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  1. Article ; Online: The Multifaceted Role of Intracellular Glycosylation in Cytoprotection and Heart Disease.

    Umapathi, Priya / Aggarwal, Akanksha / Zahra, Fiddia / Narayanan, Bhargavi / Zachara, Natasha E

    The Journal of biological chemistry

    2024  , Page(s) 107296

    Abstract: The modification of nuclear, cytoplasmic, and mitochondrial proteins by O-linked β-N-acetylglucosamine (O-GlcNAc) is an essential post-translational modification common in metazoans. O-GlcNAc is cycled on and off proteins in response to environmental and ...

    Abstract The modification of nuclear, cytoplasmic, and mitochondrial proteins by O-linked β-N-acetylglucosamine (O-GlcNAc) is an essential post-translational modification common in metazoans. O-GlcNAc is cycled on and off proteins in response to environmental and physiological stimuli impacting protein function, which, in turn, tunes pathways that include transcription, translation, proteostasis, signal transduction, and metabolism. One class of stimulus that induces rapid and dynamic changes to O-GlcNAc is cellular injury, resulting from environmental stress (for instance, heat shock), hypoxia/reoxygenation injury, ischemia reperfusion injury (heart attack, stroke, trauma hemorrhage), and sepsis. Acute elevation of O-GlcNAc before or after injury reduces apoptosis and necrosis, suggesting that injury-induced changes in O-GlcNAcylation regulate cell fate decisions. However, prolonged elevation or reduction in O-GlcNAc leads to a maladaptive response and is associated with pathologies such as hypertrophy and heart failure. In this review, we discuss the impact of O-GlcNAc in both acute and prolonged models of injury with a focus on the heart and biological mechanisms that underpin cell survival.
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2024.107296
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  2. Article ; Online: Risks of paxlovid in a heart transplant recipient.

    Stawiarski, Kristin / Avery, Robin / Strout, Sara / Umapathi, Priya

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2022  Volume 42, Issue 1, Page(s) 30–32

    Abstract: The burden of morbidity and mortality from SARS-CoV-2 infection is especially significant in heart transplant patients who are at higher risk for poor outcomes owing to immunosuppression, blunted response to vaccination, and multiple comorbid conditions. ...

    Abstract The burden of morbidity and mortality from SARS-CoV-2 infection is especially significant in heart transplant patients who are at higher risk for poor outcomes owing to immunosuppression, blunted response to vaccination, and multiple comorbid conditions. Over the last 3 years the therapeutic landscape for COVID-19 has evolved and our drug armamentaria continues to expand. With these advancements comes a time of great hope to mitigate significant illness from SARS - CoV - 2 infection. However, as with many emerging frontiers, the administration of novel therapeutics to a complex patient population remains challenging. We present a patient case encountered at our institution that highlights the need for increased awareness of nuances while managing COVID-19 infection in a heart transplant recipient.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Ritonavir ; Heart Transplantation ; Transplant Recipients
    Chemical Substances nirmatrelvir and ritonavir drug combination ; Ritonavir (O3J8G9O825)
    Language English
    Publishing date 2022-09-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2022.08.029
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    Zs.A 2056: Show issues Location:
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  3. Article ; Online: Differential Detection of O-GlcNAcylated proteins in the heart using antibodies.

    Narayanan, Bhargavi / Zahra, Fiddia / Reeves, Russell A / Aggarwal, Akanksha / O'Meally, Robert N / Henry, Roger K / Craven, Megan / Jacobson, Avital / Cole, Robert N / Kohr, Mark J / Umapathi, Priya / Zachara, Natasha E

    Analytical biochemistry

    2023  Volume 678, Page(s) 115262

    Abstract: Thousands of mammalian intracellular proteins are dynamically modified by O-linked β-N-acetylglucosamine (O-GlcNAc). Global changes in O-GlcNAcylation have been associated with the development of cardiomyopathy, heart failure, hypertension, and ... ...

    Abstract Thousands of mammalian intracellular proteins are dynamically modified by O-linked β-N-acetylglucosamine (O-GlcNAc). Global changes in O-GlcNAcylation have been associated with the development of cardiomyopathy, heart failure, hypertension, and neurodegenerative disease. Levels of O-GlcNAc in cells and tissues can be detected using numerous approaches; however, immunoblotting using GlcNAc-specific antibodies and lectins is commonplace. The goal of this study was to optimize the detection of O-GlcNAc in heart lysates by immunoblotting. Using a combination of tissue fractionation, immunoblotting, and galactosyltransferase labeling, as well as hearts from wild-type and O-GlcNAc transferase transgenic mice, we demonstrate that contractile proteins in the heart are differentially detected by two commercially available antibodies (CTD110.6 and RL2). As CTD110.6 displays poor reactivity toward contractile proteins, and as these proteins represent a major fraction of the heart proteome, a better assessment of cardiac O-GlcNAcylation is obtained in total tissue lysates with RL2. The data presented highlight tissue lysis approaches that should aid the assessment of the cardiac O-GlcNAcylation by immunoblotting.
    MeSH term(s) Mice ; Animals ; Neurodegenerative Diseases ; Antibodies/metabolism ; Proteome/metabolism ; Heart ; Contractile Proteins/metabolism ; Acetylglucosamine ; Protein Processing, Post-Translational ; Mammals/metabolism
    Chemical Substances Antibodies ; Proteome ; Contractile Proteins ; Acetylglucosamine (V956696549)
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1110-1
    ISSN 1096-0309 ; 0003-2697
    ISSN (online) 1096-0309
    ISSN 0003-2697
    DOI 10.1016/j.ab.2023.115262
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    Zs.A 389: Show issues Location:
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  4. Article ; Online: CaMKII as a Therapeutic Target in Cardiovascular Disease.

    Reyes Gaido, Oscar E / Nkashama, Lubika J / Schole, Kate L / Wang, Qinchuan / Umapathi, Priya / Mesubi, Olurotimi O / Konstantinidis, Klitos / Luczak, Elizabeth D / Anderson, Mark E

    Annual review of pharmacology and toxicology

    2022  Volume 63, Page(s) 249–272

    Abstract: CaMKII (the multifunctional ... ...

    Abstract CaMKII (the multifunctional Ca
    MeSH term(s) Humans ; Cardiovascular Diseases/drug therapy ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Arrhythmias, Cardiac ; Cardiovascular System/metabolism ; Signal Transduction/physiology
    Chemical Substances Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17)
    Language English
    Publishing date 2022-08-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 196587-6
    ISSN 1545-4304 ; 0362-1642
    ISSN (online) 1545-4304
    ISSN 0362-1642
    DOI 10.1146/annurev-pharmtox-051421-111814
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  5. Article ; Online: Transforming Ambulatory Heart Failure Care in the Coronavirus Disease-19 Era: Initial Experience From a Heart Failure Disease Management Clinic.

    Umapathi, Priya / Cuomo, Kimberly / Riley, Sarah / Hubbard, Abby / Menzel, Kathryn / Sauer, Erica / Gilotra, Nisha A

    Journal of cardiac failure

    2020  Volume 26, Issue 7, Page(s) 637–638

    MeSH term(s) Academic Medical Centers ; Aged ; Ambulatory Care/organization & administration ; Baltimore ; COVID-19 ; Cohort Studies ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Disease Management ; Female ; Follow-Up Studies ; Heart Failure/diagnosis ; Heart Failure/mortality ; Heart Failure/therapy ; Humans ; Infection Control/organization & administration ; Male ; Middle Aged ; Pandemics/prevention & control ; Patient Safety/statistics & numerical data ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Retrospective Studies ; Survival Rate ; Treatment Outcome
    Keywords covid19
    Language English
    Publishing date 2020-06-09
    Publishing country United States
    Document type Letter
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2020.06.003
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    Zs.A 4340: Show issues Location:
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  6. Article ; Online: Differential Detection of O-GlcNAcylated proteins in the heart using antibodies

    Narayanan, Bhargavi / Zahra, Fiddia / Reeves, Russell A. / Aggarwal, Akanksha / O'Meally, Robert N. / Henry, Roger K. / Craven, Megan / Jacobson, Avital / Cole, Robert N. / Kohr, Mark J. / Umapathi, Priya / Zachara, Natasha E.

    Analytical Biochemistry. 2023 Oct., v. 678 p.115262-

    2023  

    Abstract: Thousands of mammalian intracellular proteins are dynamically modified by O-linked β−N-acetylglucosamine (O-GlcNAc). Global changes in O-GlcNAcylation have been associated with the development of cardiomyopathy, heart failure, hypertension, and ... ...

    Abstract Thousands of mammalian intracellular proteins are dynamically modified by O-linked β−N-acetylglucosamine (O-GlcNAc). Global changes in O-GlcNAcylation have been associated with the development of cardiomyopathy, heart failure, hypertension, and neurodegenerative disease. Levels of O-GlcNAc in cells and tissues can be detected using numerous approaches; however, immunoblotting using GlcNAc-specific antibodies and lectins is commonplace. The goal of this study was to optimize the detection of O-GlcNAc in heart lysates by immunoblotting. Using a combination of tissue fractionation, immunoblotting, and galactosyltransferase labeling, as well as hearts from wild-type and O-GlcNAc transferase transgenic mice, we demonstrate that contractile proteins in the heart are differentially detected by two commercially available antibodies (CTD110.6 and RL2). As CTD110.6 displays poor reactivity toward contractile proteins, and as these proteins represent a major fraction of the heart proteome, a better assessment of cardiac O-GlcNAcylation is obtained in total tissue lysates with RL2. The data presented highlight tissue lysis approaches that should aid the assessment of the cardiac O-GlcNAcylation by immunoblotting.
    Keywords cardiomyopathy ; fractionation ; genetically modified organisms ; heart ; heart failure ; hypertension ; immunoblotting ; lectins ; mammals ; neurodegenerative diseases ; proteome ; O-GlcNAc ; Glycosylation ; Antibodies ; Click chemistry
    Language English
    Dates of publication 2023-10
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 1110-1
    ISSN 1096-0309 ; 0003-2697
    ISSN (online) 1096-0309
    ISSN 0003-2697
    DOI 10.1016/j.ab.2023.115262
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  7. Article: Transforming ambulatory heart failure care in the COVID-19 era: initial experience from a heart failure disease management clinic

    Umapathi, Priya / Cuomo, Kimberly / Riley, Sarah / Hubbard, Abby / Menzel, Kathryn / Sauer, Erica / Gilotra, Nisha A

    J. card. fail

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32531195
    Database COVID19

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  8. Article: Transforming Ambulatory Heart Failure Care in the Coronavirus Disease-19 Era: Initial Experience From a Heart Failure Disease Management Clinic

    Umapathi, Priya / Cuomo, Kimberly / Riley, Sarah / Hubbard, Abby / Menzel, Kathryn / Sauer, Erica / Gilotra, Nisha A

    J Card Fail

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #594830
    Database COVID19

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  9. Article ; Online: Initial Experience of A Heart Failure Disease Management Clinic During the Covid-19 Era

    Cuomo, Kimberly / Menzel, Kathryn / Hubbard, Abby / Riley, Sarah / Umapathi, Priya / Sauer, Erica / Fitts, Falisha / Gilotra, Nisha

    Journal of Cardiac Failure

    2020  Volume 26, Issue 10, Page(s) S162

    Keywords Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2020.09.466
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  10. Article ; Online: Excessive

    Umapathi, Priya / Mesubi, Olurotimi O / Banerjee, Partha S / Abrol, Neha / Wang, Qinchuan / Luczak, Elizabeth D / Wu, Yuejin / Granger, Jonathan M / Wei, An-Chi / Reyes Gaido, Oscar E / Florea, Liliana / Talbot, C Conover / Hart, Gerald W / Zachara, Natasha E / Anderson, Mark E

    Circulation

    2021  Volume 143, Issue 17, Page(s) 1687–1703

    Abstract: Background: Heart failure is a leading cause of death worldwide and is associated with the rising prevalence of obesity, hypertension, and diabetes. : Methods: We developed 2 new transgenic mouse models with myocardial overexpression of OGT and OGA ... ...

    Abstract Background: Heart failure is a leading cause of death worldwide and is associated with the rising prevalence of obesity, hypertension, and diabetes.
    Methods: We developed 2 new transgenic mouse models with myocardial overexpression of OGT and OGA to control
    Results: We found that OGT transgenic hearts showed increased
    Conclusions: Our data provide evidence that excessive
    MeSH term(s) Animals ; Death, Sudden/pathology ; Disease Models, Animal ; Heart Failure/physiopathology ; Humans ; Mice ; Mice, Transgenic ; N-Acetylglucosaminyltransferases/adverse effects
    Chemical Substances N-Acetylglucosaminyltransferases (EC 2.4.1.-) ; O-GlcNAc transferase (EC 2.4.1.-)
    Language English
    Publishing date 2021-02-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.120.051911
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