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Article ; Online: Pen Yan Jing Tablets Alleviates Pelvic Inflammatory Disease by Inhibiting Akt/NF-κB Pathway.

Tang, Ping / Ding, Qi / Lin, Juan / Yang, Xinrong / Wang, Yiting / Liu, Fangle / Zheng, Yuying / Lin, Liuqing / Wang, Deqin / Lin, Baoqin

International journal of medical sciences

2023 Volume 20, Issue 11, Page(s) 1386–1398

Abstract: Purpose: ...

Abstract	Purpose:
MeSH term(s)	Humans ; Female ; Rats ; Animals ; NF-kappa B/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; NF-KappaB Inhibitor alpha/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Pelvic Inflammatory Disease/drug therapy ; Lipopolysaccharides/pharmacology ; Interleukin-6 ; Intercellular Adhesion Molecule-1/metabolism ; Vascular Cell Adhesion Molecule-1/metabolism ; Vascular Cell Adhesion Molecule-1/pharmacology ; Cyclooxygenase 2/metabolism
Chemical Substances	NF-kappa B ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; NF-KappaB Inhibitor alpha (139874-52-5) ; Tumor Necrosis Factor-alpha ; Lipopolysaccharides ; Interleukin-6 ; Intercellular Adhesion Molecule-1 (126547-89-5) ; Vascular Cell Adhesion Molecule-1 ; Cyclooxygenase 2 (EC 1.14.99.1)
Language	English
Publishing date	2023-09-04
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2151424-0
ISSN	1449-1907 ; 1449-1907
ISSN (online)	1449-1907
ISSN	1449-1907
DOI	10.7150/ijms.87433
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The anti-MDR efficacy of YAN against A549/Taxol cells is associated with its inhibition on glycolysis and is further enhanced by 2-deoxy-d-glucose.

Gao, Minghuan / Yang, Yuying / Gao, Ying / Liu, Tong / Guan, Qi / Zhou, Tianhao / Shi, Yani / Hao, Mingjing / Li, Zengqiang / Zuo, Daiying / Zhang, Weige / Wu, Yingliang

Chemico-biological interactions

2022 Volume 354, Page(s) 109843

Abstract: ... drug resistance. 5-(4-ethoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazol-3-amine (YAN), a newly synthesized ... related with the apoptosis resistance. The effects of YAN above were relevant to the down-regulation ... of PI3K-Akt-c-Myc/HIF-1α pathway. Moreover, YAN induced the reactive oxygen species generation in A549 and ...

Abstract	Aerobic glycolysis is a hallmark of malignant tumor. Here, the hyperactive glycolysis in multidrug-resistant A549/Taxol cells was demonstrated to be essential for maintaining the vigorous cell viability and drug resistance. 5-(4-ethoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazol-3-amine (YAN), a newly synthesized tubulin inhibitor, could not only inhibit the glycolysis in A549 and A549/Taxol cells through down-regulating the glycolysis-related proteins, but also disrupt the mitochondrial localization of hexokinase-2 (HK-2) which is related with the apoptosis resistance. The effects of YAN above were relevant to the down-regulation of PI3K-Akt-c-Myc/HIF-1α pathway. Moreover, YAN induced the reactive oxygen species generation in A549 and A549/Taxol cells, which only mediated the apoptosis in A549 cells. We also showed that 2-DG, the glycolysis inhibitor, synergistically enhanced YAN-triggered apoptosis in A549/Taxol cells via further suppressing glycolysis and reducing mitotic slippage. Collectively, we illustrate the inhibition effect of YAN on the glycolysis in A549 and A549/Taxol cells, and provide a fresh insight into the mechanism for the development of YAN as a candidate for multidrug resistant cancer treatment. The finding that 2-DG improved the anti-tumor efficacy of YAN against A549/Taxol cells, offers a reference for solving mitotic slippage-mediated drug resistance.
MeSH term(s)	Paclitaxel
Chemical Substances	Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2022-02-02
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2022.109843
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Zs.A 686: Show issues

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Article: Stevens-Johnson syndrome/toxic epidermal necrolysis successfully treated with Chinese herbal medicine Pi-Yan-Ning: A case report.

Chen, Shu-Yi / Chen, Qun-Wei / Shou, Liu-Mei / Pan, Hong / Ruan, Shan-Ming / Liang, Zhe-Hao / Shu, Qi-Jin

Journal of integrative medicine

2021 Volume 19, Issue 6, Page(s) 555–560

Abstract: ... Chinese herbal medicine (CHM) therapy. The affected parts of the patient were treated with the CHM Pi-Yan ... In this case, SJS/TEN was successfully treated with Pi-Yan-Ning, suggesting that there might be tremendous ... potential for the use of Pi-Yan-Ning in the treatment of severe skin reactions to drug treatments. Further ...

Abstract	Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare adverse cutaneous reaction with a low incidence and high mortality. Despite posing a serious threat to patients' health and lives, there is no high-quality evidence for a standard treatment regimen. Here we report the case of a 62-year-old man with stage IV pancreatic cancer who experienced immunotherapy-induced SJS/TEN. After consensus-based regular treatments at a local hospital, his symptoms became worse. Thus, he consented to receive Chinese herbal medicine (CHM) therapy. The affected parts of the patient were treated with the CHM Pi-Yan-Ning which was applied externally for 20 min twice a day. After 7 days of treatment, the dead skin began peeling away from the former lesions that had covered his hands, feet, and lips, indicating that skin had regenerated. After 12 days of treatment, the patient's skin was completely recovered. In this case, SJS/TEN was successfully treated with Pi-Yan-Ning, suggesting that there might be tremendous potential for the use of Pi-Yan-Ning in the treatment of severe skin reactions to drug treatments. Further basic investigations and clinical trials to explore the mechanism and efficacy are needed.
MeSH term(s)	Drugs, Chinese Herbal/therapeutic use ; Humans ; Immunologic Factors ; Incidence ; Male ; Middle Aged ; Skin ; Stevens-Johnson Syndrome/drug therapy ; Stevens-Johnson Syndrome/etiology
Chemical Substances	Drugs, Chinese Herbal ; Immunologic Factors
Language	English
Publishing date	2021-10-11
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2705612-0
ISSN	2095-4964
ISSN	2095-4964
DOI	10.1016/j.joim.2021.10.001
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Zs.A 6322: Show issues

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Article ; Online: YAN, a novel microtubule inhibitor, inhibits P-gp and MRP1 function and induces mitotic slippage followed by apoptosis in multidrug-resistant A549/Taxol cells.

Gao, Minghuan / Liu, Tong / Li, Jingnan / Guan, Qi / Wang, Haoran / Yan, Shuqi / Li, Zengqiang / Zuo, Daiying / Zhang, Weige / Wu, Yingliang

Toxicology in vitro : an international journal published in association with BIBRA

2020 Volume 69, Page(s) 104971

Abstract: ... 5-trimethoxyphenyl)-1H-1,2,4-triazol-3-amine (YAN) exhibited strong cytotoxicity towards A549 and ... MDR-phenotype A549/Taxol cells. We demonstrated that YAN was a poor substrate of P-glycoprotein (P-gp ... and YAN inhibited their expression and function. Moreover, YAN arrested cells at mitosis phase ...

Abstract	Lung cancer is the most common cause of cancer-related death worldwide. The occurrence of multidrug resistance (MDR) affects the therapeutic efficacy of chemotherapeutics. Therefore, to develop new anticarcinogen which can overcome MDR is urgent. Here, the novel microtubule inhibitor 5-(4-ethoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazol-3-amine (YAN) exhibited strong cytotoxicity towards A549 and MDR-phenotype A549/Taxol cells. We demonstrated that YAN was a poor substrate of P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) which were over-expressed in A549/Taxol cells, and YAN inhibited their expression and function. Moreover, YAN arrested cells at mitosis phase by inhibiting microtubule polymerization. Further, YAN induced caspase-dependent apoptosis in A549 cells via mitochondria-mediated intrinsic pathway. In contrast, the multinucleation of A549/Taxol cells after YAN-treatment indicated the occurrence of mitotic catastrophe, and the subsequent apoptosis was mediated by apoptosis-inducing factor (AIF) nuclear translocation instead of p53- and caspase-dependent manner. Moreover, the inhibitory effect of YAN on PI3K/Akt activity was involved in the regulation of P-gp, MRP1 and AIF in A549/Taxol cells. Taken together, our finding indicates that YAN is a novel microtubule inhibitor and overcomes MDR by suppressing P-gp and MRP1 function and inducing cell death independent of p53 and caspase in A549/Taxol cells. Therefore, YAN possesses great potential for future development into an effective anticarcinogen especially for drug-resistant cancer.
MeSH term(s)	ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Line ; Drug Resistance, Multiple/drug effects ; Drug Resistance, Neoplasm/drug effects ; Humans ; Mice ; Mitosis/drug effects ; Multidrug Resistance-Associated Proteins/genetics ; Multidrug Resistance-Associated Proteins/metabolism ; Paclitaxel/pharmacology ; Tubulin Modulators/pharmacology
Chemical Substances	ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Antineoplastic Agents ; Multidrug Resistance-Associated Proteins ; Tubulin Modulators ; Paclitaxel (P88XT4IS4D) ; multidrug resistance-associated protein 1 (Y49M64GZ4Q)
Language	English
Publishing date	2020-08-15
Publishing country	England
Document type	Journal Article
ZDB-ID	639064-x
ISSN	1879-3177 ; 0887-2333
ISSN (online)	1879-3177
ISSN	0887-2333
DOI	10.1016/j.tiv.2020.104971
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Zs.A 2223: Show issues

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Article ; Online: Correction to: YAN, a novel microtubule inhibitor, inhibits P-gp and MRP1 function and induces mitotic slippage followed by apoptosis in multidrug-resistant A549/Taxol cells.

Gao, Minghuan / Liu, Tong / Li, Jingnan / Guan, Qi / Wang, Haoran / Yan, Shuqi / Li, Zengqiang / Zuo, Daiying / Zhang, Weige / Wu, Yingliang

Toxicology in vitro : an international journal published in association with BIBRA

2020 Volume 72, Page(s) 105033

Language	English
Publishing date	2020-10-29
Publishing country	England
Document type	Published Erratum
ZDB-ID	639064-x
ISSN	1879-3177 ; 0887-2333
ISSN (online)	1879-3177
ISSN	0887-2333
DOI	10.1016/j.tiv.2020.105033
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Article: Isolation and characterization of a goose parvovirus from Yan goose.

Wang, K / Wang, C J / Pan, L / Wang, G J / Qi, K Z / Liu, H M

Acta virologica

2016 Volume 60, Issue 3, Page(s) 333–335

Abstract: NO ABSTRACT Keywords: goose parvovirus; Yan goose; isolation; characterization. ...

Abstract	NO ABSTRACT Keywords: goose parvovirus; Yan goose; isolation; characterization.
MeSH term(s)	Animals ; Anseriformes ; Antigens, Viral/genetics ; Antigens, Viral/metabolism ; Gene Expression Regulation, Viral/physiology ; Genetic Variation ; Genome, Viral ; Parvoviridae Infections/veterinary ; Parvoviridae Infections/virology ; Parvovirus/classification ; Parvovirus/genetics ; Parvovirus/isolation & purification ; Phylogeny
Chemical Substances	Antigens, Viral
Language	English
Publishing date	2016-09-17
Publishing country	Slovakia
Document type	Letter
ZDB-ID	210452-0
ISSN	1336-2305 ; 0001-723X
ISSN (online)	1336-2305
ISSN	0001-723X
DOI	10.4149/av_2016_03_333
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Zs.A 336: Show issues

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Article ; Online: Yan-Hou-Qing formula attenuates ammonia-induced acute pharyngitis in rats via inhibition of NF-κB and COX-2.

Xu, Min / Hu, Tian-Yong / Li, Dong-Cai / Ma, Li / Zhang, Hua / Fan, Jun-Ting / Fan, Xiao-Mei / Zeng, Xian-Hai / Qiu, Shu-Qi / Liu, Zhi-Qiang / Cheng, Bao-Hui

BMC complementary medicine and therapies

2020 Volume 20, Issue 1, Page(s) 280

Abstract: Background: Yan Hou Qing (YHQ) is a Chinese medicinal formula designed to alleviate sore throat ...

Abstract	Background: Yan Hou Qing (YHQ) is a Chinese medicinal formula designed to alleviate sore throat symptoms, but underlying mechanism of YHQ treatment for pharyngitis is poorly defined up to now. Methods: In this study, the modulation of YHQ on pharyngitis is investigated in ammonia-induced acute pharyngitis rat models. After treatment with YHQ or dexamethasone respectively for five consecutive days, all rats were sacrificed for biomolecular and histopathologic study. Protein expressions of MAPKs, NF-κB, COX-2 and 5-LOX in pharyngitis tissue were evaluated by western blot analysis and the levels of TNF-α, IL-6, prostaglandin (PG) E Results: Compared with normal control group, EB dye exudation, and inflammatory cytokines in the model group were significantly increased, and the pharynx tissue was obviously infiltrated by inflammatory cells. YHQ treatment improved the inflammatory infiltrate in pharyngeal tissue, and reduced EB dye exudation in AP rat models. The up-regulated TNF-α and IL-6 in pharyngeal tissue of AP were significantly reduced by YHQ through inhibition of phosphorylation of p38, Erk and NF-κB. YHQ treatment also reversed the increased level of PGE Conclusions: YHQ formula attenuated the pharyngitis related symptoms via suppression of COX-2 and phosphorylation of p38, Erk and NF-κB (p65).
MeSH term(s)	Ammonia ; Animals ; China ; Cyclooxygenase 2/drug effects ; Cyclooxygenase 2/metabolism ; Disease Models, Animal ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Female ; Molecular Structure ; NF-kappa B/drug effects ; NF-kappa B/metabolism ; Pharyngitis/drug therapy ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Drugs, Chinese Herbal ; NF-kappa B ; Ammonia (7664-41-7) ; Cyclooxygenase 2 (EC 1.14.99.1)
Language	English
Publishing date	2020-09-14
Publishing country	England
Document type	Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-020-03077-1
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Article ; Online: Farming Influence on Physical-Mechanical Properties and Microstructural Characteristics of Backfilled Loess Farmland in Yan’an, China

Lina Ma / Shengwen Qi / Bowen Zheng / Songfeng Guo / Qiangbing Huang / Xinbao Yu

Sustainability, Vol 12, Iss 5516, p

2020 Volume 5516

Abstract: A gigantic project named Gully Land Consolidation (GLC) was launched in the hill-gully region of the Chinese Loess Plateau in 2011 to cope with land degradation and create new farmlands for cultivation. However, as a particular kind of remolded loess, ... ...

Abstract	A gigantic project named Gully Land Consolidation (GLC) was launched in the hill-gully region of the Chinese Loess Plateau in 2011 to cope with land degradation and create new farmlands for cultivation. However, as a particular kind of remolded loess, the newly created and backfilled farmland may bring new engineering and environmental problems because the soil structure was disturbed and destroyed. In this study, current situations and characteristics of GLC are introduced. Test results show that physical-mechanical properties and microstructural characteristics of backfilled loess of one-year and five-year farmland are significantly affected by the Gully Land Consolidation project. Compared to natural loess, the moisture content, density, and internal friction angle of backfilled loess increase. On the contrary, the porosity, plasticity index, particle size index, and cohesion index decrease. Through SEM tests, it is observed that the particles of backfilled loess are rounded, with large pores filled with crushed fine particles, which results in skeleton strength weakness among particles and pores. The pore size distribution (PSD) of the four types of loess (Q 3 loess, Q 2 loess, one-year farmland, and five-year farmland) was measured using mercury intrusion porosimetry (MIP) tests, showing that the pore size of Q 3 loess is mainly mesopores 4000–20,000 nm in size, accounting for 67.5%. The Q 2 , five-year, and one-year farmland loess have mainly small pores 100–4000 nm in size, accounting for 52.5%, 51.7%, and 71.7%, respectively. The microscopic analysis shows that backfill action degrades the macropores and mesopores into small pores and micropores, leading to weak connection strength among soil particles, which further affects the physical-mechanical properties of loess. The disturbance of backfilled loess leads to an obvious decrease in cohesion and a slight increase in internal friction compared to natural loess. The farming effect becomes prominent with increased backfill time, while the loess soil ...
Keywords	Gully Land Consolidation ; backfilled loess ; physical-mechanical property ; microstructural characteristic ; pore size distribution ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	620
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Yan-Hou-Qing formula attenuates allergic airway inflammation via up-regulation of Treg and suppressing Th2 responses in Ovalbumin-induced asthmatic mice.

Cheng, Bao-Hui / Hu, Tian-Yong / Mo, Li-Hua / Ma, Li / Hu, Wen-Hui / Li, Yi-Sheng / Liu, Zhi-Qiang / Qiu, Shu-Qi

Journal of ethnopharmacology

2018 Volume 231, Page(s) 275–282

Abstract: Ethnopharmacological relevance: Yan-Hou-Qing (YHQ), a Chinese medicine formula containing fourteen ...

Abstract	Ethnopharmacological relevance: Yan-Hou-Qing (YHQ), a Chinese medicine formula containing fourteen kinds of materials, has been designed for pharyngitis and cough treatment in Oriental medicine. In the present study, the anti-allergic effects and underlying mechanisms of YHQ in inhibition of airway hyper responsiveness (AHR) was explored in an ovalbumin (OVA)-induced allergic asthma mouse model. Materials and methods: BALB/c mice were sensitized by OVA and cholera toxin (CT) and challenged with OVA intranasally to induce allergic asthma mouse model. YHQ (200 mg/kg) was orally administered for 3 weeks from week-2 after OVA sensitization. The AHR and histological changes of lung tissues were evaluated by whole-body barometric plethysmography analysis and hematoxylin and eosin (H&E) staining, respectively. The serum concentration of OVA-specific IgE and T helper 2 (Th2) cytokines (IL-4 and IL-13) were determined by enzyme-linked immune sorbent assay (ELISA). Flow cytometry was performed to evaluate the percentage of CD4 Results: The elevated AHR responses, heavier inflammatory cell infiltration and Th2 cytokines in allergic asthma group indicated Ovalbumin-induced asthmatic mouse models were built successfully. Compared to allergic asthma group, OVA-induced AHR responses and eosinophil infiltration in lung were improved significantly, and the productions of OVA-specific IgE and Th2 cytokines, IL-4 and IL-13, in the serum were also reduced dramatically after the treatment of YHQ. Moreover, YHQ treatment significantly increased the percentage of CD4 Conclusions: YHQ improves the allergic asthma related symptoms via promotion of CD4
MeSH term(s)	Allergens ; Animals ; Anti-Asthmatic Agents/pharmacology ; Anti-Asthmatic Agents/therapeutic use ; Asthma/blood ; Asthma/drug therapy ; Asthma/immunology ; Cholera Toxin ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Female ; Immunoglobulin E/blood ; Interleukin-13/blood ; Interleukin-4/blood ; Mice, Inbred BALB C ; Ovalbumin ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; Th2 Cells/drug effects ; Th2 Cells/immunology
Chemical Substances	Allergens ; Anti-Asthmatic Agents ; Drugs, Chinese Herbal ; Interleukin-13 ; yan-hou-qing ; Interleukin-4 (207137-56-2) ; Immunoglobulin E (37341-29-0) ; Ovalbumin (9006-59-1) ; Cholera Toxin (9012-63-9)
Language	English
Publishing date	2018-11-26
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2018.11.038
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Zs.A 1494: Show issues

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Article ; Online: Yan-Hou-Qing formula attenuates ammonia-induced acute pharyngitis in rats via inhibition of NF-κB and COX-2

Min Xu / Tian-Yong Hu / Dong-Cai Li / Li Ma / Hua Zhang / Jun-Ting Fan / Xiao-Mei Fan / Xian-Hai Zeng / Shu-Qi Qiu / Zhi-Qiang Liu / Bao-Hui Cheng

BMC Complementary Medicine and Therapies, Vol 20, Iss 1, Pp 1-

2020 Volume 13

Abstract: Abstract Background Yan Hou Qing (YHQ) is a Chinese medicinal formula designed to alleviate sore ...

Abstract	Abstract Background Yan Hou Qing (YHQ) is a Chinese medicinal formula designed to alleviate sore throat symptoms, but underlying mechanism of YHQ treatment for pharyngitis is poorly defined up to now. Methods In this study, the modulation of YHQ on pharyngitis is investigated in ammonia-induced acute pharyngitis rat models. After treatment with YHQ or dexamethasone respectively for five consecutive days, all rats were sacrificed for biomolecular and histopathologic study. Protein expressions of MAPKs, NF-κB, COX-2 and 5-LOX in pharyngitis tissue were evaluated by western blot analysis and the levels of TNF-α, IL-6, prostaglandin (PG) E2, leukotrienes (LT)-B4 and LT-D4 in pharyngeal tissue were measured via ELISA assay. Evans blue (EB) dye exudation test was performed parallelly to assess the integrity of pharyngeal tissue. Results Compared with normal control group, EB dye exudation, and inflammatory cytokines in the model group were significantly increased, and the pharynx tissue was obviously infiltrated by inflammatory cells. YHQ treatment improved the inflammatory infiltrate in pharyngeal tissue, and reduced EB dye exudation in AP rat models. The up-regulated TNF-α and IL-6 in pharyngeal tissue of AP were significantly reduced by YHQ through inhibition of phosphorylation of p38, Erk and NF-κB. YHQ treatment also reversed the increased level of PGE2 through down-regulation of COX-2. Conclusions YHQ formula attenuated the pharyngitis related symptoms via suppression of COX-2 and phosphorylation of p38, Erk and NF-κB (p65).
Keywords	Pharyngitis ; Inflammation ; Yan Hou Qing ; NF-κB ; COX-2 ; Other systems of medicine ; RZ201-999
Subject code	630
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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