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Book ; Online: From ORAN to Cell-Free RAN

Cao, Yang / Zhang, Ziyang / Xia, Xinjiang / Xin, Pengzhe / Liu, Dongjie / Zheng, Kang / Lou, Mengting / Jin, Jing / Wang, Qixing / Wang, Dongming / Huang, Yongming / You, Xiaohu / Wang, Jiangzhou

Architecture, Performance Analysis, Testbeds and Trials

2023

Abstract: ... RAN) of the fifth generation (5G) and beyond mobile communications. As a key technology ... Starting from scalable implementation of CF-mMIMO, we study a cell-free RAN (CF-RAN) under the ORAN ... of CF-RAN under ORAN architecture, including time-frequency synchronization and over-the-air reciprocity ...

Abstract	Open radio access network (ORAN) provides an open architecture to implement radio access network (RAN) of the fifth generation (5G) and beyond mobile communications. As a key technology for the evolution to the sixth generation (6G) systems, cell-free massive multiple-input multiple-output (CF-mMIMO) can effectively improve the spectrum efficiency, peak rate and reliability of wireless communication systems. Starting from scalable implementation of CF-mMIMO, we study a cell-free RAN (CF-RAN) under the ORAN architecture. Through theoretical analysis and numerical simulation, we investigate the uplink and downlink spectral efficiencies of CF-mMIMO with the new architecture. We then discuss the implementation issues of CF-RAN under ORAN architecture, including time-frequency synchronization and over-the-air reciprocity calibration, low layer splitting, deployment of ORAN radio units (O-RU), artificial intelligent based user associations. Finally, we present some representative experimental results for the uplink distributed reception and downlink coherent joint transmission of CF-RAN with commercial off-the-shelf O-RUs.
Keywords	Computer Science - Information Theory ; Electrical Engineering and Systems Science - Signal Processing
Publishing date	2023-01-30
Publishing country	us
Document type	Book ; Online
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Article: Mapping of repeat-associated non-AUG (RAN) translation knowledge: A bibliometric analysis.

Zhao, Taiqi / Duan, Suying / Li, Jiaqi / Zheng, Honglin / Liu, Chenyang / Zhang, Hang / Luo, Haiyang / Xu, Yuming

Heliyon

2024 Volume 10, Issue 8, Page(s) e29141

Abstract: ... there's a discernible gap in comprehensive and objective articles on RAN translation. This study endeavors ... to evaluate and delineate the contemporary landscape and progress of RAN translation research via ... a bibliometric analysis. We sourced literature on RAN translation from the Web of Science Core Collection. Utilizing two ...

Abstract	Over 50 genetic human disorders are attributed to the irregular expansion of microsatellites. These expanded microsatellite sequences can experience bidirectional transcription, leading to new reading frames. Beyond the standard AUG initiation or adjacent start codons, they are translated into proteins characterized by disease-causing amino acid repeats through repeat-associated non-AUG translation. Despite its significance, there's a discernible gap in comprehensive and objective articles on RAN translation. This study endeavors to evaluate and delineate the contemporary landscape and progress of RAN translation research via a bibliometric analysis. We sourced literature on RAN translation from the Web of Science Core Collection. Utilizing two bibliometric analysis tools, CiteSpace and VOSviewer, we gauged individual impacts and interactions by examining annual publications, journals, co-cited journals, countries/regions, institutions, authors, and co-cited authors. Following this, we assessed the co-occurrence and bursts of keywords and co-cited references to pinpoint research hotspots and trending in RAN translation. Between 2011 and 2022, 1317 authors across 359 institutions from 34 countries/regions contributed to 250 publications on RAN translation, spread across 118 academic journals. This article presents a systematic, objective, and comprehensive analysis of the current literature on RAN translation. Our findings emphasize that mechanisms related to
Language	English
Publishing date	2024-04-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e29141
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fucoxanthin inhibits gastric cancer lymphangiogenesis and metastasis by regulating Ran expression.

Wang, Jia / Dong, Xue / Li, Dandan / Fang, Zhiyao / Wan, Xianyao / Liu, Jing

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 118, Page(s) 154926

Abstract: ... showed that Ran was highly expressed in metastatic lymph nodes and has some predictive value ... of Ran via hydrogen bonds. Mechanistically, fucoxanthin inhibits the nuclear transport of NF-κB ... by downregulating protein expression of Ran and importinβ, thereby inhibiting VEGF-C secretion, and ultimately ...

Abstract	Background: Lymph node metastasis is a key mechanism in gastric cancer (GC) metastasis and lymphangiogenesis is a vital step in the process of lymph node metastasis. Currently, there are no drugs which can treat lymph node metastasis in GC. Previous studies using the drug fucoxanthin have mainly focused on cell cycle arrest, induction of apoptosis, or inhibition of angiogenesis in GC. However, the effects of fucoxanthin on lymphangiogenesis and metastasis in GC have not been studied. Methods: Cell counting kit 8 and transwell experiments were used to evaluate the inhibitory effect of fucoxanthin on cell proliferation, migration and invasion. HGC-27 and HLEC cells were co-cultured in a transwell chamber and the footpad metastasis model was established to evaluate lymphangiogenesis and lymph node metastasis. The possible regulatory targets of fucoxanthin in GC were analyzed using human tissue microarrays, bioinformatics analysis, and molecular docking. The regulatory pathway of fucoxanthin was verified using confocal laser microscopy, adenovirus transfection and western blotting. Results: Tissue microarray and bioinformatics analyses showed that Ran was highly expressed in metastatic lymph nodes and has some predictive value for metastasis in GC. Molecular docking results revealed that fucoxanthin interacted with Met189 and Lys167 of Ran via hydrogen bonds. Mechanistically, fucoxanthin inhibits the nuclear transport of NF-κB by downregulating protein expression of Ran and importinβ, thereby inhibiting VEGF-C secretion, and ultimately inhibiting tumor lymphangiogenesis and lymph node metastasis in vivo and in vitro. Conclusions: Fucoxanthin suppressed GC-induced lymphangiogenesis and metastasis in vitro and in vivo by regulating Ran expression via the importinβ/NF-κB/VEGF-C nuclear transport signaling pathway. These novel findings provide the basis for the research and development of novel treatments using traditional Chinese medicine in treatment of lymph node metastasis, which has important theoretical significance and clinical value.
MeSH term(s)	Humans ; Lymphangiogenesis ; Lymphatic Metastasis ; NF-kappa B/metabolism ; Vascular Endothelial Growth Factor C/metabolism ; Stomach Neoplasms/drug therapy ; Molecular Docking Simulation ; Cell Line, Tumor
Chemical Substances	NF-kappa B ; Vascular Endothelial Growth Factor C ; fucoxanthin (06O0TC0VSM)
Language	English
Publishing date	2023-06-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.154926
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Article: Bibliometric and visual analysis of RAN methylation in cardiovascular disease.

Song, Boce / Xie, Beili / Liu, Mingwang / Li, Haohao / Shi, Dazhuo / Zhao, Fuhai

Frontiers in cardiovascular medicine

2023 Volume 10, Page(s) 1110718

Abstract: Background: RNA methylation is associated with cardiovascular disease (CVD) occurrence and development. The purpose of this study is to visually analyze the results and research trends of global RNA methylation in CVD.: Methods: Articles and reviews ... ...

Abstract	Background: RNA methylation is associated with cardiovascular disease (CVD) occurrence and development. The purpose of this study is to visually analyze the results and research trends of global RNA methylation in CVD. Methods: Articles and reviews on RNA methylation in CVD published before 6 November 2022 were searched in the Web of Science Core Collection. Visual and statistical analysis was performed using CiteSpace 1.6.R4 advanced and VOSviewer 1.6.18. Results: There were 847 papers from 1,188 institutions and 63 countries/regions. Over approximately 30 years, there was a gradual increase in publications and citations on RNA methylation in CVD. America and China had the highest output (284 and 259 papers, respectively). Nine of the top 20 institutions that published articles were from China, among which Fudan University represented the most. The Conclusions: A bibliometric analysis reveals research hotspots and trends of RNA methylation in CVD. The regulatory mechanisms of RNA methylation related to CVD and the clinical application of their results, especially m
Language	English
Publishing date	2023-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1110718
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Article ; Online: Effects on the crystallization behavior and biocompatibility of poly(LLA-ran-PDO-ran-GA) with poly(d-lactide) as nucleating agents.

Fan, Tiantang / Qin, Jingwen / Dong, Fen / Meng, Xiao / Li, Yanqi / Wang, Ying / Liu, Qing / Wang, Guannan

RSC advances

2022 Volume 12, Issue 17, Page(s) 10711–10724

Abstract: The blends of poly(l-lactide acid- ...

Abstract	The blends of poly(l-lactide acid-
Language	English
Publishing date	2022-04-06
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d2ra00525e
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Book ; Online: Open RAN Testbeds with Controlled Air Mobility

Mushi, Magreth / Liu, Yuchen / Sreenivasa, Shreyas / Ozdemir, Ozgur / Guvenc, Ismail / Sichitiu, Mihail / Dutta, Rudra / Gyurek, Russ

2023

Abstract: ... source based ecosystem in the area of Radio Access Networks, the idea of Open RAN has generated rising ... interest in the community. Even as the community races to provide and verify complete Open RAN systems ... the importance of verification of systems based on Open RAN under real-world conditions has become clear, and ...

Abstract	With its promise of increasing softwarization, improving disaggregability, and creating an open-source based ecosystem in the area of Radio Access Networks, the idea of Open RAN has generated rising interest in the community. Even as the community races to provide and verify complete Open RAN systems, the importance of verification of systems based on Open RAN under real-world conditions has become clear, and testbed facilities for general use have been envisioned, in addition to private testing facilities. Aerial robots, including autonomous ones, are among the increasingly important and interesting clients of RAN systems, but also present a challenge for testbeds. Based on our experience in architecting and operating an advanced wireless testbed with aerial robots as a primary citizen, we present considerations relevant to the design of Open RAN testbeds, with particular attention to making such a testbed capable of controlled experimentation with aerial clients. We also present representative results from the NSF AERPAW testbed on Open RAN slicing, programmable vehicles, and programmable radios.
Keywords	Computer Science - Networking and Internet Architecture ; Electrical Engineering and Systems Science - Systems and Control
Publishing date	2023-01-26
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Towards Intelligent RAN Slicing for B5G

Mazied, EmadElDin A / Liu, Lingjia / Midkiff, Scott F.

Opportunities and Challenges

2021

Abstract: ... RAN) resources, this article emphasizes RAN slicing (RAN-S) design. Forming on-demand RAN-S ... resource usage prediction, admission control, scheduling, and dynamic resource allocation in RAN-S ... Albeit these approaches grant opportunities towards intelligent RAN-S design, they raise critical challenges that need ...

Abstract	To meet the diverse demands for wireless communication, fifth-generation (5G) networks and beyond (B5G) embrace the concept of network slicing by forging virtual instances (slices) of its physical infrastructure. While network slicing constitutes dynamic allocation of core network and radio access network (RAN) resources, this article emphasizes RAN slicing (RAN-S) design. Forming on-demand RAN-S that can be flexibly (re)-configured while ensuring slice isolation is challenging. A variety of machine learning (ML) techniques have been recently introduced for traffic forecasting and classification, resource usage prediction, admission control, scheduling, and dynamic resource allocation in RAN-S. Albeit these approaches grant opportunities towards intelligent RAN-S design, they raise critical challenges that need to be examined. This article underlines the opportunities and the challenges of incorporating ML into RAN-S by reviewing the cutting-edge ML-based techniques for RAN-S. It also draws few directions for future research towards intelligent RAN-S (iRAN-S). Comment: 9 pages, 5 figures, 1 table, 15 references, Magazine article
Keywords	Computer Science - Networking and Internet Architecture ; Computer Science - Machine Learning
Subject code	670
Publishing date	2021-02-27
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Enabling Feedback-Free MIMO Transmission for FD-RAN

Liu, Jingbo / Chen, Jiacheng / Liu, Zongxi / Zhou, Haibo

A Data-driven Approach

2023

Abstract: ... network (FD-RAN) architecture is proposed for 6G. However, the decoupling of uplink (UL) and downlink (DL ... in FD-RAN makes the existing feedback mechanism ineffective. To this end, we propose an end-to-end data ... of data-driven MIMO, showcasing its potential for application in FD-RAN and 6G. ...

Abstract	To enhance flexibility and facilitate resource cooperation, a novel fully-decoupled radio access network (FD-RAN) architecture is proposed for 6G. However, the decoupling of uplink (UL) and downlink (DL) in FD-RAN makes the existing feedback mechanism ineffective. To this end, we propose an end-to-end data-driven MIMO solution without the conventional channel feedback procedure. Data-driven MIMO can alleviate the drawbacks of feedback including overheads and delay, and can provide customized precoding design for different BSs based on their historical channel data. It essentially learns a mapping from geolocation to MIMO transmission parameters. We first present a codebook-based approach, which selects transmission parameters from the statistics of discrete channel state information (CSI) values and utilizes integer interpolation for spatial inference. We further present a non-codebook-based approach, which 1) derives the optimal precoder from the singular value decomposition (SVD) of the channel; 2) utilizes variational autoencoder (VAE) to select the representative precoder from the latent Gaussian representations; and 3) exploits Gaussian process regression (GPR) to predict unknown precoders in the space domain. Extensive simulations are performed on a link-level 5G simulator using realistic ray-tracing channel data. The results demonstrate the effectiveness of data-driven MIMO, showcasing its potential for application in FD-RAN and 6G.
Keywords	Computer Science - Networking and Internet Architecture
Subject code	003
Publishing date	2023-11-24
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Prognostic potential of the small GTPase Ran and its methylation in hepatocellular carcinoma.

Liu, Hui-Hui / Wang, Ju / Zhang, Ying / Fan, Yu-Chen / Wang, Kai

Hepatobiliary & pancreatic diseases international : HBPD INT

2022 Volume 21, Issue 3, Page(s) 248–256

Abstract: ... The prognostic significance of Ran, a member of Ras superfamily, remains unclear in HCC patients.: Methods ... we analyzed the correlations among Ran expression, promoter methylation and immune cell infiltration. We also ... investigated the Ran expression levels in HCC tissues and normal tissues by using quantitative real-time PCR ...

Abstract	Background: Hepatocellular carcinoma (HCC) is a common malignant tumor with high mortality. The prognostic significance of Ran, a member of Ras superfamily, remains unclear in HCC patients. Methods: Based on The Cancer Genome Atlas (TCGA) database and Tumor Immune Estimation Resource (TIMER), we analyzed the correlations among Ran expression, promoter methylation and immune cell infiltration. We also investigated the Ran expression levels in HCC tissues and normal tissues by using quantitative real-time PCR. Results: Ran mRNA expression was significantly increased in HCC tissues compared with the normal tissues (P < 0.001). Time-dependent receiver operating characteristic (ROC) curves showed that Ran expression had predictive value of the 1-, 3- and 5-year overall survival for HCC patients, and the areas under the curves (AUC) were 0.747, 0.634 and 0.704, respectively. Cox regression analysis showed that Ran expression was an independent prognostic factor for HCC patients (HR = 1.492, 95% CI: 1.129-1.971, P = 0.005). We also found a negative relationship between Ran mRNA expression and its promoter methylation (r = -0.36, P < 0.001). High Ran expression and promoter hypomethylation predicted worse overall survival and progression-free survival (P < 0.05) and were involved in the progression of HCC. Ran expression exhibited significant correlations with immune infiltrates and prognostic immune-related genes. Conclusions: The present study provides further insight into the prognosis of HCC, and Ran could serve as a biomarker for predicting the survival of HCC patients.
MeSH term(s)	Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Hepatocellular/pathology ; DNA Methylation ; Humans ; Liver Neoplasms/pathology ; Monomeric GTP-Binding Proteins/genetics ; Monomeric GTP-Binding Proteins/metabolism ; Prognosis ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Chemical Substances	Biomarkers, Tumor ; RNA, Messenger ; Monomeric GTP-Binding Proteins (EC 3.6.5.2)
Language	English
Publishing date	2022-03-22
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2241386-8
ISSN	1499-3872
ISSN	1499-3872
DOI	10.1016/j.hbpd.2022.03.011
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Zs.A 6313: Show issues

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Article ; Online: RSL1D1 promotes the progression of colorectal cancer through RAN-mediated autophagy suppression.

Liu, Xunhua / Chen, Jianxiong / Long, Xiaoli / Lan, Jiawen / Liu, Xiaoting / Zhou, Miao / Zhang, Sijing / Zhou, Jun

Cell death & disease

2022 Volume 13, Issue 1, Page(s) 43

Abstract: ... cells by suppressing autophagy. Interestingly, RSL1D1 interacted with RAN and inhibited ... its deacetylation by competitively binding with Sirt7. By affecting the acetylation of RAN, RSL1D1 inhibited ... the key role of the RSL1D1/RAN/STAT3 regulatory axis in autophagy and tumor progression in CRC, providing ...

Abstract	RSL1D1 (ribosomal L1 domain containing 1), a member of the universal ribosomal protein uL1 family, was suggested to be a new candidate target for colorectal cancer (CRC). However, the role of RSL1D1 in cancer, including CRC, remains largely elusive. Here, we demonstrated that RSL1D1 expression was significantly elevated in tumors from CRC patients and that high expression of RSL1D1 was correlated with poorer survival of CRC patients. Functionally, RSL1D1 promoted the proliferation, invasion, and metastasis of CRC cells by suppressing autophagy. Interestingly, RSL1D1 interacted with RAN and inhibited its deacetylation by competitively binding with Sirt7. By affecting the acetylation of RAN, RSL1D1 inhibited the accumulation of nuclear STAT3 and the STAT3-regulated autophagic program. Taken together, our study uncovered the key role of the RSL1D1/RAN/STAT3 regulatory axis in autophagy and tumor progression in CRC, providing a new candidate target for CRC treatment.
MeSH term(s)	Acetylation ; Animals ; Autophagy ; Cell Line, Tumor ; Cell Movement ; Cell Nucleus/metabolism ; Cell Proliferation ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Humans ; Mice ; Neoplasm Metastasis ; Pregnancy Proteins/genetics ; Pregnancy Proteins/metabolism ; Prognosis ; Protein Binding ; Ribosomal Proteins/genetics ; Ribosomal Proteins/metabolism ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Sirtuins/metabolism ; ran GTP-Binding Protein/metabolism
Chemical Substances	Pregnancy Proteins ; RAN protein, human ; RSL1D1 protein, human ; Ribosomal Proteins ; SIRT7 protein, human ; STAT3 Transcription Factor ; STAT3 protein, human ; Sirtuins (EC 3.5.1.-) ; ran GTP-Binding Protein (EC 3.6.5.2)
Language	English
Publishing date	2022-01-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-021-04492-z
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