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Article ; Online: Building the Bridge to a Participatory Citizenship: Curricular Integration of Communal Environmental Issues in School Projects Supported by the Internet of Things.

Santos, Manuel J S / Carlos, Vânia / Moreira, António A

2023 Volume 23, Issue 6

Abstract: Generally, there is much to praise about the rise in acknowledging the need for young citizens to exercise their rights and duties, but the belief remains that this is not yet entrenched in young citizens' overall democratic involvement. A lack of ... ...

Abstract	Generally, there is much to praise about the rise in acknowledging the need for young citizens to exercise their rights and duties, but the belief remains that this is not yet entrenched in young citizens' overall democratic involvement. A lack of citizenship and engagement in community issues was revealed by a recent study conducted by the authors in a secondary school from the outskirts of Aveiro, Portugal, during the 2019/2020 school year. Under the umbrella of a Design-Based Research methodological framework, citizen science strategies were implemented in the context of teaching, learning, and assessment, and at the service of the educational project of the target school, in a STEAM approach, and under Domains of Curricular Autonomy activities. The study's findings suggest that to build the bridge for participatory citizenship, teachers should engage students in collecting and analyzing data regarding communal environmental issues in a Citizen Science approach supported by the Internet of Things. The new pedagogies addressing the lack of citizenship and engagement in community issues promoted students' involvement at school and in the community, contributed to inform municipal education policies, and promoted dialogue and communication between local actors.
MeSH term(s)	Humans ; Citizenship ; Internet of Things ; Schools ; Citizen Science ; Exercise
Language	English
Publishing date	2023-03-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23063070
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Age-Dependent Alterations in Semen Parameters and Human Sperm MicroRNA Profile.

Santiago, Joana / Silva, Joana V / Santos, Manuel A S / Fardilha, Margarida

Biomedicines

2023 Volume 11, Issue 11

Abstract: The trend to delay parenthood is increasing, impacting fertility and reproductive outcomes. Advanced paternal age (APA), defined as men's age above 40 years at conception, has been linked with testicular impairment, abnormal semen parameters, and poor ... ...

Abstract	The trend to delay parenthood is increasing, impacting fertility and reproductive outcomes. Advanced paternal age (APA), defined as men's age above 40 years at conception, has been linked with testicular impairment, abnormal semen parameters, and poor reproductive and birth outcomes. Recently, the significance of sperm microRNA for fertilization and embryonic development has emerged. This work aimed to investigate the effects of men's age on semen parameters and sperm microRNA profiles. The ejaculates of 333 Portuguese men were collected between 2018 and 2022, analyzed according to WHO guidelines, and a density gradient sperm selection was performed. For microRNA expression analysis, 16 normozoospermic human sperm samples were selected and divided into four age groups: ≤30, 31-35, 36-40, and >40 years. microRNA target genes were retrieved from the miRDB and TargetScan databases and Gene Ontology analysis was performed using the DAVID tool. No significant correlation was found between male age and conventional semen parameters, except for volume. Fifteen differentially expressed microRNAs (DEMs) between groups were identified. Enrichment analysis suggested the involvement of DEMs in the sperm of men with advanced age in critical biological processes like embryonic development, morphogenesis, and male gonad development. Targets of DEMs were involved in signaling pathways previously associated with the ageing process, including cellular senescence, autophagy, insulin, and mTOR pathways. These results suggest that although conventional semen parameters were not affected by men's age, alterations in microRNA regulation may occur and be responsible for poor fertility and reproductive outcomes associated with APA.
Language	English
Publishing date	2023-10-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11112923
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Article: Promoting advanced medical services in the framework of 3PM-a proof-of-concept by the "Centro" Region of Portugal.

Regateiro, Fernando J / Silva, Henriqueta / Lemos, Manuel C / Moura, Gabriela / Torres, Pedro / Pereira, André Dias / Dias, Luís / Ferreira, Pedro L / Amaral, Sara / Santos, Manuel A S

The EPMA journal

2024 Volume 15, Issue 1, Page(s) 135–148

Abstract: Multidisciplinary team from three universities based in the "Centro" Region of Portugal developed diverse approaches as parts of a project dedicated to enhancing and expanding Predictive, Preventive, and Personalized Medicine (3PM) in the Region. In a ... ...

Abstract	Multidisciplinary team from three universities based in the "Centro" Region of Portugal developed diverse approaches as parts of a project dedicated to enhancing and expanding Predictive, Preventive, and Personalized Medicine (3PM) in the Region. In a sense, outcomes acted as a proof-of-concept, in that they demonstrated the feasibility, but also the relevance of the approaches. The accomplishments comprise defining a new regional strategy for implementing 3PM within the Region, training of human resources in genomic sequencing, and generating good practices handbooks dedicated to diagnostic testing via next-generation sequencing, to legal and ethical concerns, and to knowledge transfer and entrepreneurship, aimed at increasing literacy on 3PM approaches. Further approaches also included support for entrepreneurship development and start-ups, and diverse and relevant initiatives aimed at increasing literacy relevant to 3PM. Efforts to enhance literacy encompassed citizens across the board, from patients and high school students to health professionals and health students. This focus on empowerment through literacy involved a variety of initiatives, including the creation of an illustrated book on genomics and the production of two theater plays centered on genetics. Additionally, authors stressed that genomic tools are relevant, but they are not the only resources 3PM is based on. Thus, they defend that other initiatives intended to enable citizens to take 3PM should include multi-omics and, having in mind the socio-economic burden of chronic diseases, suboptimal health status approaches in the 3PM framework should also be considered, in order to anticipate medical intervention in the subclinical phase. Supplementary information: The online version contains supplementary material available at 10.1007/s13167-024-00353-9.
Language	English
Publishing date	2024-02-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2545928-4
ISSN	1878-5085 ; 1878-5077
ISSN (online)	1878-5085
ISSN	1878-5077
DOI	10.1007/s13167-024-00353-9
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Article: Improved Operation of Chloralkaline Reversible Cells with Mixed Metal Oxide Electrodes Made Using Microwaves.

Ribeiro, Jamylle Y C / Santos, Gessica O S / Dória, Aline R / Requena, Iñaki / Lanza, Marcos R V / Salazar-Banda, Giancarlo R / Eguiluz, Katlin I B / Lobato, Justo / Rodrigo, Manuel A

Nanomaterials (Basel, Switzerland)

2024 Volume 14, Issue 8

Abstract: This study focuses on the synthesis of mixed metal oxide anodes (MMOs) with the composition Ti/ ... ...

Abstract	This study focuses on the synthesis of mixed metal oxide anodes (MMOs) with the composition Ti/RuO
Language	English
Publishing date	2024-04-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano14080693
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Article ; Online: Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity.

Vicente, Manuel M / Alves, Inês / Fernandes, Ângela / Dias, Ana M / Santos-Pereira, Beatriz / Pérez-Anton, Elena / Santos, Sofia / Yang, Tao / Correia, Alexandra / Münster-Kühnel, Anja / Almeida, Afonso R M / Ravens, Sarina / Rabinovich, Gabriel A / Vilanova, Manuel / Sousa, Ana E / Pinho, Salomé S

Cellular & molecular immunology

2023 Volume 20, Issue 8, Page(s) 955–968

Abstract: T-cell development ensures the formation of diverse repertoires of T-cell receptors (TCRs) that recognize a variety of antigens. Glycosylation is a major posttranslational modification present in virtually all cells, including T-lymphocytes, that ... ...

Abstract	T-cell development ensures the formation of diverse repertoires of T-cell receptors (TCRs) that recognize a variety of antigens. Glycosylation is a major posttranslational modification present in virtually all cells, including T-lymphocytes, that regulates activity/functions. Although these structures are known to be involved in TCR-selection in DP thymocytes, it is unclear how glycans regulate other thymic development processes and how they influence susceptibility to disease. Here, we discovered stage-specific glycome compositions during T-cell development in human and murine thymocytes, as well as dynamic alterations. After restricting the N-glycosylation profile of thymocytes to high-mannose structures, using specific glycoengineered mice (Rag1
MeSH term(s)	Mice ; Animals ; Humans ; Glycosylation ; Thymocytes ; Thymus Gland ; Receptors, Antigen, T-Cell/metabolism ; Homeodomain Proteins/genetics ; Polysaccharides
Chemical Substances	Receptors, Antigen, T-Cell ; Homeodomain Proteins ; Polysaccharides
Language	English
Publishing date	2023-06-21
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2435097-7
ISSN	2042-0226 ; 1672-7681
ISSN (online)	2042-0226
ISSN	1672-7681
DOI	10.1038/s41423-023-01052-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Efficient adeno-associated virus serotype 5 capture with affinity functionalized nanofiber adsorbents.

Neto, Salomé / Mendes, João P / Santos, Susana B Dos / Solbrand, Anita / Carrondo, Manuel J T / Peixoto, Cristina / Silva, Ricardo J S

Frontiers in bioengineering and biotechnology

2023 Volume 11, Page(s) 1183974

Abstract: ... dynamic binding capacity, pressure drop, and AAV5 recovery at residence times (RT) less than 5 s ...

Abstract	Adeno-associated viruses (AAVs) are one of the most promising tools for gene therapy applications. These vectors are purified using affinity and ion exchange chromatography, typically using packed beds of resin adsorbents. This leads to diffusion and pressure drop limitations that affect process productivity. Due to their high surface area and porosity, electrospun nanofiber adsorbents offer mass transfer and flow rate advantages over conventional chromatographic media. The present work investigated the use of affinity cellulose-based nanofiber adsorbents for adeno-associated virus serotype 5 (AAV5) capture, evaluating dynamic binding capacity, pressure drop, and AAV5 recovery at residence times (RT) less than 5 s. The dynamic binding capacity was found to be residence time-dependent, but nevertheless higher than 1.0 × 10
Language	English
Publishing date	2023-05-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1183974
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Article ; Online: Synthesis of Bis(3-indolyl)methanes Mediated by Potassium tert-Butoxide.

Santos, A Sofia / Ferro, Rita D / Viduedo, Nuno / Maia, Luísa B / Silva, Artur M S / Marques, M Manuel B

ChemistryOpen

2023 Volume 12, Issue 1, Page(s) e202200265

Abstract: The indole moiety is an important N-heterocycle found in natural products, and a key structural component of many value-added chemicals including pharmaceuticals. In particular, bis(3-indolyl)methanes (BIMs) are an important subgroup of indoles, composed ...

Abstract	The indole moiety is an important N-heterocycle found in natural products, and a key structural component of many value-added chemicals including pharmaceuticals. In particular, bis(3-indolyl)methanes (BIMs) are an important subgroup of indoles, composed of two indole units. Herein, we report the development of a simple method to access BIMs derivatives in yields of up to 77 % by exploiting a tBuOK-mediated coupling reaction of indoles and benzyl alcohols.
MeSH term(s)	Methane/chemistry ; Butanols ; Indoles/chemistry
Chemical Substances	tert-butoxide, potassium (865-47-4) ; Methane (OP0UW79H66) ; Butanols ; Indoles
Language	English
Publishing date	2023-01-17
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2655605-4
ISSN	2191-1363 ; 2191-1363
ISSN (online)	2191-1363
ISSN	2191-1363
DOI	10.1002/open.202200265
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Poly(ethylene imine)-chitosan carbon dots: study of its physical-chemical properties and biological in vitro performance.

Santos, Nicolás / Valenzuela, Santiago / Segura, Camilo / Osorio-Roman, Igor / Arrázola, Macarena S / Panadero-Medianero, Concepción / Santana, Paula A / Ahumada, Manuel

Discover nano

2023 Volume 18, Issue 1, Page(s) 129

Abstract: Carbon dots (CDs) have been quickly extended for nanomedicine uses because of their multiple applications, such as bioimaging, sensors, and drug delivery. However, the interest in increasing their photoluminescence properties is not always accompanied by ...

Abstract	Carbon dots (CDs) have been quickly extended for nanomedicine uses because of their multiple applications, such as bioimaging, sensors, and drug delivery. However, the interest in increasing their photoluminescence properties is not always accompanied by cytocompatibility. Thus, a knowledge gap exists regarding their interactions with biological systems linked to the selected formulations and synthesis methods. In this work, we have developed carbon dots (CDs) based on poly (ethylene imine) (PEI) and chitosan (CS) by using microwave irradiation, hydrothermal synthesis, and a combination of both, and further characterized them by physicochemical and biological means. Our results indicate that synthesized CDs have sizes between 1 and 5 nm, a high presence of amine groups on the surface, and increased positive ζ potential values. Further, it is established that the choice and use of different synthesis procedures can contribute to a different answer to the CDs regarding their optical and biological properties. In this regard, PEI-only CDs showed the longest photoluminescent emission lifetime, non-hemolytic activity, and high toxicity against fibroblast. On the other hand, CS-only CDs have higher PL emission, non-cytotoxicity associated with fibroblast, and high hemolytic activity. Interestingly, their combination using the proposed methodologies allow a synergic effect in their CDs properties. Therefore, this work contributes to developing and characterizing CD formulations based on PEI and CS and better understanding the CD's properties and biological interaction.
Language	English
Publishing date	2023-10-17
Publishing country	Switzerland
Document type	Journal Article
ISSN	2731-9229
ISSN (online)	2731-9229
DOI	10.1186/s11671-023-03907-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Fighting Bisphenol A-Induced Male Infertility: The Power of Antioxidants.

Santiago, Joana / Silva, Joana V / Santos, Manuel A S / Fardilha, Margarida

Antioxidants (Basel, Switzerland)

2021 Volume 10, Issue 2

Abstract: Bisphenol A (BPA), a well-known endocrine disruptor present in epoxy resins and polycarbonate plastics, negatively disturbs the male reproductive system affecting male fertility. In vivo studies showed that BPA exposure has deleterious effects on ... ...

Abstract	Bisphenol A (BPA), a well-known endocrine disruptor present in epoxy resins and polycarbonate plastics, negatively disturbs the male reproductive system affecting male fertility. In vivo studies showed that BPA exposure has deleterious effects on spermatogenesis by disturbing the hypothalamic-pituitary-gonadal axis and inducing oxidative stress in testis. This compound seems to disrupt hormone signalling even at low concentrations, modifying the levels of inhibin B, oestradiol, and testosterone. The adverse effects on seminal parameters are mainly supported by studies based on urinary BPA concentration, showing a negative association between BPA levels and sperm concentration, motility, and sperm DNA damage. Recent studies explored potential approaches to treat or prevent BPA-induced testicular toxicity and male infertility. Since the effect of BPA on testicular cells and spermatozoa is associated with an increased production of reactive oxygen species, most of the pharmacological approaches are based on the use of natural or synthetic antioxidants. In this review, we briefly describe the effects of BPA on male reproductive health and discuss the use of antioxidants to prevent or revert the BPA-induced toxicity and infertility in men.
Language	English
Publishing date	2021-02-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10020289
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: From data to action: a scoping review of wearable technologies and biomechanical assessments informing injury prevention strategies in sport.

Rebelo, André / Martinho, Diogo V / Valente-Dos-Santos, João / Coelho-E-Silva, Manuel J / Teixeira, Diogo S

BMC sports science, medicine & rehabilitation

2023 Volume 15, Issue 1, Page(s) 169

Abstract: Background: The purpose of this scoping review was to evaluate the current use of technologies in sports settings for training adaptation and injury prevention. The review aimed to map the existing literature, identify key concepts and themes, and ... ...

Abstract	Background: The purpose of this scoping review was to evaluate the current use of technologies in sports settings for training adaptation and injury prevention. The review aimed to map the existing literature, identify key concepts and themes, and highlight gaps in research, thus offering guidance for future studies. Methods: This study followed the guidelines of the PRISMA extension for scoping reviews and a search in four major databases was conducted. Results: A total of 21 studies were included. The findings highlighted the widespread use of various technologies, including wearable devices and force plates, to monitor athletes' performance and inform evidence-based decision-making in training and injury prevention. Variables such as Player Load, changes of direction, and acute chronic workload ratio were identified as key metrics in injury prediction. Conclusions: This review uncovers a dynamic field of research in athlete injury prevention, emphasizing the extensive use of varied technologies. A key finding is the pivotal role of Player Load data, which offers nuanced insights for customizing training loads according to sport-specific demands, player positions, and the physical requirements of various activities. Additionally, the review sheds light on the utility of tools like force plates in assessing fatigue, aiding recovery, and steering injury rehabilitation, particularly in sports prone to knee and ankle injuries. These insights not only enhance our understanding of injury prevention but also provide a strategic direction for future research, aiming to boost athlete safety, performance, and career longevity.
Language	English
Publishing date	2023-12-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2719537-5
ISSN	2052-1847
ISSN	2052-1847
DOI	10.1186/s13102-023-00783-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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