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  1. Article ; Online: COVID-19 2020: The Experience of a London Teaching Hospital's Nephrology Service.

    Wan, Elizabeth R / Unwin, Robert / Walsh, Stephen B

    Kidney & blood pressure research

    2021  Volume 46, Issue 2, Page(s) 137–141

    MeSH term(s) COVID-19 ; Hospital Departments ; Hospitals, Teaching ; Humans ; London ; Nephrology
    Language English
    Publishing date 2021-04-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1326018-2
    ISSN 1423-0143 ; 1420-4096
    ISSN (online) 1423-0143
    ISSN 1420-4096
    DOI 10.1159/000515194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1458: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Post-transplantation cutaneous and renal Aspergillus infection.

    Wan, Elizabeth R / Elands, Sophie A / Walsh, Stephen B

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2022  Volume 127, Page(s) 23–25

    Abstract: A renal transplant recipient aged 68 years experienced multiple complications after an initial good graft function from a deceased donor transplant. Late in the first week, the patient was oliguric with hematuria; the graft failed in week 2 after the ... ...

    Abstract A renal transplant recipient aged 68 years experienced multiple complications after an initial good graft function from a deceased donor transplant. Late in the first week, the patient was oliguric with hematuria; the graft failed in week 2 after the development of a hematoma from a rupture of a renal artery aneurysm. He had a recurrent bleed from the internal iliac graft site and subsequently developed painful dark patches on his leg, distal to where the transplant had been. Histology from the explanted graft and skin biopsies demonstrated Aspergillus flavus; this was also grown in the culture of the external iliac artery tissue. Systemic aspergillosis is rare but well recognized, especially in the immunocompromised. Presentations include mycotic aneurysms and secondary cutaneous aspergillosis from hematogenous spread. Diagnosis requires confirmation by histology or direct culture, but a high β-glucan concentration and positive galactomannan antigen can suggest invasive fungal infection in the early stages of the disease. Cases should be managed with systemic antifungals and involvement of local microbiology services; unfortunately, the prognosis is poor.
    MeSH term(s) Male ; Humans ; Aspergillosis/diagnosis ; Aspergillosis/drug therapy ; Kidney Transplantation/adverse effects ; Aspergillus ; Skin ; Antifungal Agents/therapeutic use
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2022-12-01
    Publishing country Canada
    Document type Case Reports
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2022.11.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4516: Show issues Location:
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  3. Article ; Online: Hyperoxaluric acute kidney injury and frontotemporal dementia.

    D'Ambrosio, Viola / Wan, Elizabeth R / Hawkins-van der Cingel, Gerlineke / Siew, Keith / Hawthorne, Mark / Crawford, Colley / Walsh, Stephen B

    Lancet (London, England)

    2023  Volume 401, Issue 10387, Page(s) 1530

    MeSH term(s) Humans ; Frontotemporal Dementia/diagnosis ; Hyperoxaluria ; Kidney ; Acute Kidney Injury/etiology
    Language English
    Publishing date 2023-02-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)02601-0
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  4. Article ; Online: Transient Renal Tubular Syndromes Associated With Acute COVID-19 Disease.

    Wan, Elizabeth R / Woolfson, Robin G / Greenwood, Richard / Walsh, Stephen B

    Kidney international reports

    2020  Volume 5, Issue 9, Page(s) 1610–1611

    Keywords covid19
    Language English
    Publishing date 2020-07-08
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2020.06.037
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  5. Article: Fumaric acid ester-induced renal Fanconi syndrome: evidence of mitochondrial toxicity.

    Wan, Elizabeth R / Siew, Keith / Heptinstall, Lauren / Walsh, Stephen B

    Clinical kidney journal

    2021  Volume 14, Issue 9, Page(s) 2085–2089

    Abstract: Background: Fumaric acid esters (FAEs) are used to treat chronic plaque psoriasis. Fumarate is a crucial component of the Krebs cycle and mitochondrial function. Proximal tubule cells have high energy demands and rely on aerobic respiration. Proximal ... ...

    Abstract Background: Fumaric acid esters (FAEs) are used to treat chronic plaque psoriasis. Fumarate is a crucial component of the Krebs cycle and mitochondrial function. Proximal tubule cells have high energy demands and rely on aerobic respiration. Proximal tubular dysfunction can cause renal Fanconi syndrome and acute kidney injury. We sought to better understand the mechanism for this in the context of FAE therapy.
    Methods: We describe a case series of 10 patients with FAE-associated Fanconi syndrome. Patients were diagnosed and managed at a tertiary renal tubular disorder clinic, with examination of serum and urine biochemistry. Five patients had a renal biopsy with examination of the specimens by electron microscopy.
    Results: The median age was 36.5 years [interquartile range (IQR) 32.25-54.25]. The median dose of FAE was 720 mg/day (IQR 390-720). There was low molecular weight proteinuria: the median urinary retinol-binding protein (RBP) at presentation was 8385 μg/mL (IQR 2793-14 600) and the RBP:creatinine ratio was 710 (IQR 390-2415). All patients had hyperphosphaturia [median fractional excretion of phosphate 24.2% (IQR 20.8-26.9), normal range <20%] as well as relative hypophosphataemia, with a median serum phosphate concentration of 0.93 mmol/L (IQR 0.83-0.97). Renal histology showed proximal tubular damage and abnormal mitochondrial morphology. Two patients had a favourable biochemical response to treatment with probenecid.
    Conclusions: We document for the first time that FAE-associated renal Fanconi syndrome is associated with mitochondrial damage visible on electron microscopy. This effect may be ameliorated by antagonism of the organic anion transporter with probenecid.
    Language English
    Publishing date 2021-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfaa270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6587: Show issues Location:
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  6. Article ; Online: Impact of extended-infusion piperacillin-tazobactam in a Canadian community hospital.

    Chan, April J / Lebovic, Gerald / Wan, Michael / Chen, Yan / Leung, Elizabeth / Langford, Bradley J / Seah, Jenny / Taggart, Linda R / Downing, Mark

    Infectious medicine

    2023  Volume 2, Issue 1, Page(s) 31–35

    Abstract: Background: Studies have demonstrated improved clinical outcomes with extended infusion (EI) piperacillin/tazobactam (TZP) compared to standard infusion (SI). However, there is less evidence on its benefits in noncritically-ill patients. Hospital-wide ... ...

    Abstract Background: Studies have demonstrated improved clinical outcomes with extended infusion (EI) piperacillin/tazobactam (TZP) compared to standard infusion (SI). However, there is less evidence on its benefits in noncritically-ill patients. Hospital-wide EI TZP was implemented at our site on February 21, 2012. Our objectives were to compare clinical, safety and economic outcomes between EI and SI TZP.
    Methods: A retrospective cohort study of all adult patients who received EI TZP (3.375 g IV q8h infused over 4 hours and SI TZP for ≥ 48 hours during 3 years pre-and postimplementation was conducted. The primary study outcome was 14-day mortality while secondary outcomes included length of hospital stay (LOS), nursing plus pharmacy cost, occurrence of
    Results: Overall, 2034 patients received EI TZP and 1364 patients received SI TZP. EI TZP was associated with lower odds of mortality (OR 0.76, 95% CI 0.63-0.91), lower odds of
    Conclusions: Hospital-wide implementation of EI TZP was associated with lower odds of 14-day mortality and incidence of
    Language English
    Publishing date 2023-02-06
    Publishing country China
    Document type Journal Article
    ISSN 2772-431X
    ISSN (online) 2772-431X
    DOI 10.1016/j.imj.2023.01.005
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  8. Article ; Online: Transient Renal Tubular Syndromes Associated With Acute COVID-19 Disease

    Wan, Elizabeth R. / Woolfson, Robin G. / Greenwood, Richard / Walsh, Stephen B.

    Kidney International Reports

    2020  Volume 5, Issue 9, Page(s) 1610–1611

    Keywords Nephrology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2468-0249
    DOI 10.1016/j.ekir.2020.06.037
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: The Effects of Black Raspberry as a Whole Food-Based Approach on Biomarkers of Oxidative Stress in Buccal Cells and Urine of Smokers.

    Chen, Kun-Ming / Sun, Yuan-Wan / Krebs, Nicolle M / Reinhart, Lisa / Sun, Dongxiao / Liao, Jiangang / Cook, Rachel / Bond, Paige Elizabeth / Mallery, Susan R / El-Bayoumy, Karam

    Cancer prevention research (Philadelphia, Pa.)

    2024  Volume 17, Issue 4, Page(s) 157–167

    Abstract: Cigarette smoke is a rich source of free radicals that can promote oxidative stress and carcinogenesis, including head and neck squamous cell carcinoma (HNSCC) development; importantly, 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-iso- ... ...

    Abstract Cigarette smoke is a rich source of free radicals that can promote oxidative stress and carcinogenesis, including head and neck squamous cell carcinoma (HNSCC) development; importantly, 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-iso-prostaglandin F2α (8-isoprostane) are biomarkers of oxidative stress. Several mechanisms, including the antioxidant properties of black raspberry (BRB), account for their chemopreventive effects. In the present clinical trial, we tested the hypothesis that BRB administration reduces biomarkers levels of oxidative stress in buccal cells and urine of smokers. One week after enrolling 21 smokers, baseline buccal cells and urine samples were collected before the administration of BRB lozenges for 8 weeks (5/day, 1 gm BRB/lozenge). Buccal cells and urine samples were collected at the middle and the end of BRB administration. The last samples were collected after the BRB cessation (washout period). We analyzed levels of 8-oxodG and 8-isoprostane (LC/MS-MS), urinary cotinine (ELISA), and creatinine (spectrophotometry). BRB significantly reduced the levels of 8-oxodG by 17.08% (P = 0.00079) in buccal cells and 12.44% (P = 0.034) in urine at the middle of BRB administration as compared with baseline; the corresponding values at the end of BRB administration were 16.46% (P = 0.026) in buccal cells and 25.72% (P = 0.202) in urine. BRB had no significant effect on the levels of urinary 8-isoprostane. BRB's capacity to inhibit 8-oxodG formation of smokers' buccal cells and urine is clearly evident and the reduction in 8-oxodG suggests that antioxidant abilities are central to BRB's HNSCC chemopreventive properties.
    Prevention relevance: Cigarette smoke contains highly active components namely free radicals that can promote oxidative stress and oral cancer. We found that black raspberry (BRB) inhibited the formation of oxidative stress markers in the oral cavity and urine of smokers suggesting the antioxidant abilities of BRB in preventing oral cancer.
    MeSH term(s) Humans ; 8-Hydroxy-2'-Deoxyguanosine/pharmacology ; 8-Hydroxy-2'-Deoxyguanosine/therapeutic use ; Antioxidants/pharmacology ; Biomarkers/urine ; Deoxyguanosine/pharmacology ; Deoxyguanosine/therapeutic use ; Deoxyguanosine/urine ; Free Radicals/pharmacology ; Free Radicals/therapeutic use ; Head and Neck Neoplasms ; Mouth Mucosa/pathology ; Mouth Neoplasms/etiology ; Mouth Neoplasms/prevention & control ; Mouth Neoplasms/drug therapy ; Oxidative Stress ; Rubus ; Smokers ; Squamous Cell Carcinoma of Head and Neck
    Chemical Substances 8-Hydroxy-2'-Deoxyguanosine (88847-89-6) ; Antioxidants ; Biomarkers ; Deoxyguanosine (G9481N71RO) ; Free Radicals
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ZDB-ID 2434717-6
    ISSN 1940-6215 ; 1940-6207
    ISSN (online) 1940-6215
    ISSN 1940-6207
    DOI 10.1158/1940-6207.CAPR-23-0153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Transient Renal Tubular Syndromes Associated With Acute COVID-19 Disease

    Elizabeth R. Wan / Robin G. Woolfson / Richard Greenwood / Stephen B. Walsh

    Kidney International Reports, Vol 5, Iss 9, Pp 1610-

    2020  Volume 1611

    Keywords Diseases of the genitourinary system. Urology ; RC870-923 ; covid19
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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