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Article: Physiological and Pathophysiological Effects of C-Type Natriuretic Peptide on the Heart.

Yasoda, Akihiro

2022 Volume 11, Issue 6

Abstract: C-type natriuretic peptide (CNP) is the third member of the natriuretic peptide family. Unlike other members, i.e., atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which are cardiac hormones secreted from the atrium and ventricle of ...

Abstract	C-type natriuretic peptide (CNP) is the third member of the natriuretic peptide family. Unlike other members, i.e., atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which are cardiac hormones secreted from the atrium and ventricle of the heart, respectively, CNP is regarded as an autocrine/paracrine regulator with broad expression in the body. Because of its low expression levels compared to ANP and BNP, early studies failed to show its existence and role in the heart. However, recent studies have revealed the physiological and pathophysiological importance of CNP in the heart; in concert with the distribution of its specific natriuretic peptide receptor-B (NPR-B), CNP has come to be regarded as the major heart-protective natriuretic peptide in the failed heart. NPR-B generates intracellular cyclic guanosine 3',5'-monophosphate (cGMP) upon CNP binding, followed by various molecular effects including the activation of cGMP-dependent protein kinases, which generates diverse cytoprotective actions in cardiomyocytes, as well as in cardiac fibroblasts. CNP exerts negative inotropic and positive lusitropic responses in both normal and failing heart models. Furthermore, osteocrin, the intrinsic and specific ligand for the clearance receptor for natriuretic peptides, can augment the effects of CNP and may supply a novel therapeutic strategy for cardiac protection.
Language	English
Publishing date	2022-06-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology11060911
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Article ; Online: Physiological and Pathophysiological Effects of C-Type Natriuretic Peptide on the Heart

Akihiro Yasoda

Biology, Vol 11, Iss 911, p

2022 Volume 911

Abstract	C-type natriuretic peptide (CNP) is the third member of the natriuretic peptide family. Unlike other members, i.e., atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which are cardiac hormones secreted from the atrium and ventricle of the heart, respectively, CNP is regarded as an autocrine/paracrine regulator with broad expression in the body. Because of its low expression levels compared to ANP and BNP, early studies failed to show its existence and role in the heart. However, recent studies have revealed the physiological and pathophysiological importance of CNP in the heart; in concert with the distribution of its specific natriuretic peptide receptor-B (NPR-B), CNP has come to be regarded as the major heart-protective natriuretic peptide in the failed heart. NPR-B generates intracellular cyclic guanosine 3′,5′-monophosphate (cGMP) upon CNP binding, followed by various molecular effects including the activation of cGMP-dependent protein kinases, which generates diverse cytoprotective actions in cardiomyocytes, as well as in cardiac fibroblasts. CNP exerts negative inotropic and positive lusitropic responses in both normal and failing heart models. Furthermore, osteocrin, the intrinsic and specific ligand for the clearance receptor for natriuretic peptides, can augment the effects of CNP and may supply a novel therapeutic strategy for cardiac protection.
Keywords	CNP ; NPR-B ; osteocrin ; Biology (General) ; QH301-705.5
Subject code	571
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Physiological and Pathophysiological Effects of C-Type Natriuretic Peptide on the Heart

Yasoda, Akihiro

Biology. 2022 June 14, v. 11, no. 6

2022

Abstract	C-type natriuretic peptide (CNP) is the third member of the natriuretic peptide family. Unlike other members, i.e., atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which are cardiac hormones secreted from the atrium and ventricle of the heart, respectively, CNP is regarded as an autocrine/paracrine regulator with broad expression in the body. Because of its low expression levels compared to ANP and BNP, early studies failed to show its existence and role in the heart. However, recent studies have revealed the physiological and pathophysiological importance of CNP in the heart; in concert with the distribution of its specific natriuretic peptide receptor-B (NPR-B), CNP has come to be regarded as the major heart-protective natriuretic peptide in the failed heart. NPR-B generates intracellular cyclic guanosine 3′,5′-monophosphate (cGMP) upon CNP binding, followed by various molecular effects including the activation of cGMP-dependent protein kinases, which generates diverse cytoprotective actions in cardiomyocytes, as well as in cardiac fibroblasts. CNP exerts negative inotropic and positive lusitropic responses in both normal and failing heart models. Furthermore, osteocrin, the intrinsic and specific ligand for the clearance receptor for natriuretic peptides, can augment the effects of CNP and may supply a novel therapeutic strategy for cardiac protection.
Keywords	atrial natriuretic peptide ; autocrine signaling ; cGMP-dependent protein kinase ; cardiomyocytes ; fibroblasts ; guanosine ; ligands ; therapeutics
Language	English
Dates of publication	2022-0614
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology11060911
Database	NAL-Catalogue (AGRICOLA)

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Article: [Secondary osteoporosis. Hyperthyroidism.]

Yasoda, Akihiro

Clinical calcium

2019 Volume 28, Issue 12, Page(s) 1619–1625

Abstract: Thyrotoxicosis, commonly seen in a condition with Graves' disease, causes increased bone absorption and results in osteoporosis with increased bone turnover. The osteoporotic state is dominant in cortical bones with slight impairment of calcium- ... ...

Abstract	Thyrotoxicosis, commonly seen in a condition with Graves' disease, causes increased bone absorption and results in osteoporosis with increased bone turnover. The osteoporotic state is dominant in cortical bones with slight impairment of calcium-homeostasis, although the precise mechanism is still elusive. It ought to be recovered in accordance with the amelioration of thyroid hormone status, but past history of thyrotoxicosis might cause bone fragility, especially in post-menopausal or senile patients.
MeSH term(s)	Graves Disease ; Humans ; Hyperthyroidism ; Osteoporosis/etiology ; Thyroid Hormones ; Thyrotoxicosis
Chemical Substances	Thyroid Hormones
Language	Japanese
Publishing date	2019-02-05
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2386417-5
ISSN	0917-5857
ISSN	0917-5857
DOI	CliCa181216191625
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Article: [Medical treatment for osteoporosis with pulmonary disorders-from a viewpoint of an endocrinologist-.]

Yasoda, Akihiro

Clinical calcium

2016 Volume 26, Issue 10, Page(s) 1475–1481

Abstract: Today, we can treat osteoporotic patients with multiple drugs of various mechanisms and in various forms. Nevertheless, there exist few clinical evidences that exhibit an efficacy of an anti-osteoporotic drug on osteoporosis with pulmonary disorders, ... ...

Abstract	Today, we can treat osteoporotic patients with multiple drugs of various mechanisms and in various forms. Nevertheless, there exist few clinical evidences that exhibit an efficacy of an anti-osteoporotic drug on osteoporosis with pulmonary disorders, including asthma, COPD and OSAS. We should use drugs for osteoporotic patients with pulmonary disorders in accordance with a guideline on the management and treatment of glucocorticoid-induced osteoporosis or a guideline on the management and treatment of osteoporosis, according to whether they are treated by glucocorticoid or not.
MeSH term(s)	Bone Density/drug effects ; Endocrinologists ; Glucocorticoids/therapeutic use ; Humans ; Lung Diseases/diagnosis ; Lung Diseases/drug therapy ; Osteoporosis/diagnosis ; Osteoporosis/drug therapy ; Practice Guidelines as Topic
Chemical Substances	Glucocorticoids
Language	Japanese
Publishing date	2016
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2386417-5
ISSN	0917-5857
ISSN	0917-5857
DOI	CliCa161014751481
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Article ; Online: C-type Natriuretic Peptide-induced PKA Activation Promotes Endochondral Bone Formation in Hypertrophic Chondrocytes.

Hirota, Keisho / Hirashima, Tsuyoshi / Horikawa, Kazuki / Yasoda, Akihiro / Matsuda, Michiyuki

Endocrinology

2022 Volume 163, Issue 3

Abstract: Longitudinal bone growth is achieved by a tightly controlled process termed endochondral bone formation. C-type natriuretic peptide (CNP) stimulates endochondral bone formation through binding to its specific receptor, guanylyl cyclase (GC)-B. However, ... ...

Abstract	Longitudinal bone growth is achieved by a tightly controlled process termed endochondral bone formation. C-type natriuretic peptide (CNP) stimulates endochondral bone formation through binding to its specific receptor, guanylyl cyclase (GC)-B. However, CNP/GC-B signaling dynamics in different stages of endochondral bone formation have not been fully clarified, especially in terms of the interaction between the cyclic guanine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) pathways. Here, we demonstrated that CNP activates the cAMP/protein kinase A (PKA) pathway and that this activation contributed to the elongation of the hypertrophic zone in the growth plate. Cells of the chondrogenic line ATDC5 were transfected with Förster resonance energy transfer (FRET)-based cGMP and PKA biosensors. Dual-FRET imaging revealed that CNP increased intracellular cGMP levels and PKA activities in chondrocytes. Further, CNP-induced PKA activation was enhanced following differentiation of ATDC5 cells. Live imaging of the fetal growth plate of transgenic mice, expressing a FRET biosensor for PKA, PKAchu mice, showed that CNP predominantly activates the PKA in the hypertrophic chondrocytes. Additionally, histological analysis of the growth plate of PKAchu mice demonstrated that CNP increased the length of the growth plate, but coadministration of a PKA inhibitor, H89, inhibited the growth-promoting effect of CNP only in the hypertrophic zone. In summary, we revealed that CNP-induced cGMP elevation activated the cAMP/PKA pathway, and clarified that this PKA activation contributed to the bone growth-promoting effect of CNP in hypertrophic chondrocytes. These results provide insights regarding the cross-talk between cGMP and cAMP signaling in endochondral bone formation and in the physiological role of the CNP/GC-B system.
MeSH term(s)	Animals ; Cell Differentiation ; Cell Line ; Chondrocytes/physiology ; Cyclic AMP/metabolism ; Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Cyclic GMP/metabolism ; Enzyme Activation/drug effects ; Fluorescence Resonance Energy Transfer ; Growth Plate/growth & development ; Mice ; Mice, Transgenic ; Natriuretic Peptide, C-Type/pharmacology ; Osteogenesis/drug effects ; Osteogenesis/physiology ; Signal Transduction/drug effects ; Signal Transduction/physiology
Chemical Substances	Natriuretic Peptide, C-Type (127869-51-6) ; Cyclic AMP (E0399OZS9N) ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11) ; Cyclic GMP (H2D2X058MU)
Language	English
Publishing date	2022-01-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	427856-2
ISSN	1945-7170 ; 0013-7227
ISSN (online)	1945-7170
ISSN	0013-7227
DOI	10.1210/endocr/bqac005
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Article ; Online: Parathyroid Carcinoma in a Patient With Secondary Hyperparathyroidism and Thyroid Hemiagenesis: A Case Report and Review of the Literature.

Kada, Shinpei / Tanaka, Miho / Yasoda, Akihiro

Ear, nose, & throat journal

2021 Volume 103, Issue 1, Page(s) NP25–NP30

Abstract: Parathyroid carcinoma is a rare endocrine tumor. Parathyroid carcinoma in patients with secondary hyperparathyroidism due to chronic kidney disease is also rare. In addition, thyroid hemiagenesis is a rare congenital anomaly. We report an extremely rare ... ...

Abstract	Parathyroid carcinoma is a rare endocrine tumor. Parathyroid carcinoma in patients with secondary hyperparathyroidism due to chronic kidney disease is also rare. In addition, thyroid hemiagenesis is a rare congenital anomaly. We report an extremely rare case of parathyroid carcinoma in a patient with secondary hyperparathyroidism and thyroid hemiagenesis. We also present a review of the literature of this rare entity. We also discuss the surgical procedure performed for this patient. Our review of the literature found 34 case reports of parathyroid carcinoma in patients undergoing dialysis due to chronic renal failure; 14 reports of thyroid hemiagenesis with parathyroid disease; and no previous reports of thyroid hemiagenesis with secondary hyperparathyroidism and parathyroid carcinoma. Although surgical treatment of parathyroid carcinoma requires combined resection with the thyroid, peritracheal dissection with total parathyroidectomy, and monitoring intact parathyroid hormone as a tumor marker, our procedure preserved the patient's thyroid function. There has been no evidence of recurrence for over 8 years.
MeSH term(s)	Humans ; Thyroid Gland/pathology ; Parathyroid Neoplasms/complications ; Parathyroid Neoplasms/surgery ; Parathyroid Neoplasms/pathology ; Hyperparathyroidism, Secondary/complications ; Hyperparathyroidism, Secondary/surgery ; Parathyroidectomy/methods ; Parathyroid Hormone ; Renal Insufficiency, Chronic/complications ; Parathyroid Glands/pathology
Chemical Substances	Parathyroid Hormone
Language	English
Publishing date	2021-07-28
Publishing country	United States
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	750153-5
ISSN	1942-7522 ; 0145-5613
ISSN (online)	1942-7522
ISSN	0145-5613
DOI	10.1177/01455613211036240
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Article: Double somatic mutations in

Nanba, Kazutaka / Blinder, Amy R / Udager, Aaron M / Hirokawa, Yuusuke / Miura, Takayoshi / Okuno, Hiroshi / Moriyoshi, Koki / Yamazaki, Yuto / Sasano, Hironobu / Yasoda, Akihiro / Satoh-Asahara, Noriko / Rainey, William E / Tagami, Tetsuya

Frontiers in endocrinology

2024 Volume 15, Page(s) 1286297

Abstract: Double somatic mutations ... ...

Abstract	Double somatic mutations in
MeSH term(s)	Adult ; Female ; Pregnancy ; Humans ; Middle Aged ; Adrenocortical Adenoma/complications ; Adrenocortical Adenoma/genetics ; Adrenocortical Adenoma/surgery ; Aldosterone/metabolism ; Cytochrome P-450 CYP11B2/metabolism ; beta Catenin/genetics ; beta Catenin/metabolism ; Hyperaldosteronism/genetics ; Hyperaldosteronism/surgery ; Adenoma/genetics ; Adenoma/surgery ; Adenoma/metabolism ; Hypertension/complications ; Mutation ; GTP-Binding Protein alpha Subunits/genetics ; GTP-Binding Protein alpha Subunits/metabolism
Chemical Substances	Aldosterone (4964P6T9RB) ; Cytochrome P-450 CYP11B2 (EC 1.14.15.4) ; beta Catenin ; CTNNB1 protein, human ; GNA11 protein, human ; GTP-Binding Protein alpha Subunits
Language	English
Publishing date	2024-03-05
Publishing country	Switzerland
Document type	Case Reports ; Journal Article
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2024.1286297
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Article: Increasing Burden of Nursing Care on the Treatment of COVID-19 Patients in the Aging Society: Analyses During the First to the Third Wave of Pandemic in Kyoto City, Japan.

Fujita, Kohei / Kashihara, Eriko / Kanai, Osamu / Hata, Hiroaki / Yasoda, Akihiro / Odagaki, Takao / Mio, Tadashi

Frontiers in medicine

2021 Volume 8, Page(s) 767110

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-11-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2021.767110
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Article ; Online: Cross-sectional association of skeletal muscle mass and strength with dietary habits and physical activity among first-year university students in Japan: Results from the KEIJI-U study.

Kusakabe, Toru / Arai, Hiroshi / Yamamoto, Yuji / Nakao, Kazuwa / Akamatsu, Yasunori / Ishihara, Yuki / Tagami, Tetsuya / Yasoda, Akihiro / Satoh-Asahara, Noriko

Nutrition (Burbank, Los Angeles County, Calif.)

2023 Volume 118, Page(s) 112265

Abstract: Objective: Recently, the high prevalence of young Japanese individuals who are underweight has received attention because of the potential risk for sarcopenia. The aim of this study was to examine the prevalence and characteristics of sarcopenia in ... ...

Abstract	Objective: Recently, the high prevalence of young Japanese individuals who are underweight has received attention because of the potential risk for sarcopenia. The aim of this study was to examine the prevalence and characteristics of sarcopenia in Japanese youth. Methods: In this cross-sectional study, we measured skeletal muscle mass using a multifrequency bioelectrical impedance analysis device and handgrip strength (HGS) and administered questionnaires on dietary habits and physical activity in 1264 first-year university students ages 18 to 20 y (838 men and 426 women). Sarcopenia was confirmed based on the presence of both low skeletal muscle mass and weak muscle strength. Results: In all, 145 men (17%) and 69 women (16%) were diagnosed as underweight. Sarcopenia was diagnosed in 8 men (1%) and 5 women (1%). There was a significantly higher prevalence of low skeletal muscle mass index (SMI) and/or weak HGS in underweight individuals than in those in other body mass index (BMI) ranges. The multivariate analyses indicated that SMI and HGS were significantly associated with BMI in both sexes. Furthermore, after adjusting for BMI, both SMI and HGS were significantly associated with physical activity in men, and SMI was significantly associated with energy intake in women. Conclusions: First-year university students showed a high incidence of being underweight with low SMI and/or weak HGS, but the prevalence of sarcopenia was low in both sexes. There may be sex differences in factors related to muscle mass and strength, but further research is needed to clarify this.
MeSH term(s)	Humans ; Female ; Male ; Adolescent ; Sarcopenia/etiology ; Cross-Sectional Studies ; Japan/epidemiology ; Hand Strength/physiology ; Thinness/complications ; Universities ; Muscle Strength/physiology ; Muscle, Skeletal/pathology ; Exercise ; Feeding Behavior ; Students
Language	English
Publishing date	2023-10-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2023.112265
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