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Article ; Online: Endotypes of occupational asthma.

Mason, Paola / Biasioli, Marco / Liviero, Filippo

Current opinion in allergy and clinical immunology

2024 Volume 24, Issue 2, Page(s) 58–63

Abstract: Purpose of review: To describe recent findings in endotyping occupational asthma by addressing the role of specific biomarkers.: Recent findings: Studies on occupational asthma endotypes have focused on immune and inflammatory patterns associated ... ...

Abstract	Purpose of review: To describe recent findings in endotyping occupational asthma by addressing the role of specific biomarkers. Recent findings: Studies on occupational asthma endotypes have focused on immune and inflammatory patterns associated with different occupational exposures to sensitizers or irritants.Sputum neutrophilia has been found in 58.5% patients with occupational asthma caused by high molecular weight (HMW) agents, and work-related dysphonia in patients with occupational asthma was described as associated with sputum neutrophilia too. Neutrophils have been associated also with irritant-induced asthma. The measurement of specific IgE has been confirmed as a valuable diagnostic tool in occupational asthma caused by HMW agents, on the contrary, for most low-molecular-weight agents, the presence of specific IgE has been proven in a small subset of affected workers. Fractional exhaled nitric oxide has been confirmed as a marker of type 2 (T2) inflammation in occupational asthma, mostly when induced by HMW agents (e.g. flour), and it has proved to be more sensitive than spirometry in measuring the efficacy of an intervention.MicroRNA-155 has been shown to contribute to airway inflammation in occupational asthma induced by toluene diisocyanate. Summary: Occupational asthma is heterogeneous, thus monitoring multiple biomarkers is crucial to understand, which inflammatory responses are prevalent.
MeSH term(s)	Humans ; Asthma, Occupational/diagnosis ; Biomarkers ; Inflammation/complications ; Neutrophils ; Immunoglobulin E ; Occupational Exposure/adverse effects ; Occupational Diseases/diagnosis ; MicroRNAs
Chemical Substances	Biomarkers ; Immunoglobulin E (37341-29-0) ; MIRN155 microRNA, human ; MicroRNAs
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2088710-3
ISSN	1473-6322 ; 1528-4050
ISSN (online)	1473-6322
ISSN	1528-4050
DOI	10.1097/ACI.0000000000000969
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Article ; Online: Persistent Increase of Sympathetic Activity in Post-Acute COVID-19 of Paucisymptomatic Healthcare Workers.

Liviero, Filippo / Scapellato, Maria Luisa / Folino, Franco / Moretto, Angelo / Mason, Paola / Pavanello, Sofia

International journal of environmental research and public health

2023 Volume 20, Issue 1

Abstract: Healthcare workers (HCWs) represent a population with a significant burden of paucisymptomatic COVID-19, as the general population. We evaluated autonomic nervous system activity by means of heart rate variability (HRV) in HCWs during health surveillance ...

Abstract	Healthcare workers (HCWs) represent a population with a significant burden of paucisymptomatic COVID-19, as the general population. We evaluated autonomic nervous system activity by means of heart rate variability (HRV) in HCWs during health surveillance visits. Short-term electrocardiogram (ECG) recordings were obtained 30 days (IQR 5.25-55.75) after a negative naso-pharyngeal swab for SARS-CoV-2 in 44 cases and compared with ECGs of 44 controls with similar age and sex distribution. Time and frequency domain HRV were evaluated. HCWs who used drugs, had comorbidities that affected HRV, or were hospitalized with severe COVID-19 were excluded. Frequency domain HRV analysis showed a significantly higher low/high-frequency power ratio (LF/HF) in the case study compared with controls (t = 2.84,
MeSH term(s)	Humans ; COVID-19/epidemiology ; SARS-CoV-2 ; Autonomic Nervous System/physiology ; Electrocardiography ; Autonomic Nervous System Diseases ; Heart Rate/physiology
Language	English
Publishing date	2023-01-01
Publishing country	Switzerland
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20010830
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Article: Transient Receptor Potential Vanilloid Subtype 1: Potential Role in Infection, Susceptibility, Symptoms and Treatment of COVID-19.

Liviero, Filippo / Campisi, Manuela / Mason, Paola / Pavanello, Sofia

Frontiers in medicine

2021 Volume 8, Page(s) 753819

Abstract: The battle against the new coronavirus that continues to kill millions of people will be still long. Novel strategies are demanded to control infection, mitigate symptoms and treatment of COVID-19. This is even more imperative given the long sequels that ...

Abstract	The battle against the new coronavirus that continues to kill millions of people will be still long. Novel strategies are demanded to control infection, mitigate symptoms and treatment of COVID-19. This is even more imperative given the long sequels that the disease has on the health of the infected. The discovery that S protein includes two ankyrin binding motifs (S-ARBMs) and that the transient receptor potential vanilloid subtype 1 (TRPV-1) cation channels contain these ankyrin repeat domains (TRPs-ARDs) suggest that TRPV-1, the most studied member of the TRPV channel family, can play a role in binding SARS-CoV-2. This hypothesis is strengthened by studies showing that other respiratory viruses bind the TRPV-1 on sensory nerves and epithelial cells in the airways. Furthermore, the pathophysiology in COVID-19 patients is similar to the effects generated by TRPV-1 stimulation. Lastly, treatment with agonists that down-regulate or inactivate TRPV-1 can have a beneficial action on impaired lung functions and clearance of infection. In this review, we explore the role of the TRPV-1 channel in the infection, susceptibility, pathogenesis, and treatment of COVID-19, with the aim of looking at novel strategies to control infection and mitigate symptoms, and trying to translate this knowledge into new preventive and therapeutic interventions.
Language	English
Publishing date	2021-11-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2021.753819
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Article: DNA Methylation-Based Age Prediction and Telomere Length Reveal an Accelerated Aging in Induced Sputum Cells Compared to Blood Leukocytes: A Pilot Study in COPD Patients.

Campisi, Manuela / Liviero, Filippo / Maestrelli, Piero / Guarnieri, Gabriella / Pavanello, Sofia

Frontiers in medicine

2021 Volume 8, Page(s) 690312

Abstract: Aging is the predominant risk factor for most degenerative diseases, including chronic obstructive pulmonary disease (COPD). This process is however very heterogeneous. Defining the biological aging of individual tissues may contribute to better assess ... ...

Abstract	Aging is the predominant risk factor for most degenerative diseases, including chronic obstructive pulmonary disease (COPD). This process is however very heterogeneous. Defining the biological aging of individual tissues may contribute to better assess this risky process. In this study, we examined the biological age of induced sputum (IS) cells, and peripheral blood leukocytes in the same subject, and compared these to assess whether biological aging of blood leukocytes mirrors that of IS cells. Biological aging was assessed in 18 COPD patients (72.4 ± 7.7 years; 50% males). We explored mitotic and non-mitotic aging pathways, using telomere length (TL) and DNA methylation-based age prediction (DNAmAge) and age acceleration (AgeAcc) (i.e., difference between DNAmAge and chronological age). Data on demographics, life style and occupational exposure, lung function, and clinical and blood parameters were collected. DNAmAge (67.4 ± 5.80 vs. 61.6 ± 5.40 years;
Language	English
Publishing date	2021-07-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2021.690312
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Article ; Online: Transient Receptor Potential Vanilloid Subtype 1

Filippo Liviero / Manuela Campisi / Paola Mason / Sofia Pavanello

Frontiers in Medicine, Vol

Potential Role in Infection, Susceptibility, Symptoms and Treatment of COVID-19

2021 Volume 8

Abstract	The battle against the new coronavirus that continues to kill millions of people will be still long. Novel strategies are demanded to control infection, mitigate symptoms and treatment of COVID-19. This is even more imperative given the long sequels that the disease has on the health of the infected. The discovery that S protein includes two ankyrin binding motifs (S-ARBMs) and that the transient receptor potential vanilloid subtype 1 (TRPV-1) cation channels contain these ankyrin repeat domains (TRPs-ARDs) suggest that TRPV-1, the most studied member of the TRPV channel family, can play a role in binding SARS-CoV-2. This hypothesis is strengthened by studies showing that other respiratory viruses bind the TRPV-1 on sensory nerves and epithelial cells in the airways. Furthermore, the pathophysiology in COVID-19 patients is similar to the effects generated by TRPV-1 stimulation. Lastly, treatment with agonists that down-regulate or inactivate TRPV-1 can have a beneficial action on impaired lung functions and clearance of infection. In this review, we explore the role of the TRPV-1 channel in the infection, susceptibility, pathogenesis, and treatment of COVID-19, with the aim of looking at novel strategies to control infection and mitigate symptoms, and trying to translate this knowledge into new preventive and therapeutic interventions.
Keywords	TRPV-1 ; SARS-CoV-2 ; COVID-19 ; SNPs ; pollution ; inflammation ; Medicine (General) ; R5-920
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Long-Term Follow-Up of Cluster-Based Diisocyanate Asthma Phenotypes.

Mason, Paola / Liviero, Filippo / Maestrelli, Piero / Frigo, Anna Chiara

The journal of allergy and clinical immunology. In practice

2021 Volume 9, Issue 9, Page(s) 3380–3386

Abstract: Background: Data on the outcome of occupational asthma (OA) are heterogeneous.: Objective: To assess the impact of being part of a specific cluster at diagnosis on the long-term outcome of diisocyanate-induced OA.: Methods: We collected data from ... ...

Abstract	Background: Data on the outcome of occupational asthma (OA) are heterogeneous. Objective: To assess the impact of being part of a specific cluster at diagnosis on the long-term outcome of diisocyanate-induced OA. Methods: We collected data from 56 patients who had a diagnosis of OA confirmed by a positive specific inhalation challenge. Patients sensitized to toluene diisocyanate were allocated to cluster 1 or 2 based on a tree analysis, using the 3 variables relevant for cluster segregation identified in a previous study: age, body mass index, and forced expiratory volume in 1 second/forced vital capacity at diagnosis. Patients sensitized to methylene diisocyanate were allocated to cluster 3, as in previous study. We defined OA remission when a patient had met a total of 3 criteria: no asthma symptoms and no antiasthma therapy for the last year, as well as having normal lung function. Results: At follow-up, 16 patients showed OA remission. They exhibited better lung function, less bronchial hyperreactivity, as well as younger age at diagnosis. Twenty-eight patients were allocated to cluster 1, 10 to cluster 2, and 18 to cluster 3. The percentage of patients with OA remission was higher in cluster 2 (50% vs 25% in cluster 1 and 22.5% in cluster 3), although the difference was not statistically significant (P = .2789). Conclusions: Age at diagnosis was a strong predictor of OA remission. The outcome of diisocyanate OA tended to be more favorable for patients with toluene diisocyanate OA allocated in cluster 2, but this finding needs to be validated by further data.
MeSH term(s)	Asthma, Occupational/diagnosis ; Asthma, Occupational/drug therapy ; Follow-Up Studies ; Humans ; Occupational Diseases ; Occupational Exposure/statistics & numerical data ; Phenotype ; Toluene 2,4-Diisocyanate
Chemical Substances	Toluene 2,4-Diisocyanate (17X7AFZ1GH)
Language	English
Publishing date	2021-04-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2843237-X
ISSN	2213-2201 ; 2213-2198
ISSN (online)	2213-2201
ISSN	2213-2198
DOI	10.1016/j.jaip.2021.04.040
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Article ; Online: Impact of occupational asthma on health and employment status: a long-term follow-up study.

Mason, Paola / Liviero, Filippo / Paccagnella, Eleonora Rachele / Biasioli, Marco / Maestrelli, Piero / Frigo, Anna Chiara

Occupational and environmental medicine

2022 Volume 80, Issue 2, Page(s) 70–76

Abstract: Objectives: The aim of this study was to assess the predictors of a favourable prognosis of occupational asthma (OA) and the employment status of patients with OA at least 2 years after diagnosis.: Methods: We collected data from 204 patients who had ...

Abstract	Objectives: The aim of this study was to assess the predictors of a favourable prognosis of occupational asthma (OA) and the employment status of patients with OA at least 2 years after diagnosis. Methods: We collected data from 204 patients who had a diagnosis of OA confirmed by a positive specific inhalation challenge. We defined OA remission as meeting the following three criteria: no asthma symptoms, no antiasthma therapy for the last year and having normal lung function at the end of follow-up. A logistic regression analysis was performed to estimate the effects of the covariates. Results: At 10.6±7.8-year follow-up, 60 of 204 possible patients participated in the study, and among them 17 showed OA remission. When compared with the 43 patients with persistent OA, these patients exhibited at diagnosis younger age (p=0.0039), shorter duration of symptomatic exposure (p=0.0512), better lung function expressed by higher forced vital capacity (FVC%) predicted (p=0.0164), forced expiratory volume in 1 s (FEV Conclusions: This monocentric study did not identify a strong predictor of OA remission, but documented a high employment rate and a good job preservation over a long timeframe after diagnosis of OA mainly induced by low molecular weight agents.
MeSH term(s)	Humans ; Asthma, Occupational ; Follow-Up Studies ; Occupational Diseases/etiology ; Forced Expiratory Volume ; Employment ; Occupational Exposure/adverse effects
Language	English
Publishing date	2022-12-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1180733-7
ISSN	1470-7926 ; 1351-0711
ISSN (online)	1470-7926
ISSN	1351-0711
DOI	10.1136/oemed-2022-108504
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Article ; Online: DNA Methylation-Based Age Prediction and Telomere Length Reveal an Accelerated Aging in Induced Sputum Cells Compared to Blood Leukocytes

Manuela Campisi / Filippo Liviero / Piero Maestrelli / Gabriella Guarnieri / Sofia Pavanello

Frontiers in Medicine, Vol

A Pilot Study in COPD Patients

2021 Volume 8

Abstract	Aging is the predominant risk factor for most degenerative diseases, including chronic obstructive pulmonary disease (COPD). This process is however very heterogeneous. Defining the biological aging of individual tissues may contribute to better assess this risky process. In this study, we examined the biological age of induced sputum (IS) cells, and peripheral blood leukocytes in the same subject, and compared these to assess whether biological aging of blood leukocytes mirrors that of IS cells. Biological aging was assessed in 18 COPD patients (72.4 ± 7.7 years; 50% males). We explored mitotic and non-mitotic aging pathways, using telomere length (TL) and DNA methylation-based age prediction (DNAmAge) and age acceleration (AgeAcc) (i.e., difference between DNAmAge and chronological age). Data on demographics, life style and occupational exposure, lung function, and clinical and blood parameters were collected. DNAmAge (67.4 ± 5.80 vs. 61.6 ± 5.40 years; p = 0.0003), AgeAcc (−4.5 ± 5.02 vs. −10.8 ± 3.50 years; p = 0.0003), and TL attrition (1.05 ± 0.35 vs. 1.48 ± 0.21 T/S; p = 0.0341) are higher in IS cells than in blood leukocytes in the same patients. Blood leukocytes DNAmAge (r = 0.927245; p = 0.0026) and AgeAcc (r = 0.916445; p = 0.0037), but not TL, highly correlate with that of IS cells. Multiple regression analysis shows that both blood leukocytes DNAmAge and AgeAcc decrease (i.e., younger) in patients with FEV1% enhancement (p = 0.0254 and p = 0.0296) and combined inhaled corticosteroid (ICS) therapy (p = 0.0494 and p = 0.0553). In conclusion, new findings from our work reveal a differential aging in the context of COPD, by a direct quantitative comparison of cell aging in the airway with that in the more accessible peripheral blood leukocytes, providing additional knowledge which could offer a potential translation into the disease management.
Keywords	DNA methylation age ; age acceleration ; induced sputum ; chronic obstructive pulmonary disease ; lung aging ; telomere length ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article: Comparison of Adverse Effects of Two SARS-CoV-2 Vaccines Administered in Workers of the University of Padova.

Mason, Paola / Rizzuto, Rosario / Iannelli, Luca / Baccaglini, Flavio / Rizzolo, Valerio / Baraldo, Andrea / Melloni, Barbara / Maffione, Francesca / Pezzoli, Camilla / Chiozza, Maria Laura / Rupolo, Giampietro / Biasioli, Marco / Liviero, Filippo / Scapellato, Maria Luisa / Trevisan, Andrea / Merigliano, Stefano / Scuttari, Alberto / Moretto, Angelo / Scarpa, Bruno

Vaccines

2023 Volume 11, Issue 5

Abstract: ... ...

Abstract	Introduction
Language	English
Publishing date	2023-05-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11050951
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Article: A Multi-Center Study Investigating Long COVID-19 in Healthcare Workers from North-Eastern Italy: Prevalence, Risk Factors and the Impact of Pre-Existing Humoral Immunity-ORCHESTRA Project.

Cegolon, Luca / Mauro, Marcella / Sansone, Donatella / Tassinari, Alice / Gobba, Fabrizio Maria / Modenese, Alberto / Casolari, Loretta / Liviero, Filippo / Pavanello, Sofia / Scapellato, Maria Luisa / Taus, Francesco / Carta, Angela / Spiteri, Gianluca / Monaco, Maria Grazia Lourdes / Porru, Stefano / Larese Filon, Francesca

Vaccines

2023 Volume 11, Issue 12

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-11-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11121769
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