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  1. Article: Immunosuppressant Therapies in COVID-19: Is the TNF Axis an Alternative?

    Palacios, Yadira / Chavez-Galan, Leslie

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 5

    Abstract: The study of cytokine storm in COVID-19 has been having different edges in accordance with the knowledge of the disease. Various cytokines have been the focus, especially to define specific treatments; however, there are no conclusive results that fully ... ...

    Abstract The study of cytokine storm in COVID-19 has been having different edges in accordance with the knowledge of the disease. Various cytokines have been the focus, especially to define specific treatments; however, there are no conclusive results that fully support any of the options proposed for emergency treatment. One of the cytokines that requires a more exhaustive review is the tumor necrosis factor (TNF) and its receptors (TNFRs) as increased values of soluble formats for both TNFR1 and TNFR2 have been identified. TNF is a versatile cytokine with different impacts at the cellular level depending on the action form (transmembrane or soluble) and the receptor to which it is associated. In that sense, the triggered mechanisms can be diversified. Furthermore, there is the possibility of the joint action provided by synergism between one or more cytokines with TNF, where the detonation of combined cellular processes has been suggested. This review aims to discuss some roles of TNF and its receptors in the pro-inflammatory stage of COVID-19, understand its ways of action, and let to reposition this cytokine or some of its receptors as therapeutic targets.
    Language English
    Publishing date 2022-05-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15050616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Immunosuppressant Therapies in COVID-19

    Yadira Palacios / Leslie Chavez-Galan

    Pharmaceuticals, Vol 15, Iss 616, p

    Is the TNF Axis an Alternative?

    2022  Volume 616

    Abstract: The study of cytokine storm in COVID-19 has been having different edges in accordance with the knowledge of the disease. Various cytokines have been the focus, especially to define specific treatments; however, there are no conclusive results that fully ... ...

    Abstract The study of cytokine storm in COVID-19 has been having different edges in accordance with the knowledge of the disease. Various cytokines have been the focus, especially to define specific treatments; however, there are no conclusive results that fully support any of the options proposed for emergency treatment. One of the cytokines that requires a more exhaustive review is the tumor necrosis factor (TNF) and its receptors (TNFRs) as increased values of soluble formats for both TNFR1 and TNFR2 have been identified. TNF is a versatile cytokine with different impacts at the cellular level depending on the action form (transmembrane or soluble) and the receptor to which it is associated. In that sense, the triggered mechanisms can be diversified. Furthermore, there is the possibility of the joint action provided by synergism between one or more cytokines with TNF, where the detonation of combined cellular processes has been suggested. This review aims to discuss some roles of TNF and its receptors in the pro-inflammatory stage of COVID-19, understand its ways of action, and let to reposition this cytokine or some of its receptors as therapeutic targets.
    Keywords TNF ; TNFR1 ; COVID-19 ; inhibitor ; therapy ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Subject code 610
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Opportunistic Infections and Immune-Related Adverse Events Associated with Administering Immune Checkpoint Inhibitors: A Narrative Review.

    Ocaña-Guzmán, Ranferi / Osorio-Pérez, Diego / Chavez-Galan, Leslie

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 8

    Abstract: Manipulating the immune system by blocking the immune checkpoint receptors is the basis of immunotherapy, a relevant tool in current clinical oncology. The strategy of blocking the immune checkpoints (Immune Checkpoint Inhibitors, ICI) consists of using ... ...

    Abstract Manipulating the immune system by blocking the immune checkpoint receptors is the basis of immunotherapy, a relevant tool in current clinical oncology. The strategy of blocking the immune checkpoints (Immune Checkpoint Inhibitors, ICI) consists of using monoclonal antibodies to inhibit the interaction between ligand and inhibitory receptors from triggering a complete activation of helper and cytotoxic T cells to fight against tumour cells. Immunotherapy has benefited patients with diverse cancers such as stomach, lung, melanoma, and head and neck squamous cell carcinoma, among others. Unfortunately, a growing number of reports have indicated that the ICI treatment also can show a dark side under specific conditions; some of the adverse effects induced by ICI are immunosuppression, opportunistic infections, and organ-specific alterations. This review discusses some immunologic aspects related to these unwanted effects.
    Language English
    Publishing date 2023-08-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16081119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Virulence Factors of

    Ramon-Luing, Lucero A / Palacios, Yadira / Ruiz, Andy / Téllez-Navarrete, Norma A / Chavez-Galan, Leslie

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 6

    Abstract: Mycobacterium ... ...

    Abstract Mycobacterium tuberculosis
    Language English
    Publishing date 2023-06-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12060839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Lipoarabinomannan as a Point-of-Care Assay for Diagnosis of Tuberculosis: How Far Are We to Use It?

    Flores, Julio / Cancino, Juan Carlos / Chavez-Galan, Leslie

    Frontiers in microbiology

    2021  Volume 12, Page(s) 638047

    Abstract: Tuberculosis (TB) is still a severe public health problem; the current diagnostic tests have limitations that delay treatment onset. Lipoarabinomannan (LAM) is a glycolipid that is a component of the cell wall of the ... ...

    Abstract Tuberculosis (TB) is still a severe public health problem; the current diagnostic tests have limitations that delay treatment onset. Lipoarabinomannan (LAM) is a glycolipid that is a component of the cell wall of the bacillus
    Language English
    Publishing date 2021-04-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2021.638047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Association of

    Gutiérrez-Pérez, Ilse Adriana / Buendía-Roldán, Ivette / Zaragoza-García, Oscar / Pérez-Rubio, Gloria / Villafan-Bernal, José Rafael / Chávez-Galán, Leslie / Parra-Rojas, Isela / Hernández-Zenteno, Rafael de Jesús / Fricke-Galindo, Ingrid / Castro-Alarcón, Natividad / Bautista-Becerril, Brandon / Falfán-Valencia, Ramcés / Guzmán-Guzmán, Iris Paola

    Heliyon

    2024  Volume 10, Issue 6, Page(s) e27997

    Abstract: Background: Enzymes of the peptidylarginine deiminase family (PADs) play a relevant role in the pathogenesis of COVID-19. However, the association of single nucleotide polymorphisms (SNPs) in their genes with COVID-19 severity and death is unknown.: ... ...

    Abstract Background: Enzymes of the peptidylarginine deiminase family (PADs) play a relevant role in the pathogenesis of COVID-19. However, the association of single nucleotide polymorphisms (SNPs) in their genes with COVID-19 severity and death is unknown.
    Methodology: We included 1045 patients who were diagnosed with COVID-19 between October 2020 and December 2021. All subjects were genotyped for
    Results: 291 patients presented had severe COVID-19 according to PaO
    Conclusions: Our results suggest that the haplotypic combination of GTACC and some individual genotypes of
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27997
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Genetic variants in

    López-Bielma, María Fernanda / Falfán-Valencia, Ramcés / Fierro-Piña, Aurelio / Abarca-Rojano, Edgar / Córdoba-Lanus, Elizabeth / Fricke-Galindo, Ingrid / Romero-Villaseñor, Priscila / Buendía-Roldán, Ivette / Chávez-Galán, Leslie / Jaime-Capetillo, María Esther / Pérez-Rubio, Gloria

    Heliyon

    2024  Volume 10, Issue 8, Page(s) e29493

    Abstract: Introduction: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of Coronavirus Disease 2019 (COVID-19). The disease has a wide range of clinical manifestations, from asymptomatic to severe. Ancestral contribution, ... ...

    Abstract Introduction: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of Coronavirus Disease 2019 (COVID-19). The disease has a wide range of clinical manifestations, from asymptomatic to severe. Ancestral contribution, sex, immune response, and genetic factors influence the presentation of the disease. The objective of the present study was to validate these genetic variants in patients with severe COVID-19 who died and in survivor patients. Methods: Single nucleotide variants (SNVs) in six genes: ATPase plasma membrane Ca
    Results: In non-related patients with severe COVID-19, carriers of GG genotype (rs2289274) in the
    Conclusions: Unrelated patients with severe COVID-19 that carry the GG genotype (rs2289274) in
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e29493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Tuberculosis en tiempos de COVID-19

    Alexia Urbán-Solano / Yerany Aguilar-Durán / Julio Flores-Gonzalez / Leslie Chavéz-Galán

    Ciencia Ergo Sum, Vol 29, Iss

    cambios y oportunidades

    2022  Volume 4

    Abstract: Se discute cómo el proyecto End TB, que planteaba erradicar la tuberculosis para 2030, se ha visto afectado por atender patologías emergentes; en consecuencia, su tasa de infección y mortalidad incrementó en 2021. Aunque la atención de la comunidad ... ...

    Abstract Se discute cómo el proyecto End TB, que planteaba erradicar la tuberculosis para 2030, se ha visto afectado por atender patologías emergentes; en consecuencia, su tasa de infección y mortalidad incrementó en 2021. Aunque la atención de la comunidad científica está centrada en COVID-19, no debe olvidarse a la tuberculosis. Ambas patologías muestran importantes similitudes, las cuales permiten sugerir que la inversión en la investigación conjunta puede aprovecharse para el desarrollo de nuevas estrategias diagnósticas y terapéuticas. Analizar la tuberculosis, enfermedad infecciosa que es un problema de salud pública, en el contexto de la pandemia por COVID-19 ayuda a evidenciar las carencias de los sistemas de salud en el mundo.
    Keywords tuberculosis ; enfermedades infecciosas ; covid ; 19 ; epidemiología ; Science ; Q ; Social Sciences ; H
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Universidad Autonoma del Estado de Mexico
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: The rs16969968 Tobacco Smoking-Related Single-Nucleotide Variant Is Associated with Clinical Markers in Patients with Severe COVID-19.

    Valencia-Pérez Rea, Daniela / Falfán-Valencia, Ramcés / Fricke-Galindo, Ingrid / Buendía-Roldán, Ivette / Chávez-Galán, Leslie / Nava-Quiroz, Karol J / Alanis-Ponce, Jesús / Pérez-Rubio, Gloria

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: Tobacco smoking is the leading risk factor for many respiratory diseases. Several genes are associated with nicotine addiction, such ... ...

    Abstract Tobacco smoking is the leading risk factor for many respiratory diseases. Several genes are associated with nicotine addiction, such as
    MeSH term(s) Humans ; C-Reactive Protein/genetics ; Receptors, Nicotinic/genetics ; Polymorphism, Single Nucleotide ; COVID-19/genetics ; Tobacco Smoking ; Biomarkers ; Fibrinogen/genetics ; Nucleotides ; Genetic Predisposition to Disease ; ADAM Proteins/genetics
    Chemical Substances C-Reactive Protein (9007-41-4) ; Receptors, Nicotinic ; Biomarkers ; Fibrinogen (9001-32-5) ; Nucleotides ; ADAM33 protein, human (EC 3.4.24.-) ; ADAM Proteins (EC 3.4.24.-)
    Language English
    Publishing date 2023-06-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24129811
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Editorial: Translational research in severe COVID-19 and long-term symptoms post-COVID-19.

    Vicens-Zygmunt, Vanesa / Pérez-Rubio, Gloria / Chavez-Galan, Leslie / Buendia-Roldan, Ivette / Falfán-Valencia, Ramcés

    Frontiers in medicine

    2023  Volume 10, Page(s) 1261211

    Language English
    Publishing date 2023-09-27
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1261211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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