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  1. Article ; Online: The external and internal structures of Amphizoa davidi Lucas (Coleoptera, Amphizoidae), using X-ray phase contrast microtomography.

    Li, Dee / Zhang, Kai / Li, Xiaoyan / Zhu, Peiping / Xu, Caifeng / Wu, Ziyu / Zhou, Hongzhang

    Zootaxa

    2015  Volume 3963, Issue 3, Page(s) 335–368

    Abstract: ... of A. davidi is here presented, by using X-ray phase contrast tomography and light microscopy. Morphological ... The Chinese endemic water beetle Amphizoa davidi Lucas, is a rare and endangered species belonging ...

    Abstract The Chinese endemic water beetle Amphizoa davidi Lucas, is a rare and endangered species belonging to the monotypic family Amphizoidae (Coleoptera: Adephaga). A study of the external and internal structures of A. davidi is here presented, by using X-ray phase contrast tomography and light microscopy. Morphological details and three dimensional (3D) structures of this species are provided: skeletons, muscles, reproductive organs of male and female, nervous system, alimentary canal and pygidial gland. The reproductive organs of females are compared in two different developmental phases (ages): before copulation without mature ovaries and after copulation with mature ovaries. Such detailed 3D tomographic study based on micro-CT technology may promote our understanding of the detailed morphology in Amphizoidae and Coleoptera in general.
    MeSH term(s) Animal Distribution ; Animal Structures/anatomy & histology ; Animal Structures/growth & development ; Animals ; Body Size ; Coleoptera/anatomy & histology ; Coleoptera/classification ; Coleoptera/growth & development ; Ecosystem ; Female ; Male ; Organ Size ; X-Ray Microtomography
    Language English
    Publishing date 2015-05-27
    Publishing country New Zealand
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.3963.3.3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Developing an Integrated Longitudinal Dataset for Patient-Centered Outcome Measures in Cost-Related Medication Nonadherence.

    Zhang, James X / Meltzer, David O

    Medical care

    2023  Volume 61, Issue 12 Suppl 2, Page(s) S139–S146

    Abstract: Background: Cost-related medication nonadherence (CRN) is an important patient-centered outcome measure. Longitudinal follow-up of CRN is rare.: Objective: We propose to develop a novel integrated dataset to study CRN longitudinally.: Research ... ...

    Abstract Background: Cost-related medication nonadherence (CRN) is an important patient-centered outcome measure. Longitudinal follow-up of CRN is rare.
    Objective: We propose to develop a novel integrated dataset to study CRN longitudinally.
    Research design: A dataset of 2000 Medicare beneficiaries at high risk of hospitalization surveyed quarterly on CRN and followed up individually for 8 quarters between 2013 and 2018 was linked to Medicare files. A metric of CRN categorizing persistent, intermittent, and transient CRN during the 8 quarters was developed. An ordered logit model and a logit model were developed to assess the factors influencing CRN overall and persistent CRN, respectively.
    Results: A total of 1761 patients were included in the analysis, among whom 869 (49.3%) reported CRN at least once in the 8-quarter study period, 178 (10%) reported persistent CRN, 395 (22.4%) reported intermittent CRN, and 296 (16.8%) reported transient CRN. The conditional effect in the logit model for persistent CRN revealed that baseline dual eligibility was negatively associated (adjusted odds ratio = 0.45, P < 0.01) and depression positively associated (adjusted odds ratio = 1.55, P = 0.01) with persistent CRN. The marginal analysis in the ordered logit model revealed a clear pattern of higher probabilities of persistent and intermittent CRN at younger ages while transient CRN was flat. Among the 252 subjects who were deceased, 31 (12.3%) reported persistent CRN, compared with 147 (9.74%) who were alive (P = 0.21 by χ2 test).
    Conclusions: A significant number of patients reported persistent CRN, including those who were at the end of life. Research is critically needed to understand behavioral patterns among the younger Medicare population.
    MeSH term(s) Humans ; Aged ; United States ; Medicare ; Medication Adherence ; Data Collection ; Logistic Models ; Patient-Centered Care
    Language English
    Publishing date 2023-11-09
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 411646-x
    ISSN 1537-1948 ; 0025-7079
    ISSN (online) 1537-1948
    ISSN 0025-7079
    DOI 10.1097/MLR.0000000000001894
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    Zs.B 518: Show issues Location:
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  3. Article ; Online: Prevalence and persistence of cost-related medication non-adherence before and during the COVID-19 pandemic among medicare patients at high risk of hospitalization.

    Zhang, James X / Meltzer, David O

    PloS one

    2023  Volume 18, Issue 8, Page(s) e0289608

    Abstract: Objective: To study cost-related medication non-adherence (CRN) for a 30-month period before and during the COVID-19 pandemic using a sample of Medicare patients at high risk of hospitalization.: Design: A novel data set of quarterly surveys of CRN ... ...

    Abstract Objective: To study cost-related medication non-adherence (CRN) for a 30-month period before and during the COVID-19 pandemic using a sample of Medicare patients at high risk of hospitalization.
    Design: A novel data set of quarterly surveys of CRN was used to evaluate CRN before and during the COVID-19 pandemic. Generalized Estimating Equation (GEE) analyses were conducted to evaluate the adjusted coefficients of change in CRN behaviors controlling for socio-demographic and health characteristics.
    Participants: Six hundred seventy-seven Medicare beneficiaries at high risk of hospitalization who were alive on January 1, 2020 and followed up through quarterly surveys on CRN for 30 months before and during the COVID-19 pandemic.
    Main outcomes and measures: Two metrics of prevalence and persistence of CRN and their adjusted coefficients in GEE with binomial family distribution and log link function controlling for socio-demographic and health characteristics.
    Results: A total of 5,990 quarterly surveys were completed by the 677 patients during the 30-month study period. Among the 677 patients, 250 (37%) were men, 591 (87%) were African American, and 288 (42%) were Medicare-Medicaid dual eligible. The unadjusted prevalence of CRN before and during the COVID-19 pandemic was 31.1% and 25.7% respectively (p = 0.02 by Chi-squared test), and persistent CRN rates were 12.1% and 9.7% respectively (p = 0.17 by Chi-squared test). The adjusted odds ratio of CRN prevalence during the pandemic compared to the pre-pandemic level was 0.75 (p<0.01), and 0.74 (p = 0.03) for persistent CRN in GEE estimations.
    Conclusion and relevance: There are coherent evidence of a reversal of CRN rates during the COVID-19 pandemic among this high-need, high-cost resource utilization Medicare population. Patients' CRN behaviors may be responsive to exogenous impacts, and the behaviors changed in the same direction with similar magnitude in terms of prevalence (the extensive margin) and persistence (the intensive margin). More research is needed to advance the understanding of the driving forces behind patients' behavioral changes and to identify factors that may be informative for reducing CRN in the long run.
    MeSH term(s) Aged ; United States/epidemiology ; Male ; Humans ; Female ; COVID-19/epidemiology ; Pandemics ; Prevalence ; Medicare ; Hospitalization ; Medication Adherence
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0289608
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  4. Article ; Online: Association Between the Modalities of Complementary and Alternative Medicine Use and Cost-Related Nonadherence to Medical Care Among Older Americans: A Cohort Study.

    Zhang, James X / Meltzer, David O

    Journal of alternative and complementary medicine (New York, N.Y.)

    2021  Volume 27, Issue 12, Page(s) 1131–1135

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Aged ; Cohort Studies ; Complementary Therapies ; Female ; Humans ; Male ; Mind-Body Therapies ; Patient Care ; Surveys and Questionnaires ; United States
    Language English
    Publishing date 2021-09-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1237383-7
    ISSN 1557-7708 ; 1075-5535
    ISSN (online) 1557-7708
    ISSN 1075-5535
    DOI 10.1089/acm.2021.0225
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    Zs.A 4366: Show issues Location:
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  5. Article ; Online: Single cell-transcriptomic analysis informs the lncRNA landscape in metastatic castration resistant prostate cancer.

    Saha, Debanjan / Dang, Ha X / Zhang, Meng / Quigley, David A / Feng, Felix Y / Maher, Christopher A

    NPJ genomic medicine

    2024  Volume 9, Issue 1, Page(s) 14

    Abstract: Metastatic castration-resistant prostate cancer (mCRPC) is a lethal form of prostate cancer. Although long-noncoding RNAs (lncRNAs) have been implicated in mCRPC, past studies have relied on bulk sequencing methods with low depth and lack of single-cell ... ...

    Abstract Metastatic castration-resistant prostate cancer (mCRPC) is a lethal form of prostate cancer. Although long-noncoding RNAs (lncRNAs) have been implicated in mCRPC, past studies have relied on bulk sequencing methods with low depth and lack of single-cell resolution. Hence, we performed a lncRNA-focused analysis of single-cell RNA-sequencing data (n = 14) from mCRPC biopsies followed by integration with bulk multi-omic datasets. This yielded 389 cell-enriched lncRNAs in prostate cancer cells and the tumor microenvironment (TME). These lncRNAs demonstrated enrichment with regulatory elements and exhibited alterations during prostate cancer progression. Prostate-lncRNAs were correlated with AR mutational status and response to treatment with enzalutamide, while TME-lncRNAs were associated with RB1 deletions and poor prognosis. Finally, lncRNAs identified between prostate adenocarcinomas and neuroendocrine tumors exhibited distinct expression and methylation profiles. Our findings demonstrate the ability of single-cell analysis to refine our understanding of lncRNAs in mCRPC and serve as a resource for future mechanistic studies.
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2813848-X
    ISSN 2056-7944 ; 2056-7944
    ISSN (online) 2056-7944
    ISSN 2056-7944
    DOI 10.1038/s41525-024-00401-3
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  6. Article ; Online: Myocardin and Kv1 Channels: A Paradigm Shift in Treating Vascular Smooth Muscle Cell-Related Proliferative Disease?

    Zhang, David X / Gutterman, David D

    Arteriosclerosis, thrombosis, and vascular biology

    2019  Volume 39, Issue 12, Page(s) 2454–2456

    MeSH term(s) Humans ; Muscle, Smooth, Vascular ; Nuclear Proteins ; Organ Culture Techniques ; Trans-Activators
    Chemical Substances Nuclear Proteins ; Trans-Activators ; myocardin
    Language English
    Publishing date 2019-11-26
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.119.313531
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    Zs.A 1705: Show issues Location:
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  7. Article ; Online: Independence of Ocular Biomarkers of Cardiac Risk in Macular Degeneration.

    Drakopoulos, Michael / Zhang, Kevin X / Zhang, David L / Nadel, Arnold / Bains, Harnaina K / Marchese, Alessandro / Mirza, Rukhsana G

    Ophthalmology. Retina

    2023  Volume 8, Issue 3, Page(s) 309–311

    MeSH term(s) Humans ; Macular Degeneration/diagnosis ; Retinal Drusen ; Eye ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Journal Article
    ISSN 2468-6530
    ISSN (online) 2468-6530
    DOI 10.1016/j.oret.2023.11.003
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  8. Article ; Online: Editorial commentary: Unraveling intricacies of cardiovascular disease at the single-cell resolution.

    Zhang, Jeffrey X / Chey, YoonChung / Paik, David T

    Trends in cardiovascular medicine

    2021  Volume 32, Issue 3, Page(s) 136–137

    MeSH term(s) Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/therapy ; Humans
    Language English
    Publishing date 2021-04-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2021.03.006
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    Zs.A 3419: Show issues Location:
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  9. Article ; Online: Retinal Ischemic Perivascular Lesions are Increased in Carotid Artery Stenosis.

    Zhang, David L / Zhang, Kevin X / Cheng, Brian T / Heisel, Curtis J / Nadel, Arnold / Eskandari, Mark K / Mirza, Rukhsana G

    Ophthalmology. Retina

    2023  Volume 7, Issue 11, Page(s) 1020–1022

    MeSH term(s) Humans ; Carotid Stenosis/complications ; Carotid Stenosis/diagnosis ; Ischemia/diagnosis ; Ischemia/etiology ; Blood Flow Velocity
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2468-6530
    ISSN (online) 2468-6530
    DOI 10.1016/j.oret.2023.07.018
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  10. Article ; Online: "I Feel Like a Fraud Who Acts Like a Feminist": The Discussion Themes and Sexual Scripts in the Porn Free Women Online Forum.

    Zhang, Xinyu / Silva, David E

    Archives of sexual behavior

    2024  

    Abstract: Research on online pornography abstinence movements has predominantly focused on men's perspectives, often within the context of the broader manosphere. This focus has overshadowed the unique experiences and viewpoints of women in these movements. Our ... ...

    Abstract Research on online pornography abstinence movements has predominantly focused on men's perspectives, often within the context of the broader manosphere. This focus has overshadowed the unique experiences and viewpoints of women in these movements. Our study aimed to fill this gap by exploring women-centric perspectives in pornography abstinence forums, particularly Porn Free Women (r/pornfreewomen). Using a mixed methods approach, this study examined the sexual scripts presented in women-dominated pornography abstinence communities. Our structural topic modeling analysis delineated the interplay of therapeutic, heteronormative, and empowerment themes that were evident in women's narratives and expressions. Further, our discourse analysis elucidated three specific scripts: the addiction script, the heterosexual script, and the liberation script. These interweaving narratives show that discussions of women's pornography abstinence are multifaceted and include a variety of perspectives to negotiate. These results contribute to a nuanced understanding of the values of health and well-being, sexual liberation, and feminism within women's pornography abstinence communities.
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 184221-3
    ISSN 1573-2800 ; 0004-0002
    ISSN (online) 1573-2800
    ISSN 0004-0002
    DOI 10.1007/s10508-024-02858-w
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