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  1. Article ; Online: Sources and spatiotemporal distribution characteristics of nitrogen and phosphorus loads in the Haihe River Basin, China.

    Li, Xianfeng / Xu, Wenzhe / Song, Shuai / Sun, Jun

    Marine pollution bulletin

    2023  Volume 189, Page(s) 114756

    Abstract: Water quality monitoring stations are crucial for detecting excess pollutants in river sections, but identifying the causes of these exceedances can be challenging, especially in heavily polluted rivers with multiple contamination sources. To address ... ...

    Abstract Water quality monitoring stations are crucial for detecting excess pollutants in river sections, but identifying the causes of these exceedances can be challenging, especially in heavily polluted rivers with multiple contamination sources. To address this issue, we used the SWAT model to simulate pollution loads from various sources in the Haihe River Basin, analyzing the spatiotemporal distribution of pollutants from seven nitrogen/phosphorus sources in sub-basins. Our results show that crop production is the primary contributor to nitrogen and phosphorus loads in the Haihe River Basin, with the highest loads occurring in summer, followed by fall, spring, and winter. However, industries, atmospheric deposition, and municipal sewage treatment plants have a greater downstream impact on nitrogen/phosphorus contributions due to land use changes. The study highlights the need for targeted prevention and control policies based on the primary sources of pollution loads in different regions.
    MeSH term(s) Environmental Monitoring/methods ; Water Pollutants, Chemical/analysis ; Nitrogen/analysis ; Phosphorus/analysis ; Water Quality ; Environmental Pollutants ; China
    Chemical Substances Water Pollutants, Chemical ; Nitrogen (N762921K75) ; Phosphorus (27YLU75U4W) ; Environmental Pollutants
    Language English
    Publishing date 2023-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001296-2
    ISSN 1879-3363 ; 0025-326X
    ISSN (online) 1879-3363
    ISSN 0025-326X
    DOI 10.1016/j.marpolbul.2023.114756
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  2. Article ; Online: Polymeric DNA Hydrogels and Their Applications in Drug Delivery for Cancer Therapy

    Jing Li / Wenzhe Song / Feng Li

    Gels, Vol 9, Iss 239, p

    2023  Volume 239

    Abstract: The biomolecule deoxyribonucleic acid (DNA), which acts as the carrier of genetic information, is also regarded as a block copolymer for the construction of biomaterials. DNA hydrogels, composed of three-dimensional networks of DNA chains, have received ... ...

    Abstract The biomolecule deoxyribonucleic acid (DNA), which acts as the carrier of genetic information, is also regarded as a block copolymer for the construction of biomaterials. DNA hydrogels, composed of three-dimensional networks of DNA chains, have received considerable attention as a promising biomaterial due to their good biocompatibility and biodegradability. DNA hydrogels with specific functions can be prepared via assembly of various functional sequences containing DNA modules. In recent years, DNA hydrogels have been widely used for drug delivery, particularly in cancer therapy. Benefiting from the sequence programmability and molecular recognition ability of DNA molecules, DNA hydrogels prepared using functional DNA modules can achieve efficient loading of anti-cancer drugs and integration of specific DNA sequences with cancer therapeutic effects, thus achieving targeted drug delivery and controlled drug release, which are conducive to cancer therapy. In this review, we summarized the assembly strategies for the preparation of DNA hydrogels on the basis of branched DNA modules, hybrid chain reaction (HCR)-synthesized DNA networks and rolling circle amplification (RCA)-produced DNA chains, respectively. The application of DNA hydrogels as drug delivery carriers in cancer therapy has been discussed. Finally, the future development directions of DNA hydrogels in cancer therapy are prospected.
    Keywords DNA hydrogel ; DNA nanotechnology ; drug delivery ; cancer therapy ; Science ; Q ; Chemistry ; QD1-999 ; Inorganic chemistry ; QD146-197 ; General. Including alchemy ; QD1-65
    Subject code 612 ; 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Research on key parameters of pipeline transportation of waste rock treatment in underground residual space

    Wenzhe Gu / Lei Zhu / Tianqi Song

    Frontiers in Earth Science, Vol

    2023  Volume 10

    Abstract: As the key link of coal gangue slurry filling, slurry pipeline transportation is an important guarantee to realize the slurry mixing and safe transportation of gangue from solid powder. To realize the underground excavation gangue of the Huangling No. 2 ... ...

    Abstract As the key link of coal gangue slurry filling, slurry pipeline transportation is an important guarantee to realize the slurry mixing and safe transportation of gangue from solid powder. To realize the underground excavation gangue of the Huangling No. 2 coal mine without raising the ground, the slurry filling technology is proposed to transport the slurry made by gangue through the pipeline and fill it into the goaf. The phase composition and microstructure characteristics of underground excavation gangue in the Huangling No. 2 coal mine were analyzed by X-ray diffraction and an electron microscope scanning test, the slurry-forming properties of gangue powder with different particle sizes and gradations were studied, and the influence of gangue slurry concentration on its rheological properties was analyzed. The experimental results show that the gangue powder crushed using a cage crusher can be made into stable slurry when the particle grading size is the natural crushing gradation with the upper limit of particle size less than 3 mm. The viscosity of the slurry is positively correlated with the concentration. When the concentration is below 70%, the increase in viscosity is small, and when the concentration is above 70%, the increase in viscosity is significant. It is determined that the concentration of the Huangling No. 2 coal mine slurry is 70%. Based on the determination of slurry preparation parameters, the simulation analysis of slurry pipeline transportation was carried out, the influence of design velocity on the velocity distribution of the pipeline section and the variation law of slurry concentration was explored, and the design velocity of the project is determined to be 1.5 m/s. The engineering practice shows that the slurry preparation parameters are reasonable. The crushing and pulping of gangue under the ground and the safe transportation of a 6 km pipeline are realized, which provides a reference for similar engineering projects.
    Keywords slurry pipeline transportation ; gangue slurry filling technology ; particle size and grading ; design velocity ; gangue disposal ; Science ; Q
    Subject code 669
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
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  4. Article ; Online: Research and engineering practice on space characteristics of gangue slurry filling

    Wenzhe Gu / Baogui Yang / Hao Pan / Tianqi Song

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 15

    Abstract: Abstract The macroscopic characteristics of the fractured space and the microscopic pore features are critical factors determining the effectiveness of gangue slurry backfilling. To identify the key areas for slurry backfilling, a combination of ... ...

    Abstract Abstract The macroscopic characteristics of the fractured space and the microscopic pore features are critical factors determining the effectiveness of gangue slurry backfilling. To identify the key areas for slurry backfilling, a combination of theoretical analysis, simulation experiments, and on-site industrial trials was used to reveal the movement laws of backfilling space overlying the fractured zone. The distribution characteristics of voids available for slurry backfilling within the fractured space were explored, and the interaction between gangue slurry and goaf voids was clarified. A formula for calculating the void ratio in the caved zone was derived, and a model for the distribution of voids in the slurry backfilling space was established. This model identified the main areas where slurry backfilling should be focused, namely the overlapping space between the free accumulation zone and the load-influenced zone. Experimental results demonstrated that the porosity of the collapsed rock mass within the goaf follows a negative logarithmic function along both the dip and strike directions, which was consistent with the theoretical calculations. Through in-situ grouting backfilling experiments on the ground, the feasibility of gangue slurry backfilling in the goaf was verified, and the process of interaction between gangue slurry and goaf voids was elaborated. This process generally involves three stages: initial flow, vertical upwelling, and horizontal diffusion, all of which are closely interconnected. Practical engineering applications of gangue slurry backfilling were carried out in the free accumulation zone and the load-influenced zone at the Huangling No. 2 coal mine. The successful validation of underground gangue slurry backfilling technology demonstrated its feasibility and the correctness of the theoretical approach. This research provides new evidence for environmentally friendly disposal of gangue materials.
    Keywords Medicine ; R ; Science ; Q
    Subject code 690
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Research and engineering practice on space characteristics of gangue slurry filling.

    Gu, Wenzhe / Yang, Baogui / Pan, Hao / Song, Tianqi

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 22006

    Abstract: The macroscopic characteristics of the fractured space and the microscopic pore features are critical factors determining the effectiveness of gangue slurry backfilling. To identify the key areas for slurry backfilling, a combination of theoretical ... ...

    Abstract The macroscopic characteristics of the fractured space and the microscopic pore features are critical factors determining the effectiveness of gangue slurry backfilling. To identify the key areas for slurry backfilling, a combination of theoretical analysis, simulation experiments, and on-site industrial trials was used to reveal the movement laws of backfilling space overlying the fractured zone. The distribution characteristics of voids available for slurry backfilling within the fractured space were explored, and the interaction between gangue slurry and goaf voids was clarified. A formula for calculating the void ratio in the caved zone was derived, and a model for the distribution of voids in the slurry backfilling space was established. This model identified the main areas where slurry backfilling should be focused, namely the overlapping space between the free accumulation zone and the load-influenced zone. Experimental results demonstrated that the porosity of the collapsed rock mass within the goaf follows a negative logarithmic function along both the dip and strike directions, which was consistent with the theoretical calculations. Through in-situ grouting backfilling experiments on the ground, the feasibility of gangue slurry backfilling in the goaf was verified, and the process of interaction between gangue slurry and goaf voids was elaborated. This process generally involves three stages: initial flow, vertical upwelling, and horizontal diffusion, all of which are closely interconnected. Practical engineering applications of gangue slurry backfilling were carried out in the free accumulation zone and the load-influenced zone at the Huangling No. 2 coal mine. The successful validation of underground gangue slurry backfilling technology demonstrated its feasibility and the correctness of the theoretical approach. This research provides new evidence for environmentally friendly disposal of gangue materials.
    Language English
    Publishing date 2023-12-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-46222-9
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  6. Article ; Online: Polymeric DNA Hydrogels and Their Applications in Drug Delivery for Cancer Therapy.

    Li, Jing / Song, Wenzhe / Li, Feng

    Gels (Basel, Switzerland)

    2023  Volume 9, Issue 3

    Abstract: The biomolecule deoxyribonucleic acid (DNA), which acts as the carrier of genetic information, is also regarded as a block copolymer for the construction of biomaterials. DNA hydrogels, composed of three-dimensional networks of DNA chains, have received ... ...

    Abstract The biomolecule deoxyribonucleic acid (DNA), which acts as the carrier of genetic information, is also regarded as a block copolymer for the construction of biomaterials. DNA hydrogels, composed of three-dimensional networks of DNA chains, have received considerable attention as a promising biomaterial due to their good biocompatibility and biodegradability. DNA hydrogels with specific functions can be prepared via assembly of various functional sequences containing DNA modules. In recent years, DNA hydrogels have been widely used for drug delivery, particularly in cancer therapy. Benefiting from the sequence programmability and molecular recognition ability of DNA molecules, DNA hydrogels prepared using functional DNA modules can achieve efficient loading of anti-cancer drugs and integration of specific DNA sequences with cancer therapeutic effects, thus achieving targeted drug delivery and controlled drug release, which are conducive to cancer therapy. In this review, we summarized the assembly strategies for the preparation of DNA hydrogels on the basis of branched DNA modules, hybrid chain reaction (HCR)-synthesized DNA networks and rolling circle amplification (RCA)-produced DNA chains, respectively. The application of DNA hydrogels as drug delivery carriers in cancer therapy has been discussed. Finally, the future development directions of DNA hydrogels in cancer therapy are prospected.
    Language English
    Publishing date 2023-03-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels9030239
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  7. Article: Ablation of the GDP-fucose transporter suppresses lung cancer cell proliferation and migration by reducing expression of PD-L1.

    Zhang, Yingshu / Zhang, Nianzhu / Song, Wanli / Yousuf, Sabiha / Li, Wenzhe

    Journal of Cancer

    2023  Volume 14, Issue 17, Page(s) 3295–3308

    Abstract: Fucosylation, an important post-translational modification, is closely related to the development of tumors. In the microenvironment of lung cancer, expression of PD-L1 and fucosylation is abnormally upregulated. However, the correlation between PD-L1 ... ...

    Abstract Fucosylation, an important post-translational modification, is closely related to the development of tumors. In the microenvironment of lung cancer, expression of PD-L1 and fucosylation is abnormally upregulated. However, the correlation between PD-L1 expression and its fucosylation in lung adenocarcinoma (LUAD) remains unclear. The GDP-fucose transporter (GFT) is a key molecule in cellular fucosylation. To explore the correlation between fucosylation and PD-L1 expression, we knocked out the GFT-encoding gene
    Language English
    Publishing date 2023-10-02
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.84652
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  8. Article ; Online: Role of excited-state hydrogen bonding in CO

    Zhang, Naitian / Li, Yuehui / Shang, Wenzhe / Song, Xuedan / Liu, Wei / Hao, Ce

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 46, Page(s) 32158–32165

    Abstract: In this paper, we report a joint experimental and computational study to elaborate the mechanism for the photocatalytic ... ...

    Abstract In this paper, we report a joint experimental and computational study to elaborate the mechanism for the photocatalytic CO
    Language English
    Publishing date 2023-11-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp03638c
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  9. Article ; Online: A Poly Aptamer Encoded DNA Nanocatcher Informs Efficient Virus Trapping.

    Guo, Yunhua / Song, Wenzhe / Dong, Yuhang / Wang, Xuejun / Nie, Guangjun / Li, Feng

    Nano letters

    2024  Volume 24, Issue 12, Page(s) 3614–3623

    Abstract: Broad-spectrum antiviral platforms are always desired but still lack the ability to cope with the threats to global public health. Herein, we develop a poly aptamer encoded DNA nanocatcher platform that can trap entire virus particles to inhibit ... ...

    Abstract Broad-spectrum antiviral platforms are always desired but still lack the ability to cope with the threats to global public health. Herein, we develop a poly aptamer encoded DNA nanocatcher platform that can trap entire virus particles to inhibit infection with a broad antiviral spectrum. Ultralong single-stranded DNA (ssDNA) containing repeated aptamers was synthesized as the scaffold of a nanocatcher via a biocatalytic process, wherein mineralization of magnesium pyrophosphate on the ssDNA could occur and consequently lead to the formation of nanocatcher with interfacial nanocaves decorated with virus-binding aptamers. Once the viruses were recognized by the apatmers, they would be captured and trapped in the nanocaves via multisite synergistic interactions. Meanwhile, the size of nanocatchers was optimized to prevent their cellular uptake, which further guaranteed inhibition of virus infection. By taking SARS-CoV-2 variants as a model target, we demonstrated the broad virus-trapping capability of a DNA nanocatcher in engulfing the variants and blocking the infection to host cells.
    MeSH term(s) Aptamers, Nucleotide/pharmacology ; DNA, Single-Stranded ; Antiviral Agents/pharmacology ; Viruses
    Chemical Substances Aptamers, Nucleotide ; DNA, Single-Stranded ; Antiviral Agents
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c04510
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  10. Article ; Online: Synergistic Effect of Co-Mo Pinning in Lay-Structured Oxide Cathode for Enhancing Stability toward Potassium-Ion Batteries.

    Han, Wenzhe / Gao, Xuan-Wen / Song, Yingying / Wang, Xuanchen / Gao, Guoping / Chen, Hong / Gu, Qinfen / Luo, Wen-Bin

    Small (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e2400252

    Abstract: Owing to the high economic efficiency and energy density potential, manganese-based layer-structured oxides have attracted great interests as cathode materials for potassium ion batteries. In order to alleviate the continuous phase transition and ... ...

    Abstract Owing to the high economic efficiency and energy density potential, manganese-based layer-structured oxides have attracted great interests as cathode materials for potassium ion batteries. In order to alleviate the continuous phase transition and K
    Language English
    Publishing date 2024-03-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202400252
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