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  1. Article: Myocardial ischemia in patients with large prior infarction: Clinical decision making and review of literature.

    Asif, Talal / Doukky, Rami

    Radiology case reports

    2022  Volume 18, Issue 2, Page(s) 538–544

    Abstract: Myocardial perfusion imaging (MPI) with single photon emission computed tomography (SPECT) or positron emission tomography (PET) is a widely used technique for the evaluation of coronary artery disease (CAD). Interpreting physicians rely on regional ... ...

    Abstract Myocardial perfusion imaging (MPI) with single photon emission computed tomography (SPECT) or positron emission tomography (PET) is a widely used technique for the evaluation of coronary artery disease (CAD). Interpreting physicians rely on regional variations in myocardial radiotracer uptake between rest and stress images to identify hemodynamically significant epicardial coronary artery stenosis. However, interpretation of MPI is very difficult in patients with large infarcts where there is no scintigraphically normal reference myocardium for comparison. In these patients, the stress and rest images appear similar due to balanced ischemia in the non-infarct territory. There are no clear guidelines on how to approach these cases. We present a case of MPI with a large right coronary artery territory (RCA) infarct where the left main (LM) coronary artery territory has no relative comparator and the images looked the same on stress and rest. However, the patient had multiple high-risk ancillary findings including electrocardiographic (ECG) changes with regadenoson, transient ischemic dilatation (TID), large severe inferior infarct, low myocardial blood flow (MBF) and myocardial flow reserve (MFR), but most notably increased right ventricular (RV) uptake on the stress images that was a subtle clue that we were dealing with LM equivalent in non-infarct zone. The coronary angiogram confirmed our findings. Through our case, we provide a comprehensive approach and review of literature on how to approach such challenging encounters.
    Language English
    Publishing date 2022-11-25
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2022.11.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Myocardial ischemia in patients with large prior infarction

    Talal Asif, MD / Rami Doukky, MD, MSc, MBA

    Radiology Case Reports, Vol 18, Iss 2, Pp 538-

    Clinical decision making and review of literature

    2023  Volume 544

    Abstract: Myocardial perfusion imaging (MPI) with single photon emission computed tomography (SPECT) or positron emission tomography (PET) is a widely used technique for the evaluation of coronary artery disease (CAD). Interpreting physicians rely on regional ... ...

    Abstract Myocardial perfusion imaging (MPI) with single photon emission computed tomography (SPECT) or positron emission tomography (PET) is a widely used technique for the evaluation of coronary artery disease (CAD). Interpreting physicians rely on regional variations in myocardial radiotracer uptake between rest and stress images to identify hemodynamically significant epicardial coronary artery stenosis. However, interpretation of MPI is very difficult in patients with large infarcts where there is no scintigraphically normal reference myocardium for comparison. In these patients, the stress and rest images appear similar due to balanced ischemia in the non-infarct territory. There are no clear guidelines on how to approach these cases. We present a case of MPI with a large right coronary artery territory (RCA) infarct where the left main (LM) coronary artery territory has no relative comparator and the images looked the same on stress and rest. However, the patient had multiple high-risk ancillary findings including electrocardiographic (ECG) changes with regadenoson, transient ischemic dilatation (TID), large severe inferior infarct, low myocardial blood flow (MBF) and myocardial flow reserve (MFR), but most notably increased right ventricular (RV) uptake on the stress images that was a subtle clue that we were dealing with LM equivalent in non-infarct zone. The coronary angiogram confirmed our findings. Through our case, we provide a comprehensive approach and review of literature on how to approach such challenging encounters.
    Keywords Multivessel coronary artery disease ; Rubidium-82 positron emission tomography ; Transient ischemic dilatation ; Myocardial blood flow ; Myocardial flow reserve ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Subject code 610
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Gastrointestinal bleeding in recipients of left ventricular assist devices-a systematic review.

    Naveed, Ali / Naveed, Bazigh / Khan, Muhammad Atif / Asif, Talal

    Heart failure reviews

    2023  Volume 28, Issue 5, Page(s) 1163–1175

    Abstract: The twenty-first century has revolutionized the management of congestive heart failure with the widespread use of left ventricular assist devices and other treatment modalities that improve morbidity and mortality after the failure of medical management. ...

    Abstract The twenty-first century has revolutionized the management of congestive heart failure with the widespread use of left ventricular assist devices and other treatment modalities that improve morbidity and mortality after the failure of medical management. These novel devices come with significant side effects. One of the most common side effects of left ventricular assist devices is the increased frequency of lower gastrointestinal bleeding compared to heart failure patients without left ventricular assist devices. Multiple etiologies of recurrent gastrointestinal bleeding in such patients have been studied. The decreased amount of von Willebrand factor polymers is now recognized as one of the most common causes of increased incidence of gastrointestinal bleeding in patients with left ventricular assist devices alongside increased arteriovenous malformations. Multiple treatment modalities have been identified to prevent and treat gastrointestinal bleeding in these patients. Since the use of left ventricular assist devices is becoming more prevalent in patients with advanced heart failure, we decided to conduct this systematic review. The article summarizes the incidence, pathophysiology, and management of lower gastrointestinal bleeding in patients with left ventricular assist devices.
    MeSH term(s) Humans ; Heart-Assist Devices/adverse effects ; Gastrointestinal Hemorrhage/epidemiology ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/therapy ; Heart Failure/complications ; Heart Failure/therapy ; Incidence
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Systematic Review ; Journal Article
    ZDB-ID 1336499-6
    ISSN 1573-7322 ; 1382-4147
    ISSN (online) 1573-7322
    ISSN 1382-4147
    DOI 10.1007/s10741-023-10313-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Heart Failure with Preserved Left Ventricular Ejection Fraction: A Complex Conundrum Simply Not Limited to Diastolic Dysfunction.

    Lopez-Candales, Angel / Asif, Talal / Sawalha, Khalid / Norgard, Nicholas B

    Cardiovascular therapeutics

    2023  Volume 2023, Page(s) 1552826

    Abstract: Over the last two decades, the changing paradigm of heart failure with preserved ejection fraction (HFpEF) has transformed our understanding not only of the pathophysiology of this clinical entity but also the diagnostic and therapeutic approaches aimed ... ...

    Abstract Over the last two decades, the changing paradigm of heart failure with preserved ejection fraction (HFpEF) has transformed our understanding not only of the pathophysiology of this clinical entity but also the diagnostic and therapeutic approaches aimed at treating this complex patient population. No longer HFpEF should be seen as simply left ventricular diastolic dysfunction but as a group of that in addition of having small and thick left ventricles with abnormal diastolic filling patterns as their main pathophysiologic abnormality; they also have whole host of different abnormalities. In fact, this heterogeneous clinical entity embodies numerous mechanisms and is linked to multiorgan dysfunction, with hypertension and obesity playing a major role. Although we have gained an enormous amount of understanding not only on the causes but also the downstream effects of HFpEF, there is still much to be learned before we can fully comprehend this complex clinical entity. It is the main intention of this review to synthesize the most recent attributes, mechanism, diagnostic tools, and most useful therapeutic alternatives to be considered when evaluating patients either complaining of dyspnea on exertion as well as exercise intolerance or those recently admitted with HF symptoms but with normal LVEF in the absence of any other valvular abnormalities.
    MeSH term(s) Humans ; Heart Failure/diagnostic imaging ; Heart Failure/drug therapy ; Stroke Volume ; Ventricular Dysfunction, Left/diagnostic imaging ; Hypertension/complications ; Obesity/complications ; Ventricular Function, Left
    Language English
    Publishing date 2023-07-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2428378-2
    ISSN 1755-5922 ; 1755-5914
    ISSN (online) 1755-5922
    ISSN 1755-5914
    DOI 10.1155/2023/1552826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: CT-Guided Pericardiocentesis in a Case of Tension Pneumopericardium and Tamponade Secondary to an Enteropericardial Fistula.

    Ibrahim, Ali O / Jaber, Fouad / Alghizzawi, Moh'd / Metzinger, Mark / Asif, Talal

    JACC. Case reports

    2023  Volume 18, Page(s) 101909

    Abstract: Tension pneumopericardium is most commonly traumatic. Nontraumatic etiologies are rare, but have been reported with gastropericardial and esophagopericardial fistulas. We present the case of a 54-year-old patient who developed a tension pneumopericardium ...

    Abstract Tension pneumopericardium is most commonly traumatic. Nontraumatic etiologies are rare, but have been reported with gastropericardial and esophagopericardial fistulas. We present the case of a 54-year-old patient who developed a tension pneumopericardium with tamponade secondary to a perforated marginal ulcer in the proximal jejunum with an enteropericardial fistula. (
    Language English
    Publishing date 2023-06-20
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2023.101909
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Correction: Mansoor et al. Effect of Currently Available Nanoparticle Synthesis Routes on Their Biocompatibility with Fibroblast Cell Lines.

    Mansoor, Afsheen / Khurshid, Zohaib / Mansoor, Emaan / Khan, Muhammad Talal / Ratnayake, Jithendra / Jamal, Asif

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 10

    Abstract: The authors wish to make the following correction to this paper [ ... ]. ...

    Abstract The authors wish to make the following correction to this paper [...].
    Language English
    Publishing date 2023-05-18
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28104173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Transient ST Segment Elevation in Two Patients with COVID-19 and a Normal Transthoracic Echocardiogram.

    Asif, Talal / Ali, Zafar

    European journal of case reports in internal medicine

    2020  Volume 7, Issue 5, Page(s) 1672

    Abstract: We continue to learn about cardiac involvement in patients with COVID-19. These patients can develop acute coronary syndrome and severe myocarditis with a reduced ejection fraction. We describe two critically ill COVID-19 patients who developed ST ... ...

    Abstract We continue to learn about cardiac involvement in patients with COVID-19. These patients can develop acute coronary syndrome and severe myocarditis with a reduced ejection fraction. We describe two critically ill COVID-19 patients who developed ST elevation that resolved on repeat ECG without any intervention.
    Learning point: ST elevation may occur in critically ill COVID-19 patients.
    Keywords covid19
    Language English
    Publishing date 2020-04-23
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2020_001672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Transient ST Segment Elevation in Two Patients with COVID-19 and a Normal Transthoracic Echocardiogram

    Talal Asif / Zafar Ali

    European Journal of Case Reports in Internal Medicine (2020)

    2020  

    Abstract: We continue to learn about cardiac involvement in patients with COVID-19. These patients can develop acute coronary syndrome and severe myocarditis with a reduced ejection fraction. We describe two critically ill COVID-19 patients who developed ST ... ...

    Abstract We continue to learn about cardiac involvement in patients with COVID-19. These patients can develop acute coronary syndrome and severe myocarditis with a reduced ejection fraction. We describe two critically ill COVID-19 patients who developed ST elevation that resolved on repeat ECG without any intervention.
    Keywords st segment elevation ; covid-19 ; Medicine ; R ; covid19
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher SMC MEDIA SRL
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Challenges of Management of Subaortic Membrane in a Young Adult Patient: A Case Report.

    Asif, Talal / Georger, Lucas A / Sardesai, Krish / Kosinska, Maya / Miran, Muhammad Shah

    Cureus

    2023  Volume 15, Issue 11, Page(s) e48571

    Abstract: This article presents a case review and literature review focused on the challenges of managing subaortic membranes (SAMs) in young adult patients with mild aortic regurgitation (AR) or aortic stenosis (AS). The study aims to discuss the diagnosis of SAM, ...

    Abstract This article presents a case review and literature review focused on the challenges of managing subaortic membranes (SAMs) in young adult patients with mild aortic regurgitation (AR) or aortic stenosis (AS). The study aims to discuss the diagnosis of SAM, the imaging studies used for assessment, the management strategies in young patients, the risk of valvular damage, and the controversy surrounding prophylactic resection in mild AR. The management of SAM in adults poses challenges due to limited treatment options and potential complications, necessitating further investigation into the progression of AS and AR in asymptomatic SAM patients. The case presentation describes a 40-year-old male with muscular dystrophy who presented with symptoms and was diagnosed with SAM. Various imaging techniques, including CT chest, transthoracic echocardiogram (TTE), and transesophageal echocardiogram (TEE), were used to confirm the presence and severity of SAM. Based on the patient's clinical profile and the absence of surgical indications, medical therapy was initiated, and regular outpatient follow-up was recommended to monitor disease progression. The discussion highlights the challenges in diagnosing SAM, the importance of imaging studies, and the potential complications associated with SAM in young patients. The article also explores the management options for SAM, emphasizing surgical resection as the definitive treatment, while acknowledging the limited success rates of alternative approaches. Close monitoring and prompt intervention for complications are crucial in the management of SAM. The concluding statement emphasizes the need for further research to explore alternative treatments for SAM in young patients.
    Language English
    Publishing date 2023-11-09
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.48571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Correction: Lidocaine-Induced Systemic Toxicity: A Case Report and Review of Literature.

    Hasan, Badar / Asif, Talal / Hasan, Maryam

    Cureus

    2019  Volume 11, Issue 8, Page(s) c24

    Abstract: This corrects the article DOI: 10.7759/cureus.1275.]. ...

    Abstract [This corrects the article DOI: 10.7759/cureus.1275.].
    Language English
    Publishing date 2019-08-23
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.c24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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