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Article ; Online: Changes in phenolics and flavonoids in amaranth and soybean sprouts after UV-C treatment.

García-Mosqueda, Cristina / Cerón-García, Abel / León-Galván, Ma Fabiola / Ozuna, César / López-Malo, Aurelio / Sosa-Morales, María Elena

Journal of food science

2023 Volume 88, Issue 4, Page(s) 1280–1291

Abstract: Sprouts, mainly from cereals, legumes, and some pseudo-cereals, are rich in nutrients and contain biocompounds, making them attractive for consumption. This research study aimed to develop treatments with UV-C light in soybean and amaranth sprouts and ... ...

Abstract	Sprouts, mainly from cereals, legumes, and some pseudo-cereals, are rich in nutrients and contain biocompounds, making them attractive for consumption. This research study aimed to develop treatments with UV-C light in soybean and amaranth sprouts and evaluate their effect on biocompounds content, compared with chlorine treatments. UV-C treatments were applied at distances of 3 and 5 cm and times of 2.5, 5, 10, 15, 20, and 30 min, whereas chlorine treatments were applied as immersion in solutions at 100 and 200 ppm for 15 min. Phenolics and flavonoid content were higher in UV-C-treated sprouts than in those treated with chlorine solutions. Ten biocompounds were identified in soybean sprouts, with increasing in apigenin C-glucoside-rhamnoside (105%), apigenin 7-O-glucosylglucoside (237%), and apigenin C-glucoside malonylated (70%) due to UV-C application (3 cm, 15 min); for amaranth sprouts, five biocompounds were identified, with higher contents of p-coumaroylquinic acid (17.7%) after UV-C treatment (3 cm, 15 min). The best treatment to achieve the highest bioactive compounds concentration was UV-C at a distance of 3 cm for 15 min, without significant modification on the color parameters, Hue and chroma. PRACTICAL APPLICATION: UV-C can be used to increase the biocompound content in amaranth and soybean sprouts. Nowadays, there is UV-C equipment available for industrial applications. In this way, sprouts may be maintained as fresh through this physical technology, and they will retain or increase the concentration of health-related compounds.
MeSH term(s)	Apigenin ; Chlorine ; Fabaceae ; Flavonoids ; Phenols ; Glycine max ; Ultraviolet Rays
Chemical Substances	Apigenin (7V515PI7F6) ; Chlorine (4R7X1O2820) ; Flavonoids ; Phenols
Language	English
Publishing date	2023-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	241615-3
ISSN	1750-3841 ; 0022-1147
ISSN (online)	1750-3841
ISSN	0022-1147
DOI	10.1111/1750-3841.16527
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Influence of plasma kinetic energy during the pulsed laser deposition of borophene films on silicon (100).

Rivera-Tello, César D / Guerrero, J A / Huerta, L / Flores-Ruiz, Francisco J / Flores, M / Quiñones-Galván, J G

RSC advances

2023 Volume 13, Issue 43, Page(s) 29819–29829

Abstract: Developing borophene films with good structural stability on non-metallic substrates to maximize their potential in photosensitivity, gas detection, photothermia, energy storage, and deformation detection, among others has been challenging in recent ... ...

Abstract	Developing borophene films with good structural stability on non-metallic substrates to maximize their potential in photosensitivity, gas detection, photothermia, energy storage, and deformation detection, among others has been challenging in recent years. Herein, we succeeded in the pulsed laser deposition of multilayered borophene films on Si (100) with β
Language	English
Publishing date	2023-10-11
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra04601j
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Childhood leukemias in Mexico: towards implementing CAR-T cell therapy programs.

Bustamante-Ogando, Juan Carlos / Hernández-López, Alejandrina / Galván-Díaz, César / Rivera-Luna, Roberto / Fuentes-Bustos, Hugo E / Meneses-Acosta, Angélica / Olaya-Vargas, Alberto

Frontiers in oncology

2024 Volume 13, Page(s) 1304805

Abstract: Leukemias are the most common type of pediatric cancer around the world. Prognosis has improved during the last decades, and many patients are cured with conventional treatment as chemotherapy; however, many patients still present with a refractory ... ...

Abstract	Leukemias are the most common type of pediatric cancer around the world. Prognosis has improved during the last decades, and many patients are cured with conventional treatment as chemotherapy; however, many patients still present with a refractory disease requiring additional treatments, including hematopoietic stem cell transplantation. Immunotherapy with monoclonal antibodies or cellular therapy is a promising strategy for treating refractory or relapsed hematological malignancies. Particularly, CAR-T cells have shown clinical efficacy in clinical trials, and different products are now commercially approved by regulatory agencies in the USA and Europe. Many challenges still need to be solved to improve and optimize the potential of these therapies worldwide. Global access to cell therapy is a significant concern, and different strategies are being explored in the middle- and low-income countries. In Mexico, leukemias represent around 50% of total cancer diagnosed in pediatric patients, and the rate of relapsed or refractory disease is higher than reported in other countries, a multi-factorial problem. Although significant progress has been made during the last decades in leukemia diagnosis and treatment, making new therapies available to Mexican patients is a priority, and cell and gene therapies are on the horizon. Efforts are ongoing to make CAR-T cell therapy accessible for patients in Mexico. This article summarizes a general landscape of childhood leukemias in Mexico, and we give a perspective about the current strategies, advances, and challenges ahead to make gene and cell therapies for leukemia clinically available.
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1304805
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Article ; Online: Sobrestimación de alergia alimentaria reportada por padres en un centro peruano de alergia, asma e inmunología.

Mendoza-Quispe, Daniel / Alvarez, Liliana / Galván, César A

Revista peruana de medicina experimental y salud publica

2019 Volume 35, Issue 4, Page(s) 708–710

Title translation	Overestimation of food allergies reported by parents in a Peruvian allergy, asthma, and immunology center.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Diagnostic Errors/statistics & numerical data ; Female ; Food Hypersensitivity/diagnosis ; Food Hypersensitivity/epidemiology ; Humans ; Infant ; Infant, Newborn ; Male ; Parents ; Peru
Language	Spanish
Publishing date	2019-02-06
Publishing country	Peru
Document type	Letter
ZDB-ID	2120092-0
ISSN	1726-4642 ; 1726-4634
ISSN (online)	1726-4642
ISSN	1726-4634
DOI	10.17843/rpmesp.2018.354.3763
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Article ; Online: Driver Identification Using Statistical Features of Motor Activity and Genetic Algorithms.

Espino-Salinas, Carlos H / Luna-García, Huizilopoztli / Celaya-Padilla, José M / Morgan-Benita, Jorge A / Vera-Vasquez, Cesar / Sarmiento, Wilson J / Galván-Tejada, Carlos E / Galván-Tejada, Jorge I / Gamboa-Rosales, Hamurabi / Villalba-Condori, Klinge Orlando

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 2

Abstract: Driver identification refers to the process whose primary purpose is identifying the person behind the steering wheel using collected information about the driver him/herself. The constant monitoring of drivers through sensors generates great benefits in ...

Abstract	Driver identification refers to the process whose primary purpose is identifying the person behind the steering wheel using collected information about the driver him/herself. The constant monitoring of drivers through sensors generates great benefits in advanced driver assistance systems (ADAS), to learn more about the behavior of road users. Currently, there are many research works that address the subject in search of creating intelligent models that help to identify vehicle users in an efficient and objective way. However, the different methodologies proposed to create these models are based on data generated from sensors that include different vehicle brands on routes established in real environments, which, although they provide very important information for different purposes, in the case of driver identification, there may be a certain degree of bias due to the different situations in which the route environment may change. The proposed method seeks to intelligently and objectively select the most outstanding statistical features from motor activity generated in the main elements of the vehicle with genetic algorithms for driver identification, this process being newer than those established by the state-of-the-art. The results obtained from the proposal were an accuracy of 90.74% to identify two drivers and 62% for four, using a Random Forest Classifier (RFC). With this, it can be concluded that a comprehensive selection of features can greatly optimize the identification of drivers.
MeSH term(s)	Humans ; Male ; Automobile Driving ; Accidents, Traffic ; Random Forest ; Learning ; Motor Activity
Language	English
Publishing date	2023-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23020784
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Article ; Online: Aplicación de biológicos en pacientes con alergia alimentaria.

Agar Muñoz, Ana María / Galván Calle, César Alberto

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)

2023 Volume 70, Issue 4, Page(s) 297–299

Abstract: Despite promising advancements in oral immunotherapy for food allergies, medical implementation faces limitations. Non-specific treatment options based on inhibiting the type 2 inflammatory pathway, including monoclonal antibodies, are under ... ...

Title translation	Application of biologicals in patients with food allergies.
Abstract	Despite promising advancements in oral immunotherapy for food allergies, medical implementation faces limitations. Non-specific treatment options based on inhibiting the type 2 inflammatory pathway, including monoclonal antibodies, are under investigation. TNX-901 and omalizumab have demonstrated increased reaction thresholds, reducing adverse events in peanut-allergic patients. Dupilumab, blocking the IL-4 receptor, shows positive results in both food allergies and eosinophilic esophagitis. Antibodies against alarmins and anti-IL-5, such as etokimab and mepolizumab, have proven efficacy in preclinical studies and clinical trials. While further studies are needed to establish their practical clinical use and determine suitability for different types of food allergies, these monoclonal antibodies present a promising horizon for the treatment of such conditions.
MeSH term(s)	Humans ; Biological Products/therapeutic use ; Antibodies, Monoclonal ; Food Hypersensitivity/complications ; Immunotherapy ; Omalizumab/therapeutic use
Chemical Substances	Biological Products ; Antibodies, Monoclonal ; Omalizumab (2P471X1Z11)
Language	Spanish
Publishing date	2023-12-31
Publishing country	Mexico
Document type	English Abstract ; Journal Article
ZDB-ID	639125-4
ISSN	2448-9190 ; 0002-5151
ISSN (online)	2448-9190
ISSN	0002-5151
DOI	10.29262/ram.v70i4.1340
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Article ; Online: Sobrestimación de alergia alimentaria reportada por padres en un centro peruano de alergia, asma e inmunología

Daniel Mendoza-Quispe / Liliana Alvarez / César A. Galván

Revista Peruana de Medicina Experimental y Salud Pública, Vol 35, Iss 4, Pp 708-

2018 Volume 10

Abstract: ...

Abstract	-
Keywords	Medicine ; R ; Medicine (General) ; R5-920
Language	Spanish
Publishing date	2018-12-01T00:00:00Z
Publisher	Instituto Nacional de Salud
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prognosis of polypoid melanoma: a comparative study with non-polypoid melanomas.

Jasso-Sosa, Velma Y / Lino-Silva, Leonardo S / Escobar-Jiménez, Marín G / Galván-Bustillos, Joab R / García-Ortega, Dorian Y / Salcedo-Hernández, Rosa A / Zepeda-Najar, César / Frías-Fernández, Pedro

Melanoma research

2023 Volume 33, Issue 3, Page(s) 257–261

Abstract: Polypoid melanoma is considered an exophytic and frequently non-pigmented variant of nodular melanoma with an adverse prognosis; however, very few studies have been published about it with contradictory results. Therefore, our objective was to determine ... ...

Abstract	Polypoid melanoma is considered an exophytic and frequently non-pigmented variant of nodular melanoma with an adverse prognosis; however, very few studies have been published about it with contradictory results. Therefore, our objective was to determine the prognostic value of this configuration in melanomas. A transversal retrospective study of 724 cases was analyzed according to the main configuration (polypoid vs. non-polypoid) regarding their clinicopathologic characteristics and survival analysis. Of the 724 cases, 35 (4.8%) met the definition of polypoid melanoma; such cases, compared with non-polypoid melanomas, were associated with a high Breslow thickness (7 mm vs. 3 mm), 68.6% had a Breslow >4 mm; showed different clinical stages of presentation, and presented more ulceration (77.1 vs. 51.4%). In the 5-year overall survival (OS) analysis, polypoid melanoma is associated with a lower 5-year OS, together with lymph node metastasis, Breslow thickness, clinical stage, mitoses per mm 2 , vertical growth phase, ulceration, and state of the surgical margins; however, in the multivariate analysis, the factors that remained independent predictors of death were the Breslow thickness groups, the clinical stage, the presence of ulceration, and the state of the surgical margins. Polypoid melanoma was not an independent predictor of OS. We found a prevalence of 4.8% of polypoid melanomas, which showed a worse prognosis than non-polypoid melanomas, explained by a higher proportion of ulcerated cases, greater Breslow thickness, and ulceration. However, polypoid melanoma was not an independent predictor of death.
MeSH term(s)	Humans ; Melanoma/pathology ; Skin Neoplasms/pathology ; Retrospective Studies ; Margins of Excision ; Prognosis ; Sentinel Lymph Node Biopsy
Language	English
Publishing date	2023-03-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1095779-0
ISSN	1473-5636 ; 0960-8931
ISSN (online)	1473-5636
ISSN	0960-8931
DOI	10.1097/CMR.0000000000000886
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Article ; Online: Participation of apoptotic markers in the process of maturation and elimination of spermatozoa in the epididymis of the Corynorhinus mexicanus bat.

Samano-Barbosa, Gihovani Ademir / López-Trinidad, Blanca Patrícia / Rodríguez-Tobón, Ahiezer / Chávez-Zamora, Julio Cesar / Cortés-Barberena, Edith / León-Galván, Miguel Angel / Rodríguez-Tobón, Ernesto / Arenas-Ríos, Edith

Molecular reproduction and development

2023 Volume 90, Issue 8-9, Page(s) 749–757

Abstract: The Corynorhinus mexicanus bat is characterized by a specific form of reproductive asynchrony between males and females. After mating, some sperm remain in the male's epididymis, the organ where the sperm had matured. It has not yet been determined if ... ...

Abstract	The Corynorhinus mexicanus bat is characterized by a specific form of reproductive asynchrony between males and females. After mating, some sperm remain in the male's epididymis, the organ where the sperm had matured. It has not yet been determined if apoptotic markers participate in the process of the maturation and/or elimination of these cells, so studying this topic is essential for our understanding of this species. Male bats were collected during three stages: Before mating; during the Mating phase; After mating and the final phase, which we call, Storage. Their epididymides were removed, weighed and measured. Sperm were extracted and the following sperm parameters were evaluated: active caspases, phosphatidylserine externalization, and mitochondrial membrane potential. Sperm from the testes enter the epididymis during Before mating, causing the organ to grow. During Mating phase, spermatozoa present a large amount of active caspases with externalization of phosphatidyl serine, even while still alive. This suggests that these two markers could participate in maturation and elimination, respectively.
Language	English
Publishing date	2023-08-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	20321-x
ISSN	1098-2795 ; 1040-452X
ISSN (online)	1098-2795
ISSN	1040-452X
DOI	10.1002/mrd.23701
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Article: Monocyte (THP-1) Response to Silver Nanoparticles Synthesized with

Alvarez-Cirerol, Francisco Javier / Galván-Moroyoqui, José Manuel / Rodríguez-León, Ericka / Candía-Plata, Carmen / Rodríguez-Beas, César / López-Soto, Luis Fernando / Rodríguez-Vázquez, Blanca Esthela / Bustos-Arriaga, José / Soto-Guzmán, Adriana / Larios-Rodríguez, Eduardo / Martínez-Soto, Juan M / Martinez-Higuera, Aaron / Iñiguez-Palomares, Ramón A

Nanomaterials (Basel, Switzerland)

2024 Volume 14, Issue 1

Abstract: The study, synthesis, and application of nanomaterials in medicine have grown exponentially in recent years. An example of this is the understanding of how nanomaterials activate or regulate the immune system, particularly macrophages. In this work, ... ...

Abstract	The study, synthesis, and application of nanomaterials in medicine have grown exponentially in recent years. An example of this is the understanding of how nanomaterials activate or regulate the immune system, particularly macrophages. In this work, nanoparticles were synthesized using
Language	English
Publishing date	2024-01-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano14010106
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