Article: Transient Complete Recovery of Chronic Refractory Idiopathic Thrombocytopenic Purpura after Treatment with Monoclonal Antibody Targeting SARS-CoV-2 Spike Protein.
2022 Volume 2022, Page(s) 8335541
Abstract: Idiopathic thrombocytopenic purpura (ITP), also known as immune thrombocytopenic purpura, is an immune-mediated acquired disease characterized by transient or persistent decrease of the platelet count due to autoimmune-related destruction of platelets. ... ...
Abstract | Idiopathic thrombocytopenic purpura (ITP), also known as immune thrombocytopenic purpura, is an immune-mediated acquired disease characterized by transient or persistent decrease of the platelet count due to autoimmune-related destruction of platelets. Therapy for ITP relies on competing and inhibiting the autoantibody binding and destruction (intravenous immunoglobulin and anti-D immunoglobulin and spleen tyrosine kinase (Syk) inhibitor fostamatinib), augmenting platelet production (thrombopoietin receptor agonists), immunosuppression to reduce the autoantibody production, as well as splenectomy. Studies on autoantigens on the platelets suggested epitopes to be located predominantly on the GP IIb/IIIa receptor or integrin |
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Language | English |
Publishing date | 2022-06-07 |
Publishing country | United States |
Document type | Case Reports |
ZDB-ID | 2627639-2 |
ISSN | 2090-6579 ; 2090-6560 |
ISSN (online) | 2090-6579 |
ISSN | 2090-6560 |
DOI | 10.1155/2022/8335541 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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