shen, Cheng-Jou / Chen, I-Ning / Chen, Yi-Tien

Food chemistry

2022 Volume 402, Page(s) 134479

Abstract: Fish tropomyosin is a latest identified fish allergen without full understanding of its biochemical characteristics from the perspective of food allergen. Accordingly, the objective of this study was to investigate the effects of species, muscle location, ...

Abstract	Fish tropomyosin is a latest identified fish allergen without full understanding of its biochemical characteristics from the perspective of food allergen. Accordingly, the objective of this study was to investigate the effects of species, muscle location, food processing, and refrigerated storage on fish tropomyosin and compare with main fish allergen, parvalbumin. The result of mass spectrometry analysis revealed tropomyosin as the most abundant thermally stable protein in fish muscle. Fish tropomyosin was ubiquitous among all 28 edible fish species tested, abundant in fish skeletal muscle, resistant to common food processing, and resistant to refrigerated storage up to six days. By contrast, parvalbumin content varied between fish species and was not as thermally stable as tropomyosin under autoclaving. This study demonstrates the intrinsic and processing factors affecting fish allergens and provides valuable information for the presence of major fish allergens and practical consideration of fish allergen detection.
MeSH term(s)	Animals ; Allergens/analysis ; Tropomyosin/chemistry ; Parvalbumins ; Food Hypersensitivity ; Fishes ; Muscles/chemistry ; Food Handling
Chemical Substances	Allergens ; Tropomyosin ; Parvalbumins
Language	English
Publishing date	2022-10-01
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2022.134479
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