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  1. Book ; Thesis: Serotonin- und volumensensitive kardiopulmonale Reflexe bei prähypertensiven DOCA-Ratten

    Ditting, Tilmann

    1997  

    Author's details vorgelegt von Tilmann Ditting
    Language German
    Size 60 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen-Nürnberg, Univ., Diss., 1997
    Note Mikrofiche-Ausg.: 1 Mikrofiche : 24x
    HBZ-ID HT008719903
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1998 MB 1536 order for loan Magazin

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  2. Book ; Online ; Thesis: Die verminderte Erregbarkeit renaler Afferenzen nach Chemokinexposition

    Lale, Nena [Verfasser] / Ditting, Tilmann [Akademischer Betreuer] / Veelken, Roland [Gutachter]

    2023  

    Author's details Nena Lale ; Gutachter: Roland Veelken ; Betreuer: Tilmann Ditting
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Article ; Online: Renal Nerve Ablation in Nephritis and Beyond.

    Rodionova, Kristina / Ditting, Tilmann / Veelken, Roland

    Journal of the American Society of Nephrology : JASN

    2021  Volume 32, Issue 10, Page(s) 2393–2395

    MeSH term(s) Humans ; Nephritis ; Sympathectomy
    Language English
    Publishing date 2021-12-01
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2021060748
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3344: Show issues Location:
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  4. Article: Myocardial infarction with a preserved ejection fraction-the impaired function of the cardio-renal baroreflex.

    Pickny, Lisa / Hindermann, Martin / Ditting, Tilmann / Hilgers, Karl F / Linz, Peter / Ott, Christian / Schmieder, Roland E / Schiffer, Mario / Amann, Kerstin / Veelken, Roland / Rodionova, Kristina

    Frontiers in physiology

    2023  Volume 14, Page(s) 1144620

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-04-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1144620
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  5. Article ; Online: Put Your Lights On: Electrocution As a Cause of an Unexplained Fall and Loss of Consciousness.

    Grzesiek, Magdalena / Ellmann, Christina / Ditting, Tilmann

    European journal of case reports in internal medicine

    2019  Volume 6, Issue 5, Page(s) 1084

    Abstract: Electrical accidents are not reported very frequently, and may occur undetected as the signs are often manifold and not very specific. We report the case of a 43-year-old woman admitted to hospital due to a fall of unclear cause, with loss of ... ...

    Abstract Electrical accidents are not reported very frequently, and may occur undetected as the signs are often manifold and not very specific. We report the case of a 43-year-old woman admitted to hospital due to a fall of unclear cause, with loss of consciousness, partial amnesia, paresis of both legs and crush syndrome. Only by thorough and repeated history-taking, and a careful physical examination that revealed burns typical of electrical current injuries, was the case resolved. With this case presentation, we would like to make the reader aware of electrocution as a possible cause of bruises and unconsciousness of unclear origin.
    Learning points: Bruises and loss of consciousness of unclear origin should make one think of electric shock as a possible cause.Rhabdomyolysis and crush syndrome are rarely seen conditions in low-voltage current accidents.Thorough physical examination and careful history-taking are very important and can provide precious hints for our clinical work.
    Language English
    Publishing date 2019-05-13
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2019_001084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Put Your Lights On

    Magdalena Grzesiek / Christina Ellmann / Tilmann Ditting

    European Journal of Case Reports in Internal Medicine (2019)

    Electrocution As a Cause of an Unexplained Fall and Loss of Consciousness

    2019  

    Abstract: Electrical accidents are not reported very frequently, and may occur undetected as the signs are often manifold and not very specific. We report the case of a 43-year-old woman admitted to hospital due to a fall of unclear cause, with loss of ... ...

    Abstract Electrical accidents are not reported very frequently, and may occur undetected as the signs are often manifold and not very specific. We report the case of a 43-year-old woman admitted to hospital due to a fall of unclear cause, with loss of consciousness, partial amnesia, paresis of both legs and crush syndrome. Only by thorough and repeated history-taking, and a careful physical examination that revealed burns typical of electrical current injuries, was the case resolved. With this case presentation, we would like to make the reader aware of electrocution as a possible cause of bruises and unconsciousness of unclear origin.
    Keywords Electric shock ; crush syndrome ; bruises and unconsciousness of unclear origin ; Medicine ; R
    Language English
    Publishing date 2019-05-01T00:00:00Z
    Publisher SMC MEDIA SRL
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Afferent neurons of the kidney with impaired firing pattern in inflammation - role of sodium currents?

    Lale, Nena / Ditting, Tilmann / Hilgers, Karl F / Linz, Peter / Ott, Christian / Schmieder, Roland E / Schiffer, Mario / Amann, Kerstin / Veelken, Roland / Rodionova, Kristina

    Pflugers Archiv : European journal of physiology

    2023  Volume 475, Issue 11, Page(s) 1329–1342

    Abstract: Peripheral neurons with renal afferents exhibit a predominantly tonic firing pattern of higher frequency that is reduced to low frequencies (phasic firing pattern) in renal inflammation. We wanted to test the hypothesis that the reduction in firing ... ...

    Abstract Peripheral neurons with renal afferents exhibit a predominantly tonic firing pattern of higher frequency that is reduced to low frequencies (phasic firing pattern) in renal inflammation. We wanted to test the hypothesis that the reduction in firing activity during inflammation is due to high-activity tonic neurons switching from higher to low frequencies depending on altered sodium currents. We identified and cultivated afferent sensory neurons with renal projections from the dorsal root ganglia (Th11-L2). Cultivated neurons were incubated with the chemokine CXCL1 (1,5 nmol/ml) for 12 h. We characterized neurons as "tonic," i.e., sustained action potential (AP) firing, or "phasic," i.e., < 5 APs upon stimulation in the current clamp. Their membrane currents were investigated in a voltage clamp. Data analyzed: renal vs. non-renal and tonic vs. phasic neurons. Renal afferent neurons exposed to CXCL1 showed a decrease in tonic firing pattern (CXCL1: 35,6% vs. control: 57%, P < 0.05). Na
    Language English
    Publishing date 2023-09-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-023-02852-6
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    Uc I Zs.35: Show issues Location:
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  8. Article ; Online: AT II Receptor Blockade and Renal Denervation: Different Interventions with Comparable Renal Effects?

    Rodionova, Kristina / Hindermann, Martin / Hilgers, Karl / Ott, Christian / Schmieder, Roland E / Schiffer, Mario / Amann, Kerstin / Veelken, Roland / Ditting, Tilmann

    Kidney & blood pressure research

    2021  Volume 46, Issue 3, Page(s) 331–341

    Abstract: Background: Angiotensin II (Ang II) and the renal sympathetic nervous system exert a strong influence on renal sodium and water excretion. We tested the hypothesis that already low doses of an Ang II inhibitor (candesartan) will result in similar ... ...

    Abstract Background: Angiotensin II (Ang II) and the renal sympathetic nervous system exert a strong influence on renal sodium and water excretion. We tested the hypothesis that already low doses of an Ang II inhibitor (candesartan) will result in similar effects on tubular sodium and water reabsorption in congestive heart failure (CHF) as seen after renal denervation (DNX).
    Methods: Measurement of arterial blood pressure, heart rate (HR), renal sympathetic nerve activity (RSNA), glomerular filtration rate (GFR), renal plasma flow (RPF), urine volume, and urinary sodium. To assess neural control of volume homeostasis, 21 days after the induction of CHF via myocardial infarction rats underwent volume expansion (0.9% NaCL; 10% body weight) to decrease RSNA. CHF rat and controls with or without DNX or pretreated with the Ang II type-1 receptor antagonist candesartan (0.5 ug i.v.) were studied.
    Results: CHF rats excreted only 68 + 10.2% of the volume load (10% body weight) in 90 min. CHF rats pretreated with candesartan or after DNX excreted from 92 to 103% like controls. Decreases of RSNA induced by volume expansion were impaired in CHF rats but unaffected by candesartan pointing to an intrarenal drug effect. GFR and RPF were not significantly different in controls or CHF.
    Conclusion: The prominent function of increased RSNA - retaining salt and water - could no longer be observed after renal Ang II receptor blockade in CHF rats.
    MeSH term(s) Angiotensin II/metabolism ; Angiotensin II Type 1 Receptor Blockers/pharmacology ; Animals ; Arterial Pressure/drug effects ; Benzimidazoles/pharmacology ; Biphenyl Compounds/pharmacology ; Denervation ; Glomerular Filtration Rate/drug effects ; Heart Rate/drug effects ; Kidney/drug effects ; Kidney/innervation ; Kidney/physiology ; Male ; Rats, Sprague-Dawley ; Sodium/metabolism ; Tetrazoles/pharmacology ; Water/metabolism ; Rats
    Chemical Substances Angiotensin II Type 1 Receptor Blockers ; Benzimidazoles ; Biphenyl Compounds ; Tetrazoles ; Water (059QF0KO0R) ; Angiotensin II (11128-99-7) ; Sodium (9NEZ333N27) ; candesartan (S8Q36MD2XX)
    Language English
    Publishing date 2021-05-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1326018-2
    ISSN 1423-0143 ; 1420-4096
    ISSN (online) 1423-0143
    ISSN 1420-4096
    DOI 10.1159/000515616
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    Zs.A 1458: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Effects of renal denervation on blood pressure in hypertensive patients with end-stage renal disease: a single centre experience.

    Ott, Christian / Schmid, Axel / Ditting, Tilmann / Veelken, Roland / Uder, Michael / Schmieder, Roland E

    Clinical and experimental nephrology

    2019  Volume 23, Issue 6, Page(s) 749–755

    Abstract: Background: Sympathetic nerve activity is a hallmark of hypertension in end-stage renal disease (ESRD). An initial proof-of-concept study implies that renal denervation (RDN) is feasible and safe in RDN, but overall data are limited.: Methods: In ... ...

    Abstract Background: Sympathetic nerve activity is a hallmark of hypertension in end-stage renal disease (ESRD). An initial proof-of-concept study implies that renal denervation (RDN) is feasible and safe in RDN, but overall data are limited.
    Methods: In this single-centre prospective pilot study six patients with ESRD and treatment resistant hypertension were consecutively included. Ambulatory blood pressure (ABP) was measured before and 6 months after RDN (Symplictiy Flex™, Medtronic Inc., Santa Rosa, CA). Moreover, haemodialysis parameters which may affect BP reduction were monitored closely.
    Results: In all patients bilateral RDN was successful done, without documentation of peri- or postprocedural complications. There was a significant reduction in 24-h ABP by 20 ± 17/15 ± 12 mmHg 6 months after RDN (systolic: 163 ± 16 versus 143 ± 9 mmHg, p = 0.043; diastolic: 96 ± 9 versus 81 ± 15 mmHg, p = 0.043), with similar results for day-, and nighttime values, respectively. Antihypertensive medication was kept stable as well as there was no change in haemodialysis parameters during follow-up. In addition, ultrafiltration/week (1.4 ± 1.4 versus 2.2 ± 1.4 l, p = 0.08) as well as hematocrit (measured at baseline and 6 months after RDN) (33.7 ± 4.3 versus 33.1 ± 3.9%, p = 0.715) revealed no change in volume status.
    Conclusion: Our single-centre pilot study not only supports current data on renal safety of RDN even in small arteries of patients with ESRD, but also enhances the knowledge towards an effective ABP reduction in this type of hypertensive patients.
    MeSH term(s) Adult ; Autonomic Nervous System/surgery ; Blood Pressure ; Female ; Humans ; Hypertension/complications ; Hypertension/surgery ; Kidney/blood supply ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Pilot Projects ; Prospective Studies ; Renal Dialysis ; Young Adult
    Language English
    Publishing date 2019-02-19
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-019-01697-7
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    Zs.A 4922: Show issues Location:
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  10. Article ; Online: Responsiveness of afferent renal nerve units in renovascular hypertension in rats.

    Rodionova, Kristina / Hilgers, Karl F / Rafii-Tabrizi, Salman / Doellner, Johannes / Cordasic, Nada / Linz, Peter / Karl, Anna-Lena / Ott, Christian / Schmieder, Roland E / Schiffer, Mario / Amann, Kerstin / Veelken, Roland / Ditting, Tilmann

    Pflugers Archiv : European journal of physiology

    2021  Volume 473, Issue 10, Page(s) 1617–1629

    Abstract: Previous data suggest that renal afferent nerve activity is increased in hypertension exerting sympathoexcitatory effects. Hence, we wanted to test the hypothesis that in renovascular hypertension, the activity of dorsal root ganglion (DRG) neurons with ... ...

    Abstract Previous data suggest that renal afferent nerve activity is increased in hypertension exerting sympathoexcitatory effects. Hence, we wanted to test the hypothesis that in renovascular hypertension, the activity of dorsal root ganglion (DRG) neurons with afferent projections from the kidneys is augmented depending on the degree of intrarenal inflammation. For comparison, a nonhypertensive model of mesangioproliferative nephritis was investigated. Renovascular hypertension (2-kidney, 1-clip [2K1C]) was induced by unilateral clipping of the left renal artery and mesangioproliferative glomerulonephritis (anti-Thy1.1) by IV injection of a 1.75-mg/kg BW OX-7 antibody. Neuronal labeling (dicarbocyanine dye [DiI]) in all rats allowed identification of renal afferent dorsal root ganglion (DRG) neurons. A current clamp was used to characterize neurons as tonic (sustained action potential [AP] firing) or phasic (1-4 AP) upon stimulation by current injection. All kidneys were investigated using standard morphological techniques. DRG neurons exhibited less often tonic response if in vivo axonal input from clipped kidneys was received (30.4% vs. 61.2% control, p < 0.05). However, if the nerves to the left clipped kidneys were cut 7 days prior to investigation, the number of tonic renal neurons completely recovered to well above control levels. Interestingly, electrophysiological properties of neurons that had in vivo axons from the right non-clipped kidneys were not distinguishable from controls. Renal DRG neurons from nephritic rats also showed less often tonic activity upon current injection (43.4% vs. 64.8% control, p < 0.05). Putative sympathoexcitatory and impaired sympathoinhibitory renal afferent nerve fibers probably contribute to increased sympathetic activity in 2K1C hypertension.
    MeSH term(s) Afferent Pathways ; Animals ; Ganglia, Spinal ; Glomerulonephritis/chemically induced ; Glomerulonephritis/classification ; Glomerulonephritis/pathology ; Hypertension, Renovascular/physiopathology ; Kidney/innervation ; Male ; Rats ; Rats, Sprague-Dawley
    Language English
    Publishing date 2021-07-07
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-021-02591-6
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