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Article ; Online: CCL12 induces trabecular bone loss by stimulating RANKL production in BMSCs during acute lung injury

Chao Ma / Juan Gao / Jun Liang / Feizhen Wang / Long Xu / Jinhui Bu / Bo He / Guangpu Liu / Ru Niu / Guangwang Liu

Experimental and Molecular Medicine, Vol 55, Iss 4, Pp 818-

2023 Volume 830

Abstract: Abstract In the last three years, the capacity of health care systems and the public health policies of governments worldwide were challenged by the spread of SARS-CoV-2. Mortality due to SARS-CoV-2 mainly resulted from the development of acute lung ... ...

Abstract	Abstract In the last three years, the capacity of health care systems and the public health policies of governments worldwide were challenged by the spread of SARS-CoV-2. Mortality due to SARS-CoV-2 mainly resulted from the development of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Moreover, millions of people who survived ALI/ARDS in SARS-CoV-2 infection suffer from multiple lung inflammation-induced complications that lead to disability and even death. The lung-bone axis refers to the relationship between lung inflammatory diseases (COPD, asthma, and cystic fibrosis) and bone diseases, including osteopenia/osteoporosis. Compared to chronic lung diseases, the influence of ALI on the skeleton has not been investigated until now. Therefore, we investigated the effect of ALI on bone phenotypes in mice to elucidate the underlying mechanisms. In vivo bone resorption enhancement and trabecular bone loss were observed in LPS-induced ALI mice. Moreover, chemokine (C-C motif) ligand 12 (CCL12) accumulated in the serum and bone marrow. In vivo global ablation of CCL12 or conditional ablation of CCR2 in bone marrow stromal cells (BMSCs) inhibited bone resorption and abrogated trabecular bone loss in ALI mice. Furthermore, we provided evidence that CCL12 promoted bone resorption by stimulating RANKL production in BMSCs, and the CCR2/Jak2/STAT4 axis played an essential role in this process. Our study provides information regarding the pathogenesis of ALI and lays the groundwork for future research to identify new targets to treat lung inflammation-induced bone loss.
Keywords	Medicine ; R ; Biochemistry ; QD415-436
Subject code	616
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: CCL3 in the bone marrow microenvironment causes bone loss and bone marrow adiposity in aged mice

Degang Yu / Shuhong Zhang / Chao Ma / Sen Huang / Long Xu / Jun Liang / Huiwu Li / Qiming Fan / Guangwang Liu / Zanjing Zhai

JCI Insight, Vol 8, Iss

2023 Volume 1

Abstract: The central physiological role of the bone marrow renders bone marrow stromal cells (BMSCs) particularly sensitive to aging. With bone aging, BMSCs acquire a differentiation potential bias in favor of adipogenesis over osteogenesis, and the underlying ... ...

Abstract	The central physiological role of the bone marrow renders bone marrow stromal cells (BMSCs) particularly sensitive to aging. With bone aging, BMSCs acquire a differentiation potential bias in favor of adipogenesis over osteogenesis, and the underlying molecular mechanisms remain unclear. Herein, we investigated the factors underlying age-related changes in the bone marrow and their roles in BMSCs’ differentiation. Antibody array revealed that CC chemokine ligand 3 (CCL3) accumulation occurred in the serum of naturally aged mice along with bone aging phenotypes, including bone loss, bone marrow adiposity, and imbalanced BMSC differentiation. In vivo Ccl3 deletion could rescue these phenotypes in aged mice. CCL3 improved the adipogenic differentiation potential of BMSCs, with a positive feedback loop between CCL3 and C/EBPα. CCL3 activated C/EBPα expression via STAT3, while C/EBPα activated CCL3 expression through direct promoter binding, facilitated by DNA hypomethylation. Moreover, CCL3 inhibited BMSCs’ osteogenic differentiation potential by blocking β-catenin activity mediated by ERK-activated Dickkopf-related protein 1 upregulation. Blocking CCL3 in vivo via neutralizing antibodies ameliorated trabecular bone loss and bone marrow adiposity in aged mice. This study provides insights regarding age-related bone loss and bone marrow adiposity pathogenesis and lays a foundation for the identification of new targets for senile osteoporosis treatment.
Keywords	Aging ; Bone biology ; Medicine ; R
Subject code	616
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	American Society for Clinical investigation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Postoperative MRI Findings Following PELD and Their Correlations with Clinical Prognosis are Investigated by Injecting Contrast into Annulus Fibrosus Intraoperatively.

Bu, Jinhui / Wang, Zhenfei / Ma, Chao / Gao, Juan / Liu, Guangpu / Pang, Libo / He, Bo / Dong, Minghui / Zhang, Quan / Lei, Yan / Xu, Long / Huang, Sen / Li, Yuming / Liu, Guangwang

Journal of pain research

2024 Volume 17, Page(s) 381–392

Abstract: Objective: To validate whether a residual mass demonstrated on early postoperative MR after percutaneous endoscopic lumbar discectomy (PELD) is indeed an intraoperatively retained annulus fibrosus, and explore the correlation between imaging changes in ... ...

Abstract	Objective: To validate whether a residual mass demonstrated on early postoperative MR after percutaneous endoscopic lumbar discectomy (PELD) is indeed an intraoperatively retained annulus fibrosus, and explore the correlation between imaging changes in the residual mass and clinical prognosis of patients. Methods: A prospective study of 118 patients were included. During surgery, a contrast medium, Gadopentetate Dimeglumine, was injected around the ruptured annulus fibrosus. The intensity of the T2 signal, the size of the remaining mass (SR), and the cross-sectional area of the spinal canal (SCSA), VAS, and ODI were assessed at preoperative, 1-h (7-day), 6-month, and 12-month postoperative intervals. Based on VAS at 7 days post-surgery, patients were classified into either a non-remission group (Group A, VAS > 3) or a remission group (Group B, VAS ≤ 3). Results: Six patients who developed recurrent LDH were excluded. A residual mass was detected on MRI 1 h after surgery in 94.6% (106/112). During one year of follow-up, 90.1% (101/112) of the patients displayed fibrous annulus remodeling, although 68.7% (77/112) still exhibited herniation. Significant differences were found in the ODI between Groups A and B one week after surgery (p < 0.001). However, no significant differences were observed in T2 signal intensity, SR, and SCSA at 1-h, 6-month and 12-month post-surgery (p > 0.05) between the two groups. In a multiple linear regression analysis, early postoperative ODI changes were associated with T2 signal (B = -10.22, sig < 0.05), long-term changes were associated with alterations in SR (B = 5.63, sig < 0.05) and SCSA (B = -0.13, sig < 0.05). Conclusion: The residual mass observed in early postoperative MR images after PELD was the retained annulus fibrosus intraoperatively. Short-term changes in clinical symptoms after PELD were linked to T2 signal intensity, while long-term changes were associated with changes in SR and SCSA.
Language	English
Publishing date	2024-01-30
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495284-9
ISSN	1178-7090
ISSN	1178-7090
DOI	10.2147/JPR.S442224
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: CCL3 in the bone marrow microenvironment causes bone loss and bone marrow adiposity in aged mice.

Yu, Degang / Zhang, Shuhong / Ma, Chao / Huang, Sen / Xu, Long / Liang, Jun / Li, Huiwu / Fan, Qiming / Liu, Guangwang / Zhai, Zanjing

JCI insight

2023 Volume 8, Issue 1

Abstract	The central physiological role of the bone marrow renders bone marrow stromal cells (BMSCs) particularly sensitive to aging. With bone aging, BMSCs acquire a differentiation potential bias in favor of adipogenesis over osteogenesis, and the underlying molecular mechanisms remain unclear. Herein, we investigated the factors underlying age-related changes in the bone marrow and their roles in BMSCs' differentiation. Antibody array revealed that CC chemokine ligand 3 (CCL3) accumulation occurred in the serum of naturally aged mice along with bone aging phenotypes, including bone loss, bone marrow adiposity, and imbalanced BMSC differentiation. In vivo Ccl3 deletion could rescue these phenotypes in aged mice. CCL3 improved the adipogenic differentiation potential of BMSCs, with a positive feedback loop between CCL3 and C/EBPα. CCL3 activated C/EBPα expression via STAT3, while C/EBPα activated CCL3 expression through direct promoter binding, facilitated by DNA hypomethylation. Moreover, CCL3 inhibited BMSCs' osteogenic differentiation potential by blocking β-catenin activity mediated by ERK-activated Dickkopf-related protein 1 upregulation. Blocking CCL3 in vivo via neutralizing antibodies ameliorated trabecular bone loss and bone marrow adiposity in aged mice. This study provides insights regarding age-related bone loss and bone marrow adiposity pathogenesis and lays a foundation for the identification of new targets for senile osteoporosis treatment.
MeSH term(s)	Mice ; Animals ; Osteogenesis/physiology ; Adiposity ; Bone Marrow/pathology ; Ligands ; Cell Differentiation ; Osteoporosis/metabolism ; Obesity/complications ; Chemokine CCL3/genetics
Chemical Substances	Ligands ; Ccl3 protein, mouse ; Chemokine CCL3
Language	English
Publishing date	2023-01-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2379-3708
ISSN (online)	2379-3708
DOI	10.1172/jci.insight.159107
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: CCL12 induces trabecular bone loss by stimulating RANKL production in BMSCs during acute lung injury.

Ma, Chao / Gao, Juan / Liang, Jun / Wang, Feizhen / Xu, Long / Bu, Jinhui / He, Bo / Liu, Guangpu / Niu, Ru / Liu, Guangwang

Experimental & molecular medicine

2023 Volume 55, Issue 4, Page(s) 818–830

Abstract: In the last three years, the capacity of health care systems and the public health policies of governments worldwide were challenged by the spread of SARS-CoV-2. Mortality due to SARS-CoV-2 mainly resulted from the development of acute lung injury (ALI)/ ... ...

Abstract	In the last three years, the capacity of health care systems and the public health policies of governments worldwide were challenged by the spread of SARS-CoV-2. Mortality due to SARS-CoV-2 mainly resulted from the development of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Moreover, millions of people who survived ALI/ARDS in SARS-CoV-2 infection suffer from multiple lung inflammation-induced complications that lead to disability and even death. The lung-bone axis refers to the relationship between lung inflammatory diseases (COPD, asthma, and cystic fibrosis) and bone diseases, including osteopenia/osteoporosis. Compared to chronic lung diseases, the influence of ALI on the skeleton has not been investigated until now. Therefore, we investigated the effect of ALI on bone phenotypes in mice to elucidate the underlying mechanisms. In vivo bone resorption enhancement and trabecular bone loss were observed in LPS-induced ALI mice. Moreover, chemokine (C-C motif) ligand 12 (CCL12) accumulated in the serum and bone marrow. In vivo global ablation of CCL12 or conditional ablation of CCR2 in bone marrow stromal cells (BMSCs) inhibited bone resorption and abrogated trabecular bone loss in ALI mice. Furthermore, we provided evidence that CCL12 promoted bone resorption by stimulating RANKL production in BMSCs, and the CCR2/Jak2/STAT4 axis played an essential role in this process. Our study provides information regarding the pathogenesis of ALI and lays the groundwork for future research to identify new targets to treat lung inflammation-induced bone loss.
MeSH term(s)	Animals ; Mice ; Acute Lung Injury/pathology ; Cancellous Bone/pathology ; COVID-19 ; Lipopolysaccharides/adverse effects ; Lung/pathology ; Lung Diseases ; Mesenchymal Stem Cells ; Monocyte Chemoattractant Proteins/adverse effects ; Pneumonia ; Respiratory Distress Syndrome ; SARS-CoV-2 ; Bone Resorption
Chemical Substances	Ccl12 protein, mouse ; Lipopolysaccharides ; Monocyte Chemoattractant Proteins
Language	English
Publishing date	2023-04-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1328915-9
ISSN	2092-6413 ; 1226-3613 ; 0378-8512
ISSN (online)	2092-6413
ISSN	1226-3613 ; 0378-8512
DOI	10.1038/s12276-023-00970-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4775: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Percutaneous endoscopic lumbar discectomy

Huang, Sen / Wang, Zhenfei / Xu, Long / Bu, Jinhui / He, Bo / Xia, Mengjiao / Chen, Tao / Gao, Juan / Liu, Guangpu / Niu, Ru / Ma, Chao / Liu, Guangwang

Frontiers in surgery

2022 Volume 9, Page(s) 990751

Abstract: Objective: The purpose of this study was to analyze the clinical effect of percutaneous endoscopic medial foraminal discectomy (PEMFD) in the treatment of lumbar disc herniation (LDH).: Methods: We retrospectively examined and compared clinical data ... ...

Abstract	Objective: The purpose of this study was to analyze the clinical effect of percutaneous endoscopic medial foraminal discectomy (PEMFD) in the treatment of lumbar disc herniation (LDH). Methods: We retrospectively examined and compared clinical data from 39 single-level LDH patients who underwent PEID and 47 who underwent PEMFD. All the patients were diagnosed with single-level LDH and were treated in Xuzhou Central Hospital for single-segmental lumbar disc herniation between June 2017 and December 2019. Collect and count surgical-related indicators, intraoperative bleeding volume and 24-hour postoperative drainage volume, lower extremity numbness Visual Analogue Scale (VAS), the pain VAS and lumbar Oswestry Disability Index (ODI) scores. Results: Intraoperative bleeding volume and 24-hour postoperative drainage volume were significantly lower in the PEMFD group ( Conclusion: PEMFD and PEID have similar short- and medium-term outcomes. However, PEMFD has several advantages: simplicity, lower bleeding volume, and preservation of the LF.
Language	English
Publishing date	2022-11-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2022.990751
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Article: A retrospective study of the mid-term efficacy of full-endoscopic annulus fibrosus suture following lumbar discectomy.

Wang, Zhenfei / Huang, Sen / Xu, Long / Bu, Jinhui / Liu, Guangpu / Wang, Hui / Liang, Jun / Xia, Mengjiao / Chen, Tao / Ma, Chao / Dai, Kerong / Liu, Guangwang

Frontiers in surgery

2022 Volume 9, Page(s) 1011746

Abstract: Aims: Full-endoscopic discectomy is associated with a high risk of disc reherniation due to the poor mechanical strength of the annulus fibrosus after scar healing. It is technically difficult to place a full-endoscopic annulus fibrosus suture. We ... ...

Abstract	Aims: Full-endoscopic discectomy is associated with a high risk of disc reherniation due to the poor mechanical strength of the annulus fibrosus after scar healing. It is technically difficult to place a full-endoscopic annulus fibrosus suture. We designed an annulus fibrosus suture device that can be used to suture annulus defects under microendoscopy. The present study investigated the safety and feasibility of this technology. Patients and methods: We retrospectively analyzed the outcomes of patients who underwent surgical treatment for lumbar disc herniation (LDH) from January 2018 to October 2020. We compared 40 patients with LDH treated with full-endoscopic annulus fibrosus suture following lumbar discectomy (LD + AFS group) with 42 patients treated with lumbar discectomy alone (LD group) regarding demographic data, symptoms, and recurrence and reoperation rates. Lumbar MRI and CT were performed 3 and 12 months. A 10-point visual analog scale (VAS) and the Oswestry Disability Index (ODI) was used to evaluate pain and the lumbar spine function. Results: The cohort comprised 82 patients, including 40 patients in the LD + AFS group and 42 in the LD group. All operations were successfully completed without serious complications. Reherniation occurred in no patients in the LD + AFS group and three patients in the LD group. The VAS scores for lumbar and leg pain and ODI score were significantly improved postoperatively ( Conclusion: Compared with conventional lumbar discectomy, full-endoscopic annulus fibrosus suture following full-endoscopic lumbar discectomy is a safe and effective minimally invasive technique that reduces the LDH recurrence rate.
Language	English
Publishing date	2022-10-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2022.1011746
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Interleukin-6 from subchondral bone mesenchymal stem cells contributes to the pathological phenotypes of experimental osteoarthritis.

Wu, Xiaofeng / Cao, Lei / Li, Fan / Ma, Chao / Liu, Guangwang / Wang, Qiugen

American journal of translational research

2018 Volume 10, Issue 4, Page(s) 1143–1154

Abstract: As a main cause of morbidity in the aged population, osteoarthritis (OA) is characterized by cartilage destruction, synovium inflammation, osteophytes, and subchondral bone sclerosis. To date its etiology remains elusive. Recent data highlight an ... ...

Abstract	As a main cause of morbidity in the aged population, osteoarthritis (OA) is characterized by cartilage destruction, synovium inflammation, osteophytes, and subchondral bone sclerosis. To date its etiology remains elusive. Recent data highlight an important role of subchondral bone in the onset and progression of OA. Therefore, elucidating the mechanisms underlying abnormal subchondral bone could be of importance in the treatment of OA. Interleukin-6 is a proinflammatory cytokine involved in many physiological and pathological processes. Although
Language	English
Publishing date	2018-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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Article ; Online: MiR-199a-3p inhibits proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes via suppressing retinoblastoma 1.

Wangyang, Yufan / Yi, Linhong / Wang, Tao / Feng, Yanbo / Liu, Guangwang / Li, Dongya / Zheng, Xin

Bioscience reports

2018 Volume 38, Issue 6

Abstract: ... ...

Abstract	Background
MeSH term(s)	Apoptosis/genetics ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/pathology ; Caspase 3/genetics ; Cell Proliferation/genetics ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Gene Expression Regulation/genetics ; Humans ; MicroRNAs/genetics ; Proto-Oncogene Proteins c-bcl-2/genetics ; Retinoblastoma Binding Proteins/genetics ; Synovial Membrane/metabolism ; Synovial Membrane/pathology ; Synoviocytes/metabolism ; Synoviocytes/pathology ; Ubiquitin-Protein Ligases/genetics ; bcl-2-Associated X Protein/genetics
Chemical Substances	MicroRNAs ; Proto-Oncogene Proteins c-bcl-2 ; RB1 protein, human ; Retinoblastoma Binding Proteins ; bcl-2-Associated X Protein ; mirn199 microRNA, human ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Caspase 3 (EC 3.4.22.-)
Language	English
Publishing date	2018-11-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	764946-0
ISSN	1573-4935 ; 0144-8463
ISSN (online)	1573-4935
ISSN	0144-8463
DOI	10.1042/BSR20180982
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1676: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Erratum for Li et al., "Antibacterial Properties of Magnesium

Li, Yang / Liu, Guangwang / Zhai, Zanjing / Liu, Lina / Li, Haowei / Yang, Ke / Tan, Lili / Wan, Peng / Liu, Xuqiang / Ouyang, Zhengxiao / Yu, Zhifeng / Tang, Tingting / Zhu, Zhenan / Qu, Xinhua / Dai, Kerong

Antimicrobial agents and chemotherapy

2019 Volume 63, Issue 4

Language	English
Publishing date	2019-03-27
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/AAC.00313-19
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Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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