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  1. Article: Survey of Dermatology Practitioners' Opinions and Prescribing Habits of Oral Minoxidil for the Treatment of Androgenetic Alopecia.

    Sanfilippo, Eric / Friedman, Adam

    Journal of drugs in dermatology : JDD

    2024  Volume 23, Issue 3, Page(s) 136–140

    Abstract: Background: Utilization of low-dose oral minoxidil has increased in recent years in association with several clinical studies that have shown its efficacy in treating androgenetic alopecia (AGA).  Objective: To assess dermatology providers' attitudes ... ...

    Abstract Background: Utilization of low-dose oral minoxidil has increased in recent years in association with several clinical studies that have shown its efficacy in treating androgenetic alopecia (AGA).  Objective: To assess dermatology providers' attitudes and recommendation behaviors of oral minoxidil for the treatment of AGA.
    Methods: An online survey gauging the professional opinions, prescribing behaviors, and use of oral minoxidil was sent using the Orlando Dermatology Aesthetic and Clinical Conference email listserv which included multiple levels of dermatology practitioners including MD/DOs, NPs, and PAs across the United States.
    Results: Overall, the survey was sent to 2200 providers, and 201 (9.1%) responses were collected. 81% (n=139) of respondents supported the use of oral minoxidil for AGA. Support varied significantly (P=.03) by providers' number of years in practice with those in practice for greater than 30 years with the least amount of support. 92% of respondents (130, n=141) reported feeling comfortable prescribing oral minoxidil, and 83% (116, n=140) found oral minoxidil to be better than its topical formulation. 78% (108, n=139) felt their patients were satisfied with their results, and 89% (124, n=140) felt oral minoxidil was well tolerated by their patients.
    Conclusions: This study found that most prescribers use oral minoxidil as a treatment for AGA and find it to be an effective and tolerable option for patients. Support for oral minoxidil was significantly impacted by providers' years in practice. J Drugs Dermatol. 2024;23(3): doi:10.36849/JDD.7519.
    MeSH term(s) Humans ; Minoxidil/adverse effects ; Dermatology ; Alopecia/diagnosis ; Alopecia/drug therapy ; Habits ; Emotions
    Chemical Substances Minoxidil (5965120SH1)
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2145090-0
    ISSN 1545-9616
    ISSN 1545-9616
    DOI 10.36849/jdd.7519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5931: Show issues Location:
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  2. Article ; Online: Title 42 Exclusions of Asylum Seekers-A Misuse of Public Health Powers.

    Gostin, Lawrence O / Friedman, Eric A

    JAMA health forum

    2023  Volume 4, Issue 1, Page(s) e230078

    MeSH term(s) Humans ; Public Health ; Refugees ; Health Services Accessibility
    Language English
    Publishing date 2023-01-06
    Publishing country United States
    Document type Journal Article
    ISSN 2689-0186
    ISSN (online) 2689-0186
    DOI 10.1001/jamahealthforum.2023.0078
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  3. Article: Oral Minoxidil Media Coverage: The Impact on Patient Perceptions and Practitioner Approaches to Androgenetic Alopecia.

    Desai, Sapana / Sanfilippo, Eric / Friedman, Adam

    Journal of drugs in dermatology : JDD

    2024  Volume 23, Issue 1, Page(s) 1364–1366

    MeSH term(s) Humans ; Minoxidil/adverse effects ; Alopecia/diagnosis ; Alopecia/drug therapy
    Chemical Substances Minoxidil (5965120SH1)
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2145090-0
    ISSN 1545-9616
    ISSN 1545-9616
    DOI 10.36849/JDD.7730
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  4. Article ; Online: The Global Health Architecture: Governance and International Institutions to Advance Population Health Worldwide.

    Gostin, Lawrence O / Friedman, Eric A / Finch, Alexandra

    The Milbank quarterly

    2023  Volume 101, Issue S1, Page(s) 734–769

    Abstract: Policy Points Global health institutions and instruments should be reformed to fully incorporate the principles of good health governance: the right to health, equity, inclusive participation, transparency, accountability, and global solidarity. New ... ...

    Abstract Policy Points Global health institutions and instruments should be reformed to fully incorporate the principles of good health governance: the right to health, equity, inclusive participation, transparency, accountability, and global solidarity. New legal instruments, like International Health Regulations amendments and the pandemic treaty, should be grounded in these principles of sound governance. Equity should be embedded into the prevention of, preparedness for, response to, and recovery from catastrophic health threats, within and across nations and sectors. This includes the extant model of charitable contributions for access to medical resources giving way to a new model that empowers low- and middle-income countries to create and produce their own diagnostics, vaccines, and therapeutics-such as through regional messenger RNA vaccine manufacturing hubs. Robust and sustainable funding of key institutions, national health systems, and civil society will ensure more effective and just responses to health emergencies, including the daily toll of avoidable death and disease disproportionately experienced by poorer and more marginalized populations.
    MeSH term(s) Global Health ; International Cooperation ; Population Health ; Government Programs
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632829-5
    ISSN 1468-0009 ; 0887-378X
    ISSN (online) 1468-0009
    ISSN 0887-378X
    DOI 10.1111/1468-0009.12627
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    Zs.A 285: Show issues Location:
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  5. Article ; Online: Postpartum Psychosis.

    Friedman, Susan Hatters / Reed, Eric / Ross, Nina E

    Current psychiatry reports

    2023  Volume 25, Issue 2, Page(s) 65–72

    Abstract: Purpose of review: Postpartum psychosis is a psychiatric emergency that can affect the health and life of mothers, infants, and families. Postpartum psychosis (PPP) is distinct from non-postpartum psychosis in many ways, and it is crucial to study and ... ...

    Abstract Purpose of review: Postpartum psychosis is a psychiatric emergency that can affect the health and life of mothers, infants, and families. Postpartum psychosis (PPP) is distinct from non-postpartum psychosis in many ways, and it is crucial to study and understand PPP to identify, treat, and possibly prevent this condition. We therefore sought to review the latest research findings about PPP with the intention of updating readers about the latest evidence base.
    Recent findings: Multiple physiologic pathways have been implicated in the development of PPP, and further understanding these pathways may allow for early detection and treatment. Risk assessment and treatment should include consideration of the woman patient but also the mother-infant dyad and the larger family. It is our hope that this review of research updates in postpartum psychosis may inform clinical practice and promote specialized, evidence-based diagnosis, risk assessment, and treatment.
    MeSH term(s) Female ; Infant ; Humans ; Psychotic Disorders/drug therapy ; Puerperal Disorders/diagnosis ; Puerperal Disorders/psychology ; Puerperal Disorders/therapy ; Mothers/psychology ; Risk Assessment ; Postpartum Period/psychology ; Depression, Postpartum/diagnosis
    Language English
    Publishing date 2023-01-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055376-6
    ISSN 1535-1645 ; 1523-3812
    ISSN (online) 1535-1645
    ISSN 1523-3812
    DOI 10.1007/s11920-022-01406-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5520: Show issues Location:
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  6. Article ; Online: Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need.

    Tan, Bowen / Browne, Caleb J / Nöbauer, Tobias / Vaziri, Alipasha / Friedman, Jeffrey M / Nestler, Eric J

    Science (New York, N.Y.)

    2024  Volume 384, Issue 6693, Page(s) eadk6742

    Abstract: Drugs of abuse are thought to promote addiction in part by "hijacking" brain reward systems, but the underlying mechanisms remain undefined. Using whole-brain FOS mapping and in vivo single-neuron calcium imaging, we found that drugs of abuse augment ... ...

    Abstract Drugs of abuse are thought to promote addiction in part by "hijacking" brain reward systems, but the underlying mechanisms remain undefined. Using whole-brain FOS mapping and in vivo single-neuron calcium imaging, we found that drugs of abuse augment dopaminoceptive ensemble activity in the nucleus accumbens (NAc) and disorganize overlapping ensemble responses to natural rewards in a cell type-specific manner. Combining FOS-Seq, CRISPR-perturbation, and single-nucleus RNA sequencing, we identified
    MeSH term(s) Nucleus Accumbens/metabolism ; Nucleus Accumbens/drug effects ; Animals ; Reward ; Mice ; Homeostasis ; Neurons/metabolism ; Illicit Drugs/adverse effects ; Ras Homolog Enriched in Brain Protein/metabolism ; Ras Homolog Enriched in Brain Protein/genetics ; Male ; Mice, Inbred C57BL ; Proto-Oncogene Proteins c-fos/metabolism ; Proto-Oncogene Proteins c-fos/genetics ; Signal Transduction ; Substance-Related Disorders ; Single-Cell Analysis ; Cocaine/pharmacology ; Calcium/metabolism
    Chemical Substances Illicit Drugs ; Ras Homolog Enriched in Brain Protein ; Proto-Oncogene Proteins c-fos ; Cocaine (I5Y540LHVR) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2024-04-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adk6742
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  7. Article ; Online: The safety and accuracy of intratumoral catheter placement to infuse viral immunotherapies in children with malignant brain tumors: a multi-institutional study.

    Barkley, Ariana / Butler, Eric / Park, Christine / Friedman, Allan / Landi, Daniel / Ashley, David M / Bigner, Darell / Bernstock, Joshua D / Friedman, Gregory K / Johnston, James M / Thompson, Eric M

    Journal of neurosurgery. Pediatrics

    2024  Volume 33, Issue 4, Page(s) 359–366

    Abstract: Objective: Relatively little is known about the safety and accuracy of catheter placement for oncolytic viral therapy in children with malignant brain tumors. Accordingly, this study combines data from two phase I clinical trials that employed viral ... ...

    Abstract Objective: Relatively little is known about the safety and accuracy of catheter placement for oncolytic viral therapy in children with malignant brain tumors. Accordingly, this study combines data from two phase I clinical trials that employed viral immunotherapy across two institutions to describe the adverse event profile, safety, and accuracy associated with the stereotactic placement and subsequent removal of intratumoral catheters.
    Methods: Children with progressive/recurrent supratentorial malignant tumors were enrolled in two clinical trials (NCT03043391 and NCT02457845) and treated with either the recombinant polio:rhinovirus (lerapolturev) or the genetically modified oncolytic herpesvirus (G207). Age, sex, race, tumor diagnosis, and tumor location were analyzed. Events related to the catheter placement or removal were categorized. A catheter that was either pulled back or could not be used was defined as "misplaced." Neuronavigation software was used to analyze the accuracy of catheter placement for NCT03043391. Descriptive statistics were performed.
    Results: Nineteen patients were treated across the two completed trials with a total of 49 catheters. The mean ± SD (range) age was 14.1 ± 3.6 (7-19) years. All tumors were grade 3 or 4 gliomas. Nonlobar catheter tip placement included the corpus callosum, thalamus, insula, and cingulate gyrus. Six of 19 patients (31.6%) had minor hemorrhage noted on CT; however, no patients were symptomatic and/or required intervention related to these findings. One of 19 patients had a delayed CSF leak after catheter removal that required oversewing of the surgical site. No patients developed infection or a neurological deficit. In 7 patients with accuracy data, the mean ± SD distance of the planned trajectory (PT) to the catheter tip was 1.57 ± 1.6 mm, the mean angle of the PT to the catheter was 2.43° ± 2.1°, and the greatest distance of PT to the catheter in the parallel plane was 1.54 ± 1.5 mm. Three of 49 (6.1%) catheters were considered misplaced.
    Conclusions: Although instances of minor hemorrhage were encountered, they were clinically asymptomatic. One of 49 catheters required intervention for a CSF leak. Congruent with previous studies in the literature, the stereotactic placement of catheters in these pediatric tumor patients was accurate with approximately 95% of catheters having been adequately placed.
    MeSH term(s) Child ; Humans ; Adolescent ; Neoplasm Recurrence, Local/therapy ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/therapy ; Catheters ; Immunotherapy ; Hemorrhage
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2403985-8
    ISSN 1933-0715 ; 1933-0707
    ISSN (online) 1933-0715
    ISSN 1933-0707
    DOI 10.3171/2023.12.PEDS23404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The authors reply.

    Higgins, Thomas L / Freeseman-Friedman, Laura / Henson, Kathy N / Ringle, Eric

    Critical care medicine

    2021  Volume 49, Issue 12, Page(s) e1272–e1273

    Language English
    Publishing date 2021-09-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005345
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  9. Article ; Online: Clonazepam to the Rescue? Post-Steroid Mania and a Paradoxical Response to an Atypical Antipsychotic.

    Schoenfeld, Eric / Viswanathan, Ramaswamy / Larios, Daniel Azzopardi / Friedman, Daniel

    The primary care companion for CNS disorders

    2022  Volume 24, Issue 4

    MeSH term(s) Antipsychotic Agents/adverse effects ; Bipolar Disorder/chemically induced ; Bipolar Disorder/drug therapy ; Clonazepam/adverse effects ; Humans ; Mania ; Steroids
    Chemical Substances Antipsychotic Agents ; Steroids ; Clonazepam (5PE9FDE8GB)
    Language English
    Publishing date 2022-08-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2675414-9
    ISSN 2155-7780 ; 2155-7780
    ISSN (online) 2155-7780
    ISSN 2155-7780
    DOI 10.4088/PCC.21cr03086
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  10. Article: Transitioning Out of the Coronavirus Lockdown: A Framework for Evaluating Zone-Based Social Distancing.

    Friedman, Eric / Friedman, John / Johnson, Simon / Landsberg, Adam

    Frontiers in public health

    2020  Volume 8, Page(s) 266

    Abstract: In the face of elevated pandemic risk, canonical epidemiological models imply the need for extreme social distancing over a prolonged period. Alternatively, people could be organized into zones, with more interactions inside their zone than across zones. ...

    Abstract In the face of elevated pandemic risk, canonical epidemiological models imply the need for extreme social distancing over a prolonged period. Alternatively, people could be organized into zones, with more interactions inside their zone than across zones. Zones can deliver significantly lower infection rates, with less social distancing, particularly if combined with simple quarantine rules and contact tracing. This paper provides a framework for understanding and evaluating the implications of zones, quarantines, and other complementary policies.
    MeSH term(s) Basic Reproduction Number ; COVID-19/prevention & control ; Communicable Disease Control ; Contact Tracing ; Global Health ; Humans ; Models, Statistical ; Physical Distancing ; Quarantine ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2020.00266
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