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  1. Article: [Observation of effect of Wu Yun Liu Qi on reproductive hormones in varicocele patients].

    Shi, Qing-Jing / Pan, Lian-Jun / Pan, Feng / Zhao, Dan / Zhang, Xing-Yuan / Li, Hai-Bo / Liao, Kai / Zhang, Feng-Lei

    Zhonghua nan ke xue = National journal of andrology

    2024  Volume 29, Issue 12, Page(s) 1018–1021

    Abstract: ... of Wu Yun Liu Qi, and explore whether the cycle had effect on the roproductive hormone levels. Methods ... in 2016 than other years except 2018 and 2020( All P< 0.05). Conclusions: Shi Xiang factors of Wu Yun Liu ...

    Abstract Objective: To observe roproductive hormone levels in varicocele patients during a cycle (6 years) of Wu Yun Liu Qi, and explore whether the cycle had effect on the roproductive hormone levels. Methods: Data of roproductive hormone levels in varicocele patients from 2015 to 2020 were analyzed retrospectively. FSH、LH、T、PRL、E2 levels and T/E2 ratio were compared among the six years. According to Chinese sexagenary cycle heavenly stems and earthly branches of each year from 2015 to 2020 its yunqi characteristics were determined. Results: Totally data of 848 cases of varicocele patients were collected from 2015 to 2020. Among which, in 2015 (Yiwei year) there were 57 cases, in 2016 (Bingshen year) 83 cases, in 2017 (Dingyou year ) 133 cases, in 2018(Wuxu year) 156 cases, in 2019(Sihai year) 274 cases, and in 2020(Gengzi year) 145 cases. The levels of FSH、LH、PRL、T were not diferrent statistically from the six years except individual year. However, the level of E2 in 2016 when the Yunqi was Shao Yang Xiang Huo Si Tian and Jue Yin Feng Mu Zai Quan obviously higher than other years excpet 2018( All P< 0.05). And T/E2 ratio was lower in 2016 than other years except 2018 and 2020( All P< 0.05). Conclusions: Shi Xiang factors of Wu Yun Liu Qi had effect on roproductive hormone levels in varicocele patients, showing by higher E2 level in Yinshen year when the Shi Xiang factors may have bad effect on human fertility.
    MeSH term(s) Male ; Humans ; Qi ; Varicocele ; Retrospective Studies ; Follicle Stimulating Hormone
    Chemical Substances Follicle Stimulating Hormone (9002-68-0)
    Language Chinese
    Publishing date 2024-04-19
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2267480-9
    ISSN 1009-3591
    ISSN 1009-3591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Yun/Prohibitin complex regulates adult

    Zhao, Hang / Shi, Lin / Li, Zhengran / Kong, Ruiyan / Ren, Xuejing / Ma, Rui / Jia, Lemei / Ma, Meifang / Lu, Shan / Xu, Ran / Binari, Richard / Wang, Jian-Hua / Dong, Meng-Qiu / Perrimon, Norbert / Li, Zhouhua

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 6

    Abstract: Stem cells constantly divide and differentiate to maintain adult tissue homeostasis, and uncontrolled stem cell proliferation leads to severe diseases such as cancer. How stem cell proliferation is precisely controlled remains poorly understood. Here, ... ...

    Abstract Stem cells constantly divide and differentiate to maintain adult tissue homeostasis, and uncontrolled stem cell proliferation leads to severe diseases such as cancer. How stem cell proliferation is precisely controlled remains poorly understood. Here, from an RNA interference (RNAi) screen in adult
    MeSH term(s) Adult Stem Cells/metabolism ; Animals ; Animals, Genetically Modified ; Cell Differentiation/physiology ; Cell Proliferation/physiology ; Drosophila Proteins/metabolism ; Drosophila melanogaster/metabolism ; E2F1 Transcription Factor/metabolism ; Homeostasis/physiology ; Intestines/metabolism ; Prohibitins/metabolism ; RNA Interference/physiology ; Signal Transduction/physiology
    Chemical Substances Drosophila Proteins ; E2F1 Transcription Factor ; Prohibitins
    Language English
    Publishing date 2022-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2111711119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Phosphorylation of Yun is required for stem cell proliferation and tumorigenesis.

    Ren, Xuejing / Zhao, Hang / Shi, Lin / Li, Zhengran / Kong, Ruiyan / Ma, Rui / Jia, Lemei / Lu, Shan / Wang, Jian-Hua / Dong, Meng-Qiu / Wang, Yingchun / Li, Zhouhua

    Cell proliferation

    2022  Volume 55, Issue 5, Page(s) e13230

    Abstract: ... understood. Phosphorylation of Yun is essential for ISC proliferation. Yun is essential for the proliferation ... of normal and transformed intestinal stem cells. Our mass spectrometry and biochemical data suggest that Yun ... among these residues is likely interdependent. Furthermore, phosphorylation of each residue in Yun is important ...

    Abstract Stem cells maintain adult tissue homeostasis under physiological conditions. Uncontrolled stem cell proliferation will lead to tumorigenesis. How stem cell proliferation is precisely controlled is still not fully understood. Phosphorylation of Yun is essential for ISC proliferation. Yun is essential for the proliferation of normal and transformed intestinal stem cells. Our mass spectrometry and biochemical data suggest that Yun can be phosphorylated at multiple residues in vivo. Interestingly, we show that the phosphorylation among these residues is likely interdependent. Furthermore, phosphorylation of each residue in Yun is important for its function in ISC proliferation regulation. Thus, our study unveils the important role of post-translational modification of Yun in stem cell proliferation.
    MeSH term(s) Adult ; Cell Proliferation ; Cell Transformation, Neoplastic ; Drosophila Proteins/metabolism ; Humans ; Intestines ; Phosphorylation
    Chemical Substances Drosophila Proteins
    Language English
    Publishing date 2022-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1064202-x
    ISSN 1365-2184 ; 0008-8730 ; 0960-7722
    ISSN (online) 1365-2184
    ISSN 0008-8730 ; 0960-7722
    DOI 10.1111/cpr.13230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Novel intrinsic factor Yun maintains female germline stem cell fate through Thickveins.

    Zhao, Hang / Li, Zhengran / Kong, Ruiyan / Shi, Lin / Ma, Rui / Ren, Xuejing / Li, Zhouhua

    Stem cell reports

    2022  Volume 17, Issue 9, Page(s) 1914–1923

    Abstract: ... is not fully understood. Here, we find that the novel intrinsic factor Yun is required for female GSC ... factor Bam by defective BMP/Dpp signaling in the absence of yun. Mechanistically, Yun associates with and ...

    Abstract Germline stem cells (GSCs) are critical for the reproduction of an organism. The self-renewal and differentiation of GSCs must be tightly controlled to avoid uncontrolled stem cell proliferation or premature stem cell differentiation. However, how the self-renewal and differentiation of GSCs are properly controlled is not fully understood. Here, we find that the novel intrinsic factor Yun is required for female GSC maintenance in Drosophila. GSCs undergo precocious differentiation due to de-repression of differentiation factor Bam by defective BMP/Dpp signaling in the absence of yun. Mechanistically, Yun associates with and stabilizes Thickveins (Tkv), the type I receptor of Dpp/BMP signaling. Finally, ectopic expression of a constitutively active Tkv (Tkv
    MeSH term(s) Animals ; Cell Differentiation/physiology ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Female ; Germ Cells ; Intrinsic Factor/metabolism ; Oogonial Stem Cells/metabolism ; Ovary/metabolism ; Protein Serine-Threonine Kinases ; Receptors, Cell Surface/metabolism
    Chemical Substances Drosophila Proteins ; Receptors, Cell Surface ; dpp protein, Drosophila ; Intrinsic Factor (9008-12-2) ; tkv protein, Drosophila (EC 2.7.1.-) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2022-08-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2022.07.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Letter by Lei Wang and Yun-Tao Zhao Regarding Article, "Young Male With Incessantly Wide Complex Tachycardia: What Is the Substrate of the Arrhythmia?"

    Wang, Lei / Zhao, Yun-Tao

    Circulation

    2018  Volume 138, Issue 2, Page(s) 211

    MeSH term(s) Arrhythmias, Cardiac ; Humans ; Male ; Tachycardia
    Language English
    Publishing date 2018-07-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.118.034580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Erratum: SHUO QI, ZHI-TONG LYU, JIAN WANG, YUN-MING MO, ZHAO-CHI ZENG, YANG-JIN ZENG, KE-YUAN DAI, YUAN-QIU LI, L. LEE GRISMER amp; YING-YONG WANG (2022) Three new species of the genus Boulenophrys (Anura, Megophryidae) from southern China. Zootaxa, 5072: 401438.

    Qi, Shuo / Lyu, Zhi-Tong / Wang, Jian / Mo, Yun-Ming / Zeng, Zhao-Chi / Zeng, Yang-Jin / Dai, Ke-Yuan / Li, Yuan-Qiu / Grismer, L Lee / Wang, Ying-Yong

    Zootaxa

    2022  Volume 5115, Issue 4, Page(s) 600

    Language English
    Publishing date 2022-03-16
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.5115.4.10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Dissecting the Underlying Pharmaceutical Mechanism of Chinese Traditional Medicine Yun-Pi-Yi-Shen-Tong-Du-Tang Acting on Ankylosing Spondylitis through Systems Biology Approaches.

    Xie, Duoli / Huang, Lin / Zhao, Guanghui / Yu, Yiran / Gao, Jiawei / Li, Haichang / Wen, Chengping

    Scientific reports

    2017  Volume 7, Issue 1, Page(s) 13436

    Abstract: ... Spondylitis (AS) treatment for a long time. Yun-Pi-Yi-Shen-Tong-Du-Tang (Y-Y-T) is a novel empirical formula ...

    Abstract Traditional Chinese Medicine (TCM) has been served as complementary medicine for Ankylosing Spondylitis (AS) treatment for a long time. Yun-Pi-Yi-Shen-Tong-Du-Tang (Y-Y-T) is a novel empirical formula designed by Prof. Chengping Wen. In this study, a retrospective investigation supported efficacy of Y-Y-T and then we deciphered the underlying molecular mechanism of the efficacy. Herbal ingredients and targeting proteins were collected from TCMID. PPI networks were constructed to further infer the relationship among Y-Y-T, drugs used for treating AS, differentially expressed genes of AS patients and AS disease proteins. Finally, it was suggested that TLR signaling pathway and T cell receptor signaling pathway may involve in the biological processes of AS progression and contribute to the curative effect and proteins such as JAK2, STAT3, HSP90AA1, TNF and PTEN were the key targets. Our systemic investigation to infer therapeutic mechanism of Y-Y-T for AS treatment provides a new insight in understanding TCM pharmacology.
    MeSH term(s) Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; HSP90 Heat-Shock Proteins/metabolism ; Humans ; Janus Kinase 2/metabolism ; PTEN Phosphohydrolase/metabolism ; STAT3 Transcription Factor/metabolism ; Signal Transduction/drug effects ; Spondylitis, Ankylosing/drug therapy ; Systems Biology ; Toll-Like Receptors/metabolism ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Drugs, Chinese Herbal ; HSP90 Heat-Shock Proteins ; HSP90AA1 protein, human ; STAT3 Transcription Factor ; STAT3 protein, human ; Toll-Like Receptors ; Tumor Necrosis Factor-alpha ; JAK2 protein, human (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2) ; PTEN Phosphohydrolase (EC 3.1.3.67) ; PTEN protein, human (EC 3.1.3.67)
    Language English
    Publishing date 2017-10-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-017-13723-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Dissecting the Underlying Pharmaceutical Mechanism of Chinese Traditional Medicine Yun-Pi-Yi-Shen-Tong-Du-Tang Acting on Ankylosing Spondylitis through Systems Biology Approaches

    Duoli Xie / Lin Huang / Guanghui Zhao / Yiran Yu / Jiawei Gao / Haichang Li / Chengping Wen

    Scientific Reports, Vol 7, Iss 1, Pp 1-

    2017  Volume 9

    Abstract: ... for Ankylosing Spondylitis (AS) treatment for a long time. Yun-Pi-Yi-Shen-Tong-Du-Tang (Y-Y-T) is a novel ...

    Abstract Abstract Traditional Chinese Medicine (TCM) has been served as complementary medicine for Ankylosing Spondylitis (AS) treatment for a long time. Yun-Pi-Yi-Shen-Tong-Du-Tang (Y-Y-T) is a novel empirical formula designed by Prof. Chengping Wen. In this study, a retrospective investigation supported efficacy of Y-Y-T and then we deciphered the underlying molecular mechanism of the efficacy. Herbal ingredients and targeting proteins were collected from TCMID. PPI networks were constructed to further infer the relationship among Y-Y-T, drugs used for treating AS, differentially expressed genes of AS patients and AS disease proteins. Finally, it was suggested that TLR signaling pathway and T cell receptor signaling pathway may involve in the biological processes of AS progression and contribute to the curative effect and proteins such as JAK2, STAT3, HSP90AA1, TNF and PTEN were the key targets. Our systemic investigation to infer therapeutic mechanism of Y-Y-T for AS treatment provides a new insight in understanding TCM pharmacology.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2017-10-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Book ; Online: Deux cultures, deux niveaux d' exposition au risque de SIDA / Marco Shuguang Wang, Melissa Yun Gao et Jainwei Zhao

    Shuguang Wang, Marco / Yun Gao, Melissa / Zhao, Jianwei

    1999  

    Keywords Acquired immunodeficiency syndrome ; Employment ; Sexual behavior ; Risk factors ; Cross-cultural comparison ; Cohort studies ; China ; AIDS and its Control ; prevention and control
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Journal ; Article ; Online: Deux cultures, deux niveaux d' exposition au risque de SIDA / Marco Shuguang Wang, Melissa Yun Gao et Jainwei Zhao

    Shuguang Wang, Marco / Yun Gao, Melissa / Zhao, Jianwei

    1999  

    Keywords Acquired Immunodeficiency Syndrome ; Employment ; Sexual Behavior ; Risk Factors ; Cross-Cultural Comparison ; Cohort Studies ; China ; AIDS and its Control ; prevention and control
    Language French
    Document type Journal ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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