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Article: My home-my castle? Self-reported anxiety varies in relation to the subjective evaluation of home environment.

Weber, Sandra / Mascherek, Anna / Augustin, Jobst / Cheng, Bastian / Thomalla, Götz / Hoven, Hanno / Harth, Volker / Augustin, Matthias / Gallinat, Jürgen / Kühn, Simone

Frontiers in psychology

2024 Volume 14, Page(s) 1267900

Abstract: Introduction: Although people spend most of the day in their home environment, the focus of research in environmental psychology to date has been on factors outside the home. However, it stands to reason that indoor quality likewise has an impact on ... ...

Abstract	Introduction: Although people spend most of the day in their home environment, the focus of research in environmental psychology to date has been on factors outside the home. However, it stands to reason that indoor quality likewise has an impact on psychological well-being. Therefore, the present study addresses the question of whether the subjective evaluation of home environmental parameters are related to self-reported anxiety and whether they can additionally explain variance beyond the usual sociodemographic and general lifestyle variables. Methods: Data from the Hamburg City Health Study (first 10,000 participants) was analyzed. A subsample of Results: Using the integrated model, we were able to explain about 13% of the variance in self-reported anxiety scores. This included both the demographic, lifestyle, and subjective evaluation of home environment variables. Protection from disturbing night lights, a greater sense of security, less disturbing noises, brighter accommodations, and a satisfactory window view explained almost 6% of the variance and was significantly associated with lower anxiety scores. Conclusion: The home as a place of refuge plays an increasingly important role as home office hours rise. It is therefore crucial to identify domestic factors contributing to people's mental well-being. The subjective evaluation of one's home environment has proven influential over and above modifiable lifestyle variables.
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1267900
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Article ; Online: Management of moderate to severe psoriasis with brodalumab-Real-world evidence from the LIBERO study.

von Kiedrowski, R / Hinz, T / Mauer, G / Schwinn, A / Timmel, A / Hutt, H J / Augustin, M

Journal of the European Academy of Dermatology and Venereology : JEADV

2024

Abstract: Background: Brodalumab, a fully human monoclonal immunoglobulin IgG2 antibody that binds the human interleukin 17 receptor subunit A, is available for the treatment of moderate-to-severe plaque psoriasis in Europe since September 2017, but so far there ... ...

Abstract	Background: Brodalumab, a fully human monoclonal immunoglobulin IgG2 antibody that binds the human interleukin 17 receptor subunit A, is available for the treatment of moderate-to-severe plaque psoriasis in Europe since September 2017, but so far there are only a few studies on its use in real-world conditions. Objectives: To assess the management of moderate-to-severe psoriasis with brodalumab 210 mg in daily practice after 12 and 52 weeks (W). In addition, patient profiles and treatment pathways are described. Methods: LIBERO is a prospective, multicenter, non-interventional study including adult patients with plaque psoriasis treated with brodalumab 210 mg. Results: In total, 638 patients (65% male, mean age: 49.3 ± 14.4 years) from 148 sites in Germany were enrolled. The majority suffered from severe (51.1%) or very severe (13.1%) psoriasis according to physician global assessment (PGA0-5). When starting with brodalumab, 58.5% were biologic naïve and 41.5% were previously treated with another biologic, mainly adalimumab (18.5%) and secukinumab (17.9%). About 74.0% of patients met the primary endpoint of an absolute PASI ≤3 at ~W12 (n = 618, LOCF). The mean PASI was reduced significantly as of ~W2 from 17.2 (±11.7) to 9.7 (±8.8) and improved further to 3.3 (±6.3) at ~W12 (p < 0.001). At ~W52 85.5% of patients reached a PGA0/1-response (primary endpoint) and 54.1% patients were assessed as completely clear (PGA0) (both n = 399, as observed). Effectiveness of brodalumab was confirmed in relevant subgroup analysis by previous treatment regimen. Most frequently reported adverse events were nasopharyngitis (4.6%), psoriasis (4.6%) and arthralgia (4.1%), new safety signals were not detected. Conclusion: This representative, non-interventional study confirms the short- and long-term effectiveness and safety profile of brodalumab in the management of psoriasis in daily practice as well as in relevant treatment pathways.
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.19974
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Zs.MO 413: Show issues

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Article ; Online: SSTR Antagonists as Theranostic Option in Merkel Cell Carcinoma.

Kircher, Malte / Amerein, Adriana / Augustin, Mareike / Reitsam, Nic G / Enke, Johanna S / Patt, Marianne / Wienand, Georgine / Bundschuh, Ralph A / Pfob, Christian H / Lapa, Constantin / Dierks, Alexander

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2024

Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.123.267124
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Zs.A 114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 328: Show issues

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Conference proceedings: Biomechanische Analyse von tomographisch unauffälligen Keratokonus-Partneraugen

Augustin, Victor A. / Son, H.-S. / Kovalchuk, B. / Köppe, M.K. / Auffarth, G. U. / Khoramnia, R.

2023 , Page(s) 23dgii33

Event/congress	37. Kongress der Deutschsprachigen Gesellschaft für Intraokularlinsen-Implantation, interventionelle und refraktive Chirurgie; Weimar; Deutschsprachige Gesellschaft für Intraokularlinsen-Implantation, Interventionelle und Refraktive Chirurgie; 2023
Keywords	Medizin, Gesundheit
Publishing date	2023-03-02
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/23dgii33
Database	German Medical Science

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Conference proceedings: Intraokularlinsenaustausch bei primärer Kalzifikation: eine klinische Studie

Yildirim, Timur M. / Henningsen, N. / Son, H.-S. / Augustin, V. A. / Khoramnia, R. / Auffarth, G. U.

2023 , Page(s) 23dgii15

Event/congress	37. Kongress der Deutschsprachigen Gesellschaft für Intraokularlinsen-Implantation, interventionelle und refraktive Chirurgie; Weimar; Deutschsprachige Gesellschaft für Intraokularlinsen-Implantation, Interventionelle und Refraktive Chirurgie; 2023
Keywords	Medizin, Gesundheit
Publishing date	2023-03-02
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/23dgii15
Database	German Medical Science

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Article ; Online: Gender Differences in Vitamin D Status and Determinants of Vitamin D Insufficiency in Patients with Chronic Obstructive Pulmonary Disease.

Minter, Maria / Augustin, Hanna / van Odijk, Jenny / Vanfleteren, Lowie E G W

Nutrients

2023 Volume 15, Issue 2

Abstract: Low vitamin D levels are common in Chronic Obstructive Pulmonary Disease (COPD) and have been associated with various adverse COPD-related outcomes. Recent data on vitamin D status in representative COPD cohorts in Scandinavia is lacking. This study ... ...

Abstract	Low vitamin D levels are common in Chronic Obstructive Pulmonary Disease (COPD) and have been associated with various adverse COPD-related outcomes. Recent data on vitamin D status in representative COPD cohorts in Scandinavia is lacking. This study aimed to assess vitamin D status and determinants of vitamin D insufficiency in patients with COPD who were attending a specialist secondary care COPD clinic in Southwestern Sweden. All patients who visited the COPD clinic for their first medical visit during two periods, 2017−2018 and 2021, were included in this observational study. Measurements of 25-Hydroxyvitamin D (25(OH)D), clinical data and documentation of supplements containing vitamin D were collected retrospectively from patients’ medical records. Multivariable logistic regression analysis was performed to identify determinants of the primary outcome, vitamin D insufficiency (25(OH)D < 50 nmol/L). A total of 667 patients were included, and 33% had vitamin D insufficiency. The median 25(OH)D was 62 nmol/L (43.5−83.1 nmol/L). Vitamin D insufficiency was related to the male gender, current smoking habits, a lack of supplements containing vitamin D and the winter season for blood sampling. In conclusion, vitamin D insufficiency is common in patients with COPD. Men had significantly lower levels of vitamin D but took vitamin D-containing supplements less frequently compared to women. Our findings can help clinicians to identify patients who are at risk of vitamin D insufficiency and allow correction with supplementation where appropriate.
MeSH term(s)	Humans ; Male ; Female ; Retrospective Studies ; Sex Factors ; Vitamin D Deficiency ; Vitamin D ; Vitamins ; Pulmonary Disease, Chronic Obstructive ; Dietary Supplements ; Seasons
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins
Language	English
Publishing date	2023-01-13
Publishing country	Switzerland
Document type	Observational Study ; Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15020426
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Article ; Online: Commentary on Folkman: "How Is Blood Vessel Growth Regulated in Normal and Neoplastic Tissue?".

Augustin, Hellmut G

Cancer research

2016 Volume 76, Issue 10, Page(s) 2854–2856

Abstract: ... the 1985 G.H.A. Clowes Memorial Award Lecture delivered by Dr. Judah Folkman. Thirty years later ...

Abstract	Angiogenesis is a prerequisite for tumor growth and metastatic progression. The discovery of the first specific angiogenic cytokine, VEGF, in 1989 paved the way for the clinical approval of the first antiangiogenic tumor drug 15 years later. This brief commentary highlights and puts into historical perspective the 1985 G.H.A. Clowes Memorial Award Lecture delivered by Dr. Judah Folkman. Thirty years later, this award lecture is a lively testimony of the visionary mind of Dr. Folkman, whose legacy continues to inspire contemporary angiogenesis research. Cancer Res; 76(10); 2854-6. ©2016 AACRSee related article by Folkman J, Cancer Res 1986;46:467-73.
MeSH term(s)	Angiogenesis Inhibitors ; Humans ; Neoplasms ; Neovascularization, Pathologic
Chemical Substances	Angiogenesis Inhibitors
Language	English
Publishing date	2016--15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-16-1123
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Article ; Online: Sterol interactions influence the function of Wsc sensors.

Bernauer, Lukas / Berzak, Paula / Lehmayer, Leonie / Messenlehner, Julia / Oberdorfer, Gustav / Zellnig, Günther / Wolinski, Heimo / Augustin, Christoph / Baeck, Melanie / Emmerstorfer-Augustin, Anita

Journal of lipid research

2023 Volume 64, Issue 12, Page(s) 100466

Abstract: The Wsc1, Wsc2, and Wsc3 proteins are essential cell surface sensors that respond to cell wall perturbation by activating the cell wall integrity pathway (CWIP). We show here that in situ production of cholesterol (in place of ergosterol) induces hyper- ... ...

Abstract	The Wsc1, Wsc2, and Wsc3 proteins are essential cell surface sensors that respond to cell wall perturbation by activating the cell wall integrity pathway (CWIP). We show here that in situ production of cholesterol (in place of ergosterol) induces hyper-phosphorylation of Slt2, the MAPK of the CWIP, and upregulates cell wall biosynthesis. Deletion of all three Wsc genes in K. phaffii reverts these phenotypes. In the cholesterol-producing strain, both Wsc1 and Wsc3 accumulate in the plasma membrane. Close inspection of the transmembrane domains of all three Wsc proteins predicted by AlphaFold2 revealed the presence of CRAC sterol-binding motifs. Experiments using a photoreactive cholesterol derivative indicate intimate interaction of this sterol with the Wsc transmembrane domain, and this apparent sterol binding was abrogated in Wsc mutants with substitutions in the CRAC motif. We also observed cholesterol interaction with CRAC-like motifs in the transmembrane domains of mammalian integrins, analogs of Wsc proteins. Our results suggest that proper signaling of the Wsc sensors requires highly specific binding of the native endogenous terminal sterol, ergosterol.
MeSH term(s)	Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Sterols/metabolism ; Cholesterol/metabolism ; Ergosterol/metabolism
Chemical Substances	Saccharomyces cerevisiae Proteins ; Membrane Proteins ; Sterols ; Cholesterol (97C5T2UQ7J) ; Ergosterol (Z30RAY509F)
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80154-9
ISSN	1539-7262 ; 0022-2275
ISSN (online)	1539-7262
ISSN	0022-2275
DOI	10.1016/j.jlr.2023.100466
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Book ; Online: Robust Statistical Comparison of Random Variables with Locally Varying Scale of Measurement

Jansen, Christoph / Schollmeyer, Georg / Blocher, Hannah / Rodemann, Julian / Augustin, Thomas

2023

Abstract: Spaces with locally varying scale of measurement, like multidimensional structures with differently scaled dimensions, are pretty common in statistics and machine learning. Nevertheless, it is still understood as an open question how to exploit the ... ...

Abstract	Spaces with locally varying scale of measurement, like multidimensional structures with differently scaled dimensions, are pretty common in statistics and machine learning. Nevertheless, it is still understood as an open question how to exploit the entire information encoded in them properly. We address this problem by considering an order based on (sets of) expectations of random variables mapping into such non-standard spaces. This order contains stochastic dominance and expectation order as extreme cases when no, or respectively perfect, cardinal structure is given. We derive a (regularized) statistical test for our proposed generalized stochastic dominance (GSD) order, operationalize it by linear optimization, and robustify it by imprecise probability models. Our findings are illustrated with data from multidimensional poverty measurement, finance, and medicine. Comment: Accepted for the 39th Conference on Uncertainty in Artificial Intelligence (UAI 2023)
Keywords	Statistics - Machine Learning ; Computer Science - Machine Learning ; Mathematics - Statistics Theory ; 62G10 ; 62G35
Subject code	310
Publishing date	2023-06-22
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dermatologische Videosprechstunden für deutsche Justizvollzugsanstalten : Erfahrungen aus teledermatologischen Konsilen 2020 bis 2022.

Stephan, B / Girbig, G / Scherer, M / Blozik, E / Augustin, M

Dermatologie (Heidelberg, Germany)

2022 Volume 73, Issue 11, Page(s) 859–865

Abstract: ... an acute presentation within 24 h. The spectrum of skin diseases was comparable to cases presenting ...

Title translation	Dermatological video consultations for German prisons : Experiences from teledermatological consultations 2020 to 2022.
Abstract	Background: With increasing shortage of medical personnel also in the medical care in German correctional facilities, telemedicine has been used since 2016, initially in projects and then for regular medical care. Since 2019, there is the possibility of dermatological expertise in regular video consultations. Objective: The benefits of an interdisciplinary online consultation with video and store and forward technology for dermatological issues are highlighted in terms of efficiency and feasibility. Material and methods: A descriptive analysis of 450 dermatological video consultations for German correctional facilities from February 2020 to July 2022 was carried out with respect to procedures, indications and demand. Results: Requests were made via a standardised form with optional photographs, which were sent via a secure cloud to the dermatology department in store and forward mode. The majority of cases could be presented live in a regular weekly video consultation and only single cases required an acute presentation within 24 h. The spectrum of skin diseases was comparable to cases presenting to a dermatology outpatient clinic. The interdisciplinary consultation management together with colleagues from general medicine enabled the transfer of the cases to the medical personnel at the correctional facility on site for follow-up and further medical procedures. Treatment could be started in all cases without delay. Conclusion: Teledermatology represents an important contribution to medical care in German correctional facilities and the interdisciplinary cooperation saves time and resources in the presentation and treatment of skin diseases.
MeSH term(s)	Humans ; Dermatology/methods ; Prisons ; Remote Consultation/methods ; Skin Diseases/diagnosis ; Telemedicine/methods
Language	German
Publishing date	2022-09-23
Publishing country	Germany
Document type	English Abstract ; Journal Article ; Review
ISSN	2731-7013
ISSN (online)	2731-7013
DOI	10.1007/s00105-022-05060-y
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