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  1. Article ; Online: Response to Aspirin Therapy in COVID-19: Prevention of NETosis.

    Lal, Amos / Gajic, Ognjen

    Archivos de bronconeumologia

    2022  Volume 59, Issue 2, Page(s) 130

    MeSH term(s) Humans ; COVID-19/prevention & control ; Analgesics ; Aspirin/therapeutic use
    Chemical Substances Analgesics ; Aspirin (R16CO5Y76E)
    Language Spanish
    Publishing date 2022-10-20
    Publishing country Spain
    Document type Letter
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2022.10.004
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    Zs.B 2655: Show issues Location:
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  2. Article ; Online: Correction to: Kidney and lung crosstalk during critical illness: large-scale cohort study.

    Tomasi, Alessandra / Song, Xuan / Gajic, Ognjen / Kashani, Kianoush

    Journal of nephrology

    2023  Volume 36, Issue 4, Page(s) 1213–1217

    Language English
    Publishing date 2023-02-09
    Publishing country Italy
    Document type Published Erratum
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01594-z
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    Zs.A 3369: Show issues Location:
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  3. Article ; Online: Challenges, obstacles, and unknowns in implementing principles of modern intensive care medicine in low-resource settings: an insider's perspective.

    Kovacevic, Pedja / Meyer, F Joachim / Gajic, Ognjen

    Intensive care medicine

    2023  Volume 50, Issue 1, Page(s) 141–143

    MeSH term(s) Humans ; Critical Care ; Health Resources
    Language English
    Publishing date 2023-12-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07270-x
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    Zs.A 1089: Show issues Location:
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  4. Article: The Neutrophil/Lymphocyte Ratio and Outcomes in Hospitalized Patients with Community-Acquired Pneumonia: A Retrospective Cohort Study.

    Tekin, Aysun / Wireko, Felix W / Gajic, Ognjen / Odeyemi, Yewande E

    Biomedicines

    2024  Volume 12, Issue 2

    Abstract: We aimed to assess the prognostic role of the neutrophil/lymphocyte ratio (NLR) in community-acquired pneumonia (CAP) via a single-center retrospective cohort of hospitalized adult patients from 1/2009 to 12/2019. Patients were dichotomized into lower ... ...

    Abstract We aimed to assess the prognostic role of the neutrophil/lymphocyte ratio (NLR) in community-acquired pneumonia (CAP) via a single-center retrospective cohort of hospitalized adult patients from 1/2009 to 12/2019. Patients were dichotomized into lower NLR (≤12) and higher NLR (>12). The primary outcome was mortality. ICU admission and hospital- and ICU-free days were secondary outcomes. The pneumonia severity index (PSI) and the NLR's ability to predict outcomes was also tested. An NLR ≤12 was observed in 2513 (62.2%) patients and >12 in 1526 (37.8%). After adjusting for PSI, the NLR was not associated with hospital mortality (odds ratio [OR] 1.115; 95% confidence interval [CI] 0.774, 1.606;
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12020260
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  5. Article ; Online: Inhaled NO in COVID-19 Acute Respiratory Distress Syndrome: Yes or No?

    Lal, Amos / Gladwin, Mark T / Gajic, Ognjen

    American journal of respiratory and critical care medicine

    2023  Volume 208, Issue 12, Page(s) 1259–1261

    MeSH term(s) Humans ; Nitric Oxide ; COVID-19 ; Respiratory Distress Syndrome/drug therapy ; Respiratory Insufficiency
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2023-11-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202310-1823ED
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    Uh II Zs.80: Show issues Location:
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  6. Article ; Online: Supporting Health Care Workers During the Armed Conflict in Ukraine.

    Niven, Alexander S / Skomro, Robert P / Dziuba, Dmytro / Gajic, Ognjen

    Chest

    2023  Volume 163, Issue 6, Page(s) 1365–1367

    MeSH term(s) Humans ; Ukraine ; Mass Casualty Incidents ; Emergency Medical Services ; Health Personnel ; Armed Conflicts ; Disaster Planning
    Language English
    Publishing date 2023-06-13
    Publishing country United States
    Document type Editorial
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2022.12.021
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    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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  7. Article ; Online: Kidney and lung crosstalk during critical illness: large-scale cohort study.

    Tomasi, Alessandra / Song, Xuan / Gajic, Ognjen / Kashani, Kianoush

    Journal of nephrology

    2023  Volume 36, Issue 4, Page(s) 1037–1046

    Abstract: Background: The relationship between the lung and kidney investigated in animal and clinical models has demonstrated substantial crosstalk. We aimed to evaluate the association between single vs. concurrent AKI and ARDS and its impact on patient ... ...

    Abstract Background: The relationship between the lung and kidney investigated in animal and clinical models has demonstrated substantial crosstalk. We aimed to evaluate the association between single vs. concurrent AKI and ARDS and its impact on patient outcomes. Secondly, we aimed to assess whether the order of appearance of these pathologies affected patient outcomes in patients with both diseases.
    Methods: This single-center retrospective cohort study included adult patients admitted to the ICU from January 1, 2007 through May 1, 2018 (n = 76,988). Baseline characteristics and outcomes were compared among patients without ARDS or AKI and those with one or both ARDS and AKI. We also assessed outcomes across the order of appearance of these diseases among patients with both AKI and ARDS.
    Results: We enrolled 76,988 unique patients in the final analysis: 47,043 patients with neither AKI nor ARDS, 491 patients with ARDS alone, 27,928 patients with AKI alone, and 1,526 patients with both ARDS and AKI. Patients with both ARDS and AKI had higher ICU (21.2%) and hospital (28.4%) mortality compared to patients with ARDS alone (9.0% ICU mortality, 14.0% hospital mortality) or AKI alone (4.4% ICU mortality, 8.4% hospital mortality) (p < 0.001). These findings remained unchanged after adjusting for illness severity and comorbidities. Of the 1136 patients with both AKI and ARDS, 136 (12%) developed AKI first, 303 (27%) ARDS first, and 697 (61%) had simultaneous diseases. Patients who developed ARDS after AKI had significantly increased ICU (29.4%) and hospital (36.8%) mortality compared to patients who developed AKI after ARDS (13.9% ICU mortality, 21.5% hospital mortality) (p < 0.001).
    Conclusions: The combination of AKI and ARDS leads to worse outcomes, including longer hospital and ICU lengths of stay, higher mortality, longer kidney replacement therapy, and longer ventilation requirements than in patients with AKI or ARDS alone. Among patients with both diagnoses, those who developed ARDS after AKI had the highest mortality.
    MeSH term(s) Humans ; Cohort Studies ; Intensive Care Units ; Retrospective Studies ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/therapy ; Critical Illness ; Kidney ; Lung ; Respiratory Distress Syndrome/therapy ; Hospital Mortality
    Language English
    Publishing date 2023-01-24
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-022-01558-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3369: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Association between the shock index on admission and in-hospital mortality in the cardiac intensive care unit.

    Padkins, Mitchell / Kashani, Kianoush / Tabi, Meir / Gajic, Ognjen / Jentzer, Jacob C

    PloS one

    2024  Volume 19, Issue 4, Page(s) e0298327

    Abstract: Background: An elevated shock index (SI) predicts worse outcomes in multiple clinical arenas. We aimed to determine whether the SI can aid in mortality risk stratification in unselected cardiac intensive care unit patients.: Methods: We included ... ...

    Abstract Background: An elevated shock index (SI) predicts worse outcomes in multiple clinical arenas. We aimed to determine whether the SI can aid in mortality risk stratification in unselected cardiac intensive care unit patients.
    Methods: We included admissions to the Mayo Clinic from 2007 to 2015 and stratified them based on admission SI. The primary outcome was in-hospital mortality, and predictors of in-hospital mortality were analyzed using multivariable logistic regression.
    Results: We included 9,939 unique cardiac intensive care unit patients with available data for SI. Patients were grouped by SI as follows: < 0.6, 3,973 (40%); 0.6-0.99, 4,810 (48%); and ≥ 1.0, 1,156 (12%). After multivariable adjustment, both heart rate (adjusted OR 1.06 per 10 beats per minute higher; CI 1.02-1.10; p-value 0.005) and systolic blood pressure (adjusted OR 0.94 per 10 mmHg higher; CI 0.90-0.97; p-value < 0.001) remained associated with higher in-hospital mortality. As SI increased there was an incremental increase in in-hospital mortality (adjusted OR 1.07 per 0.1 beats per minute/mmHg higher, CI 1.04-1.10, p-Value < 0.001). A higher SI was associated with increased mortality across all examined admission diagnoses.
    Conclusion: The SI is a simple and universally available bedside marker that can be used at the time of admission to predict in-hospital mortality in cardiac intensive care unit patients.
    MeSH term(s) Humans ; Hospital Mortality ; Retrospective Studies ; Intensive Care Units ; Blood Pressure ; Heart Rate
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0298327
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  9. Article: Regulatory oversight and ethical concerns surrounding software as medical device (SaMD) and digital twin technology in healthcare.

    Lal, Amos / Dang, Johnny / Nabzdyk, Christoph / Gajic, Ognjen / Herasevich, Vitaly

    Annals of translational medicine

    2022  Volume 10, Issue 18, Page(s) 950

    Language English
    Publishing date 2022-10-04
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-22-4203
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  10. Article ; Online: Utility of AI models in critical care: union of man and the machine.

    Lal, Amos / Herasevich, Vitaly / Gajic, Ognjen

    Critical care (London, England)

    2021  Volume 25, Issue 1, Page(s) 46

    MeSH term(s) Artificial Intelligence ; Critical Care ; Humans ; Intelligence ; Machine Learning
    Language English
    Publishing date 2021-02-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-021-03478-9
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