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  1. Article ; Online: Characterization of critical health promotion: a scoping review protocol.

    Fincham, Susanne / O'Hara, Lily / Cole, Rachel / Taylor, Jane

    JBI evidence synthesis

    2023  Volume 21, Issue 11, Page(s) 2264–2271

    Abstract: Objective: This scoping review will explore how critical health promotion is characterized in the health promotion literature.: Introduction: Critical health promotion has emerged as a social justice approach to health promotion to address the ... ...

    Abstract Objective: This scoping review will explore how critical health promotion is characterized in the health promotion literature.
    Introduction: Critical health promotion has emerged as a social justice approach to health promotion to address the persistent global issue of health inequity. Whilst critical health promotion is not conceptually new and the term has been used in the literature, albeit sparingly, this approach has not been adopted as standard health promotion practice, compromising the advancement of health equity. Given that language shapes the understanding and practice of health promotion, it is imperative to explore how critical health promotion is characterized in the literature to increase uptake of the approach.
    Inclusion criteria: This review will consider sources that explore critical health promotion and are explicitly positioned as health promotion sources.
    Methods: Scopus, CINAHL (EBSCOhost), PubMed, Global Health (CABI), and the Public Health Database (ProQuest) will be searched to identify relevant full-text papers, including original research, reviews, editorials, and opinion papers. Searches of Google Scholar, Google, and ProQuest Dissertations & Theses Global (ProQuest) will be undertaken to identify gray literature. No language or date restrictions will be applied. Two reviewers will screen sources and extract data using a tool that will be pilot tested, modified, and revised, as necessary. Analysis will involve basic frequency counts and descriptive qualitative content analysis through basic coding. The results will be presented in tables, charts, and word clouds, accompanied by a narrative summary.
    MeSH term(s) Humans ; Health Promotion ; Databases, Factual ; Review Literature as Topic
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ISSN 2689-8381
    ISSN (online) 2689-8381
    DOI 10.11124/JBIES-23-00008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A comparative genetic study of the mating-type chromosomes of two species of Neurospora.

    FINCHAM, J R S

    Journal of genetics

    2014  Volume 50, Issue 2, Page(s) 221–229

    MeSH term(s) Chromosomes ; Neurospora
    Language English
    Publishing date 2014-02-17
    Publishing country India
    Document type Journal Article
    ZDB-ID 3039-9
    ISSN 0973-7731 ; 0022-1333 ; 0958-8361
    ISSN (online) 0973-7731
    ISSN 0022-1333 ; 0958-8361
    DOI 10.1007/BF02996218
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  3. Article ; Online: Distinct states of nucleolar stress induced by anticancer drugs.

    Potapova, Tamara A / Unruh, Jay R / Conkright-Fincham, Juliana / Banks, Charles A S / Florens, Laurence / Schneider, David Alan / Gerton, Jennifer L

    eLife

    2023  Volume 12

    Abstract: Ribosome biogenesis is a vital and highly energy-consuming cellular function occurring primarily in the nucleolus. Cancer cells have an elevated demand for ribosomes to sustain continuous proliferation. This study evaluated the impact of existing ... ...

    Abstract Ribosome biogenesis is a vital and highly energy-consuming cellular function occurring primarily in the nucleolus. Cancer cells have an elevated demand for ribosomes to sustain continuous proliferation. This study evaluated the impact of existing anticancer drugs on the nucleolus by screening a library of anticancer compounds for drugs that induce nucleolar stress. For a readout, a novel parameter termed 'nucleolar normality score' was developed that measures the ratio of the fibrillar center and granular component proteins in the nucleolus and nucleoplasm. Multiple classes of drugs were found to induce nucleolar stress, including DNA intercalators, inhibitors of mTOR/PI3K, heat shock proteins, proteasome, and cyclin-dependent kinases (CDKs). Each class of drugs induced morphologically and molecularly distinct states of nucleolar stress accompanied by changes in nucleolar biophysical properties. In-depth characterization focused on the nucleolar stress induced by inhibition of transcriptional CDKs, particularly CDK9, the main CDK that regulates RNA Pol II. Multiple CDK substrates were identified in the nucleolus, including RNA Pol I- recruiting protein Treacle, which was phosphorylated by CDK9 in vitro. These results revealed a concerted regulation of RNA Pol I and Pol II by transcriptional CDKs. Our findings exposed many classes of chemotherapy compounds that are capable of inducing nucleolar stress, and we recommend considering this in anticancer drug development.
    MeSH term(s) Cell Nucleolus/metabolism ; Cell Nucleus/metabolism ; Ribosomes/metabolism ; RNA Polymerase I/metabolism ; Cyclin-Dependent Kinases/metabolism ; RNA Polymerase II/metabolism ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/metabolism ; RNA/metabolism
    Chemical Substances RNA Polymerase I (EC 2.7.7.6) ; Cyclin-Dependent Kinases (EC 2.7.11.22) ; RNA Polymerase II (EC 2.7.7.-) ; Antineoplastic Agents ; RNA (63231-63-0)
    Language English
    Publishing date 2023-12-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.88799
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  4. Article ; Online: External validation of the Oldham composite Covid-19 associated mortality model (OCCAM), a prognostic model for death in patients hospitalised with Covid-19.

    Thompson, J V / Clark, J M / Fincham, T / Harkness, R / Meghani, N J / Powell, B M / McLeneghan, D / Ng Man Kwong, G

    Infectious diseases now

    2023  Volume 53, Issue 6, Page(s) 104722

    Abstract: Objective: External validation of the Oldham Composite Covid-19 associated Mortality Model (OCCAM), a prognostic model for Covid-19 mortality in hospitalised patients comprised of age, history of hypertension, current or previous malignancy, admission ... ...

    Abstract Objective: External validation of the Oldham Composite Covid-19 associated Mortality Model (OCCAM), a prognostic model for Covid-19 mortality in hospitalised patients comprised of age, history of hypertension, current or previous malignancy, admission platelet count < 150 × 10
    Patients and methods: Retrospective study assessing discrimination (c-statistic) and calibration of OCCAM for death in hospital or within 30 days of discharge. 300 adults admitted to six district general and teaching hospitals in North West England for treatment of Covid-19 between September 2020 and February 2021 were included.
    Results: Two hundred and ninety-seven patients were included in the validation cohort analysis, with a mortality rate of 32.8%. The c-statistic was 0.794 (95% confidence interval 0.742-0.847) vs. 0.805 (95% confidence interval 0.766 - 0.844) in the development cohort. Visual inspection of calibration plots demonstrate excellent calibration across risk groups, with a calibration slope for the external validation cohort of 0.963.
    Conclusion: The OCCAM model is an effective prognostic tool that can be utilised at the time of initial patient assessment to aid decisions around admission and discharge, use of therapeutics, and shared decision-making with patients. Clinicians should remain aware of the need for ongoing validation of all Covid-19 prognostic models in light of changes in host immunity and emerging variants.
    MeSH term(s) Adult ; Humans ; COVID-19 ; Prognosis ; Retrospective Studies ; Cohort Studies ; Risk Factors
    Language English
    Publishing date 2023-05-16
    Publishing country France
    Document type Journal Article
    ISSN 2666-9919
    ISSN (online) 2666-9919
    DOI 10.1016/j.idnow.2023.104722
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  5. Article ; Online: Using music to assist language learning in autistic children with minimal verbal language: The MAP feasibility RCT.

    Williams, Tim I / Loucas, Tom / Sin, Jacqueline / Jeremic, Mirjana / Meyer, Sina / Boseley, Sam / Fincham-Majumdar, Sara / Aslett, Georgia / Renshaw, Ruan / Liu, Fang

    Autism : the international journal of research and practice

    2024  , Page(s) 13623613241233804

    Abstract: Lay abstract: Research has shown that autistic individuals often have unusually good musical skills and that combining words and music helps autistic individuals to focus on spoken words. This study tests the idea that music will help with early ... ...

    Abstract Lay abstract: Research has shown that autistic individuals often have unusually good musical skills and that combining words and music helps autistic individuals to focus on spoken words. This study tests the idea that music will help with early language learning of preschool autistic children. The results show that when caregivers sing words to autistic children, the children pay more attention to the caregiver than when the words are spoken and that they learn word combinations more easily.
    Language English
    Publishing date 2024-03-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1338513-6
    ISSN 1461-7005 ; 1362-3613
    ISSN (online) 1461-7005
    ISSN 1362-3613
    DOI 10.1177/13623613241233804
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  6. Article: How many additional parameters in a conversion model can be evaluated using "corresponding-site" events?

    Fincham, J R

    Genome

    2008  Volume 37, Issue 1, Page(s) 179–180

    Abstract: Contrary to a recent claim by B.C. Lamb and S.A. Zwolinski (1992), the frequencies of "corresponding-site" conversion events (all four chromatids involved in conversion at the same locus in the same meiotic cell) can be used to evaluate only two ... ...

    Abstract Contrary to a recent claim by B.C. Lamb and S.A. Zwolinski (1992), the frequencies of "corresponding-site" conversion events (all four chromatids involved in conversion at the same locus in the same meiotic cell) can be used to evaluate only two parameters not otherwise calculable: a coincidence parameter and the frequency of conversion-type events in which a normal 1:1 ratio is restored.
    Language English
    Publishing date 2008-05-05
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 639031-6
    ISSN 1480-3321 ; 0831-2796
    ISSN (online) 1480-3321
    ISSN 0831-2796
    DOI 10.1139/g94-024
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  7. Article ; Online: Is Pornography Consumption Related to Risky Behaviors During Friends With Benefits Relationships?

    Henderson, Elena / Aaron, Sean / Blackhurst, Zachary / Maddock, Meghan / Fincham, Frank / Braithwaite, Scott R

    The journal of sexual medicine

    2020  Volume 17, Issue 12, Page(s) 2446–2455

    Abstract: ... During Friends with Benefits Relationships?. J Sex Med 2020;17:2446-2455. ...

    Abstract Background: Friends with benefits encounters are a relatively new pattern of relating among emerging adults where risky sexual behavior may occur.
    Aim: To understand whether pornography consumption is associated with riskier behaviors during friends with benefits encounters.
    Methods: Cross-sectional study of 2 samples of emerging adults who have engaged in friends with benefits relationships (study 1, N = 411; study 2, N = 394). For binary outcomes, we used logistic regression and report odds ratios. For ordinal outcomes, we used ordered logistic regression and reported odds ratios. We tested for moderation by biological sex.
    Results: Men who consumed pornography more frequently were more likely to engage in risky sexual behaviors during their friends with benefits encounters. More frequent pornography consumption was associated with increased likelihood and amount of intoxication for both the respondent and his partner, less frequent condom use, and a higher probability of having penetrative friends with benefits encounters while intoxicated and not using a condom. For each of these outcomes, our parameter estimates from study 2 fell within the 95% confidence intervals from study 1. These associations persisted when controlling for the effects of binge drinking frequency, broader patterns of problematic alcohol use, trait self-control, openness to experience, and permissive attitudes toward casual sex. The findings of this study may inform interventions to reduce risky behaviors among emerging adults.
    Limitations: Our cross-sectional studies examined only emerging adults in college with measurement that was exclusively self-reported.
    Conclusions: These results are discussed in terms of sexual script theory, and several implications for intervention are outlined. Henderson E, Aaron S, Blackhurst Z, et al. Is Pornography Consumption Related to Risky Behaviors During Friends with Benefits Relationships?. J Sex Med 2020;17:2446-2455.
    MeSH term(s) Adult ; Cross-Sectional Studies ; Erotica ; Friends ; Humans ; Male ; Risk-Taking ; Sexual Behavior
    Language English
    Publishing date 2020-10-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2251959-2
    ISSN 1743-6109 ; 1743-6095
    ISSN (online) 1743-6109
    ISSN 1743-6095
    DOI 10.1016/j.jsxm.2020.08.017
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  8. Book: Genetically engineered organisms

    Fincham, John R. / Ravetz, Jerome R.

    benefits and risks

    1991  

    Author's details J.R.S. Fincham and J.R. Ravetz
    Keywords Genetic Engineering
    Size XIII, 158 S. : Ill., graph. Darst.
    Publisher Open University Press
    Publishing place Milton Keynes
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT003846482
    ISBN 0-335-09619-0 ; 0-335-09618-2 ; 978-0-335-09619-0 ; 978-0-335-09618-3
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1991 B 975 order for loan Magazin

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  9. Article ; Online: Dopamine receptor antagonists as potential therapeutic agents for ADPKD.

    Paul, Parama / Ramachandran, Sreekumar / Xia, Sheng / Unruh, Jay R / Conkright-Fincham, Juliana / Li, Rong

    PloS one

    2019  Volume 14, Issue 5, Page(s) e0216220

    Abstract: Autosomal dominant polycystic kidney disease (ADPKD) is caused mostly by mutations in polycystin-1 or polycystin-2. Fluid flow leads to polycystin-dependent calcium influx and nuclear export of histone deacetylase 5 (HDAC5), which facilitates the ... ...

    Abstract Autosomal dominant polycystic kidney disease (ADPKD) is caused mostly by mutations in polycystin-1 or polycystin-2. Fluid flow leads to polycystin-dependent calcium influx and nuclear export of histone deacetylase 5 (HDAC5), which facilitates the maintenance of renal epithelial architecture by de-repression of MEF2C target genes. Here, we screened a small-molecule library to find drugs that promotes nuclear export of HDAC5. We found that dopamine receptor antagonists, domperidone and loxapine succinate, stimulate export of HDAC5, even in Pkd1-/-cells. Domperidone targets Drd3 receptor to modulate the phosphorylation of HDAC5. Domperidone treatment increases HDAC5 phosphorylation likely by reducing protein phosphatase 2A (PP2A) activity, thus shifting the equilibrium towards HDAC5-P and export from the nucleus. Treating Pkd1-/-mice with domperidone showed significantly reduced cystic growth and cell proliferation. Further, treated mice displayed a reduction in glomerular cyst and increased body weight and activity. These results suggest that HDAC5 nucleocytoplasmic shuttling may be modulated to impede disease progression in ADPKD and uncovers an unexpected role for a class of dopamine receptors in renal epithelial morphogenesis.
    MeSH term(s) Active Transport, Cell Nucleus ; Animals ; Cell Proliferation/drug effects ; Domperidone/pharmacology ; Domperidone/therapeutic use ; Dopamine Antagonists/pharmacology ; Dopamine Antagonists/therapeutic use ; Drug Evaluation, Preclinical/methods ; Epithelial Cells/metabolism ; Histone Deacetylases/metabolism ; Kidney/pathology ; Mice ; Polycystic Kidney, Autosomal Dominant/drug therapy
    Chemical Substances Dopamine Antagonists ; Domperidone (5587267Z69) ; HDAC5 protein, human (EC 3.5.1.98) ; Hdac5 protein, mouse (EC 3.5.1.98) ; Histone Deacetylases (EC 3.5.1.98)
    Language English
    Publishing date 2019-05-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0216220
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  10. Article: Genetically controlled differences in enzyme activity.

    FINCHAM, J R

    Advances in enzymology and related subjects of biochemistry

    2003  Volume 22, Page(s) 1–43

    MeSH term(s) Enzymes ; Genetics ; Humans
    Chemical Substances Enzymes
    Language English
    Publishing date 2003-10-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 27-9
    ISSN 0065-258X
    ISSN 0065-258X
    DOI 10.1002/9780470122679.ch1
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