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Article: Intra-patient Variability of FDG Standardized Uptake Values in Mediastinal Blood Pool, Liver, and Myocardium during R-CHOP Chemotherapy in Patients with Diffuse Large B-cell Lymphoma.

Kim, Soo Jeong / Yi, Hyun Kyung / Lim, Chae Hong / Cho, Young Seok / Choi, Joon Young / Choe, Yearn Seong / Lee, Kyung-Han / Kim, Byung-Tae / Moon, Seung Hwan

Nuclear medicine and molecular imaging

2016 Volume 50, Issue 4, Page(s) 300–307

Abstract: ... cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) treatment and underwent baseline, interim ... The SUV of the liver was not significantly changed during R-CHOP chemotherapy in patients with DLBCL ... FDG uptake was more frequently observed after R-CHOP chemotherapy, it did not affect the SUV ...

Abstract	Purpose: 18 Methods: We analyzed 60 patients with DLBCL who received rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) treatment and underwent baseline, interim, and final FDG PET/CT scans. The FDG uptakes of lymphoma lesions, MBP, liver, and myocardium were assessed, and changes in the MBP and liver SUV and possible associated factors were evaluated. Results: The SUV of the liver did not change significantly during the chemotherapy. However, the SUV Conclusions: The SUV of the liver was not significantly changed during R-CHOP chemotherapy in patients with DLBCL, whereas the MBP SUV of the interim scan decreased slightly. However, the SUV of the reference organs may be affected by tumor burden, and this should be considered when assessing follow-up scans. Although myocardial FDG uptake was more frequently observed after R-CHOP chemotherapy, it did not affect the SUV of the MBP and liver.
Language	English
Publishing date	2016-07-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2541855-5
ISSN	1869-3482 ; 1869-3474
ISSN (online)	1869-3482
ISSN	1869-3474
DOI	10.1007/s13139-016-0432-y
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Article ; Online: Safety assessment of five candidate probiotic lactobacilli using comparative genome analysis.

Altavas, Patrick Josemaria D R / Amoranto, Mia Beatriz C / Kim, Sang Hoon / Kang, Dae-Kyung / Balolong, Marilen P / Dalmacio, Leslie Michelle M

Access microbiology

2024 Volume 6, Issue 1

Abstract: Micro-organisms belonging to ... ...

Abstract	Micro-organisms belonging to the
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ISSN	2516-8290
ISSN (online)	2516-8290
DOI	10.1099/acmi.0.000715.v4
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Article ; Online: Biological activities, identification, method development, and validation for analysis of polyphenolic compounds in Nymphaea rubra flowers and leaves by UHPLC-Q-cIM-TOF-MS and UHPLC-TQ-MS.

Naznin, Marufa / Alam, Rafiqul / Alam, Md Badrul / Jung, Maeng-Joon / Lee, Sang-Han / Kim, Sunghwan

Phytochemical analysis : PCA

2024

Abstract: ... and among them 21 significant polyphenols were quantified. Each calibration curve had R: Conclusion ...

Abstract	Introduction: Nymphaea rubra belongs to the Nymphaea family and is regarded as a vegetable used in traditional medicine to cure several ailments. These species are rich in phenolic acid, flavonoids, and hydrolysable tannin. Objective: This study aimed to assess the biological activities of Nymphaea rubra flowers (NRF) and leaves (NRL) by identifying and quantifying their polyphenolic compounds using ultra-performance liquid chromatography coupled to quadrupole cyclic ion mobility time-of-flight mass spectrometry (UHPLC-Q-cIM-TOF-MS) and triple quadrupole mass spectrometry (UHPLC-TQ-MS). Methodology: NRF and NRL powder was extracted with methanol and fractionated using hexane, ethylacetate, and water. Antioxidant and α-glucosidase, and tyrosinase enzyme inhibitory activities were evaluated. The polyphenolic components of NRF and NRL were identified and quantified using UHPLC-Q-cIM-TOF-MS and UHPLC-TQ-MS. The method was validated using linearity, precision, accuracy, limit of detection (LOD), and lower limit of quantification (LLOQ). Results: Bioactive substances and antioxidants were highest in the ethylacetate fraction of flowers and leaves. Principal component analysis showed how solvent and plant components affect N. rubra's bioactivity and bioactive compound extraction. A total of 67 compounds were identified, and among them 21 significant polyphenols were quantified. Each calibration curve had R Conclusion: The developed method is simple, rapid, and selective for the identification and quantification of bioactive molecules. These findings provide a scientific basis for N. rubra's well-documented biological effects.
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1073576-8
ISSN	1099-1565 ; 0958-0344
ISSN (online)	1099-1565
ISSN	0958-0344
DOI	10.1002/pca.3329
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Article ; Online: Non-Born-Oppenheimer effects in molecular photochemistry: an experimental perspective.

Ashfold, Michael N R / Kim, Sang Kyu

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

2022 Volume 380, Issue 2223, Page(s) 20200376

Abstract: Non-adiabatic couplings between Born-Oppenheimer (BO)-derived potential energy surfaces are now recognized as pivotal in describing the non-radiative decay of electronically excited molecules following photon absorption. This opinion piece illustrates ... ...

Abstract	Non-adiabatic couplings between Born-Oppenheimer (BO)-derived potential energy surfaces are now recognized as pivotal in describing the non-radiative decay of electronically excited molecules following photon absorption. This opinion piece illustrates how non-BO effects provide photostability to many biomolecules when exposed to ultraviolet radiation, yet in many other cases are key to facilitating 'reactive' outcomes like isomerization and bond fission. The examples are presented in order of decreasing molecular complexity, spanning studies of organic sunscreen molecules in solution, through two families of heteroatom containing aromatic molecules and culminating with studies of isolated gas phase H
MeSH term(s)	Photochemistry ; Ultraviolet Rays
Language	English
Publishing date	2022-03-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	208381-4
ISSN	1471-2962 ; 0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
ISSN (online)	1471-2962
ISSN	0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
DOI	10.1098/rsta.2020.0376
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Article ; Online: Progesterone increases hepatic lipid content and plasma lipid levels through PR- B-mediated lipogenesis.

Jeong, Kang Ju / Mukae, Moeka / Lee, Sang R / Kim, Sang-Yun / Kim, Seong Hyeon / Cho, Young-Eun / An, Beum-Soo / Ko, Je-Won / Kwun, Hyo-Jung / Baek, In-Jeoung / Hong, Eui-Ju

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Volume 172, Page(s) 116281

Abstract: Progesterone (P4) is a crucial reproductive hormone that acts as a precursor for all other endogenous steroids. P4 modulates transcriptional activity during reproduction by binding to progesterone receptors (PR). However, the physiological role of P4 in ... ...

Abstract	Progesterone (P4) is a crucial reproductive hormone that acts as a precursor for all other endogenous steroids. P4 modulates transcriptional activity during reproduction by binding to progesterone receptors (PR). However, the physiological role of P4 in the liver is understudied. P4-mediated lipid metabolism in the liver was investigated in this study, as P4 facilitates insulin resistance and influences energy metabolism. While exogenous lipids are mainly obtained from food, the liver synthesizes endogenous triglycerides and cholesterol from a carbohydrate diet. Hepatic de novo lipogenesis (DNL) is primarily determined by acetyl-CoA and its biosynthetic pathways, which involve fatty acid and cholesterol synthesis. While P4 increased the hepatic levels of sterol regulatory element-binding protein 1 C (SREBP-1 C), peroxisome proliferator-activated receptor-gamma (PPARγ), acetyl-CoA carboxylase (ACC), and CD36, co-treatment with the P4 receptor antagonist RU486 blocked these proteins and P4-mediated lipogenesis. RNA sequencing was used to assess the role of P4 in lipogenic events, such as fatty liver and fatty acid metabolism, lipoprotein signaling, and cholesterol metabolism. P4 induced hepatic DNL and lipid anabolism were confirmed in the liver of ovarian resection mice fed a high-fat diet or in pregnant mice. P4 increased lipogenesis directly in mice exposed to P4 and indirectly in fetuses exposed to maternal P4. The lipid balance between lipogenesis and lipolysis determines fat build-up and is linked to lipid metabolism dysfunction, which involves the breakdown and storage of fats for energy and the synthesis of structural and functional lipids. Therefore, P4 may impact the lipid metabolism and reproductive development during gestation.
MeSH term(s)	Female ; Pregnancy ; Animals ; Mice ; Lipogenesis ; Progesterone/pharmacology ; Liver ; Cholesterol ; Fatty Acids ; Lipids
Chemical Substances	Progesterone (4G7DS2Q64Y) ; Cholesterol (97C5T2UQ7J) ; Fatty Acids ; Lipids
Language	English
Publishing date	2024-02-15
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2024.116281
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Article: In vitro

Cho, Hyunki / Kim, Young Jun / Chae, Jung-Woo / Meyer, Markus R / Kim, Sang Kyum / Ryu, Chang Seon

Frontiers in pharmacology

2023 Volume 14, Page(s) 1067408

Abstract: The SARS-CoV-2 pandemic requires a new therapeutic target for viral infection, and papain-like protease (Plpro) has been suggested as a druggable target. ... ...

Abstract	The SARS-CoV-2 pandemic requires a new therapeutic target for viral infection, and papain-like protease (Plpro) has been suggested as a druggable target. This
Language	English
Publishing date	2023-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1067408
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Article ; Online: Dietary supplementation with nicotinamide riboside improves fetal growth under hypoglycemia.

Lee, Sang R / Jeong, Su Hee / Mukae, Moeka / Kim, Sang-Yun / Ko, Je-Won / Kwun, Hyo-Jung / Hong, Eui-Ju

The Journal of nutritional biochemistry

2023 Volume 116, Page(s) 109310

Abstract: Nicotinamide riboside (NR) is considered a super-supplement that prevents obesity and diabetes. While NR has been investigated for various effects depending on nutritional conditions, metabolic research on women and pregnant women has rarely been ... ...

Abstract	Nicotinamide riboside (NR) is considered a super-supplement that prevents obesity and diabetes. While NR has been investigated for various effects depending on nutritional conditions, metabolic research on women and pregnant women has rarely been discussed. In this study, we focused on the glycemic control of NR in females and found the protective role of NR in pregnant animals under hypoglycemic conditions. Metabolic-tolerance tests were performed in vivo under progesterone (P4) exposure after ovariectomy (OVX). NR enhanced resistance to energy deprivation and showed a slight increase in gluconeogenesis in naïve control mice. However, NR reduced hyperglycemia and significantly induced gluconeogenesis in OVX mice. While NR reduced hyperglycemia in the P4-treated OVX mice, it reduced insulin response and substantially increased gluconeogenesis. Similar to animal experiments, NR increased gluconeogenesis and mitochondrial respiration in Hep3B cells. The gluconeogenic function of NR is mediated by tricarboxylic acid cycle (TCA) cycle enrichment, as residual pyruvate could induce gluconeogenesis. NR recovered fetal growth by increasing blood glucose levels when hypoglycemia was induced by diet-restriction during pregnancy. Our study revealed the glucose-metabolic function of NR in hypoglycemic pregnant animals, suggesting NR as a dietary supplement to improve fetal growth. Because diabetic women suffer from hypoglycemia due to insulin therapy, NR has therapeutic potential for use as a glycemic control pill.
MeSH term(s)	Female ; Humans ; Mice ; Pregnancy ; Animals ; Niacinamide/pharmacology ; Hypoglycemia/prevention & control ; Insulin ; Dietary Supplements ; Hypoglycemic Agents ; Fetal Development ; Hyperglycemia/prevention & control
Chemical Substances	nicotinamide-beta-riboside (0I8H2M0L7N) ; Niacinamide (25X51I8RD4) ; Insulin ; Hypoglycemic Agents
Language	English
Publishing date	2023-03-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1014929-6
ISSN	1873-4847 ; 0955-2863
ISSN (online)	1873-4847
ISSN	0955-2863
DOI	10.1016/j.jnutbio.2023.109310
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Article: Rice husk-derived mesoporous biogenic silica nanoparticles for gravity chromatography.

Shrestha, Devendra / Nayaju, Tulsi / Kandel, M R / Pradhananga, Raja Ram / Park, Chan Hee / Kim, Cheol Sang

Heliyon

2023 Volume 9, Issue 4, Page(s) e15142

Abstract: Biogenic silica nanoparticle is a superb alternative to synthetic silica because of their highly active, polar, and porous nanostructure with a large interior area. Among the available agricultural bioresources, biogenic silica extracted from rice husks ... ...

Abstract	Biogenic silica nanoparticle is a superb alternative to synthetic silica because of their highly active, polar, and porous nanostructure with a large interior area. Among the available agricultural bioresources, biogenic silica extracted from rice husks could be a simple, easily available, and cost-effective resource to use as the stationary phase for the column chromatographic technique. In the present study, highly pure amorphous biogenic silica nanoparticles (bSNPs) were synthesized using rice husk by a controlled combustion route followed by the sol-gel method. The bSNPs show better performance for the separation and isolation of ortho- and
Language	English
Publishing date	2023-04-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e15142
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Article ; Online: Biology, distribution, and management of invasive South American tomato leafminer, Tuta absoluta (Meyrick) (Lepidoptera; Gelechiidae), in Asia.

Acharya, Rajendra / Barman, Apurba K / Sharma, Sushant R / Kafle, Lekhnath / Kim, Sang-Mok / Lee, Kyeong-Yeoll

Archives of insect biochemistry and physiology

2023 Volume 114, Issue 4, Page(s) e22056

Abstract: South American tomato leafminer, Tuta absoluta (Meyrick, 1917) (Lepidoptera: Gelechiidae), is native to South America, but is a major invasive and quarantine pest species in Europe, Africa, and Asia. It causes extensive damage of up to 100% yield loss in ...

Abstract	South American tomato leafminer, Tuta absoluta (Meyrick, 1917) (Lepidoptera: Gelechiidae), is native to South America, but is a major invasive and quarantine pest species in Europe, Africa, and Asia. It causes extensive damage of up to 100% yield loss in tomatoes (Solanum lycopersicum) in open and greenhouse conditions. Since its first invasion in Spain in 2006, it has spread rapidly into many countries in the Mediterranean and Western Europe and further invaded Africa and Asia. In Asia, it was first recorded in August 2009 in Turkey and spread to most South and East Asian countries. In this study, we reviewed existing work on the biology and distribution of T. absoluta in Asia, as well as the damage it causes. This review will help to develop efficient management tactics as well as establish quarantine and phytosanitary precautions in uninvaded countries.
MeSH term(s)	Animals ; Lepidoptera ; Solanum lycopersicum ; Moths ; Asia ; South America ; Biology
Language	English
Publishing date	2023-10-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	11323-2
ISSN	1520-6327 ; 0739-4462
ISSN (online)	1520-6327
ISSN	0739-4462
DOI	10.1002/arch.22056
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Article ; Online: Microencapsulation for Food Applications: A Review.

Yan, Cuie / Kim, Sang-Ryoung / Ruiz, Daniela R / Farmer, Jordan R

ACS applied bio materials

2022 Volume 5, Issue 12, Page(s) 5497–5512

Abstract: Food products contain various active ingredients, such as flavors, nutrients, unsaturated fatty acids, color, probiotics, etc., that require protection during food processing and storage to preserve their quality and shelf life. This review provides an ... ...

Abstract	Food products contain various active ingredients, such as flavors, nutrients, unsaturated fatty acids, color, probiotics, etc., that require protection during food processing and storage to preserve their quality and shelf life. This review provides an overview of standard microencapsulation technologies, processes, materials, industrial examples, reasons for market success, a summary of recent applications, and the challenges in the food industry, categorized by active food ingredients: flavors, polyunsaturated fatty acids, probiotics, antioxidants, colors, vitamins, and others. We also provide a comprehensive analysis of the advantages and disadvantages of the most common microencapsulation technologies in the food industry such as spray drying, coacervation, extrusion, and spray cooling. This review ends with future perspectives on microencapsulation for food applications.
MeSH term(s)	Food Handling ; Food Ingredients ; Vitamins ; Antioxidants ; Food Industry
Chemical Substances	Food Ingredients ; Vitamins ; Antioxidants
Language	English
Publishing date	2022-11-17
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2576-6422
ISSN (online)	2576-6422
DOI	10.1021/acsabm.2c00673
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