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Article ; Online: Integrated serum pharmacochemistry and network pharmacology to explore the mechanism of Yi-Shan-Hong formula in alleviating chronic liver injury.

Zhao, Xinyi / Su, Hua / Chen, Haiyan / Tang, Xiusong / Li, Wenling / Huang, An / Fang, Gang / Chen, Qing / Luo, Yudong / Pang, Yuzhou

Phytomedicine : international journal of phytotherapy and phytopharmacology

2024 Volume 128, Page(s) 155439

Abstract: ... interventions. The Yi-Shan-Hong (YSH) formula is an empirically derived remedy that has shown effectiveness and ...

Abstract	Background: Chronic liver injury (CLI) is a complex condition that requires effective therapeutic interventions. The Yi-Shan-Hong (YSH) formula is an empirically derived remedy that has shown effectiveness and safety in the management of chronic liver damage. However, the bioactive components and multifaceted mechanisms of YSH remain inadequately understood. Purpose: To examine the bioactive compounds and functional processes that contribute to the therapeutic benefits of YSH against CLI. Methods: Serum pharmacochemistry and network pharmacology were employed to identify active compounds and possible targets of YSH in CLI. In addition, YSH was also given in three doses to Results: The analysis of serum samples successfully detected 25 compounds from YSH. Searches on the databases resulted in 277 genes as being correlated with chemicals in YSH, and 397 genes associated with CLI. In vivo experiments revealed that YSH displayed a notable therapeutic impact on liver injury caused by Conclusion: These findings provide preclinical evidence of YSH's therapeutic value in CLI and highlight its hepatoprotective action via the PI3K/AKT signaling pathway.
MeSH term(s)	Animals ; Drugs, Chinese Herbal/pharmacology ; Network Pharmacology ; Male ; Oxidative Stress/drug effects ; Rats, Sprague-Dawley ; Rats ; Liver/drug effects ; Galactosamine ; Chemical and Drug Induced Liver Injury, Chronic/drug therapy ; Signal Transduction/drug effects
Chemical Substances	Drugs, Chinese Herbal ; Galactosamine (7535-00-4)
Language	English
Publishing date	2024-02-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2024.155439
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Article ; Online: Bu Shen Yi Sui Capsule Promotes Myelin Repair by Modulating the Transformation of A1/A2 Reactive Astrocytes

Zha, Zheng / Liu, Yi-Jiang / Liu, Si-Si / Zhang, Nan / Li, Jun-Ling / Qi, Fang / Jin, Liang-Yun / Xue, Bing / Yang, Tao / Fan, Yong-Ping / Zhao, Hui / Wang, Lei

Oxidative medicine and cellular longevity

2022 Volume 2022, Page(s) 3800004

Abstract: Background/ ... ...

Abstract	Background/Aims
MeSH term(s)	Animals ; Astrocytes/metabolism ; Central Nervous System ; Complement C1q/metabolism ; Complement C1q/pharmacology ; Mice ; Mice, Inbred C57BL ; MicroRNAs/metabolism ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/metabolism ; Myelin Sheath ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	MicroRNAs ; Tumor Necrosis Factor-alpha ; Complement C1q (80295-33-6)
Language	English
Publishing date	2022-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2022/3800004
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Article ; Online: Two Novel Flavonoids with Lipid-Lowering Activity from Yi Medicine Shekaqi.

Lin, Yu-Ping / Fu, Sheng-Nan / Li, Xin-Ping / Wang, Meng-Meng / Fang, Qiong-Lian / Qiao, Xue / Yan, Qi / Hua, Yan

Chemistry & biodiversity

2022 Volume 19, Issue 9, Page(s) e202200363

Abstract: Yi medicine Shekaqi is the most attractive traditional ethnic medicine due to its significant and ... isolated from Yi medicine Shekaqi. Their structures were elucidated based on the analysis ...

Abstract	Yi medicine Shekaqi is the most attractive traditional ethnic medicine due to its significant and diverse pharmacological activities. Two novel flavonoids, including 5,2'-dihydroxy-6-methoxy-7-decyloxyflavone and tenaxin II-7-O-β-D-glucuronopyranosyl acid butyl ester, along with six known flavonoids, were isolated from Yi medicine Shekaqi. Their structures were elucidated based on the analysis of their comprehensive spectral data. The in vitro lipid-lowering activities of the eight compounds showed that all the compounds significantly inhibited the lipopolysaccharide (LPS)-induced increase in the total cholesterol (TC) level, while compounds 1, 4, 6, 7, and 8 significantly inhibited the LPS-induced increase in the triglyceride (TG) level.
MeSH term(s)	Cholesterol ; Esters ; Flavonoids/chemistry ; Flavonoids/pharmacology ; Lipopolysaccharides/pharmacology ; Triglycerides
Chemical Substances	Esters ; Flavonoids ; Lipopolysaccharides ; Triglycerides ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2022-08-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202200363
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Article ; Online: Increasing prevalence of overweight and obesity in Yi farmers and migrants from 2007 to 2015 in China: the Yi migrant study.

Wang, Ye / Pan, Li / Wan, Shaoping / Yi, Huowuli / Yang, Fang / He, Huijing / Li, Zheng / Zhang, Jia / Wang, Xiaoyang / Yong, Zhengping / Shan, Guangliang

BMC public health

2018 Volume 18, Issue 1, Page(s) 659

Abstract: ... and related factors of overweight and obesity in Yi farmers and migrants in southwest China from 2007 ... prevalence of overweight increased in both groups (from 5.54 to 16.65% in Yi farmers, from 27.91 to 33.61 ... in Yi migrants). Standardized prevalence of obesity increased only in Yi farmers (from 0.37 to 3.13 ...

Abstract	Background: With the social development and lifestyle transition, increasing trends of overweight and obesity prevalence are commonly reported worldwide. Data focusing on overweight and obesity trends in rural residents and rural-to-urban migrants in China are limited. This study aims to assess the changes and related factors of overweight and obesity in Yi farmers and migrants in southwest China from 2007 to 2015, and to assess the disparities in prevalence changes. Methods: Pseudo-panel data was obtained from two cross-sectional studies conducted in Sichuan province, southwest China in 2007 and 2015. Standardized prevalence of overweight and obesity were evaluated by direct method using the 2010 national census population as the standard. Prevalence differences of overweight and obesity were calculated in each group and compared between groups to evaluate the disparity in prevalence changes. Generalized linear mixed model was performed to determine factors related to overweight/obesity. Results: Standardized prevalence of overweight increased in both groups (from 5.54 to 16.65% in Yi farmers, from 27.91 to 33.61% in Yi migrants). Standardized prevalence of obesity increased only in Yi farmers (from 0.37 to 3.13%). Prevalence difference of overweight in Yi farmers was higher than that in Yi migrants (11.11 vs. 5.70), but prevalence differences of obesity were not significantly different between Yi farmers and migrants. Conclusions: Prevalence of overweight and obesity in Yi farmers, and prevalence of overweight in Yi migrants increased from 2007 to 2015. Yi farmers were developing overweight at a greater pace than migrants. More attention should be paid to spread health knowledge and encourage healthy lifestyle in Yi people, especially Yi farmers.
MeSH term(s)	Adult ; Agriculture/statistics & numerical data ; China/epidemiology ; Cross-Sectional Studies ; Farmers/statistics & numerical data ; Female ; Health Status ; Humans ; Male ; Middle Aged ; Obesity/epidemiology ; Prevalence ; Rural Population/statistics & numerical data ; Transients and Migrants/statistics & numerical data
Language	English
Publishing date	2018-05-24
Publishing country	England
Document type	Journal Article
ISSN	1471-2458
ISSN (online)	1471-2458
DOI	10.1186/s12889-018-5577-4
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Article ; Online: Network pharmacology and experimental evidence reveal the protective mechanism of Yi-Qi Cong-Ming decoction on age-related hearing loss.

Yang, Yi-Fang / Yan, Xi-Rui / Wu, Rui-Xin / Li, Ning / Chu, Min / Dong, Yang / Fu, Shu-Ping / Shi, Jian-Rong / Liu, Qing

Pharmaceutical biology

2022 Volume 60, Issue 1, Page(s) 1478–1490

Abstract: Context: Yi-Qi Cong-Ming (YQCM) decoction has been widely used to prevent age-related hearing loss ...

Abstract	Context: Yi-Qi Cong-Ming (YQCM) decoction has been widely used to prevent age-related hearing loss (ARHL), the most prevalent neurodegenerative disease in the elderly. Objective: To explore the mechanism of YQCM decoction in the treatment of ARHL. Materials and methods: The chemical constituents of YQCM were screened from the Traditional Chinese Medicine Systems Pharmacology Database. Potential targets of YQCM against ARHL were predicted by DrugBank, GeneCards, and OMIM database. Protein-protein network and enrichment analysis were used for exploring possible molecular mechanisms. Molecular docking and an Results: The main compounds have good affinities with hub targets, especially AKT1, PTGS2, and CASP3. GO and KEGG analysis showed that the main biological process and key targets were related to negative regulation of the apoptotic process. H Conclusions: Our study suggested that YQCM prevents ARHL by modulating the apoptosis process in auditory hair cells. Moreover, this study proved that bioinformatics analysis combined with molecular docking and cell model is a promising method to explore other possible pharmacological interventions of ARHL.
MeSH term(s)	Aged ; Caspase 3 ; Drugs, Chinese Herbal/therapeutic use ; Hearing Loss/drug therapy ; Humans ; Hydrogen Peroxide/toxicity ; Medicine, Chinese Traditional/methods ; Molecular Docking Simulation ; Network Pharmacology ; Neurodegenerative Diseases/drug therapy
Chemical Substances	Drugs, Chinese Herbal ; Hydrogen Peroxide (BBX060AN9V) ; Caspase 3 (EC 3.4.22.-)
Language	English
Publishing date	2022-08-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2022.2101671
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Article ; Online: Study on the Anti-demyelination Mechanism of Bu-Shen-Yi-Sui Capsule in the Central Nervous System Based on Network Pharmacology and Experimental Verification.

Zha, Zheng / Liu, Yi-Jiang / Liu, Si-Si / Zhang, Nan / Li, Jun-Ling / Qi, Fang / Jin, Liang-Yun / Xue, Bing / Yang, Tao / Fan, Yong-Ping / Zhao, Hui / Wang, Lei

Mediators of inflammation

2022 Volume 2022, Page(s) 9241261

Abstract: Methods: The potential active ingredients and corresponding potential targets of BSYS Capsule were obtained from the TCMSP, BATMAN-TCM, Swiss Target Prediction platform, and literature research. Disease targets of CNSD were explored through the ... ...

Abstract	Methods: The potential active ingredients and corresponding potential targets of BSYS Capsule were obtained from the TCMSP, BATMAN-TCM, Swiss Target Prediction platform, and literature research. Disease targets of CNSD were explored through the GeneCards and the DisGeNET databases. The matching targets of BSYS in CNSD were identified from a Venn diagram. The protein-protein interaction (PPI) network was constructed using bioinformatics methods. Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to predict the mechanisms of BSYS. Furthermore, the neuroprotective effects of BSYS were evaluated using a cell model of hydrogen peroxide- (H Results: A total of 59 potential bioactive components of BSYS Capsule and 227 intersection targets were obtained. Topological analysis showed that AKT had the highest connectivity degrees in the PPI network. Enrichment analysis revealed that the targets of BSYS in the treatment of CNSD were the PI3K-Akt and MAPK signaling pathway, among other pathways. GO analysis results showed that the targets were associated with various biological processes, including apoptosis, reactive oxygen species metabolic process, and response to oxidative stress, among others. The experimental results demonstrated that BSYS drug-containing serum alleviated the H Conclusion: BSYS Capsule alleviated H
MeSH term(s)	Animals ; Central Nervous System ; Drugs, Chinese Herbal/therapeutic use ; Hydrogen Peroxide/pharmacology ; Medicine, Chinese Traditional/methods ; Network Pharmacology ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt
Chemical Substances	Drugs, Chinese Herbal ; Hydrogen Peroxide (BBX060AN9V) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2022-07-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137605-3
ISSN	1466-1861 ; 0962-9351
ISSN (online)	1466-1861
ISSN	0962-9351
DOI	10.1155/2022/9241261
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Article: [Analysis of changes in reporting and diagnosis of pulmonary tuberculosis among children in Liangshan Yi Autonomous Prefecture, Sichuan Province from 2019 to 2021].

Yu, X R / Wang, S J / Yang, X M / Fang, M / Zeng, X / Qi, H / Jiao, W W / Sun, L

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine

2023 Volume 57, Issue 8, Page(s) 1153–1159

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; Child ; Rifampin/therapeutic use ; Isoniazid/therapeutic use ; Tuberculosis, Pulmonary/diagnosis ; Tuberculosis, Pulmonary/epidemiology ; Tuberculosis, Pulmonary/drug therapy ; Tuberculosis ; China/epidemiology
Chemical Substances	Rifampin (VJT6J7R4TR) ; Isoniazid (V83O1VOZ8L)
Language	Chinese
Publishing date	2023-08-11
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	604575-3
ISSN	0253-9624
ISSN	0253-9624
DOI	10.3760/cma.j.cn112150-20230315-00192
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Article ; Online: Correlation between negative life events and suicide attempts among Yi adolescents with HIV/AIDS in Liangshan Prefecture.

Song, Xiaozhen / Zou, Shoukang / Li, Yangling / Chen, Liyu / Feng, Ping / Xu, Peiwei / Zhang, Hang / Deng, Fang / Xu, Hanmei / Tao, Yuanmei / Jin, Meijiang / Ran, Maojia / Zhang, Hong / Ma, Fanghua / Wang, Ying / Yin, Li

BMC public health

2023 Volume 23, Issue 1, Page(s) 1600

Abstract: ... exercise, drug therapy and suicide attempts.: Methods: A total of 180 Yi adolescents aged 11-19 years ... that the incidence rate of suicide attempts among Yi adolescents with HIV/AIDS in Liangshan Prefecture was 13.9%. Negative ... of suicide attempts among Yi adolescents with HIV/AIDS in Liangshan Prefecture is high and should be considered ...

Abstract	Objective: To investigate the incidence of suicide attempts among adolescents with HIV/AIDS in Liangshan Prefecture, Sichuan Province, as well as the correlation between negative life events, sleep, exercise, drug therapy and suicide attempts. Methods: A total of 180 Yi adolescents aged 11-19 years with HIV/AIDS in a county of Liangshan Prefecture, Sichuan Province, China, were investigated by census. The main outcome indicators included the incidence of suicide attempts and whether negative life events, sleep, exercise, drug therapy and other factors were related to suicide attempts. Results: We found that the incidence rate of suicide attempts among Yi adolescents with HIV/AIDS in Liangshan Prefecture was 13.9%. Negative life events were a risk factor for suicide attempts (OR = 1.047, p < 0.001, 95% CI 1.027-1.067). In the factors of negative life events, adaptation was a risk factor for suicide attempts (OR = 1.203, p = 0.026, 95% CI 1.022-1.416), and academic pressure showed a tendency to be a risk factor for suicide attempts (OR = 1.149, p = 0.077, 95% CI 0.985-1.339). However, the punishment factor, interpersonal stress factor and loss factor had no significant correlation with suicide attempts. There was no significant correlation between sleep, exercise, drug therapy and suicide attempts. Conclusion: The proportion of suicide attempts among Yi adolescents with HIV/AIDS in Liangshan Prefecture is high and should be considered. Negative life events are independent risk factors for suicide attempts, and it is necessary to strengthen the screening and early intervention for suicide attempts in HIV/AIDS adolescents with definite negative life events.
MeSH term(s)	Humans ; Adolescent ; Suicide, Attempted ; Acclimatization ; Acquired Immunodeficiency Syndrome ; Censuses ; China/epidemiology
Language	English
Publishing date	2023-08-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-023-16377-1
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Article ; Online: Identification of the perpetrator imperatorin in Xin-yi-san-theophylline interaction: observed and predicted herb-drug interaction in rats.

Wang, Hong-Jaan / Chen, An-Chi / Chen, Hsin-Ying / Cheng, Hsin-Chung / Kao, Li-Ting / Lu, Chung-Kuang / Tsai, Keng-Chang / Lee, I-Jung / Ueng, Yune-Fang

The Journal of pharmacy and pharmacology

2023 Volume 75, Issue 9, Page(s) 1225–1236

Abstract: ... metabolised by cytochrome P450 (CYP) 1A2. Xin-yi-san (XYS) is a herbal formula frequently used to ameliorate ...

Abstract	Objectives: Theophylline is a bronchodilator with a narrow therapeutic index and primarily metabolised by cytochrome P450 (CYP) 1A2. Xin-yi-san (XYS) is a herbal formula frequently used to ameliorate nasal inflammation. This study aimed to investigate the effects of XYS and its ingredient, imperatorin, on theophylline pharmacokinetics in rats. Methods: The kinetics of XYS- and imperatorin-mediated inhibition of theophylline oxidation were determined. Pharmacokinetics of theophylline were analysed. Comparisons were made with the CYP1A2 inhibitor, fluvoxamine. Key findings: XYS extract and its ingredient, imperatorin, non-competitively inhibited theophylline oxidation. Fluvoxamine (50 and 100 mg/kg) and XYS (0.5 and 0.9 g/kg) significantly prolonged the time to reach the maximum plasma concentration (tmax) of theophylline by 3-10 fold. In a dose-dependent manner, XYS and imperatorin (0.1-10 mg/kg) treatments significantly decreased theophylline clearance by 27-33% and 19-56%, respectively. XYS (0.9 g/kg) and imperatorin (10 mg/kg) significantly prolonged theophylline elimination half-life by 29% and 142%, respectively. Compared with the increase (51-112%) in the area under curve (AUC) of theophylline by fluvoxamine, the increase (27-57%) by XYS was moderate. Conclusions: XYS decreased theophylline clearance primarily through imperatorin-suppressed theophylline oxidation. Further human studies are essential for the dose adjustment in the co-medication regimen.
MeSH term(s)	Rats ; Humans ; Animals ; Theophylline/pharmacokinetics ; Herb-Drug Interactions ; Fluvoxamine/pharmacology ; Bronchodilator Agents/pharmacokinetics
Chemical Substances	Theophylline (C137DTR5RG) ; imperatorin (K713N25C78) ; Fluvoxamine (O4L1XPO44W) ; Bronchodilator Agents
Language	English
Publishing date	2023-06-14
Publishing country	England
Document type	Journal Article
ZDB-ID	3107-0
ISSN	2042-7158 ; 0022-3573 ; 0373-1022
ISSN (online)	2042-7158
ISSN	0022-3573 ; 0373-1022
DOI	10.1093/jpp/rgad054
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Article ; Online: Association between age at arrival, duration of migration, and overweight/obesity in Chinese rural-to-urban migrants: the Yi migrant study.

Wang, Ye / Pan, Li / Wan, Shao-Ping / Yi, Huo-Wu-Li / Yang, Fang / He, Hui-Jing / Li, Zheng / Zhang, Jia / Yong, Zheng-Ping / Shan, Guang-Liang

Chinese medical journal

2020 Volume 134, Issue 1, Page(s) 60–67

Abstract: ... duration of migration, and the corresponding association with overweight/obesity in Yi migrants in China ... of migration and overweight/obesity (BMI ≥ 25 kg/m2).: Results: A total of 3056 Yi people (1894 Yi farmers ... and 1162 Yi migrants) aged 20 to 80 years were enrolled. After adjusting for age, sex, and ...

Abstract	Background: Urbanization in China is rapidly proceeding, but rural-to-urban migration and its association with overweight and obesity is not well studied. This study aimed to explore the age at arrival, duration of migration, and the corresponding association with overweight/obesity in Yi migrants in China. Methods: A cross-sectional study was conducted in rural and urban areas in 2015 in Sichuan province, China. Demographic characteristics, lifestyle factors, and anthropometry were collected. General linear regression models were used to assess the effect of duration of migration (1-10, 11-20, 21-30, and >30 years) on body mass index (BMI). Multi-variable logistic regression was used to examine the association between duration of migration and overweight/obesity (BMI ≥ 25 kg/m2). Results: A total of 3056 Yi people (1894 Yi farmers and 1162 Yi migrants) aged 20 to 80 years were enrolled. After adjusting for age, sex, and other potential confounders, Yi migrants had 1.71 kg/m2 (95% confidence interval [CI]: 1.36-2.06) higher BMI and a 2.13-fold (95% CI: 1.71-2.65) higher risk of overweight/obesity than Yi farmers. In Yi migrants, stratified by age at arrival, no significant association between duration of migration and overweight/obesity was observed in those who were 0 to 20 years old at arrival. In comparison, in migrants >20 years old at arrival, compared with the reference group (1-10 years), long-term migration (>30 years) was found to be associated with overweight/obesity after adjustment (odds ratio: 1.85, 95% CI: 1.04-3.29). Conclusions: Yi migrants were observed to have greater risk of overweight/obesity than Yi farmers. In Yi migrants, the risk of overweight/obesity increased according to the duration of migration, especially in those who were older upon their arrival.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; China/epidemiology ; Cross-Sectional Studies ; Humans ; Middle Aged ; Obesity/epidemiology ; Overweight/epidemiology ; Prevalence ; Rural Population ; Transients and Migrants ; Urban Population ; Young Adult
Language	English
Publishing date	2020-08-20
Publishing country	China
Document type	Journal Article
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000000973
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