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  1. Article ; Online: Estimation of two wear factors for total hip arthroplasty: A simulation study based on musculoskeletal modelling.

    Moissenet, Florent / Beauseroy, Victor / Gasparutto, Xavier / Armand, Stéphane / Hannouche, Didier / Dumas, Raphaël

    Clinical biomechanics (Bristol, Avon)

    2023  Volume 107, Page(s) 106035

    Abstract: Background: Primary causes of surgical revision after total hip arthroplasty are polyethylene wear and implant loosening. These factors are particularly related to joint friction and thus patients' physical activity. Assessing implant wear over time ... ...

    Abstract Background: Primary causes of surgical revision after total hip arthroplasty are polyethylene wear and implant loosening. These factors are particularly related to joint friction and thus patients' physical activity. Assessing implant wear over time according to patients' morphology and physical activity level is key to improve follow-up and patients' quality of life.
    Methods: An approach initially proposed for tibiofemoral prosthetic wear estimation was adapted to compute two wear factors (force-velocity, directional wear intensity) using a musculoskeletal model. It was applied on 17 participants with total hip arthroplasty to compute joint angular velocity, contact force, sliding velocity, and wear factors during common daily living activities.
    Findings: Differences were observed between gait, sitting down, and standing up tasks. An incremental increase of both global wear factors (time-integral) was observed during gait from slow to fast speeds (p ≤ 0.01). Interestingly, these two wear factors did not result in same trend for sitting down and standing up tasks. Compared to gait, one cycle of sitting down or standing up tends to induce higher friction-related wear but lower cross-shear-related wear. Depending on the wear factor, significant differences can be found between sitting down and gait at slow speed (p ≤ 0.05), and between sitting down (p ≤ 0.05) or standing up (p ≤ 0.05) and gait at fast speed. Furthermore, depending on the activity, wear can be fostered by joint contact force and/or sliding velocity.
    Interpretation: This study demonstrated the potential of wear estimation to highlight activities inducing a higher risk of implant wear after total hip arthroplasty from motion capture data.
    MeSH term(s) Humans ; Arthroplasty, Replacement, Hip/adverse effects ; Hip Prosthesis/adverse effects ; Quality of Life ; Polyethylene ; Gait ; Prosthesis Failure
    Chemical Substances Polyethylene (9002-88-4)
    Language English
    Publishing date 2023-06-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632747-3
    ISSN 1879-1271 ; 0268-0033
    ISSN (online) 1879-1271
    ISSN 0268-0033
    DOI 10.1016/j.clinbiomech.2023.106035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Recurrent Acute Septic Arthritis Caused by Kingella kingae in a 16-Month-Old Boy.

    Chosidow, Anais / Bonacorsi, Stéphane / Moissenet, Didier / Bidet, Philippe / Schnuriger, Aurélie / Grimprel, Emmanuel / Vialle, Raphael / Lorrot, Mathie

    The Pediatric infectious disease journal

    2019  Volume 38, Issue 10, Page(s) e270–e271

    Abstract: We describe the first case of 2 consecutive acute septic arthritis infections of both knees caused by the same virulent strain of Kingella kingae belonging to the virulent sequence type complex 14, in a 16-month-old boy. Both infections occurred after ... ...

    Abstract We describe the first case of 2 consecutive acute septic arthritis infections of both knees caused by the same virulent strain of Kingella kingae belonging to the virulent sequence type complex 14, in a 16-month-old boy. Both infections occurred after viral upper respiratory tract infections.
    MeSH term(s) Arthritis, Infectious/diagnosis ; Arthritis, Infectious/pathology ; Humans ; Infant ; Kingella kingae/classification ; Kingella kingae/genetics ; Kingella kingae/isolation & purification ; Knee Joint/pathology ; Male ; Neisseriaceae Infections/diagnosis ; Neisseriaceae Infections/pathology ; Recurrence ; Respiratory Tract Infections/complications ; Virus Diseases/complications
    Language English
    Publishing date 2019-06-24
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000002375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Detection of β-D-glucan for the diagnosis of invasive fungal infection in children with hematological malignancy.

    Guitard, Juliette / Tabone, Marie-Dominique / Senghor, Yaye / Cros, Cyrille / Moissenet, Didier / Markowicz, Karine / Valin, Nadia / Leverger, Guy / Hennequin, Christophe

    The Journal of infection

    2016  Volume 73, Issue 6, Page(s) 607–615

    Abstract: Objectives: The ß-D-glucan assay (BDG) has been added to the EORTC/MSG criteria for the diagnosis of invasive fungal infections (IFI), but data from pediatric populations is scarce. The aim of this study was to evaluate performance of BDG in a cohort of ...

    Abstract Objectives: The ß-D-glucan assay (BDG) has been added to the EORTC/MSG criteria for the diagnosis of invasive fungal infections (IFI), but data from pediatric populations is scarce. The aim of this study was to evaluate performance of BDG in a cohort of hemato-oncological children with hematological malignancy at risk for IFI.
    Methods: 113 patients were included through an 18-month period. In addition to routine IFI screening, BDG was assayed once a week. IFIs were classified using EORTC/MSG criteria without including the BDG results. Performances were assessed after a ROC analysis for optimization and multivariate analysis to detect the causes of false positivity.
    Results: 8 proven and 4 probable IFIs, and 7 possible IFIs were diagnosed in 9 and 7 patients, respectively. Sensitivity and specificity increased from 75% and 56% to 100% and 91.1%, respectively when considering the whole population and patients not having received any antifungals prior to the test. Multivariate analysis revealed that being younger than 7, severe colitis/mucositis, recent administration of polyvalent immunoglobulins and digestive colonization with Enterococcus sp were independent risk factors for false positivity.
    Conclusions: BDG is a valuable test to detect IFI in pediatric patients not previously treated with antifungals and to detect the occurrence of chronic infection.
    MeSH term(s) Adolescent ; Candida/isolation & purification ; Candidiasis/diagnosis ; Candidiasis/microbiology ; Child ; Child, Preschool ; Female ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/microbiology ; Humans ; Infant ; Invasive Fungal Infections/diagnosis ; Invasive Fungal Infections/microbiology ; Male ; Predictive Value of Tests ; ROC Curve ; Reagent Kits, Diagnostic ; Sensitivity and Specificity ; beta-Glucans/blood ; beta-Glucans/isolation & purification
    Chemical Substances Reagent Kits, Diagnostic ; beta-Glucans
    Language English
    Publishing date 2016-12
    Publishing country England
    Document type Evaluation Studies ; Journal Article
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2016.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: CHAC1 Is Differentially Expressed in Normal and Cystic Fibrosis Bronchial Epithelial Cells and Regulates the Inflammatory Response Induced by

    Perra, Léa / Balloy, Viviane / Foussignière, Tobias / Moissenet, Didier / Petat, Hortense / Mungrue, Imran N / Touqui, Lhousseine / Corvol, Harriet / Chignard, Michel / Guillot, Loic

    Frontiers in immunology

    2018  Volume 9, Page(s) 2823

    Abstract: In cystic fibrosis (CF), ...

    Abstract In cystic fibrosis (CF),
    MeSH term(s) A549 Cells ; Adult ; Aged ; Bronchi/immunology ; Bronchi/microbiology ; Bronchi/pathology ; Cystic Fibrosis/genetics ; Cystic Fibrosis/immunology ; Cystic Fibrosis/microbiology ; Cystic Fibrosis/pathology ; Epithelial Cells/immunology ; Epithelial Cells/microbiology ; Epithelial Cells/pathology ; Female ; Gene Expression Regulation/immunology ; Humans ; Male ; Middle Aged ; Pseudomonas Infections/genetics ; Pseudomonas Infections/immunology ; Pseudomonas Infections/pathology ; Pseudomonas aeruginosa/immunology ; gamma-Glutamylcyclotransferase/immunology
    Chemical Substances CHAC1 protein, human (EC 4.3.2.7) ; gamma-Glutamylcyclotransferase (EC 4.3.2.9)
    Keywords covid19
    Language English
    Publishing date 2018-11-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.02823
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Transfer between an Algerian and a French hospital of four multi-drug resistant bacterial strains together via a single patient.

    Moissenet, Didier / Richard, Patrick / Granados, Maria / Mérens, Audrey / Fournier, Damien / Fines-Guyon, Marguerite / Arlet, Guillaume / Vu-Thien, Hoang

    International journal of burns and trauma

    2015  Volume 5, Issue 3, Page(s) 82–85

    Abstract: A 5 years-old girl, seriously burnt with fire, was first hospitalized during four days in an hospital at Alger, and then transferred to our hospital at Paris. Admitted in our intensive care burns unit, she was third degree burnt on 78% of total body ... ...

    Abstract A 5 years-old girl, seriously burnt with fire, was first hospitalized during four days in an hospital at Alger, and then transferred to our hospital at Paris. Admitted in our intensive care burns unit, she was third degree burnt on 78% of total body surface area, already treated with imipenem and vancomycin at her arrival. Clinical aggravation was rapidly observed and death occurred within 24 hours. Cultures of blood and multiple wound swabs yielded 3 multi-drug resistant bacterial strains: Acinetobacter baumannii with carbapenemase OXA-23, Pseudomonas aeruginosa serotype O11 with metallo-ß-lactamase VIM-4 and Klebsiella pneumoniae with CTX-M-15 extended-spectrum ß-lactamase. Culture of a rectal swab showed colonization by Enterococcus faecium with vanA glycopeptides resistance. Patients colonized with one or two multi-drug-resistant strains were not rare in our burns unit, especially those transferred from Algeria, but this case of a single patient harboring four multi-drug-resistant strains is exceptional.
    Language English
    Publishing date 2015-10-12
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2664425-3
    ISSN 2160-2026
    ISSN 2160-2026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Persistent bloodstream infection with Kocuria rhizophila related to a damaged central catheter.

    Moissenet, Didier / Becker, Karsten / Mérens, Audrey / Ferroni, Agnès / Dubern, Béatrice / Vu-Thien, Hoang

    Journal of clinical microbiology

    2012  Volume 50, Issue 4, Page(s) 1495–1498

    Abstract: A case of persistent bloodstream infection with Kocuria rhizophila related to a damaged central venous catheter in a 3-year-old girl with Hirschsprung's disease is reported. The strain was identified as K. rhizophila by 16S rRNA gene sequencing and ... ...

    Abstract A case of persistent bloodstream infection with Kocuria rhizophila related to a damaged central venous catheter in a 3-year-old girl with Hirschsprung's disease is reported. The strain was identified as K. rhizophila by 16S rRNA gene sequencing and matrix-assisted laser desorption ionization-time of flight mass spectrometry. Arbitrarily primed PCR analysis showed a clonal strain. The repeated septic episodes were resolved with the catheter repair.
    MeSH term(s) Actinomycetales Infections/diagnosis ; Actinomycetales Infections/microbiology ; Bacteremia/diagnosis ; Bacteremia/microbiology ; Catheterization, Central Venous/adverse effects ; Catheterization, Central Venous/instrumentation ; Catheters/microbiology ; Child, Preschool ; Equipment Failure ; Female ; Humans ; Micrococcaceae/genetics ; Micrococcaceae/isolation & purification ; Molecular Diagnostic Techniques ; Molecular Sequence Data ; RNA, Bacterial/genetics ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA
    Chemical Substances RNA, Bacterial ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2012-01-18
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.06038-11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: First case of multidrug-resistant blaNDM-1- and blaOXA-232-carrying Klebsiella pneumoniae and its probable cross-transmission in a French hospital.

    Bousquet, Aurore / Duprilot, Marion / Moissenet, Didier / Salauze, Béatrice / Rambaud, Jérôme / Genel, Nathalie / Vu-Thien, Hoang / Arlet, Guillaume / Decré, Dominique

    International journal of antimicrobial agents

    2014  Volume 44, Issue 5, Page(s) 469–470

    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Cross Infection/microbiology ; Cross Infection/transmission ; Drug Resistance, Multiple, Bacterial ; France ; Hospitals ; Humans ; Klebsiella Infections/microbiology ; Klebsiella Infections/transmission ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/enzymology ; Klebsiella pneumoniae/genetics ; Klebsiella pneumoniae/isolation & purification ; Microbial Sensitivity Tests ; Polymerase Chain Reaction ; beta-Lactamases/genetics
    Chemical Substances Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2014-11
    Publishing country Netherlands
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2014.06.004
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  8. Article ; Online: Septic arthritis caused by Bordetella holmesii in an adolescent with chronic haemolytic anaemia.

    Moissenet, Didier / Leverger, Guy / Mérens, Audrey / Bonacorsi, Stéphane / Guiso, Nicole / Vu-Thien, Hoang

    Journal of medical microbiology

    2011  Volume 60, Issue Pt 11, Page(s) 1705–1707

    Abstract: We describe a case of septic arthritis caused by Bordetella holmesii in a 15-year-old boy with chronic haemolytic anaemia. B. holmesii was identified by 16S rRNA gene sequence analysis. The patient outcome was favourable. To our knowledge, this is the ... ...

    Abstract We describe a case of septic arthritis caused by Bordetella holmesii in a 15-year-old boy with chronic haemolytic anaemia. B. holmesii was identified by 16S rRNA gene sequence analysis. The patient outcome was favourable. To our knowledge, this is the first case of B. holmesii septic arthritis in an asplenic patient.
    MeSH term(s) Adolescent ; Anemia, Hemolytic/complications ; Arthritis, Infectious/complications ; Arthritis, Infectious/immunology ; Arthritis, Infectious/microbiology ; Base Sequence ; Bordetella/genetics ; Bordetella/immunology ; Bordetella Infections/complications ; Bordetella Infections/immunology ; Bordetella Infections/microbiology ; DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; Humans ; Knee Joint/immunology ; Knee Joint/microbiology ; Male ; Molecular Sequence Data ; Polymerase Chain Reaction ; RNA, Ribosomal, 16S/chemistry ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA
    Chemical Substances DNA, Bacterial ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2011-07-21
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 218356-0
    ISSN 1473-5644 ; 0022-2615
    ISSN (online) 1473-5644
    ISSN 0022-2615
    DOI 10.1099/jmm.0.033829-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Les facteurs de virulence de Pseudomonas aeruginosa : mécanismes et modes de régulations.

    Ben Haj Khalifa, Anis / Moissenet, Didier / Vu Thien, Hoang / Khedher, Mohamed

    Annales de biologie clinique

    2011  Volume 69, Issue 4, Page(s) 393–403

    Abstract: Pseudomonas aeruginosa is a bacterium responsible for severe nosocomial infections, life-threatening infections in immunocompromised persons, and chronic infections in cystic fibrosis patients. The bacterium's virulence depends on a large number of cell- ... ...

    Title translation Virulence factors in Pseudomonas aeruginosa: mechanisms and modes of regulation.
    Abstract Pseudomonas aeruginosa is a bacterium responsible for severe nosocomial infections, life-threatening infections in immunocompromised persons, and chronic infections in cystic fibrosis patients. The bacterium's virulence depends on a large number of cell-associated and extracellular factors. The virulence factors play an important pathological role in the colonization, the survival of the bacteria and the invasion of tissues. There are two types of virulence factors: (1) factors involved in the acute infection: these factors are either on the surface of P. aeruginosa, either secreted. The pili allow adherence to the epithelium. The exoenzyme S and other adhesins reinforce the adherence to epithelial cells. The exotoxin A is responsible of tissue necrosis. Phospholipase C is a thermolabile haemolysin. The pathogenic role of exoenzyme S is attributable to the disruption of normal cytoskeletal organization, the destruction of immunoglobulin G and A, leads to depolymerization of actin filaments and contributes to the resistance to macrophages. P. aeruginosa produces at least four proteases causing bleeding and tissue necrosis; (2) factors involved in the chronic infection: siderophores (pyoverdin and pyochelin), allow the bacteria to multiply in the absence of ferrous ions. The strains isolated from patients with cystic fibrosis have a pseudocapsule of alginate that protects the bacterium from phagocytosis, dehydration and antibiotics. Moreover, it improves adherence to epithelial cells forming a biofilm. Two different types of regulation systems control the expression of the majority of these virulence factors: the two-component transcriptional regulatory system and the quorum sensing system. These two mechanisms are necessary to the survival and the proliferation of this microorganism in the host.
    MeSH term(s) Bacterial Toxins/metabolism ; Cross Infection/microbiology ; Humans ; Immunocompromised Host ; Pseudomonas Infections/immunology ; Pseudomonas Infections/metabolism ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/pathogenicity ; Quorum Sensing ; Risk Factors ; Transcription, Genetic ; Virulence ; Virulence Factors/metabolism
    Chemical Substances Bacterial Toxins ; Virulence Factors
    Language French
    Publishing date 2011-07
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 418098-7
    ISSN 0003-3898
    ISSN 0003-3898
    DOI 10.1684/abc.2011.0589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: DNA fingerprinting of Ralstonia paucula by infrequent-restriction-site PCR and randomly amplified polymorphic DNA analysis.

    Moissenet, Didier / Vu-Thien, Hoang / Benzerara, Yahia / Arlet, Guillaume

    Journal of clinical microbiology

    2003  Volume 41, Issue 12, Page(s) 5747–5749

    Abstract: Ralstonia paucula (formerly CDC group IV c-2) is an environmental organism that can cause serious human infections, occasionally clusters of nosocomial infections. In the present work, 26 strains of R. paucula (4 from the American Centers for Disease ... ...

    Abstract Ralstonia paucula (formerly CDC group IV c-2) is an environmental organism that can cause serious human infections, occasionally clusters of nosocomial infections. In the present work, 26 strains of R. paucula (4 from the American Centers for Disease Control and Prevention collection, 10 from the Belgian Laboratorium voor Microbiologie [LMG] collection, and 12 French clinical isolates) were analyzed with infrequent-restriction-site PCR and randomly amplified polymorphic DNA analysis. Both techniques accurately distinguished between collection strains. Two close patterns obtained for all the French isolates suggested a clonal strain. Two LMG collection strains originating from human sources in the United States also showed patterns close to those of French isolates.
    MeSH term(s) Child ; DNA Fingerprinting/methods ; DNA, Bacterial/genetics ; Gram-Negative Bacterial Infections/diagnosis ; Gram-Negative Bacterial Infections/microbiology ; Humans ; Polymerase Chain Reaction/methods ; Polymorphism, Genetic ; Ralstonia/genetics ; Ralstonia/isolation & purification ; Random Amplified Polymorphic DNA Technique ; Restriction Mapping ; Sepsis/microbiology
    Chemical Substances DNA, Bacterial
    Language English
    Publishing date 2003-11-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.41.12.5747-5749.2003
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