Article ; Online: The Entangled World of Memory T Cells and Implications in Transplantation.
2023 Volume 108, Issue 1, Page(s) 137–147
Abstract: Memory T cells that are specific for alloantigen can arise from a variety of stimuli, ranging from direct allogeneic sensitization from prior transplantation, blood transfusion, or pregnancy to the elicitation of pathogen-specific T cells that are cross- ... ...
Abstract | Memory T cells that are specific for alloantigen can arise from a variety of stimuli, ranging from direct allogeneic sensitization from prior transplantation, blood transfusion, or pregnancy to the elicitation of pathogen-specific T cells that are cross-reactive with alloantigen. Regardless of the mechanism by which they arise, alloreactive memory T cells possess key metabolic, phenotypic, and functional properties that render them distinct from naive T cells. These properties affect the immune response to transplantation in 2 important ways: first, they can alter the speed, location, and effector mechanisms with which alloreactive T cells mediate allograft rejection, and second, they can alter T-cell susceptibility to immunosuppression. In this review, we discuss recent developments in understanding these properties of memory T cells and their implications for transplantation. |
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MeSH term(s) | Memory T Cells ; Graft Rejection/prevention & control ; Transplantation, Homologous ; Skin Transplantation ; Isoantigens ; Immunologic Memory |
Chemical Substances | Isoantigens |
Language | English |
Publishing date | 2023-12-13 |
Publishing country | United States |
Document type | Review ; Journal Article |
ZDB-ID | 208424-7 |
ISSN | 1534-6080 ; 0041-1337 |
ISSN (online) | 1534-6080 |
ISSN | 0041-1337 |
DOI | 10.1097/TP.0000000000004647 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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